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Sunscreen Activity Testing of Robusta Coffee (Coffea cenephora ex froehner) Leave Extract and Fractions Kiki Mulkiya Yuliawati; Esti Rachmawati Sadiyah; Riski Solehati; Aldi Elgiawan
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Coffee leaves are part of a plant that has not been optimally utilized. The purpose of this study was to explore the potential use of coffee leaves to help maintain skin health. Extraction method was carried out with maceration method using 70% ethanol solvent. Fractionation process was carried out by Liquid-Liquid Extraction method, using different solvents to accumulate the n-hexane, ethyl acetate [A1] and methanol fractions. Activity testing was carried out on all samples at concentrations of 50, 100 and 150 ppm including measurements of Sun Protecting Factor (SPF), Erythema and Pigmentation Transmittance Percentages (%Te [A2] and %Tp[A3] ) using UV-visible spectrophotometry at 290 and 400 nm wavelengths. The results showed that the ethyl acetate [A4] fraction at a concentration of 150 ppm had a higher potential as a sunscreen than other samples with SPF value of 19.82; %Te [A5] 10.96 and %Tp [A6] 18.14 and included in the category of fast tanning sunscreen.Keywords: coffee leaves, sunscreen, sun protecting factor, erythema, pigmentation

SUNSCREEN ACTIVITY OF SUGAR PALM (ARENGA PINNATA (WURMB) MERR.) LEAF STALK ASHES EXTRACT Esti Rachmawati Sadiyah
Jurnal Ilmiah Farmasi Farmasyifa Vol 2, No 1 (2019)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiff.v2i1.4225

Sugar palm leaf stalk (petioles) ashes traditionally used as a daily cosmetic by Sundanese women to keep their skin smooth. Sugar palm leaf stalk ashes also used to treat acne, smallpox, and burns. The study was aimed to test the sunscreen activity of ashes extracts from sugar palm leaf stalk. The ashes were extracted using soxhlet and 96% ethanol as solvent. The sunscreen activity test was performed on the extract using UV-Vis spectrophotometer. Determination of Sun Protection Factor (SPF) value was done at 290-320 nm (UV-B wavelength) with 5 nm interval. The ashes extract of sugar palm leaf stalk showed the effectiveness of sunscreen activity at 10,000 ppm (SPF value = 9) as maximum protection. The SPF value was determined using Mansur mathematical equation. The determination of pigmentation transmittant was done at 322.5 – 372.5 nm, with 2.5 nm interval. Based on the result of pigmentation transmittance percentages, the sunscreen profile of sugar palm leaf stalk ashes extract (2000-10.000 ppm) showed the category of extra protection up to sunblock, according to classification from Balsam & Sagarin (1972). To be concluded, the ashes extract of sugar palm leaf stalk was a potential sunscreen. Further in vivo analysis should be done to confirm this potency.

FORMULASI MINUMAN TEPUNG CACING TANAH (Lumbricus rubellus Hoffmeister) TERGANULASI DISERTAI UJI DAYA INGATNYA PADA MENCIT JANTAN Gita Cahya Eka Darma; Wulandari Putri Saraswati; Esti Rachmawati Sadiyah
Jurnal Ilmiah Farmasi Farmasyifa Vol 1, No 1 (2018)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiff.v1i1.3117

Protein is a chemical compound that is important for body. Earthworm (Lumbricus rubellus Hoffmeister) is known to have high protein content that can be used as alternative protein. This study aimed to determine the activity of earthworm flour in improving memory on mice (Mus musculus) and its formulation in the form of granulated earthworm flour beverage. Memory activity test was performed using Y labyrinth with observation parameter in the form of latency time (second) and number of errors. The optimum dose resulted from the memory test is 325 mg/kg BB which is equivalent to the use of two times the preparation containing 1.25 g of earthworm flour. Optimization of suspending agent was done singly and combination and obtained 3 formulae combination of best suspending agent and then continued to granulation proces. Formula evaluation conducted were organoleptic test, moisture, flow properties, particle size distribution, reconstitution time, redispersion time, sedimentation volume, viscosity, stability, hedonic test and quantitative analysis of protein content. Based of evaluation, one optimum formula was chosen which was, combination of 0,5% CMC-Na, 0,1% Sodium Alginate, 3,75% turmeric powder, 10% white sugar, 3% talk and Mg stearat 1%. The protein contained in the best formula was 26.03%

