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ARTICLE REVIEW: UTILIZATION OF CURCUMIN AS AN ANTI-CANCER AGENT Abdul Mulki Irpani; Deden Indra Dinata; Garnadi Jafar
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1062

The uncontrolled growth of abnormal cells in one area of the body can spread to other tissues and create more cancer cells, a disease known as cancer. Malignant cancer cells have the potential to become fatal. After cardiovascular disease, cancer is the second most common cause of mortality. Numerous cancer types exist, including stomach, liver, colorectal, lung, breast, and cervical cancers. More than 70% of cancer-related deaths occur in low- and middle-income nations, and the number of cancer-related deaths is predicted to rise steadily, hitting 11.5 million by 2030. Some of the resources utilized to look up information on curcumin's application as an anticancer agent are PubMed, Science Direct, and Google Scholar. Most of the articles that were used were published between 2013 and 2023, or within the last ten years. These journals were found using the following keywords: "Curcumin," "Cancer," "Curcumin as an Anticancer," and "Utilization of Curcumin as an Anticancer Agent." Scholars from many nations have conducted comparable investigations on the application of curcumin as an anticancer agent. Furthermore, it has been established that curcumin directly inhibits cancer cells when used as an anticancer drug. This suggests that curcumin does have anticancer properties. Keywords: Curcumin, Cancer, Curcumin as an Anticancer agent

UJI IN-SILICO SENYAWA TURUNAN KURKUMINOID SEBAGAI INHIBITOR BRUTON TYROSINE KINASE PADA LEUKIMIA LIMFOSITIK KRONIS Mulki Irpani, Abdul; Ilham Bintang, Muhamad; Putriyanti, Al-fira; Adinda, Deistha; Japar Sodik, Jajang
Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-ilmu Keperawatan, Analis Kesehatan dan Farmasi Vol. 25 No. 1 (2025): Jurnal Kesehatan Bakti Tunas Husada Volume 25 Nomor 1 Tahun 2025
Publisher : LPPM Universitas Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jkbth.v25i1.1496

Leukemia is a blood cancer that occurs due to abnormal blood cell growth, especially white blood cells in the bone marrow. Research shows that curcumin is proven to be effective in inhibiting the activity of the NF-κB transcription factor which is often involved in the proliferation of cancer cells. This study aims to determine the potential of natural curcuminoid compounds against specific blood cancers, namely chronic lymphocytic leukemia. Through in-silico testing of curcuminoid derivative compounds against the Bruton Tyrosine Kinase protein target which plays a role in the pathophysiological process of chronic lymphocytic leukemia. The results of docking the test ligand molecule on the Tyrosine-protein kinase BTK enzyme, the native ligand has the lowest binding energy value (ΔG) of -12.04 kcal/mol with an inhibition constant (KI) of 1.49 nM. As a comparison drug, imatinib showed ΔG -11.05 kcal/mol with a KI of 7.88 nM. Test ligands s02, s05, and s08. Ligand s02 showed a ΔG of -9.43 kcal/mol with a KI of 123.19 nM, while s05 had a ΔG of -9.09 kcal/mol with a KI of 218.10 nM. Meanwhile, s08 recorded a ΔG of -9.33 kcal/mol and a KI of 143.83 nM. Although the affinity values of the three test ligands were lower than those of the natural ligands, they had the potential to bind to the target enzyme. Based on the interaction analysis, it was seen that s05 had the potential for competitive inhibition, while s02 and s08 showed lower interaction stability compared to imatinib. This indicates that s05 has the greatest potential as a potential inhibitor of the BTK enzyme compared to other test ligands.

