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All Journal Jurnal Kelautan Tropis Journal of Islamic Pharmacy ad-Dawaa : Journal of Pharmaceutical Sciences Science Midwifery Journal of Pharmaceutical Care Anwar Medika Journal Pharmasci (Journal of Pharmacy and Science) Jurnal Farmasi Sains dan Praktis Journal of Pharmacy Science and Technology JPMP Acta Holistica Pharmaciana Borneo Journal of Pharmacy Indonesian Journal of Jamu
Pramudita Riwanti
Universitas Hang Tuah
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Prediction Activity Pharmacology and Molecular Docking of Secondary Metabolite Compounds of Tamarind Leaves (Tamarindus indica) as Anticancer Muslikh, Faisal Akhmal; Riwanti, Pramudita; Alrayan, Reza
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.57090

Abstract

Introduction: Cancer remains one of the leading causes of morbidity and mortality worldwide, with incidence and death rates increasing annually. One of the most effective therapeutic targets for cancer is the Epidermal Growth Factor Receptor (EGFR). However, the use of synthetic EGFR inhibitors is often associated with significant side effects.  Aims: This study aims to evaluate the potential of compounds derived from Tamarindus indica (tamarind) leaves as anticancer agents through an in silico approach, including pharmacological activity prediction (PASS) and molecular docking against the EGFR receptor.  Methods: Pharmacological activities were predicted using the Way2Drug webtool, while molecular docking analysis was performed using Molegro Virtual Docker (MVD).  Result: The PASS prediction results indicated that the compounds in Tamarindus indica leaves possess a broad spectrum of anticancer activities. Docking analysis revealed that isovitexin exhibited the lowest rerank score among the test compounds and controls (erlotinib and the native ligand), indicating stronger binding affinity to EGFR. Conclusion: These findings support the potential of tamarind leaves, particularly isovitexin, as a promising computationally-predicted anticancer therapeutic candidate.
Antioxidant activity of brown algae extract (Sargassum sp): A review Riwanti, Pramudita; Mahmiah, Mahmiah; Juniar, Kiki
Science Midwifery Vol 11 No 6 (2024): February: Midwifery and Health Sciences
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v11i6.1420

Abstract

Free radicals are compounds that trigger oxidative stress and harm human health. Uncontrolled oxidative stress causes several degenerative diseases. Antioxidants are needed to prevent or reduce oxidative stress. One of the plants with a high content of antioxidant compounds is brown algae (Sargassum sp). The study aimed to examine Sargassum sp.'s antioxidant activity, which is expressed in the IC50 value using the DPPH method as measured by a UV-Vis spectrophotometer. It is a narrative review, with literature searches from the Science Direct, Pubmed, and Google Scholar databases. The results showed that the methanol extract of Sargassum sp. has strong antioxidant activity consisting of phenolic compounds, flavonoids, and carotenoids. This review concludes that Sargassum sp extract has antioxidant activity.
Co-Authors Alrayan, Reza Amaliyah, Amaliyah Anisah Mahardiani Arinil Hidayati Astrid Kusuma Bambang Widjaja Burhan Ma'arif Dewi Pinangkaan, Hanifah Mutiara Dilla Amalia Eka Putri, Safira Dinda Ersanda Nurma Faisal Akhmal Muslikh Hening Laswati Putra Izazih, Farizah Juniar, Kiki Luthfi Achmad Muchlasi Ma'arif, Burhan Mahmiah Mahmiah Mahmiah Mangestuti Agil Maulidiah, Erika Nur Maximus M Taek Ma’arif, Burhan Mu'alim, Ade Ianaini Mujib, Naili Nabila Najih, Yuli Ainun Primadini, Filicia Regya Ramadhan, Ravy Irsyad Riami Rina Andayani, Rina Ronald Pratama Adiwinoto Serdian Pinaris Rama Siswandono, Siswandono Sylvia Rizki Tamam Jauhar Trinanda, Lia