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All Journal JURNAL FARMASIMED (JFM) REMIK : Riset dan E-Jurnal Manajemen Informatika Komputer Community Development Journal: Jurnal Pengabdian Masyarakat Indian Journal of Forensic Medicine & Toxicology Journal of Agropharmacy
Kusumaningrum , Yunita Dyah
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Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Public Health

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Effect of Mannitol Hydration as Renoprotective on Cisplatin Induced Nephrotoxicity (CIN) in Head and Neck Cancer Patients Mareta Rindang, Andarsari; Yunita Dyah, Kusumaningrum; Rosy Nurlita, Hapsari; Dwi Hari, Susilo; Dewi Wara, Shinta
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16958

Abstract

Background: Cisplatin is a cytostatic agent used as treatments in head and neck cancer patients.Nephrotoxicity is one of cisplatin major side effects. This study aimed to evaluate the renoprotectiveeffect of mannitol-hydration administration in head and neck cancer patients who receive cisplatinchemotherapy. Methods: This was a cohort observational study to analyze the renal function of head andneck cancer patients who receives cisplatin before and after mannitol-hydration administration in IRNASurgery and Soekardja Room of Chemotherapy at RSUD Dr. Soetomo Surabaya during June – September2018. The data obtained were BUN, SCr, and eClCr Cockroft-Gault of each cycle. Result: A total of 52patients were evaluated. The average value of creatinine serum, creatinine clearance, and BUN at each cyclewere fluctuate. However, the average value of creatinine serum and BUN were within the normal limit.The result of statistical analysis using paired t-test in those parameters at each cycle were not statisticallysignificant (p > 0,05) after mannitol administration except during first cycle to second cycle the SCr increasedsignificantly and eClCr was decreased significantly (p-value 0,024; 0,006, CI 95% respectively ). At fourthcycle the eClCr also decreased significantly (p value 0,008, CI 95%). Conclusion: The renoprotective effectof mannitol in head and neck cancer patients who receive cisplatin chemotherapy is sufficiently adequatewhich can maintain the value of BUN and creatinine serum of patients at each cycle within the normal limit.
Pemetaan Potensi Persebaran Kasus Tuberkulosis di Kabupaten Jember dengan Pendekatan Analisis Spasial Kartiko, Erik; Kusumaningrum, Yunita; Arief, Habibullah; Afandi, Khoirunnisa'; Atmoko, Rizky
REMIK: Riset dan E-Jurnal Manajemen Informatika Komputer Vol. 8 No. 4 (2024): Call for Paper: Volume 8 Nomor 4 Oktober 2024
Publisher : Politeknik Ganesha Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33395/remik.v8i4.14372

Abstract

Tuberkulosis (TBC) merupakan salah satu penyakit menular yang menjadi tantangan kesehatan masyarakat di Indonesia, termasuk di Kabupaten Jember. Penyakit ini memiliki dampak yang signifikan terhadap kualitas hidup masyarakat serta membutuhkan perhatian khusus dari berbagai pihak, baik pemerintah, tenaga kesehatan, maupun masyarakat umum. Penelitian ini bertujuan untuk memetakan potensi persebaran kasus TBC di wilayah Kabupaten Jember dengan menggunakan pendekatan analisis spasial. Pendekatan ini memberikan gambaran yang lebih akurat mengenai distribusi kasus TBC berdasarkan wilayah geografis sehingga dapat membantu pengambilan keputusan yang berbasis data. Penelitian ini mengintegrasikan data profil kesehatan Kabupaten Jember yang diperoleh secara aktual dan mutakhir. Data TBC yang digunakan merupakan data hasil pencatatan dan pelaporan dari setiap fasilitas kesehatan di Jember, yang mencakup periode waktu dari tahun 2020 hingga 2023. Data ini dianalisis untuk mengetahui pola persebaran, proyeksi, dan prediksi kasus TBC pada tahun 2024 dan 2025 untuk setiap kecamatan di Kabupaten Jember. Selain itu, analisis ini juga mencakup identifikasi faktor risiko yang berkontribusi terhadap penyebaran TBC di berbagai wilayah. Hasil penelitian ini diharapkan dapat memberikan kontribusi penting dalam menyusun strategi pencegahan dan penanggulangan TBC yang lebih efektif dan efisien. Rekomendasi yang dihasilkan dapat menjadi acuan bagi pemerintah daerah dalam merancang program kesehatan yang terintegrasi, dengan fokus pada pengendalian penyakit menular seperti TBC. Pendekatan berbasis data ini diharapkan mampu meningkatkan keberhasilan program kesehatan masyarakat di Kabupaten Jember secara berkelanjutan
Evaluation of Pioglitazone Vildagliptin Combination on Lipid Profiles for Outpatients with Type II Diabetes Mellitus Kusumaningrum, Yunita Dyah; Firandi, Adelia; Hasmono, Didik; Aryani, Dhita; Wardhani, Firdha Aprillia
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2645