UJI IN-SILICO SENYAWA TURUNAN KURKUMINOID SEBAGAI INHIBITOR BRUTON TYROSINE KINASE PADA LEUKIMIA LIMFOSITIK KRONIS Mulki Irpani, Abdul; Ilham Bintang, Muhamad; Putriyanti, Al-fira; Adinda, Deistha; Japar Sodik, Jajang
Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-ilmu Keperawatan, Analis Kesehatan dan Farmasi Vol 25 No 1 (2025)
Publisher : LPPM Universitas Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jkbth.v25i1.1496

Leukemia is a blood cancer that occurs due to abnormal blood cell growth, especially white blood cells in the bone marrow. Research shows that curcumin is proven to be effective in inhibiting the activity of the NF-κB transcription factor which is often involved in the proliferation of cancer cells. This study aims to determine the potential of natural curcuminoid compounds against specific blood cancers, namely chronic lymphocytic leukemia. Through in-silico testing of curcuminoid derivative compounds against the Bruton Tyrosine Kinase protein target which plays a role in the pathophysiological process of chronic lymphocytic leukemia. The results of docking the test ligand molecule on the Tyrosine-protein kinase BTK enzyme, the native ligand has the lowest binding energy value (ΔG) of -12.04 kcal/mol with an inhibition constant (KI) of 1.49 nM. As a comparison drug, imatinib showed ΔG -11.05 kcal/mol with a KI of 7.88 nM. Test ligands s02, s05, and s08. Ligand s02 showed a ΔG of -9.43 kcal/mol with a KI of 123.19 nM, while s05 had a ΔG of -9.09 kcal/mol with a KI of 218.10 nM. Meanwhile, s08 recorded a ΔG of -9.33 kcal/mol and a KI of 143.83 nM. Although the affinity values of the three test ligands were lower than those of the natural ligands, they had the potential to bind to the target enzyme. Based on the interaction analysis, it was seen that s05 had the potential for competitive inhibition, while s02 and s08 showed lower interaction stability compared to imatinib. This indicates that s05 has the greatest potential as a potential inhibitor of the BTK enzyme compared to other test ligands.

Studi Penambatan Molekul Senyawa Turunan Kurkuminoid Terhadap Enzim Penicillin Binding Protein 2A Pada Bakteri MRSA Mulki Irpani, Abdul; Indra Dinata, Deden
JURNAL FARMASI GALENIKA Vol 10 No 3 (2023): Jurnal Farmasi Galenika Vol 10 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v10i3.322

Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterium that is resistant to ?-lactam antibiotics such as methicillins, a clinical problem that continues to affect the entire world. Resistance occurs as a result of the structural modification of Penicillin Binding Protein Penicilin Binding (PBP) MRSA. An organic active compound with antibacterial properties has sparked public interest, one of which is curcumin, which is known to have powerful antibacteric potential and can damage bacterial membranes. The aim of this study is to identify a compound of curcuminoid derivatives that could potentially be an antibacterial drug candidate for MRSA with in silico studies using molecular docking methods. The results obtained curcumin compounds have a free-binding energy of -5,56 kcal/mol, de-methoxy curcumine -6,25 kcal /mol and bis-demethoxy curcumin -6,24 kkal /mol. The interactions formed indicate the affinity of binding, from the data obtained all ligans possess good affinities even though the value of free-binding energy is lower than natural ligans.

Articel Inovasi Bubur Kering Kaya Nutrisi Solusi Praktis Pemenuhan Gizi Balita dalam Masa Pertumbuhan Irpani, Abdul Mulki
Karya Kesehatan Journal of Community Engagement Vol 6 No 2 (2025): Karya Kesehatan Journal of Community Engangement
Publisher : Sekolah Tinggi Ilmu Kesehatan Karya Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46233/k2jce.v6i2.1632

