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All Journal Martabe : Jurnal Pengabdian Kepada Masyarakat JURNAL FARMASIMED (JFM)
Prima Putra, Deddi
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Agriculture, Biological Sciences & Forestry Arts Humanities Education Medicine & Pharmacology Social Sciences

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Isolation and Structural Analysis of Active Antioxidant Phenolic Compounds from Elephantopus mollis Kunth Verawati, Verawati; Almahdy, Almahdy; Febriyenti, Febriyenti; Prima Putra, Deddi
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/a2hcyr24

Abstract

Elephantopus mollis is a common weed found in West Sumatra, known for its diverse traditional uses and rich phytochemical content. This study aimed to isolate phenolic compounds and evaluate the antioxidant activity of the polar extract of E. mollis herb. The polar extract was obtained through successive extraction using solvents of increasing polarity. Separation of the polar extract was carried out using Amberlite XAD-4 resin chromatography with methanol and water eluents, followed by isolation through silica gel column chromatography using a step-gradient polarity elution system. The separation and isolation processes were monitored by thin-layer chromatography (TLC). Total phenolic content was determined by the Folin–Ciocalteu method, while antioxidant activity was assessed using the DPPH radical scavenging assay. Structural identification of the isolated compound was performed using UV-Vis, IR, NMR, and LC-MS spectroscopic techniques. Subfraction D of the polar extract exhibited a high phenolic content of 618.06 ± 3.38 mg GAE /g. From subfraction D, a phenolic compound designated D3a was isolated as a yellowish-white powder (95.30 mg) with an Rf value of 0.64, producing a dark blue color upon reaction with 10% FeCl₃. The antioxidant activity of compound D3a was classified as very strong, with an IC₅₀ value of 12.42 ppm. Based on physicochemical characterization, compound D3a was identified as caffeic acid with a molecular formula of C₉H₈O₄ and a molecular weight of 180.049.
OPTIMALISASI FARMAKOTERAPI: IDENTIFIKASI DAN EDUKASI TENTANG ADRs DAN DRPs PADA PESERTA PROLANIS WILAYAH PUSKESMAS SURIAN, KABUPATEN SOLOK, SUMATERA BARAT Gumala, Azhoma; Armenia, Armenia; Prima Putra, Deddi; Syafni, Nova; Handayani, Fitri; Eka Putri, Desi; Furqan, Mainal; Sentat, Triswanto; Gusnelti, Yessi; Lucida, Henny
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 9, No 1 (2026): MARTABE : JURNAL PENGABDIAN KEPADA MASYARAKAT
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v9i1.%p

Abstract

Peningkatan risiko reaksi obat yang tidak diinginkan (adverse drug reactions/ADRs) dan masalah terkait obat (drug-related problems/DRPs) pada pasien penyakit kronis, khususnya peserta Program Pengelolaan Penyakit Kronis (PROLANIS), sangat membutuhkan informasi dan edukasi intensif terkait optimalisasi terapi. Kegiatan pengabdian ini bertujuan untuk mengidentifikasi insiden ADRs dan DRPs pada kelompok PROLANIS di Puskesmas Surian dan memberikan edukasi yang terfokus untuk meminimalkan risiko, demi mencapai terapi optimal. Kegiatan diawali dengan wawancara dan pengumpulan data kuesioner dari 30 responden (semua perempuan). Hasil demografi menunjukkan mayoritas responden (70,00%) berusia 45–64 tahun, dan dua pertiga (66,67%) mengalami polifarmasi (menderita 3–7 penyakit kronis). Empat penyakit utama yang diderita adalah artritis, hipertensi, hiperurisemia, dan dislipidemia. Penting untuk dicatat, 60% responden melaporkan keluhan yang mengindikasikan ADRs dan DRPs. Sebagian besar subjek memperoleh obat dari tenaga kesehatan formal (86,67%). Tindak lanjut kegiatan mencakup pemeriksaan kesehatan gratis (tekanan darah, gula darah, kolesterol, dan asam urat) serta konseling langsung. Pasien PROLANIS menerima edukasi mendalam tentang cara penggunaan obat yang benar, terutama dalam terapi polifarmasi, untuk meminimalkan masalah terkait obat. Disimpulkan bahwa edukasi intensif dan berkelanjutan mengenai obat-obatan, pengobatan alternatif, dan suplemen kesehatan kepada komunitas PROLANIS sangat penting. Intervensi ini secara signifikan berkontribusi pada keselamatan pasien dan meningkatkan pemahaman masyarakat dalam pengelolaan penyakit kronis.
Co-Authors Almahdy A Armenia, Armenia Eka Putri, Desi Fitri Handayani Furqan, Mainal Gumala, Azhoma Gusnelti, Yessi Henny Lucida Nova Syafni Triswanto Sentat Verawati Verawati