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All Journal Jurnal Biosense Quagga: Jurnal Pendidikan dan Biologi Bioeksperimen
Rizka Fatriani
Institut Teknologi Sumatera
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Medicine & Pharmacology Public Health

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Antioxidant Activity and Immunomodulatory Effect of Stachytarpheta sp. Leaf Extract on Phagocytic Activity of Mice Peritoneal Macrophages in Alloxan Induction Iffa Afiqa Khairani; Wahyuni Dian Lestari; Elisa Nurma Riana; Jeane Siswitasari Mulyana; Hida Arliani Nur Anisa; Rizka Fatriani; Silvia Andriani
Quagga: Jurnal Pendidikan dan Biologi Vol 17 No 2 (2025): QUAGGA : Jurnal Pendidikan dan Biologi
Publisher : Program Studi Pendidikan Biologi, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25134/quagga.v17i2.404

Abstract

Hyperglycemia is a condition characterized by elevated blood glucose levels, which is a hallmark of diabetes mellitus. Prolonged hyperglycemia not only disrupts glucose homeostasis but also impairs the immune response. The condition of hyperglycemia in the body can increase free radicals and oxidative stress, thus can impair various macrophage functions, including their ability to engulf and eliminate pathogens. The bioactive constituents in Stachytarpheta sp. may contribute to reducing oxidative damage and enhancing immune system function. This study aims to evaluate both the antioxidant capacity and the immunomodulatory effects of Stachytarpheta sp. leaf extract on the phagocytic activity of peritoneal macrophages in alloxan-induced diabetic mice. Alloxan is widely used in research to induce hyperglycemia (diabetic conditions) in experimental animals. The antioxidant activity of the extract was evaluated using the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay, while phagocytic activity of peritoneal macrophages was performed in vivo using male mice. Stachytarpheta sp. leaf extract from Beteng Sari Village, East Lampung has very strong antioxidant activity against DPPH with IC50 value 14,85 ± 0,30 μg/mL. This extract at doses of 200, 300, and 400 mg/kgBW can be an immunomodulator that maintains the phagocytic activity of macrophage cells in alloxan-induced mice.
EFEK EKSTRAK KULIT BUAH KABAU (Archidendron bubalinum (Jack) I.C Nielsen) TERHADAP AKTIVITAS MAKROFAG MENCIT JANTAN SETELAH DIPAPARKAN CdCl2 Elisa Nurma Riana; Iffa Afiqa Khairani; Hida Arliani Nur Anisa; Rizka Fatriani; Silvia Andriani
JURNAL BIOSENSE Vol 9 No 2 (2026): Edisi April 2026
Publisher : Universitas PGRI Banyuwangi, Jalan Ikan Tongkol No 01, Telp (0333) 421593, 428592 Banyuwangi 68416

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/biosense.v9i2.7817

Abstract

Logam kadmium (Cd) yang berasal dari kegiatan industri seperti produksi baterai, pelapisan logam, penggunaan pupuk fosfat, pembakaran bahan bakar fosil, dan pembuatan plastik dapat meningkatkan produksi reactive oxygen species (ROS). Produksi ROS berlebih dalam tubuh akan menyebabkan penyakit dan mempengaruhi sistem imun tubuh akibat stres oksidatif. Stres oksidatif merupakan suatu kondisi ketidakseimbangan antara radikal bebas dan antioksidan. Untuk melindungi tubuh dari stres oksidatif diperlukan suatu senyawa antioksidan, seperti yang terkandung dalam kulit buah kabau (Archidendron bubalinum). Penelitian ini bertujuan mengetahui mengetahui adanya peningkatan aktivitas fagositosis makrofag pada mencit Jantan yang dipaparkan CdCl2. Penelitian ini bersifat eksperimental menggunakan rancangan acak lengkap (RAL). Mencit yang digunakan 24 ekor dengan 6 kelompok yang terdiri dari 3 kelompok kontrol dan 3 kelompok perlakuan. Hasil pengujian menunjukkan bahwa pemberian ekstrak kulit buah kabau dosis 95 mg/kgBB, 190 mg/kgBB dan 380 mg/kgBB pada uji aktivitas fagositosis makrofag menunjukkan hasil yang signifikan sebesar p = 0,005. Hal ini berarti bahwa ekstrak kulit buah kabau dapat meningkatkan sistem imun mencit dengan perlakuan P2 memiliki aktivitas fagositosis tertinggi yaitu 55,91%.
The Effect of Noise Exposure on Blood Profiles and Weight Gain in Broiler Chicks (Gallus domesticus L.) Lisa Yesi Hutapea; Iffa Afiqa Khairani; Andy Darmawan; Rizka Fatriani; Yopi Haryandi
Bioeksperimen: Jurnal Penelitian Biologi Vol. 12 No. 2: September 2026
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v12i2.19298

Abstract

Noise is an environmental stress factor that can affect the physiological condition of livestocks. In modern farms, noise sources such as ventilation and automatic equipment can potentially disrupt the health and growth of chickens. This study aimed to examine the effects of noise exposure on the blood profile and weight gain of broiler chicks (Gallus domesticus L.). Fifteen one-week-old male broiler chicks were divided into three treatment groups—control, 85 dB noise, and 100 dB noise—with five chicks per group housed in a single cage. Exposure of noise was given for 30 days. The observed parameters included the number of erythrocyte, leukocyte, heterophile/lymphocyte ratio (H/L), random blood glucose (RBG) levels, and body weight gain. The data were analyzed using ANOVA, followed by Tukey-HSD test (α = 0.05). The results of this study showed that noise exposure significantly (p < 0.05) reduced the number of erythrocyte (control: 3.658, 85dB: 3.136, and 100dB: 2.802 ×10⁶cells/mm³) and RBG levels (control: 191.4, 85 dB: 180.0, and 100 dB: 156.8 mg/dL), but had no significant effect (p > 0.05) on the number of leukocyte (control: 1.620, 85 dB: 1.300, 100 dB: 1.100 ×103cells/mm³) and the H/L ratio (control: 0.087, 85 dB: 0.099, 100 dB: 0.093). Body weight gain in the noise-exposed groups was significantly lower than that in the control group (p < 0.05; control: 399.8, 85dB: 341.8, and 100dB: 312 g). These findings indicate that noise exposure at 85 and 100 dB may have negative effects on physiological conditions and growth.
Co-Authors Andy Darmawan Hida Arliani Nur Anisa Hida Arliani Nur Anisa Iffa Afiqa Khairani Jeane Siswitasari Mulyana Lisa Yesi Hutapea Riana, Elisa Nurma Silvia Andriani Wahyuni Dian Lestari Yopi Haryandi