Penelusuran Pustaka Senyawa yang Berpotensi Aktivitas Larvasida dari Tanaman Suku Rutaceae terhadap Larva Nyamuk Aedes aegypti. Muhammad Shofiyanta; Esti Rachmawati Sadiyah
Jurnal Riset Farmasi Volume 1, No. 2, Desember 2021, Jurnal Riset Farmasi (JRF)
Publisher : UPT Publikasi Ilmiah Unisba

Abstract. The Aedes aegypti mosquito is a vector for the spread of Dengue Hemorrhagic Fever, and the use of natural larvicides is needed as an alternative to synthetic larvicides to control its growth. The plant family that is widely used in the development of larvicidal active ingredients is Rutaceae. This literature review was conducted with the aim of collecting and analyzing research results related to the content of compounds that have the potential to produce larvicidal activity in the Rutaceae plant family. There are 11 plant species from the Rutaceae family that have larvicidal activity against Aedes aegypti mosquito larvae based on a literature review, with the plant part commonly used in testing larvicidal activity against Aedes aegypti mosquito larvae, namely the leaf part, and chemical content with high potency of larvacide is essential oils with various components. Abstrak.Nyamuk Aedes aegypti merupakan vektor penyebaran penyakit Demam Berdarah Dengue, dan penggunaan larvasida alami dibutuhkan sebagai alternatif larvasida sintetis untuk mengendalikan pertumbuhannya. Suku tumbuhan yang banyak dimanfaatkan dalam pengembangan bahan aktif larvasida adalah Rutaceae. Penelusuran pustaka yang di lakukan bertujuan untuk mengumpulkan dan menganalisis hasil-hasil penelitian terkait kandungan senyawa yang berpotensi menghasilkan aktivitas larvasida pada keluarga tanaman Rutaceae. Terdapat 11 spesies tanaman dari keluarga Rutaceae yang memiliki aktivitas larvasida terhadap larva nyamuk Aedes aegypti berdasarkan penelaahan literatur, dengan bagian tanaman yang umum digunakan pada pengujian aktivitas larvasida terhadap larva nyamuk Aedes aegypti yaitu bagian daun, dan kandungan senyawa kimia yang berpotensi kuat sebagai larvasida adalah minyak atsiri dengan komponen yang beragam.

Studi Literatur Tanaman yang Memiliki Potensi terhadap Penyembuhan Luka Akut Khaerunnisa; Indra Topik Maulana; Esti Rachmawati Sadiyah
Bandung Conference Series: Pharmacy Vol. 2 No. 2 (2022): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Abstract. Wound is a condition characterized by damage to body tissue, damage to body tissue can involve connective tissue, muscles, skin, nerves and tearing of blood vessels which will interfere with the body's hemostasis. Wound healing process consists of various complex processes to restore tissue integrity. During this process, blood clots, acute and chronic inflammatory responses, neovascularization, cell proliferation and apoptosis occur. This literature study aims to examine the potential of various types of plants that can accelerate wound healing and examine the mechanism of action of secondary metabolites in plants that play a role in the wound healing process from several articles. Leaves of red andong (Cordyline fruticosa) (L) A.Chev; Ixora coccinea root; papaya stem (Carica papaya); Ficus deltoidea leaves; neem leaves (Azadirachta indica A. Juss); javan bark (Lannea coromandelica); and betadine leaf (Jatropha muitifida linn) has a class of compounds that play a role in the wound healing process, namely alkaloids, flavonoids, saponins and tannins which have antiseptic, astringent, anti-inflammatory, antioxidant and antibacterial potential. Abstrak. Luka merupakan suatu keadaan yang ditandai dengan terjadinya kerusakan pada jaringan tubuh, kerusakan jaringan tubuh dapat melibatkan jaringan ikat, otot, kulit syaraf dan robeknya pembuluh darah yang akan mengganggu hemeostatis tubuh. Proses penyembuhan luka terdiri dari berbagai proses yang kompleks untuk mengembalikan integritas jaringan. Selama proses ini terjadi pembekuan darah, respon inflamasi akut dan kronis, neovaskularisasi, proliferasi sel hingga apoptosis. Studi literatur ini bertujuan untuk mengkaji potensi berbagai jenis tanaman yang dapat mempercepat penyembuhan luka serta mengkaji mekanisme kerja senyawa metabolit sekunder dalam tanaman yang berperan dalam proses penyembuhan luka dari beberapa artikel. Daun andong merah (Cordyline fruticosa) (L) A.Chev; akar Ixora coccinea; batang pepaya (Carica papaya); daun Ficus deltoidea; daun mimba (Azadirachta indica A. Juss); kulit kayu jawa (Lannea coromandelica); dan daun betadine (Jatropha muitifida linn) memiliki golongan senyawa yang berperan pada proses penyembuhan luka yaitu alkaloid, flavonoid, saponin dan tannin yang memiliki potensi antiseptik, astringen, antiinflamasi, antioksidan dan antibakteri).