Program Pengabdian kepada Masyarakat (PKM) telah dilaksanakan di wilayah RW 23 Desa Cinunuk, Kecamatan Cileunyi dengan tujuan meningkatkan pengetahuan dan keterampilan warga dalam penyediaan Makanan Pendamping ASI (MP-ASI) bergizi berbasis pangan lokal sederhana. Kegiatan diawali dengan tahap penjajakan mitra untuk mengidentifikasi permasalahan terkait rendahnya kualitas asupan gizi balita akibat keterbatasan pengetahuan, waktu, dan akses bahan pangan bergizi. Solusi yang ditawarkan berupa edukasi gizi dan pelatihan pembuatan bubur kering instan berbahan beras yang diperkaya sayuran atau sumber protein sebagai alternatif pangan praktis dan bergizi. Selain itu, dilakukan pemeriksaan kesehatan orang tua balita serta kegiatan senam sehat sebagai upaya holistik meningkatkan kesehatan masyarakat. Hasil evaluasi menunjukkan adanya peningkatan signifikan terhadap pemahaman warga setelah mengikuti kegiatan, ditandai dengan kenaikan nilai posttest sebesar 70% dibandingkan pretest pada 50 responden. Peningkatan ini mencerminkan efektivitas program dalam membangun kesadaran dan kemampuan masyarakat mengolah pangan lokal sebagai upaya pemenuhan gizi anak dan peluang ekonomi berbasis rumah tangga. Pemantauan pasca kegiatan menunjukkan respon positif dan tingginya komitmen masyarakat terhadap keberlanjutan program. Dengan demikian, kegiatan PKM ini telah memberikan dampak nyata bagi peningkatan kualitas gizi balita dan pemberdayaan masyarakat.

Analisis Kadar Nitrit pada Daun Katuk dan Daun Pegagan dengan Pereaksi Griess: Analysis of Nitrite Levels in Katuk Leaves and Pegagan Leaves with Griess Reagent Emma Emawati; Egy Rizky Maulana; Fauzan Zein Muttaqin; Lilis Silviana; Reza Pratama; Abdul Mulki Irpani
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 7 No. 1 (2026): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v7i1.13535

Vegetables are an important source of nutrition for humans. Katuk (Sauropus androgynus) and pegagan (Centella asiatica) are vegetables rich in nutrients and fibre, which are beneficial for the body. In addition to their many health benefits, these vegetables contain compounds that can be harmful to the body, such as nitrite (NO₂⁻). The harmful effect caused by nitrite is methemoglobinemia. This study aims to analyze the nitrite levels contained in katuk (Sauropus androgynus) and pegagan vegetables using a visible spectrophotometric method using the Griess reagent based on the diazotization reaction principle. Before the analysis of nitrite levels, method validation was carried out, including linearity, accuracy, and precision tests. From the results of the linearity test, the linear regression line equation was obtained, namely, y = 0.0551x + 0.153, r = 0.9977, BD = 0.5647 μ,g / mL, BK = 1.8824 μg / mL. The results of the similarity test obtained the coefficient of variation of the first day, 0.88%, the second 1.12%, and the third day, 1.26%. While the percentage of nitrate recovery at concentrations of 3, 6, and 9 μg / ml with the standard addition method was obtained, respectively, 116, 88, and 90%. The nitrite content in katuk yielded an average of 0,1684 mg/g, and in pegagan was 0,4218 mg/g.

Ethanol Extract of Grass Jelly Leaves: Bioactive Analysis and In silico Study on Estrogen Receptor Alpha Related to MCF-7 Breast Cancer Irpani, Abdul Mulki; Yuliantini, Anne; Bintang, Muhammad Ilham; Sella, Arinda Tri Pramay; Sodik, Jajang Japar
Sciences of Pharmacy Volume 5 Issue 3 (2026)
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0502619

Breast cancer is a major cause of mortality among women and requires the development of alternative therapies derived from natural products. This study aimed to profile bioactive compounds in the ethanol extract of gras jelly leaves (Cyclea barbata Miers) and evaluate their predicted interactions with estrogen receptor alpha (ERα), a key regulator of proliferation in ER-positive MCF-7 breast cancer cells using an in silico approach. LC–HRMS analysis followed by database matching tentatively annotataed 44 major compounds based on peak intensity after data filtering. Molecular docking and simulation results indicated that several compounds exhibited favorable predicted binding affinity toward estrogen receptor targets. Among them, (3β,24R,24′R)-fucosterol epoxide demonstrated the most stable interaction. These findings suggest that the compound showed promising interaction stability toward the estrogen receptor in computational analysis. However, further in vitro and in vivo studies are required to validate its biological activity.

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