Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Medfarm: Jurnal Farmasi dan Kesehatan Journal of Pharmaceutical and Sciences.
Moh. Firmansah
Universitas Sriwijaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Sistem Penghantaran Obat Mutakhir: Tantangan Formulasi Nano untuk Fitokimia yang Sulit Larut dalam Air Juliana Palungan; Rona Hawa Kamilah; Moh. Firmansah; Sima Asmara Dewa Marya Mahardika Putri; Winda Wahyu Setya Rahmah; M Iman Tarmizi Thaher
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1537

Abstract

The poor water solubility and low oral bioavailability of various phytochemical compounds (BCS Classes II and IV) continue to be major obstacles in the development of modern therapeutics, despite their remarkable therapeutic potential. This narrative review critically evaluates the use of nanoscale drug delivery systems to overcome the biopharmaceutical limitations of hydrophobic phytochemicals and pinpoints key challenges in clinical translation and industrial-scale production. The review provides a comprehensive analysis of the latest literature on the effectiveness of nanotechnology-based physicochemical modifications, including solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), nanosuspensions, polymeric micelles, liposomes, and phytosomes. The review's results indicate that nano-carrier engineering significantly enhances solubility, avoids first-pass metabolic degradation, and enables targeted delivery. Specifically, nanoformulations have proven effective at penetrating the dense matrix of the tumor microenvironment (TME) in cancer therapy, crossing the blood-brain barrier (BBB) in neurodegenerative diseases, and protecting drugs from stomach acid in infectious and metabolic conditions. However, the transition toward commercialization is hindered by issues of long-term physicochemical stability (e.g., lipid polymorphic transitions) and challenges in standardizing botanical raw materials. These issues affect the reproducibility of large-scale production, ultimately delaying the availability of these promising therapies to patients in need. In conclusion, while nanoformulations offer transformative solutions for overcoming phytochemical biological barriers, standardizing protocols, innovating green synthesis, and fostering interdisciplinary collaboration are essential for overcoming scalability barriers and preparing these innovations for clinical application.
Test Antioxidant Content In Herb Kyllinga nemoralis Extract With DPPH Method Moh. Firmansah; Beta Herilla Sekti; Alfa Frista Arta
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.676

Abstract

Antioxidants are compounds capable of slowing or preventing oxidation, even in relatively low concentrations, thereby contributing to various physiological functions in the body. The antioxidant components found in plants act as free radical scavengers by transforming them into less reactive molecules. Jukut Pendul (Kyllinga nemoralis) contains several bioactive substances, including flavonoids, tannins, and alkaloids, which are recognized for their potential as natural antioxidants. Flavonoids, for instance, exhibit antioxidant activity by donating hydrogen atoms or through their metal-chelating properties. These compounds can be present as glycosides (with glucose moieties) or in the free form known as aglycones. This research aimed to evaluate the antioxidant capacity of Kyllinga nemoralis extract. The plant material was sourced from Banyuwangi, East Java. Extraction was performed using the maceration method with 70% ethanol as the solvent. The free radical scavenging activity was assessed using the DPPH (1 radical) method. Ascorbic acid was used as positive control. Measurement of absorbance was carried out through UV-Vis spectrophotometry. The extract was tested at concentrations of 20, 40, 60, 80, and 100 μg/mL. The findings revealed that the value of Kyllinga nemoralis extract was 11.351 μg/mL, whereas ascorbic acid exhibited an IC50 of 3.43 μg/mL. The antioxidant activity of Kyllinga nemoralis ethanol extract falls into the very strong category, ranging <50-100 μg/mL. These results suggest that although the antioxidant strength of Kyllinga nemoralis is lower than that of , the extract still possesses detectable radical-scavenging activity.
Co-Authors Alfa Frista Arta Beta Herilla Sekti M Iman Tarmizi Thaher Palungan, Juliana Rona Hawa Kamilah Sima Asmara Dewa Marya Mahardika Putri Winda Wahyu Setya Rahmah