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All Journal HAYATI Journal of Biosciences IJEMS (Indonesian Journal of Environmental Management and Sustainability)
Sulistyana, Yanti
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Agriculture, Biological Sciences & Forestry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Energy Environmental Science Public Health

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Effects of Physalis angulata Leaf Extract on Female Reproductive Organs Following Busulfan Injection in Rats Satyaningtijas, Aryani; Ekastuti, Damiana Rita; Tarigan, Ronald; Prasetyaningtyas, Wahono Esthi; Adnyane, I Ketut Mudite; Mohamad, Kusdiantoro; Rahmadhani, Elsi; Sulistyana, Yanti; Mahendra, Arindina
HAYATI Journal of Biosciences Vol. 33 No. 2 (2026): March 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.2.490-498

Abstract

Physalis angulata L. (ciplukan) is traditionally used as an herbal remedy with anticancer and antioxidant properties. At the same time, busulfan, a chemotherapy alkylating agent, causes gonadotoxicity and oxidative stress that impair female reproduction. This study aimed to evaluate the effect of P. angulata on reproductive function after busulfan administration in female rats. Twenty-five 6-week-old female rats were randomly divided into: Group I (control), Group II (busulfan only), Group III (P. angulata only), Group IV (busulfan followed by P. angulata after 14 days), and Group V (busulfan and P. angulata administered for 28 days). FSHR and LHR expression in the ovaries and MDA levels in the ovaries and uterus were measured to assess reproductive changes. Busulfan showed no significant effect on FSHR and LHR, whereas P. angulata induced downregulation, suggesting a potential negative feedback mechanism on ovarian receptors. Ovarian MDA showed a decreasing trend with combined treatments, while uterine MDA peaked after busulfan but declined markedly with P. angulata, indicating its role in alleviating oxidative stress. In conclusion, P. angulata may modulate hormonal balance in rat ovaries and decrease oxidative stress in the uterus after busulfan treatment.
Strategic Formulation for Sustainable Campus Development: A SWOT-TOWS Analysis of Sebelas Maret University, Indonesia Muzzazinah; Rahayu, Murtanti Jani; Suryanto; Sulistyana, Yanti; Andriani, Feni
Indonesian Journal of Environmental Management and Sustainability Vol. 10 No. 1 (2026): March
Publisher : Magister Program of Material Science, Graduate School of Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/ijems.2026.10.1.47-59

Abstract

Higher education institutions must implement appropriate evaluation and strategy determination to support their role in establishing a Sustainable Campus. This study aims to (1) evaluate the implementation of the sustainable campus program at Universitas Sebelas Maret (UNS), (2) analyze the dominance of internal (IFAS) and external (EFAS) factors at UNS, and (3) formulate strategies that UNS should implement to strengthen its sustainable campus initiatives-the implementation evaluation utilized data from the UNS GreenMetric report. The factor dominance analysis employed IFAS and EFAS, while the strategy formulation used SWOT-TOWS analysis. The findings indicate that UNS has stagnant scores in the Water (WR) and Transportation (TR) indicators. Furthermore, UNS’s strengths lie in its open space availability and sustainable academic programs, though this advantage is hindered by limited budget allocation for toxic waste management. Based on the analysis, the recommended course of action for UNS is the Strengths-Opportunities (SO) strategy. The implementation of this SO strategy is necessary for UNS to advance its role as a sustainable campus successfully. This study implies that the integration of sustainability performance evaluation using UI GreenMetric data with IFAS, EFAS, and SWOT-TOWS analysis provides a structured basis for identifying dominant strategic conditions and formulating strength-oriented strategies to improve sustainable campus implementation at Universitas Sebelas Maret. The study implies that Universitas Sebelas Maret should utilize sustainability assessment results as strategic inputs rather than merely as reporting tools, enabling more targeted interventions in critical areas such as water and transportation management. These findings may further contribute to the development of management strategies derived from SWOT and TOWS analyses in other universities across Indonesia.
Co-Authors A.S. Satyaningtijas Damiana Rita Ekastuti Feni Andriani Ketut Adnyane Mudite Kusdiantoro Mohamad Mahendra, Arindina Murtanti Jani Rahayu Muzzazinah Rahmadhani, Elsi Suryanto Tarigan, Ronald Wahono Esthi Prasetyaningtyas