Abstract

Pioglitazone and vildagliptin combination is one of the recommended alternatives as antidiabetic therapy to achieve the therapeutic target. This combination with complementary mechanisms of action can improve lipid profiles. This study aims to evaluate lipid profile achievement for outpatients with Type II DM on administering pioglitazone/vildagliptin combination therapy. Methods of the study were an observational prospective study in outpatients with Type II DM who use pioglitazone/vildagliptin combination at RS. Bhayangkara Surabaya during November 2021 – April 2022. Patients were included if aged between 18-80 y.o, used this combination ? 3 months before the study, HbA1C >7%, and were voluntarily involved by signing the informed consent. Laboratory examination of HbA1c, HDL-C, and triglycerides was done initially when patients were voluntarily involved as baseline data and after 3 months as post-data. The final sample in this study consisted of 25 patients who met the inclusion and exclusion criteria. The results of the study show mean value of HDL-C significantly increases from baseline to endpoint (p < 0.05). At the end of 3 months, the lipid profile of HDL-C and triglyceride increases by 30% and 4%, respectively, in patients who achieve the target compared to baseline conditions. The combination therapy of pioglitazone and vildagliptin improved lipid profile control in patients with type 2 diabetes mellitus after 3 months of treatment.
Baricitinib for the treatment of COVID-19 Firdha Aprillia Wardhani; Syafika, Devina Sarah; Kusumaningrum, Yunita Dyah; Adelia Firandi
Journal of Agropharmacy Vol. 1 No. 2 (2024)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/joa.v1i2.1422

Abstract

Baricitinib which is one of the therapies for rheumatoid arthritis is a JAK inhibitor. WHO recommended therapy with the combination of baricitinib and corticosteroids in COVID-19 patients with severe or critical condition. Effectivity and safety assessment of Baricitinib use were carried out by reviewing the literature published between December 2019 – February 2022, and showed that the use of Baricitinib in COVID-19 patients resulted in an improvement of lung function, improvement of oxygen saturation, higher recovery rate, and lower mortality, with similar adverse event incidence. A loading dose or a higher dose can be recommended for patient with caution and consideration of higher possibility in the incidence of adverse events
Evaluasi Perencanaan dan Pengadaan Obat dengan Dana JKN di Puskesmas Rambipuji Jember Norcahyanti, Ika; Firandi, Adelia; Ramadhani, Nuril Izzati Farihatur; Rachmawati, Sinta; Rachmawati, Ema; Aryani, Dhita Evi; Wardhani, Firdha Aprillia; Kusumaningrum , Yunita Dyah
Journal of Agropharmacy Vol. 1 No. 3 (2024)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/joa.v1i3.1811

