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All Journal Jurnal Teknik Kimia USU Jurnal Riset Kimia JURNAL PHOTON Acta Biochimica Indonesiana Turast: Jurnal Penelitian dan Pengabdian Jurnal Inovasi Pendidikan dan Sains Jurnal Pengabdian kepada Masyarakat Nusantara Unri Conference Series: Community Engagement Current Research on Biosciences and Biotechnology Jurnal Media Informatika pendidikan, science, teknologi, dan ekonomi Jurnal Teknik Kimia USU
Novianty, Riryn
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Journal : JURNAL PHOTON

 1 
MEMPELAJARI DAYA INHIBISI ION CU2+ DAN CA2+ SERTA POLA INHIBISINYA TERHADAP ENZIM AKONITASE YANG DIISOLASI DARI BUAH KALIKIH ALANG (RICINUS COMMUNIS) Novianty, Riryn; Chaidir, Zulkarnain; Mardiah, Elida
Sistem Informasi Vol 5 No 1 (2014): Jurnal Photon
Publisher : Fakultas MIPA dan Kesehatan Universitas Muhammadiyah Riau

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Abstract

Penelitian tentang inhibisi aktivitas enzim akonitase dengan menggunakan inhibitor ion Cu2+ dan Ca2+ telah dilakukan. Enzim akonitase diisolasi dari buah Ricinus communis dengan menggunakan aseton dingin. Untuk menentukan aktivitas dari akonitase digunakan metoda pengukuran substrat asam sitrat sisa berdasarkan metoda LStahre’s test. Kadar protein ditentukan dengan menggunakan metoda Lowry. Optimasi dari enzim akonitase didapatkan dari hasil pH optimum 7,3, temperatur optimum 40 oC, dan konsentrasi substrat 1 %. Dari kurva Lineaweaver Burk diperoleh harga Km = 0,104 M. Sedangkan untuk mengetahui daya pola inhibisi ion Cu2+ dan Ca2+ dilakukan dengan menvariasikan konsentrasi dari masing-masing ion tersebut. Daya inhibisi ion Cu2+ dengan konsentrasi 0,1 M adalah 93,347 % dan daya ion Ca2+ pada konsentrasi 0,1 M adalah 60,124 %. Hasil tersebut menunjukkan pola inhibisi yang sama yakni inhibisi non kompetitif dan masing-masing ion memiliki daya inhibisi yang berbeda.
MEMPELAJARI DAYA INHIBISI ION CU2+ DAN CA2+ SERTA POLA INHIBISINYA TERHADAP ENZIM AKONITASE YANG DIISOLASI DARI BUAH KALIKIH ALANG (RICINUS COMMUNIS) Riryn Novianty; Zulkarnain Chaidir; Elida Mardiah
Sistem Informasi Vol 5 No 1 (2014): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v5i1.411

Abstract

Penelitian tentang inhibisi aktivitas enzim akonitase dengan menggunakan inhibitor ion Cu2+ dan Ca2+ telah dilakukan. Enzim akonitase diisolasi dari buah Ricinus communis dengan menggunakan aseton dingin. Untuk menentukan aktivitas dari akonitase digunakan metoda pengukuran substrat asam sitrat sisa berdasarkan metoda LStahre’s test. Kadar protein ditentukan dengan menggunakan metoda Lowry. Optimasi dari enzim akonitase didapatkan dari hasil pH optimum 7,3, temperatur optimum 40 oC, dan konsentrasi substrat 1 %. Dari kurva Lineaweaver Burk diperoleh harga Km = 0,104 M. Sedangkan untuk mengetahui daya pola inhibisi ion Cu2+ dan Ca2+ dilakukan dengan menvariasikan konsentrasi dari masing-masing ion tersebut. Daya inhibisi ion Cu2+ dengan konsentrasi 0,1 M adalah 93,347 % dan daya ion Ca2+ pada konsentrasi 0,1 M adalah 60,124 %. Hasil tersebut menunjukkan pola inhibisi yang sama yakni inhibisi non kompetitif dan masing-masing ion memiliki daya inhibisi yang berbeda.
Analisis Interaksi Senyawa Guvakolin dan Homoarekolin terhadap MAO-A secara in Silico Riryn Novianty
Sistem Informasi Vol 13 No 1 (2022): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v13i1.5042

Abstract

This study was aimed to conduct the inhibitory activity of the MAO-A enzyme (PDB ID: 2Z5Y) by the active compounds of Areca catechu L. The method used is in silico approach using AutoDock Vina, PyMol, and Discovery Studio (DSV). The prediction of pharmacokinetic properties and drug-likeness used the Swiss-ADME online website. The docking results exhibited guvacoline has a binding free energy value of -5.9 kcal / mol compared to homoarecoline (-5.4 kcal / mol), and positive control (-5.7 kcal / mol). Guvacoline compounds have a hydrogen bond in the active site of the enzyme. Areca nut compounds obtained good results on pharmacokinetic properties, but not so good on the BBB parameter. The compounds obtained good results for the parameters of the Lipinski, Veber rule, bioavailability score, but the guvacoline compounds could not meet Ghose's rule. The results of the bioavailability radar showed that the compounds have properties as oral drug.
Innovation of Areca catechu Compounds Combined with Fluoxetine as Antidepressant by In Silico Method Riryn Novianty; Rexi Dwi Wardana; Ulya Putri Ningsih; Rahmad Setiawan Rabb
Sistem Informasi Vol 13 No 2 (2023): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v13i2.5041