Uji Aktivitas Tabir Surya Ekstrak Kulit Buah Sirsak (Annona muricata L.) yang Diekstraksi Dengan Metode Ultrasonic Assisted Extraction Jihan Fadillah; Kiki Mulkiya Yuliawati; Esti Rachmawati Sadiyah
Bandung Conference Series: Pharmacy Vol. 2 No. 2 (2022): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Abstract. Ultraviolet (UV) rays are one of the spectrum of the sun that adversely affects the skin such as erythema or pigmentation, which in long-term effects may cause photoaging and photocarcinogenesis. These adverse effects can be prevented by using sunscreen that can be made from synthetic or natural materials. The peel of soursop fruit (Annona muricata L.) is a natural material that has been known to contain phenol and flavonoid compounds, both of these compounds are reported to have activities as sunscreen. The extraction method uses Ultrasonic Assisted Extraction (UAE) with aquadest as solvent. Time variations of extraction are 15, 30, 45, and 60 minutes. The sunscreen activity test was carried out on all samples at concentrations of 625, 1.250, 1.875, 2.500, 3.125, 3.750, 4.375, and 5000 ppm. Determination of sunscreen activities involves sun protection factor, erythema transmittance percentages (%Te), and pigmentation transmittance percentages (%Tp) by using UV-Vis spectrophotometer (wavelength range 290-375 nm). The result showed that UAE extract of 15 minutes at the concentration 5.000 ppm has the highest sunscreen activities than the other samples with SPF value 12,78 which belongs to the maximum protection type; %Te 5,08% and %Tp 20,00% which belongs to the extra protection category. Abstrak. Sinar Ultraviolet (UV) merupakan salah satu spektrum dari sinar matahari yang dapat memberikan dampak buruk pada kulit seperti eritema atau pigmentasi, yang mana efek jangka panjang dapat menyebabkan photoaging dan photocarcinogenesis. Dampak buruk ini dapat dicegah dengan penggunaan tabir surya, baik tabir surya dengan bahan aktif sintesis maupun alami. Kulit buah sirsak (Annona muricata L.) merupakan salah satu bahan alam yang telah diketahui mengandung senyawa fenol dan flavonoid, dimana kedua senyawa tersebut telah dilaporkan memiliki aktivitas sebagai tabir surya. Metode ekstraksi dilakukan melalui metode Ultrasonic Assisted Extraction (UAE) dengan menggunakan aquadest sebagai pelarut pada beberapa variasi waktu yaitu 15, 30, 45, dan 60 menit. Pengujian aktivitas tabir surya dilakukan terhadap semua sampel pada konsentrasi 625, 1.250, 1.875, 2.500, 3.125, 3.750, 4.375, dan 5000 ppm yang meliputi penentuan nilai Sun Protection Factor (SPF), nilai persen transmisi eritema (%Te), dan nilai persen transmisi pigmentasi (%Tp) dengan menggunakan spektrofotometer UV-Vis (panjang gelombang 290-375 nm). Hasil pengujian menujukkan bahwa ekstrak UAE 15 menit pada konsentrasi 5000 ppm memiliki aktivitas tabir surya lebih tinggi dibandingkan sampel lain dengan nilai SPF sebesar 12,78 yang termasuk ke dalam tipe proteksi maksimal; serta %Te 5,08% dan %Tp 20,00% yang termasuk ke dalam kategori proteksi ekstra.

