Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal SINTA Journal (Science, Technology, and Agricultural) Sciences of Pharmacy
Sella, Arinda Tri Pramay
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Environmental Science Health Professions Medicine & Pharmacology Physics Public Health Veterinary

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Effect of Kupa Fruit Extract Concentration (Syzygium polycephalum) on Decreasing Blood Sugar Levels of Alloxan-Induced Male Mice (Mus musculus) Dharmayanti, Luky; Novia, Devi; Sella, Arinda Tri Pramay
SINTA Journal (Science, Technology, and Agricultural) Vol. 5 No. 1 (2024)
Publisher : Perkumpulan Dosen Muda (PDM) Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37638/sinta.5.1.93-100

Abstract

Kupa fruit is a rare fruit that has a blackish purple color which has antioxidant potential, in vitro research is supported by the high levels of antioxidants and vitamin C in kupa fruit so that it can reduce blood sugar levels. Syzygium polycephalum is a plant that contains flavonoids so it has pharmacological potential as an antidiabetic, because it contains flavonoid compounds which can be used as antidiabetic prevention. This research aims to find out how effective Kupa fruit extract is and determine the right dose to reduce minimum blood sugar levels in mice that have been induced by alloxan. The research used an alloxan-induced testing method. There were 30 mice grouped into 6 treatments including normal control group mice, negative group mice, positive control mice, kupa fruit extract at a dose of 500 mg/Kg BW, fruit extract at a dose of 750 mg/kg BW and fruit extract at a dose of 1000 mg/Kg BW. The inducer to increase blood sugar levels in mice was Aloxan monohydrate using a dose of 150 Mg/KgBW using the intraperitoneal route of administration. The extract was administered for 14 days, the blood sugar levels of H0, H7 and H14 were measured using a glucotest strip (Easy Touch GCU) by taking samples from mice whose blood was taken through the tail of the lateral vein. Analysis of Results Through the SPSS One Way Anova test, the test was continued with a confidence level of 95% (p<0.05) using Posct Hoc. The results of the research were that there was a change in effect, namely a decrease in blood sugar levels in mice treated with extract from kupa fruit and the most effective dose was a decrease in blood sugar levels in mice, namely a dose of 1000 Mg/KgBW, followed by a dose of kupa fruit extract of 750 Mg/KgBW and finally with a dose of 500 Mg/KgBB.
Ethanol Extract of Grass Jelly Leaves: Bioactive Analysis and In silico Study on Estrogen Receptor Alpha Related to MCF-7 Breast Cancer Irpani, Abdul Mulki; Yuliantini, Anne; Bintang, Muhammad Ilham; Sella, Arinda Tri Pramay; Sodik, Jajang Japar
Sciences of Pharmacy Volume 5 Issue 3 (2026)
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0502619

Abstract

Breast cancer is a major cause of mortality among women and requires the development of alternative therapies derived from natural products. This study aimed to profile bioactive compounds in the ethanol extract of gras jelly leaves (Cyclea barbata Miers) and evaluate their predicted interactions with estrogen receptor alpha (ERα), a key regulator of proliferation in ER-positive MCF-7 breast cancer cells using an in silico approach. LC–HRMS analysis followed by database matching tentatively annotataed 44 major compounds based on peak intensity after data filtering. Molecular docking and simulation results indicated that several compounds exhibited favorable predicted binding affinity toward estrogen receptor targets. Among them, (3β,24R,24′R)-fucosterol epoxide demonstrated the most stable interaction. These findings suggest that the compound showed promising interaction stability toward the estrogen receptor in computational analysis. However, further in vitro and in vivo studies are required to validate its biological activity.
Co-Authors Abdul Mulki Irpani Bintang, Muhammad Ilham dharmayanti, luky dharmayanti Jajang Japar Sodik Novia, Devi Yuliantini, Anne