Abstract

Depression is a mental illness that has become a common problem worldwide with more than 300 million cases. The study aimed to determine the effectiveness of natural compound modification with synthetic compounds as new antidepressant drug candidates. The method used in the research is In Silico approach using ChemSketch software, BIOVIA Discovery Studio Visualizer (DSV), and Autodock Vina. The bond-free energy result from a combination of arecoline, homoarecoline and guvacoline with fluoxetine on 2Z5Y protein were -7.1 kcal/mol; -7.1 kcal/mol and -7.6 kcal/mol, respectively. Meanwhile, in 2NW8 protein, the bond free energy observed were -6.3 kcal/mol; -6.3 kcal/mol, and -8.8 kcal/mol, respectively. Based on bond-free energy data, the additive interaction of arecoline-fluoxetine and fluoxetine-homoarecoline on MAO-A protein (2Z5Y) was barely different from fluoxetine itself. Meanwhile, the additive interaction of guvacoline-fluoxetine was better with serotonin precursor protein (2NW8) rather than MAO-A protein (2Z5Y).
Biodegradasi Hidrokarbon Crude Oil di Kawasan PT. Bumi Siak Pusako-Pertamina Hulu menggunakan Konsorsium Bakteri Indigen Riryn Novianty; Yuharmen Yuharmen
Sistem Informasi Vol 13 No 2 (2023): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v13i2.5053

Abstract

Riau Province is one of the largest producing areas of crude oil. Drilling and refining petroleum often produce waste crude oil in large quantities. One method that can be used to degrade waste is biodegradation using a consortium of microorganisms. This study examined the effectiveness of a consortium of indigenous bacteria in degrading hydrocarbon compounds. Growth tests and the ability of isolates to degrade hydrocarbons were carried out by inoculating isolates in liquid Bushnell Haas media containing crude oil of about 5% and incubating for 16 days. The potency of the indigen bacterial consortium during the degradation process is influenced by several parameters, including pH, OD (Optical Density), dan CO2 observed on days 0, 4, 8, 12 and 16 days of incubation. KB4 is the superior consortium in degrading hydrocarbon crude oil. Based on the analysis using GC-MS instruments, the bacteria consortium can degrade two hydrocarbon compounds in crude oil.
Nut in Swiss Albino Mice Independently Assessed by the Forced Swim Test Novianty, Riryn; Yuharmen, Yuharmen; Sofyanti, Nery; Ya’la, Fitra Audhi
Photon: Jurnal Sain dan Kesehatan Vol. 15 No. 2 (2025): Journal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v15i2.9294

Abstract

Depression is a global mental health issue and herbal antidepressants are increasingly sought due to the side effects of synthetic drugs. The present study aimed to evaluate the potential of ethyl acetate extract of old areca nut in treating depression of mice subjected to acute and sub-chronic Forced Swim Test (FST). Ethyl acetate extract was injected intraperitoneally 1 h before the FST at a dose of 50 and 100 mg/kg. The 100 mg/kg dose showed the greatest reduction in immobility time (22.29%) during acute testing. Following seven days of treatment, it was discovered that the extract significantly alleviated the immobility time in sub-chronic FST. The results of the phytochemical analysis showed that phenolics present in the ethyl acetate extract are probably active constituents with antidepressant properties. After prolonged administration, the substance has no toxic effects on the bodies of test animals.
Co-Authors Aisyah Fitrida Amir Awaluddin Andi Dahliaty Elida Mardiah Endang Maya Sari Evelin Natasyah Fitra Audhi Ya’la Haryati Haryati HENDRI WASITO Indriani, Dwi Wahyu Jasril Jasril Muhdarina Musyima Rahmah Nst Naila Rahmi Nery Sofiyanti Nery Sofyanti Nova Wahyu Pratiwi Nova Wahyu Pratiwi Nst, Musyima Rahmah Nuraini Ramadhani Nurul Iflah Nasution Prima Fitra Rahmad Setiawan Rabb Rexi Dwi Wardana Rina Amtarina Rizki Dwi Ningsih Roza Elvyra Saryono Saryono Saryono Silvera Devi Silvera Devy Sofyanti, Nery Sony Ananta Ulya Putri Ningsih Wahyu Pratiwi , Nova Ya'la, Fitra Audhi Ya’la, Fitra Audhi Yuharmen Yuharmen - Yuharmen, Yuharmen Zulkarnain Chaidir