Kajian Pustaka Potensi Aktivitas Antibakteri Minyak Atsiri Daun Nilam (Pogostemon cablin Benth.) terhadap Bakteri Patogen pada Kulit Nisa Rahma Aniyati; Yani Lukmayani; Esti Rachmawati Sadiyah
Bandung Conference Series: Pharmacy Vol. 2 No. 2 (2022): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Abstract. Skin infection becomes one of the most common skin problems in Indonesia. It is usually caused by bacterial infections, fungi, and viruses Antibacterial is a compound used to inhibit and kill pathogenic bacteria, one of the examples is patchouli (Pogostemon cablin Benth.) with one of the ingredients called essential oil. The study examined the antibacterial activity of patchouli leaf essential oil against pathogenic bacteria, namely Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, and Pseudomonas aeruginosa, using literature review method. Analysis performed based on inhibition zone diameter and Minimum Inhibition Concentration (MIC) value resulted from selected papers. The results of this literature study indicate that the better diameter of the inhibitor is to inhibit Staphylococcus aureus bacteria by 22.5 mm at a concentration of 2%. So that patchouli essential oil as an antibacterial is more likely to be against Gram positive bacteria than Gram negative bacteria, with the MIC value of Gram positive bacteria (Staphylococcus aureus) ranging from 250-2000 g/mL, while Gram negative bacteria (Pseudomonas aeruginosa) are in the range of 1200 – > 4000 g/mL. Abstrak. Permasalahan kulit yang sering terjadi di Indonesia salah satunya adalah infeksi kulit, biasanya disebabkan karena infeksi bakteri, jamur dan virus. Antibakteri adalah suatu senyawa yang digunakan untuk menghambat dan membunuh bakteri patogen. Salah satu tanaman yang berkhasiat sebagai antibakteri yaitu daun nilam (Pogostemon cablin Benth.) dengan salah satu kandungannya yaitu minyak atsiri. Penelitian ini mengkaji aktivitas antibakteri minyak atsiri daun nilam terhadap bakteri patogen yaitu Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes dan Pseudomonas aeruginosa yang dilakukan dengan metode studi literatur menggunakan data sekunder. Kemudian dilakukan pengamatan berdasarkan hasil pengukuran diameter zona hambat dan nilai KHM. Hasil studi literatur ini menunjukkan bahwa diameter hambat yang lebih baik yaitu menghambat bakteri Staphylococcus aureus sebesar 22,5 mm pada konsentrasi 2%. Sehingga minyak atsiri daun nilam sebagai antibakteri lebih berpotensi terhadap bakteri Gram positif dibandingkan dengan bakteri Gram negatif, dengan nilai KHM bakteri Gram positif (Staphylococcus aureus) berada pada rentang 250-2000 μg/mL, sedangkan bakteri Gram negatif (Pseudomonas aeruginosa) berada pada rentang 1200 - >4000 μg/mL.

UJI AKTIVITAS SITOTOKSIK EKSTRAK ASETON DAUN SIRIH (Piper betle L.) DENGAN METODE BRINE SHRIMP LETHALITY TEST (BSLT) Raihan Dzaky Ath Thaariq; Esti Rachmawati Sadiyah; Sri Peni Fitrianingsih
Bandung Conference Series: Pharmacy Vol. 3 No. 2 (2023): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v3i2.8947

