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All Journal MEDISAINS Alami Journal (Alauddin Islamic Medical) Journal Physical Therapy Journal of Indonesia Journal of Clinical Microbiology and Infectious Diseases Biodiversitas Journal of Biological Diversity
Andi Rofian Sultan
Department of Microbiology, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia ; Clinical Microbiology Laboratory, Universitas Hasanuddin Hospital, Makassar, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Identification of Paenibacillus amylolyticus as the true causative agent for a nasal septum abscess: a case report Rizalinda Sjahril; Valentine Hursepuny; Prajayanti Palulun; Nadyah; Andi Rofian Sultan
Journal of Clinical Microbiology and Infectious Diseases Vol. 1 No. 2 (2021): Available Online: December 2021
Publisher : Indonesian Society for Clinical Microbiology (Perhimpunan Dokter Spesialis Mikrobiologi Klinik Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/jcmid.v1i2.7

Abstract

Introduction: A bacteria commonly found in the environment was identified in a nasal septum abscess in a diabetic patient. The isolation of a common environment bacteria Paenibacillus amylolyticus from nasal septum abscess, particularly in a diabetic type 2 patient, was initiated argumentation whether to consider it a true pathogen that needs to be treated with antibiotics or as a contaminant that does not require antibiotic treatment. Thus, in this case, report, an evaluation of the pre-analytical and analytical phase of the laboratory identification aided in determining whether the bacterium is a contaminant or causative agent. Case description: A 58-year-old woman came to the Emergency Department with foul yellowish secretion from her left nostril that started three weeks before. She confessed to being diabetic but not under common control. Physical examination of the left nasal cavity showed signs of crust and fistula on the medial mucosal membrane, and an ulcer was seen at the upper sulcus ginggivo-buccal. Her blood pressure was 230/120 mmHg, her blood glucose was 270 mg/ dL, and her HbA1c was 13.5. Clinically, the diagnosis was nasal septum abscess with diabetes type 2 and hypertension grade 2. A swab sample was collected from the nasal lesion and transported to the laboratory at room temperature less than 2 hours. Direct Gram staining showed Gram-positive, rod-shaped bacteria1+, polymorphonuclear cells 3+ and epithelial 1+. Ziehl Neelsen staining was negative. While no growth was seen on chocolate agar, MacConkey agar and Saboraud dextrose agar, small greyish colonies grew on blood agar, which by Vitek2 System were identified as Paenibacillus amylolyticus. Conventional antibiotic sensitivity tests showed sensitivity to erythromycin and vancomycin. Accordingly, the patient was treated with erythromycin and metronidazole for ten days, and the nasal septum abscess was healed. Conclusion: The presence of spore-forming rod-shaped bacteria on blood agar identified as Paenibacillus amylolyticus. It was confirmed as the true causative agent of the nasal septum abscess based on the acceptable pre-analytical and analytical phases.
Prevalence human papillomavirus type 6 and type 11 in pregnant women Haruna, Nadyah; Hatta, Mochammad; Hamid, Firdaus; Sultan, Andi Rofian; Safri, Safri; Farid, Monika Fitria; Lestari, Esa
MEDISAINS Early Release
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v0i0.23103

Abstract

Background: Pregnancy reduces the effectiveness of cell-mediated immunity, making the body more vulnerable to Human Papilloma Virus (HPV) infection. HPV comes in multiple variants, including non-pro-oncogenic varieties like 6 and 11. Less research has been done on low-risk HPV infections than on high-risk HPV since they are more frequently linked to genital warts and rarely result in cancer. Examples of these infections are types 6 and 11. It is necessary to conduct this study to ascertain whether asymptomatic pregnant women have been exposed to HPV types 6 and 11.Purpose: This study aims to determine prevalence HPV types 6 and 11 in pregnant women.Methods: A descriptive cross-sectional survey was carried out in Makassar in May 2023. The study Population consisted of pregnant women who underwent antenatal care at Tajuddin Chalid Hospital Makassar during the specified research period. After providing clarification and obtaining consent from eligible mothers, we collected a swab from the vaginal area. A PCR examination was conducted on the 167 maternal swabs that were received. Statistical analyses included frequency distribution using SPSS.Results: According to the study, 121 (72.5%) of the 167 samples tested positive for HPV type 6 DNA, while 46 (27.5%) tested negative. Meanwhile, 67% of 167 patients tested positive for HPV type 11 but were negative for the virus. Only 21 respondents with negative identification were found to be harboring both low-risk Human Papillomavirus types. In addition, 78 respondents received positive results for HPV types 6 and 11.Conclusion: Pregnant women can be infected with HPV types 6 and 11 even if they are asymptomatic. The high percentage of positive results suggests that routine maternal screening is recommended, especially during pregnancy.
Positive Blood Culture Results Predominantly Unrevealed among Adults Patients with Sepsis Hursepuny, Valentine; Baedah Madjid; Firdaus Hamid; Mochammad Hatta; Muh. Nasrum Massi; Rizalinda Sjahril; Yoeke Dewi Rasita; Lisa Tenriesa; Andi Rofian Sultan
Alami Journal (Alauddin Islamic Medical) Journal Vol 8 No 1 (2024): JANUARY
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/alami.v8i1.41777

