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Sima Asmara Dewa Marya Mahardika Putri
Universitas Sriwijaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Sistem Penghantaran Obat Mutakhir: Tantangan Formulasi Nano untuk Fitokimia yang Sulit Larut dalam Air Juliana Palungan; Rona Hawa Kamilah; Moh. Firmansah; Sima Asmara Dewa Marya Mahardika Putri; Winda Wahyu Setya Rahmah; M Iman Tarmizi Thaher
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1537

Abstract

The poor water solubility and low oral bioavailability of various phytochemical compounds (BCS Classes II and IV) continue to be major obstacles in the development of modern therapeutics, despite their remarkable therapeutic potential. This narrative review critically evaluates the use of nanoscale drug delivery systems to overcome the biopharmaceutical limitations of hydrophobic phytochemicals and pinpoints key challenges in clinical translation and industrial-scale production. The review provides a comprehensive analysis of the latest literature on the effectiveness of nanotechnology-based physicochemical modifications, including solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), nanosuspensions, polymeric micelles, liposomes, and phytosomes. The review's results indicate that nano-carrier engineering significantly enhances solubility, avoids first-pass metabolic degradation, and enables targeted delivery. Specifically, nanoformulations have proven effective at penetrating the dense matrix of the tumor microenvironment (TME) in cancer therapy, crossing the blood-brain barrier (BBB) in neurodegenerative diseases, and protecting drugs from stomach acid in infectious and metabolic conditions. However, the transition toward commercialization is hindered by issues of long-term physicochemical stability (e.g., lipid polymorphic transitions) and challenges in standardizing botanical raw materials. These issues affect the reproducibility of large-scale production, ultimately delaying the availability of these promising therapies to patients in need. In conclusion, while nanoformulations offer transformative solutions for overcoming phytochemical biological barriers, standardizing protocols, innovating green synthesis, and fostering interdisciplinary collaboration are essential for overcoming scalability barriers and preparing these innovations for clinical application.
Edukasi Postur Ergonomis dan Pencegahan Nyeri Muskuloskeletal di SMA IT Izzudin Palembang Indri Seta Septadina; Wardiansah Wardiansah; Tri Suciati; Sima Asmara Dewa Marya Mahardika Putri; Msy Rulan Adnindya; Legiran Legiran; Muhammad Ramadhan Odiesta
Journal of Community Development Vol. 6 No. 1 (2025): August
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/comdev.v6i1.1750

Abstract

Santri merupakan kelompok yang berisiko tinggi mengalami keluhan muskuloskeletal akibat kebiasaan duduk statis dan postur tubuh yang tidak ergonomis selama belajar dan menghafal Al-Qur’an. Kegiatan pengabdian ini bertujuan untuk meningkatkan pengetahuan santri mengenai postur duduk yang sehat dan pencegahan nyeri muskuloskeletal melalui edukasi ergonomis. Metode pelaksanaan meliputi penyuluhan interaktif ​menggunakan media booklet, video pendek, serta peragaan langsung teknik duduk ergonomis dan peregangan ringan bersama santri dan guru. Program ini diikuti oleh 82 peserta dari SMA IT Izzudin Palembang. Hasil evaluasi menunjukkan peningkatan pengetahuan yang signifikan, terutama pada aspek pemahaman tentang dampak keluhan muskuloskeletal (97,6%) dan gerakan peregangan (93,9%). Kegiatan ini efektif dalam meningkatkan kesadaran dan pemahaman santri mengenai pentingnya postur ergonomis, serta diharapkan menjadi langkah awal untuk penerapan perilaku duduk sehat di lingkungan pesantren.​
Co-Authors Adnindya, Rulan Indri Seta Septadina Legiran Legiran M Iman Tarmizi Thaher Moh. Firmansah Muhammad Ramadhan Odiesta Palungan, Juliana Rona Hawa Kamilah Tri Suciati Wardiansah, Wardiansah Winda Wahyu Setya Rahmah