Daun sirih (Piper betle L.) merupakan tumbuhan yang tersebar luas diseluruh Indonesia. Daun sirih (Piper betle L.) telah digunakan secara empiris dan telah terbukti memiliki berbagai macam aktivitas farmakologi. Penelitian ini bertujuan untuk mengatahui aktivitas sitotoksik dari ekstrak aseton daun sirih dengan metode BSLT. Hasil uji fitokimia pada ekstrak aseton daun sirih mengandung senyawa flavonoid, steroid, dan saponin yang berpotensi memiliki aktivitas sitotoksik. Kelompok uji penelitian ini yaitu ekstrak aseton daun sirih dengan konsentrasi 10 ppm, 100 ppm, 250 ppm, 500 ppm, dan 1000 ppm. Kontrol negatif yang digunakan pada penelitian ini yaitu DMSO yang ditambahkan kedalam air laut. Parameter pengamatan uji aktivitas sitotoksik dengan metode BSLT yaitu kematian larva setelah pengujian selama 24 jam. Nilai LC50 dari hasil uji yaitu sebesar 30,7777 ppm, sehingga menunjukkan bahwa ekstrak aseton daun sirih memiliki aktivitas sitotoksik. Betel leaf (Piper betle L.) is a plant that is widespread throughout Indonesia. Betel leaf (Piper betle L.) has been used empirically and has been shown to have various pharmacological activities. This study aims to determine the cytotoxic activity of betel leaf acetone extract using the BSLT method. Phytochemical test results on betel leaf acetone extract contained flavonoids, steroids, and saponins which have the potential to have cytotoxic activity. The test group for this research was betel leaf acetone extract with concentrations of 10 ppm, 100 ppm, 250 ppm, 500 ppm, and 1000 ppm. The negative control used in this study was DMSO added to seawater. The parameter observed for the cytotoxic activity test with the BSLT method was the death of the larvae after 24 hours of testing. The LC50 value of the test results was 30.7777 ppm, indicating that the acetone extract of betel leaf had cytotoxic activity.

Karakterisasi dan Pengujian Kadar Flavonoid Total Ekstrak dan Kombucha Bunga Telang (Clitoria ternatea L) Nazwa Latiefah Firdaus; Vinda Maharani Patricia; Esti Rachmawati Sadiyah
Bandung Conference Series: Pharmacy Vol. 3 No. 2 (2023): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v3i2.8997

Abstract. Telang Flower (Clitoria ternatea L) has several benefits, especially as a medicinal plant, containing secondary metabolite compounds that can potentially be antioxidant, antibacterial, antiparasitic and anticidal, antidiabetic, and anti-cancer. Eagles are known to contain compounds that act as natural antioxidants that contain phenolic and flavonoid group compounds. Therefore, this study aims to determine the characterization of simplisia and extract of telang flowers as well as total flavonoid levels in extracts and kombucha of telang flowers using the AlCl3 method.Specific characterization carried out includes organoleptic tests and determination of soluble water and ethanol levels, while non-specific characterization carried out includes determination of moisture content, filtration loss, determination of total ash content and acid insoluble ash content. Determination of total flavonoid levels was carried out by the AlCl3 method using a UV-Vis spectrophotometer and quercetin as a comparison. From the results of the study showed that the simplisia of telang flowers has the characteristics was blue color, fine powder shape, characteristic smell, and bitter taste. As for the results of greenish-brown telang flower extract, thick shape, characteristic smell, and bitter taste. In the water soluble-extract test, the results were 38.615%, ethanol soluble extract content was 31.80%, water content was 10%, drying loss was 18.580%, total ash content was 5.298%, and acid insoluble ash content was 0.588%. The total flavonoid content in the striped flower extract was 7.2188 mgQE/mg extract and in the telang flower kombucha amounted to 197 mgQE/mL Kombucha. Keywords: Telang Flowers, Total Flavonoid, Characterization. Abstrak. Bunga Telang (Clitoria ternatea L) memiliki beberapa manfaat terutama sebagai tanaman obat, mengandung senyawa metabolit sekunder yang dapat berpotensi sebagai antioksidan, antibakteri, antiparasit dan antisida, antidiabetes, dan anti-kanker. Bunga telang diketahui mengandung senyawa yang berperan sebagai antioksidan alami yang mengandung senyawa golongan fenolik dan flavonoid. Maka dari itu penelitian ini bertujuan untuk mengetahui karakterisasi dari simplisia dan ekstrak bunga telang serta kadar flavonoid total pada ekstrak dan kombucha bunga telang menggunakan metode AlCl3. Karakterisasi spesifik yang dilakukan meliputi uji organoleptik dan penetapan kadar sari larut dalam air dan etanol, sedangkan karakterisasi non-spesifik yang dilakukan meliputi penetapan kadar air, susut pengeeringan, penetapan kadar abu total dan kadar abu tak larut asam. Penetapan kadar flavonoid total dilakukan dengan metode AlCl3 menggunakan spektrofotometer UV-Vis dan kuersetin sebagai pembanding. Dari hasil penelitian menunjukkan simplisia bunga telang memiliki karakteristik warna biru, bentuk serbuk halus, bau khas, dan berasa pahit. Adapun untuk hasil ekstrak bunga telang berwarna coklat kehijauan, bentuk kental, bau khas, dan rasa pahit. Pada uji kadar sari larut air didapatkan hasil sebesar 38,615%, kadar sari larut etanol sebesar 31,80%, kadar air sebesar 10%, susut pengeringan sebesar 18,580%, kadar abu total sebesar 5,298%, dan kadar abu tak larut asam sebesar 0,588%. Adapun kadar flavonoid total dalam ekstrak bunga telang adalah sebesar 7,2188 mgQE/mg Ekstrak dan pada kombucha bunga telang sebesar 197 mgQE/mL Kombucha. Kata Kunci: Bunga Telang, Flavonoid Total, Karakterisasi.