Abstract

Sepsis is increasing every year and can be life-threatening. In the diagnosis of sepsis, it is challenging to identify the causative agent of infection. This research aims to determine the proportion of positive blood culture in sepsis patients at Hasanuddin University Hospital, Makassar. Blood cultures were collected from 98 adult patients with sepsis manifestations. This research design is cross-sectional with a descriptive observation approach. The data analysed in descriptive statistics were utilised to summarise patient demographics, treatments, and outcomes. Thirteen of 98 samples were positive for microbial pathogens (13.26%). The elderly group had the highest percentage (76.5%); eighty-seven patients (88.77%) were treated with antibiotic therapy prior to blood culture collection. Cephalosporins are the most administered antibiotics (72.4%). Administration of empirical therapy prior to blood culture collection may decrease the sensitivity of culture results. The culture of the infectious focus should be done to assist in the consideration of antimicrobial treatment.
Methicillin-Resistant Staphylococcus Aureus in orthopedic surgery: Current evidence from diagnosis until rehabilitative management Yosia Handoko; Muhammad P. Johan; Muhammad A. Usman; Muhammad Sakti; Jainal Arifin; Rizalinda Sjahril; Andi Rofian Sultan; Yunialthy Dwia Pertiwi; Rafael Marvin Yushan; Samuel Andi Kusuma
Physical Therapy Journal of Indonesia Vol. 7 No. 1 (2026): January-June 2026
Publisher : Universitas Udayana dan Diaspora Taipei Medical University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ptji.v7i1.342

Abstract

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a significant threat in orthopaedic surgery. This study aimed to evaluate the current evidence from diagnosis to rehabilitative management of MRSA in orthopedic surgery Methods: This narrative overview synthesized current evidence across the care pathway in orthopaedics, epidemiology and pathogenesis (including key resistance/virulence determinants), diagnostic approaches (sampling strategies and rapid molecular tests), therapeutic strategies (surgery plus tailored antimicrobials and local delivery), rehabilitation considerations, prevention and stewardship programs, and emerging modalities (new antibiotics, bacteriophages, and nanotechnology-enabled delivery). Results: MRSA resistance is primarily mediated by mecA (PBP2a) and augmented by additional virulence factors (e.g., panton-valentine leukocidin). Biofilm on orthopaedic implants protects bacteria from host defences and antibiotics, underpinning recurrent infection. Diagnostic yield improves with deep tissue or implant-associated sampling, while polymerase chain reaction expedites detection of resistance genes to guide early management. Optimal treatment typically combines surgical debridement with implant retention or exchange where appropriate and prolonged, targeted antimicrobials; adjuncts include local antibiotic carriers and negative-pressure wound strategies. Innovative options—novel agents, bacteriophage therapy, and nanotechnology-based delivery—show promise in early studies. Conclusion: Integrated programs, preoperative screening/decolonization, risk-adapted prophylaxis, and antimicrobial stewardship have helped lower MRSA infection rates, yet biofilm biology and rising resistance sustain a substantial burden. Emerging options include linezolid/tedizolid or minocycline plus rifampicin, with efficacy superior to vancomycin, bacteriophage therapy as an adjunct in refractory prosthetic joint infections, and nanotechnology-enabled implant coatings to deter biofilm formation.
Porphyromonas gingivalis prevalence and gyrA gene detection linked to mercury exposure in periodontitis among gold miners HELENA JELITA; HARUN ACHMAD; SYAMSUL ARIFIN; DAHLIA HERAWATI; IRENE EDITH RIEUWPASSA; RASMIDAR SAMAD; ANDI ROFIAN SULTAN; HANASIA HANASIA; FIRDAUS HAMID
Biodiversitas Journal of Biological Diversity Vol. 27 No. 4 (2026)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d270437

