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All Journal Best Journal (Biology Education, Sains and Technology) Journal of Pharmaceutical and Sciences.
Winda Wahyu Setya Rahmah
Universitas Sriwijaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Sistem Penghantaran Obat Mutakhir: Tantangan Formulasi Nano untuk Fitokimia yang Sulit Larut dalam Air Juliana Palungan; Rona Hawa Kamilah; Moh. Firmansah; Sima Asmara Dewa Marya Mahardika Putri; Winda Wahyu Setya Rahmah; M Iman Tarmizi Thaher
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1537

Abstract

The poor water solubility and low oral bioavailability of various phytochemical compounds (BCS Classes II and IV) continue to be major obstacles in the development of modern therapeutics, despite their remarkable therapeutic potential. This narrative review critically evaluates the use of nanoscale drug delivery systems to overcome the biopharmaceutical limitations of hydrophobic phytochemicals and pinpoints key challenges in clinical translation and industrial-scale production. The review provides a comprehensive analysis of the latest literature on the effectiveness of nanotechnology-based physicochemical modifications, including solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), nanosuspensions, polymeric micelles, liposomes, and phytosomes. The review's results indicate that nano-carrier engineering significantly enhances solubility, avoids first-pass metabolic degradation, and enables targeted delivery. Specifically, nanoformulations have proven effective at penetrating the dense matrix of the tumor microenvironment (TME) in cancer therapy, crossing the blood-brain barrier (BBB) in neurodegenerative diseases, and protecting drugs from stomach acid in infectious and metabolic conditions. However, the transition toward commercialization is hindered by issues of long-term physicochemical stability (e.g., lipid polymorphic transitions) and challenges in standardizing botanical raw materials. These issues affect the reproducibility of large-scale production, ultimately delaying the availability of these promising therapies to patients in need. In conclusion, while nanoformulations offer transformative solutions for overcoming phytochemical biological barriers, standardizing protocols, innovating green synthesis, and fostering interdisciplinary collaboration are essential for overcoming scalability barriers and preparing these innovations for clinical application.
Infeksi Soil-Transmitted Helminth (STH) : Dinamika Penularan, Patogenesis dan Faktor Risiko Winda Wahyu Setya Rahmah; Dwi Handayani; Susilawati Susilawati; Dalilah Dalilah; Gita Dwi Prasasty
BEST Journal (Biology Education, Sains and Technology) Vol 9, No 1 (2026): Juni 2026
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v9i1.13743

Abstract

Infeksi Soil-Transmitted Helminth (STH) merupakan salah satu infeksi yang masih banyak ditemukan baik di wilayah tropis maupun subtropis, terutama di wilayah dengan kondisi higiene dan sanitasi yang buruk sehingga mendorong perkembangan cacing. Kelompok cacing ini yaitu Ascaris lumbricoides, Tricuris trichiura, Ancylostoma duodenale dan Necator americanus yang ditularkan melalui kontak dengan tanah yang mengandung stadium infektif cacing tersebut yang berpotensi menyebabkan gangguan kesehatan mulai dari anemia, gangguan pertumbuhan dan gangguan organ tubuh. Studi ini bertujuan untuk mengkaji dinamika penularan, patogenesis dan faktor risiko infeksi STH dari tinjauan literatur ilmiah yang dipublikasikan sepuluh tahun terakhir. Metode penelitian ini menggunakan PRISMA dengan basis data meliputi PubMed, ScienceDirect, dan Cochrane. Hasil kajian menunjukkan bahwa dinamika penularan STH melalui rute fekal-oral dari telur infektif cacing dan penetrasi kulit larva infekstif cacing tambang, yang didukung dengan kondisi lingkungan dan perilaku host. Patogenesis infeksi STH erat kaitannya dengan paparan atau intensitas infeksi dan respon imun host yang berimplikasi pada gangguan maupun kerusakan jaringan tubuh. Praktik higiene dan sanitasi, akses air bersih, kondisi toilet, sistem pembungan limbah feses dan aspek sosio-ekonomi serta kondisi lingkungan berpengaruh pada faktor risiko infeksi STH. Pemahaman dari ketiga aspek tersebut penting dan menjadi dasar dalam strategi peengendalian dan eliminasi infeksi STH yang lebih efektif.
Co-Authors Dalilah Dalilah Dwi Handayani Gita Dwi Prasasty Hamzah Hasyim M Iman Tarmizi Thaher Moh. Firmansah Palungan, Juliana Rona Hawa Kamilah Sima Asmara Dewa Marya Mahardika Putri Susilawati Susilawati Yuanita Windusari