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All Journal Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ
Surya Sumantri Abdullah
Department of Pharmacy, Sam Ratulangi University
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health

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PENGARUH KONSENTRASI GLUKOMANAN TERHADAP SIFAT FISIK SEDIAAN GEL ASAM ASKORBAT Surya Sumantri Abdullah; Irma Antasionasti; Gerald Edward Rundengan; Ezrani Tasiam; Rezky Putri Indarwati Abdullah
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 7 No. 2 (2024): Jurnal Farmasi Medica/Pharmacy Medical Journal
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v7i2.59166

Abstract

Gel preparations usually contain gelling agents which are critical factors that can affect the physical properties of the gel. The purpose to determine the appropriate variation of glucomannan concentration in the formulation of ascorbic acid gel on the physical characteristics of the gel. The research method began with the formulation of gel preparations using glucomannan as a gelling agent with variations in glucomannan concentrations at F1 (1%), F2 (1.5%) and F3 (2%). The gels were evaluated by their physical properties, including in the organoleptic, pH, homogeneity, adhesion, and spreadability tests. The research showed that in the pH and adhesiveness tests, increasing the concentration of glucomannan could increased the pH and adhesiveness of the gel. However, the spreadability of the gel decreased with increasing glucomannan concentration. The gel formula with 2% glucomannan concentration (F3) showed higher adhesion, as well as higher pH, although the gel spreadability decreased. From the evaluation results, all meet requirement for physically stable.
Physicochemical Profile of Red Ginger (Zingiber officinale) SNEDDS as Potential Antidiabetic Surya Sumantri Abdullah; Sri Sudewi; Irma Antasionasti; Rezky Putri Indarwati Abdullah
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 8 No. 2 (2025): Jurnal Farmasi Medica
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v8i2.64731

Abstract

This study developed a Self-Nanoemulsifying Drug Delivery System (SNEDDS) of red ginger (Zingiber officinale var. rubrum) to enhance its stability and bioavailability. 8 formulations (F1–F8) were tested with varying Tween 80 : PEG 400 ratios (Smix 4.5 mL). Formula F7 (2.8 : 1.8 mL) produced a water-clear emulsion with pH 5.20 ± 0.02 and excellent stability for 28 days. PSA results showed droplet size 20.33 ± 0.57 nm, PDI 0.430 ± 0.053, and zeta potential −19.58 ± 1.50 mV. These findings indicated that F7 is the optimum, physicochemically stable SNEDDS formulation, potentially improving solubility and oral bioavailability of red ginger’s active compounds as a phytopharmaceutical antidiabetic candidate Keywords: red ginger, SNEDDS, nanoemulsion, physicochemical stability
Co-Authors Abdullah, Rezky Putri Indarwati Ezrani Tasiam GERALD EDWARD RUNDENGAN Irma Antasionasti Irma Antasionasti Rezky Putri Indarwati Abdullah Sri Sudewi