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All Journal Biotropika Organisms: Journal of Biosciences
Amalia, Fia
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Veterinary

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Case Report: Clinical Diagnostic Challenges of Hypertrophic Cardiomyopathy (HCM) in a Persian Cat Fitranda, Mulya; Ryadi, Agus Shafiq; Amalia, Fia; Dion Andiriesta Dewananda; Nururrozi, Alfarisa; Salasia, Siti Isrina Oktavia
ORGANISMS: JOURNAL OF BIOSCIENCES Vol. 5 No. 2 (2025): Organisms: Journal of Biosciences
Publisher : Pusat HKI, Paten, dan Publikasi Ilmiah Universitas Islam Negeri Raden Intan Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24042/47y0dt96

Abstract

Hypertrophic Cardiomyopathy (HCM) is a common and clinically significant cardiomyopathies affecting felines characterized by excessive thickening of the left ventricular myocardium and decreased systolic pressure. This report describes the case of a 9-year-old, 4 kg, female Persian cat presented with dyspnea, anorexia, and lethargy. On physical examination, the normal rectal temperature, slight pallor mucous membranes, increases capillary refill time with respiratory distress were observed. Auscultation of the thorax revealed arrhythmia. Blood pressure and mean arterial pressure (MAP) indicated hypertension. Serial blood counts were consistent with anemia, eosinopenia and monocytosis suggesting chronic stress. Thorax radiograph revealed the heart enlargement through vertebral heart scale (VHS) and cardiothoracic ratio (CTR) score measurement. Complementary diagnostic test with biomarker pro-Brain Natriuretic Peptide (proBNP) confirmed the diagnosis of HCM. This case report describes the clinical findings, cardiac evaluation, and HCM diagnosis in a geriatric cat.
The Effect of Avocado Oil Cream on Accelerating Wound Healing Process: A Macroscopic Analysis Amalia, Fia; Paramanandi, Dini Agusti; Monica, Yelis Tria
Biotropika: Journal of Tropical Biology Vol. 13 No. 3 (2025)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2025.013.03.03

Abstract

Wound healing is a complex physiological process involving hemostasis, inflammatory, proliferative and remodelling phases. Natural compounds such as avocado (Persea americana) oil, rich in oleic and linoleic acids, have shown potential in supporting tissue regeneration. This study aimed to analyse the macroscopic wound healing effects of avocado oil cream at different concentrations in mice. Eighteen male Swiss Webster mice (8 weeks old, 30 g) were divided into three groups: K (0%) as a control group, P1 (25%) and P2 (50%) as the treatment groups. A 6 mm excisional wound was created on each mouse, and cream was applied once daily for seven days. Wound area and contraction were measured on days 1-7 using a digital calliper and analysed using one-way ANOVA (p>0.05). Results showed a consistent decrease in wound area and an increase in wound contraction across all groups, indicating progressive healing. Although statistical differences were not significant (p>0.05), the P2 (50%) group demonstrated a faster rate of wound area reduction and higher contraction compared to other groups. Macroscopically, P2 (50%) wound exhibited cleaner surfaces, earlier granulation tissue formation, and better epithelial coverage. These effects are likely related to the bioactive properties of avocado oil, which modulate inflammation, stimulate fibroblast proliferation, and enhance collagen remodelling. In conclusion, the topical application of avocado oil cream, particularly at a 50% concentration, showed promising macroscopic improvement in wound healing. Further studies with longer observation periods and histological analysis are recommended to confirm its therapeutic potential.
Co-Authors Alfarisa Nururrozi, Alfarisa Dion Andiriesta Dewananda Monica, Yelis Tria Mulya Fitranda Paramanandi, Dini Agusti Ryadi, Agus Shafiq Siti Isrina Oktavia Salasia