Antifungal Activity Assay of Brown Algae Extract (Turbinaria oranata J. Agardh) against Fungi Caused Dermatophytosis in Cats (Microsporum gypseum and Trichophyton rubrum): UJI AKTIVITAS ANTIFUNGI EKSTRAK ALGA COKLAT (Turbinaria ornata J. Agardh) TERHADAP FUNGI PENYEBAB DERMATOFITOSIS PADA KUCING (Microsporum gypseum dan Trichophyton rubrum) Siti Nur Fadhiilah; Esti Rachmawati Sadiyah; Indra Topik Maulana
Bandung Conference Series: Pharmacy Vol. 3 No. 2 (2023): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v3i2.9068

Abstract. Cats are one of the popular pets, but the threat of contracting dermatophytosis caused by the fungi Microsporum gypseum and Trichophyton rubrum requires innovation in the manufacture of antifungals such as macroalgae Turbinaria ornata, because they contain tannin compounds, especially phlorotannin which can act as antifungals. Based on that, aim this research was to carry out antifungal activity in extract Turbinaria ornata against Microsporum gypseum and Trichophyton rubrum which illustrated by inhibit zone. The method used is maceration for 3x24 hours using water. Antifungal testing was carried out by disc method using various test concentrations namely 250.000 ppm, 500.000 ppm, 750.000 ppm, and 1.000.000 ppm then incubated for 5x24 hours at 27oC. The results of this study showed that water extract of Turbinaria ornata has no antifungal activity against Microsporum gypseum. However, it has antifungal activity on Trichophyton rubrum with a minimum inhibition diameter of 6,2 mm at a concentration of 750.000 ppm.Keywords: Dermatophytosis, Macroalgae, Turbinaria ornata, Antifungal activity, Microsporum gypseum, Trichophyton rubrum. Abstrak. Kucing merupakan salah satu hewan yang digemari oleh sebagian masyarakat Indonesia, tetapi ancaman terjangkit penyakit dermatofitosis yang disebabkan oleh fungi Microsporum gypseum dan Trichophyton rubrum menjadi permasalahan bagi pecinta kucing tersebut. Sehingga diperlukan inovasi pembuatan antifungi seperti makroalga Turbinaria ornata karena mengandung senyawa tannin khususnya florotanin yang dapat berperan sebagai antifungi. Berdasrkan hal tersebut, penelitian ini memiliki rumusan masalah apakah Turbinaria ornata mampu menghambat pertumbuhan fungi Microsporum gypseum dan Trichophyton rubrum serta berapa nilai diameter hambat minimum yang dihasilkan. Metode yang digunakan adalah maserasi selama 3x24 jam menggunakan pelarut air. Pengujian antifungi dilakukan dengan cara cakram menggunakaan berbagai konsentrasi uji yaitu 250.000 ppm, 500.000 ppm, 750.000 ppm, dan 1.000.000 ppm kemudian diinkubasi selama 3x24 jam pada suhu 27oC. Hasil dari penelitian ini bahwa ekstrak air dari Turbinaria ornata tidak memiliki aktivitas antifungi terhadap Microsporum gypseum. Namun memiliki aktivitas antifungi pada Trichophyton rubrum dengan nilai diameter hambat minimum sebesar 6,2 mm pada konsentrasi 750.000 ppm. Kata Kunci: Dermatofitosis, Makroalga, Turbinaria ornate, Aktivitas Antifungi, Microsporum gypseum, Trichophyton rubrum.

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