Abstract

Abstract. Jelita H, Achmad H, Arifin S, Herawati D, Rieuwpassa IE, Samad R, Sultan AR, Hanasia, Hamid F. 2026. Porphyromonas gingivalis prevalence and gyrA gene detection linked to mercury exposure in periodontitis among gold miners. Biodiversitas 27 (4): d270437. https://doi.org/10.13057/biodiv/d270437. The oral cavity is a dynamic ecosystem hosting diverse anaerobic microorganisms that influence oral health. Porphyromonas gingivalis, a key Gram-negative anaerobe, is strongly implicated in periodontitis pathogenesis. Chronic mercury (Hg) exposure, particularly among artisanal gold miners, has been associated with microbial dysbiosis and antibiotic resistance genes. This study investigated the relationship between salivary Hg levels, subgingival anaerobic bacteria, detection of P. gingivalis and gyrA in periodontitis among gold miners. A cross-sectional design included 60 participants (30 gold miners and 30 non-gold miners). Subgingival plaque was cultured anaerobically and identified using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS); Polymerase Chain Reaction (PCR) detected P. gingivalis and gyrA. Salivary Hg concentrations were determined using Atomic Absorption Spectrophotometry with a Mercury Vapor Unit (AAS-MVU). Median salivary Hg levels were significantly higher in miners than non-miners (0.09 µg/L [0.03-0.22] vs. 0.03 µg/L [0.03-0.03]; p<0.001), although all values remained below the 5 µg/L salivary threshold. Culture recovery was low, identifying Prevotella denticola and P. melaninogenica among miners and Bifidobacterium sp. among non-miners. PCR detected P. gingivalis in 80.00% of miners and 63.33% of non-miners (p = 0.152). In contrast, gyrA detection was higher in miners (19/30, 63.33%) than in non-miners (10/30, 33.33%, p = 0.020). Mann–Whitney analysis showed no significant differences between salivary Hg and detection of P. gingivalis (p = 0.420) or gyrA (p = 0.953). However, a significant association between P. gingivalis and gyrA was observed using the Chi-square test (χ² = 22.191, p<0.001; φ = 0.61). Although P. gingivalis prevalence did not differ significantly, chronic low-dose Hg exposure was associated with higher gyrA detection and distinct anaerobic bacteria in miners, suggesting Hg may be associated with resistance-related microbial dynamics in periodontal biofilms. Larger studies using quantitative PCR and metagenomic approaches are needed to clarify underlying mechanisms.
Diagnostic Challenges in Non-albicans Candida Bloodstream Infection in an Immunocompromised Patient: A Case Report Valentine Hursepuny; Yunialthy Dwia Pertiwi; Utma Laela Warka; Nadyah; Baedah Madjid; Andi Rofian Sultan; Mochammad Hatta; Firdaus Hamid
Journal of Clinical Microbiology and Infectious Diseases Vol. 6 No. 1 (2026): Available online : 1 June 2026
Publisher : Indonesian Society for Clinical Microbiology (Perhimpunan Dokter Spesialis Mikrobiologi Klinik Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/jcmid.v6i1.64

Abstract

Introduction: Candidemia has increased in recent years, leading to prolonged hospital stay, increased healthcare costs, and high mortality. Patients with underlying conditions such as malignancy and those requiring invasive medical devices are at higher risk of Candida bloodstream infection. Therefore, this study aims to describe a rare case of non-albicans Candida bloodstream infection in an immunocompromised patient, with emphasis on diagnostic challenges and clinical implications of discordant laboratory identification in guiding appropriate management. Case Description: A 48-year-old female with cervical cancer undergoing chemotherapy and hemodialysis via a right-thigh double-lumen catheter presented to the emergency department with prolonged vaginal bleeding, oliguria, nausea, and significant weight loss. Laboratory findings revealed leukocytosis and renal impairment. She received a combination of ceftazidime, moxifloxacin, and metronidazole in the ICU. The patient had multiple invasive devices, including intravenous catheters, parenteral nutrition, and urinary catheters. Blood culture performed on day 15 of hospitalisation identified Candida lipolytica, which was sensitive to voriconazole, amphotericin B, and flucytosine. Moreover, PCR and phylogenetic sequencing were performed to ensure accurate species identification. Despite the final identification and clinical management efforts, the patient’s clinical condition continued to deteriorate, and she eventually succumbed after three weeks of hospitalisation. Conclusion: This case highlights a rare non-albicans Candida bloodstream infection in an immunocompromised patient, emphasising the diagnostic challenges associated with accurate species identification. A stepwise diagnostic approach with culture, proteomic, and molecular confirmation, including PCR and phylogenetic analysis, is essential to ensure accurate identification and optimal clinical management.
Co-Authors Baedah Madjid Baedah Madjid DAHLIA HERAWATI Farid, Monika Fitria Firdaus Hamid FIRDAUS HAMID Hamid, Firdaus HANASIA HANASIA HARUN ACHMAD Haruna, Nadyah HELENA JELITA Hursepuny, Valentine IRENE EDITH RIEUWPASSA Jainal Arifin Lestari, Esa Lisa Tenriesa Mochammad Hatta Mochammad Hatta Muh. Nasrum Massi Muhammad A. Usman Muhammad P. Johan Muhammad Sakti Nadyah Prajayanti Palulun Rafael Marvin Yushan RASMIDAR SAMAD Rizalinda Sjahril Rizalinda Sjahril Rizalinda Sjahril Safri Safri Samuel Andi Kusuma SYAMSUL ARIFIN Utma Laela Warka Valentine Hursepuny Valentine Hursepuny Yoeke Dewi Rasita Yosia Handoko Yunialthy Dwia Pertiwi Yunialthy Dwia Pertiwi