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All Journal Journal of Pharmaceutical and Sciences. Proceedings National Conference Sisi Indonesia
Rona Hawa Kamilah
Universitas Sriwijaya
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Pemanfaatan Produk Alam dalam Mengatasi Resistensi Antimikroba: Tinjauan Naratif Sistematis Menuju Inovasi Kesehatan Berkelanjutan Rona Hawa Kamilah; Fatmawati
Proceedings National Conference Sinesia Vol. 1 No. 2 (2025): Accelerating SDGs Implementation in Indonesia towards a Golden Indonesia 2045
Publisher : Yayasan Penelitian dan Pengabdian Masyarakat Sisi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69836/ncrcs-sinesia.v1i2.92

Abstract

Resistensi antimikroba (AMR) telah menjadi ancaman kesehatan global yang serius, mengurangi efektivitas antibiotik konvensional dan menantang sistem kesehatan masyarakat. Produk alam, termasuk senyawa turunan tumbuhan dan jamur endofit, merupakan sumber potensial agen antimikroba baru. Tinjauan naratif sistematis ini bertujuan untuk mengidentifikasi dan merangkum studi-studi terbaru (2020–2025) mengenai potensi antimikroba produk alam dan perannya dalam inovasi kesehatan berkelanjutan. Pencarian literatur dilakukan secara komprehensif di PubMed, ScienceDirect, Google Scholar, dan ResearchGate. Studi disaring berdasarkan relevansi, kualitas metodologi, dan ketersediaan teks lengkap. Sebanyak 38 studi memenuhi kriteria inklusi, menyoroti efektivitas flavonoid, alkaloid, terpenoid, dan fenolik terhadap bakteri resisten obat, seperti Staphylococcus aureus, Pseudomonas aeruginosa, dan Escherichia coli. Mekanisme aksi meliputi gangguan membran sel, inhibisi pembentukan biofilm, dan intervensi pada quorum sensing bakteri. Meskipun bukti in vitro kuat, translasi klinis masih terbatas karena variasi metode ekstraksi, standar dosis, dan data farmakokinetik. Temuan ini menekankan potensi produk alam dalam menangani AMR sekaligus mendukung inovasi kesehatan berkelanjutan, khususnya di Indonesia dan Asia Tenggara. Upaya kolaboratif diperlukan untuk menstandarisasi metodologi, memvalidasi efektivitas in vivo, dan mengintegrasikan produk alam ke strategi kesehatan yang sejalan dengan Sustainable Development Goals.
Sistem Penghantaran Obat Mutakhir: Tantangan Formulasi Nano untuk Fitokimia yang Sulit Larut dalam Air Juliana Palungan; Rona Hawa Kamilah; Moh. Firmansah; Sima Asmara Dewa Marya Mahardika Putri; Winda Wahyu Setya Rahmah; M Iman Tarmizi Thaher
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1537

Abstract

The poor water solubility and low oral bioavailability of various phytochemical compounds (BCS Classes II and IV) continue to be major obstacles in the development of modern therapeutics, despite their remarkable therapeutic potential. This narrative review critically evaluates the use of nanoscale drug delivery systems to overcome the biopharmaceutical limitations of hydrophobic phytochemicals and pinpoints key challenges in clinical translation and industrial-scale production. The review provides a comprehensive analysis of the latest literature on the effectiveness of nanotechnology-based physicochemical modifications, including solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), nanosuspensions, polymeric micelles, liposomes, and phytosomes. The review's results indicate that nano-carrier engineering significantly enhances solubility, avoids first-pass metabolic degradation, and enables targeted delivery. Specifically, nanoformulations have proven effective at penetrating the dense matrix of the tumor microenvironment (TME) in cancer therapy, crossing the blood-brain barrier (BBB) in neurodegenerative diseases, and protecting drugs from stomach acid in infectious and metabolic conditions. However, the transition toward commercialization is hindered by issues of long-term physicochemical stability (e.g., lipid polymorphic transitions) and challenges in standardizing botanical raw materials. These issues affect the reproducibility of large-scale production, ultimately delaying the availability of these promising therapies to patients in need. In conclusion, while nanoformulations offer transformative solutions for overcoming phytochemical biological barriers, standardizing protocols, innovating green synthesis, and fostering interdisciplinary collaboration are essential for overcoming scalability barriers and preparing these innovations for clinical application.
Co-Authors Fatmawati M Iman Tarmizi Thaher Moh. Firmansah Palungan, Juliana Sima Asmara Dewa Marya Mahardika Putri Winda Wahyu Setya Rahmah