Abstract

Public Health Center is a health facility that organizes drug management activities, including planning and procurement activities. Evaluation needs to assess the success of achieving the objectives and results of the action. Indicators that can use are efficiency indicators published by the Ministry of Health of the Republic of Indonesia and efficiency indicators developed by Pudjaningsih. Rambipuji Public Health Center with spending funds for the most significant drug procurement in Jember Regency in 2020. Therefore, it is necessary to evaluate the results that can improve the quality of service in the next period. This research aims to determine the results of the evaluation of drug planning and procurement with JKN funds at Rambipuji Public Health Center for 2020. This research is descriptive, primary data through interview results. Secondary data includes total funds available, drug procurement funds, Drug Usage Reports, and Drug Demand Sheets for drugs purchased through JKN funds and stock cards. The data is analyzed descriptively, presented in the form of tables supported by interview results. The results showed that the Government of Indonesia had governed drug planning and procurement activities with JKN funds. The percentage indicator of available funds compared to the general funds needed is 114.26%. The percentage indicator of drug procurement fund allocation is 3.46%. Results on percentage indicator procurement conformity with the reality of the use of each drug item amounted to 133.33% and on the procurement frequency indicator of each drug item once a year. Through this research, it can be concluded that the evaluation results on indicators of the efficiency of drug planning and procurement activities at Rambipuji Public Health Center have not been by established standards. This matter was influenced by several factors, including a decrease in the number of patient visits due to the COVID-19 pandemic, changes in the organizational structure in the Jember Health Office that resulted in the frequency of procurement activities only once throughout 2020, and the absence of government regulations that regulate in more detail about the percentage of JKN funds allowed for drug procurement activities.
PENINGKATAN PENGETAHUAN DAGUSIBU (DAPATKAN, GUNAKAN, SIMPAN, BUANG) OBAT DI DESA JEMBER KIDUL Holidah, Diana; Firandi, Adelia; Kusumaningrum, Yunita Dyah; Rachmawati, Ema
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 6 No. 2 (2025): Volume 6 No. 2 Tahun 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v6i2.44095

Abstract

Kesehatan merupakan kondisi fisik dan mental yang bebas dari penyakit dan dapat meningkatkan kesejahteraaan masyarakat. Obat adalah bahan yang digunakan untuk mencegah, menyembuhkan, dan meningkatkan kesehatan, namun, obat juga dapat bersifat toksik bila tidak digunakan secara rasional. Diketahui bahwa lebih dari 60% masyarakat Indonesia melakukan pengobatan sendiri atau swamedikasi, dan diantaranya, ada yang menyimpan obat keras tanpa resep termasuk antibiotik, menyimpan obat kadaluarsa, dan membuang obat dengan cara yang salah. Hal ini disebabkan karena kurangnya pemahaman dan kesadaran masyarakat terkait cara mendapatkan, menggunakan, menyimpan, dan membuang obat dengan benar. Apoteker memiliki peran dalam meningkatkan derajat kesehatan masyarakat melalui berbagai pelayanan kefarmasian, salah satunya melalui DAGUSIBU (Dapatkan, Gunakan, Simpan, Buang) Obat. Ibu adalah pilar kesehatan yang berperan penting dalam mengatur berbagai hal dalam keluarga, termasuk penyediaan dan pengelolaan obat-obatan dirumah, Oleh karena itu, dilakukan penyuluhan terkait DAGUSIBU secara lisan dan tertulis melalui power point dan leaflet pada ibu-ibu kader PKK di Desa Jember Kidul, Kecamatan Kaliwates, Kabupaten Jember. Evaluasi kegiatan didapatkan terdapat peningkatan pengetahuan peserta sebanyak 27.5% melalui hasil pre-test dan post-test. Oleh karena itu, tema ini layak diadakan secara rutin dan diperluas cakupannya ke wilayah lain untuk meningkatkan pemahaman dan kesadaran individu sehingga dapat mencegah penyalahgunaan obat dan permasalahan kesehatan lainnya
Co-Authors Adelia Firandi Afandi, Khoirunnisa Aryani, Dhita Aryani, Dhita Evi Atmoko, Rizky Dewi Wara Shinta Diana Holidah Didik Hasmono Ema Rachmawati Firandi, Adelia Ika Norcahyanti Kartiko, Erik Yohan M. Habibullah Arief Mareta Rindang Andarsari Ramadhani, Nuril Izzati Farihatur Rosy Nurlita, Hapsari RR. Ella Evrita Hestiandari Sinta Rachmawati Susilo, Dwi Hari Syafika, Devina Sarah Wardhani, Firdha Aprillia