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All Journal Briliant: Jurnal Riset dan Konseptual Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ
Ezrani Tasiam
Universitas Sam Ratulangi
Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Education Immunology & microbiology Medicine & Pharmacology Public Health

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PENGARUH KONSENTRASI GLUKOMANAN TERHADAP SIFAT FISIK SEDIAAN GEL ASAM ASKORBAT Surya Sumantri Abdullah; Irma Antasionasti; Gerald Edward Rundengan; Ezrani Tasiam; Rezky Putri Indarwati Abdullah
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 7 No. 2 (2024): Jurnal Farmasi Medica/Pharmacy Medical Journal
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v7i2.59166

Abstract

Gel preparations usually contain gelling agents which are critical factors that can affect the physical properties of the gel. The purpose to determine the appropriate variation of glucomannan concentration in the formulation of ascorbic acid gel on the physical characteristics of the gel. The research method began with the formulation of gel preparations using glucomannan as a gelling agent with variations in glucomannan concentrations at F1 (1%), F2 (1.5%) and F3 (2%). The gels were evaluated by their physical properties, including in the organoleptic, pH, homogeneity, adhesion, and spreadability tests. The research showed that in the pH and adhesiveness tests, increasing the concentration of glucomannan could increased the pH and adhesiveness of the gel. However, the spreadability of the gel decreased with increasing glucomannan concentration. The gel formula with 2% glucomannan concentration (F3) showed higher adhesion, as well as higher pH, although the gel spreadability decreased. From the evaluation results, all meet requirement for physically stable.
Green Synthesis dan Optimasi AgNPs melalui Ekstrak Etanol Daun Nipah (Nypa fruticans Wurmb.) Yuanita Amalia Hariyanto; Elly Juliana Suoth; Ezrani Tasiam; Della Elshaday Ronga
BRILIANT: Jurnal Riset dan Konseptual Vol 11 No 3 (2026): Volume 11 Nomor 3, Agustus 2026
Publisher : Universitas Nahdlatul Ulama Blitar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28926/briliant.v11i3.2360

Abstract

Nypa fruticans Wurmb. is a rich source of bioactive phytochemicals, including flavonoids, phenolic, and tannins. This study aimed to evaluate the antioxidant activity of Nypa fruticans Wurmb. leaf extract and investigate its potential as a bioreducing agent for the green synthesis of AgNPs. The leaf extract was prepared using the maceration method, while antioxidant activity was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. AgNPs were synthesized via a precipitation-based green synthesis approach and subsequently characterized by UV–Visible spectroscopy to monitor the formation of the surface plasmon resonance band. The extraction process yielded a crude extract with a recovery of 17%. The DPPH assay demonstrated a strong antioxidant activity, with an IC₅₀ value of 7 μg/mL. Optimization of the biosynthesis process revealed that an extract volume of 7 mL, a reaction temperature of 50 °C, and a reaction time of 90 min were the optimal conditions for the reduction of Ag⁺ ions, resulting in optically stable AgNPs. The successful formation of AgNPs was confirmed by an increase in SPR intensity accompanied by a red shift in the absorption wavelength, indicating nanoparticle growth. These findings suggest that Nypa fruticans Wurmb. is not only an effective source of natural antioxidants but also a promising eco-friendly bioreducing agent for the green synthesis of silver nanoparticles.
Co-Authors Della Elshaday Ronga Elly Suoth GERALD EDWARD RUNDENGAN Hariyanto, Yuanita Amalia Irma Antasionasti Rezky Putri Indarwati Abdullah Surya Sumantri Abdullah