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Sohilait, Mario Rowan
Chemistry Department Mathematics And Natural Science Faculty Pattimura University
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Education Engineering Environmental Science Materials Science & Nanotechnology Physics Social Sciences Other

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Journal : Chemistry Indonesian Journal of Chemical Research

 1 
Penambatan Molekuler α, β, dan γ-mangostin Sebagai Inhibitor α-amilase Pankreas Manusia Gaspersz, Nelson; Sohilait, Mario Rowan
Indonesian Journal of Chemical Research Vol 6 No 2 (2019): Edisi Bulan Januari (Edition For January)
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2019.6-nel

Abstract

The in silico studies of interactions between the human pancreatic α-amylase (HPA) enzyme to α, β, and γ-mangostin ligands has been carried out using the molecular docking method. Ligands α, β, and γ-mangostin interacting through the formation of hydrogen and van der waals bonds to residues on the enzyme active side. The α-mangostin ligands resulting seven hydrogen and six van der waals bonds with the residues involved were Trp59, Gln63, Trp96, Thr163, Thr164, Ala198, His201, Glu233, and Asp300. β-mangostin resulting five hydrogen and eight van der waals bonds with residues involved were Gln63, Trp96, Thr163, Thr164, Arg195, Asp197, His201, Glu233, Asp300, and His305; while γ-mangostin forms nine hydrogen and five van der waals bonds with residues involved were Trp59, Gln63, Trp96, Thr163, Asp197, Ala198, His201, Glu233, and Asp300. The binding affinity of α, β, and γ-mangostin to the HPA enzyme obtained were -7.0; -6.6; and -7.4 kcal/mol with root mean square deviation (RMSD) value were 1,850; 1,956; and 1,811 Å respectively. Ligand γ-mangostin has potential activity as an inhibitor of HPA enzyme due to the stabilization of the complexes formation with lower binding affinity (validated with RMSD value) when compared to α and β-mangostin.
Isolation of Na-alginate from Brown Seaweed (Padina sp.) and Synthesis of Na-alginate-chitosan Polyelectrolytecomplex (PEC) Film as Methylene Blue Adsorbent Rahayu, Rahayu; Bandjar, Adriani; Nurlete, Samsul; Sohilait, Mario Rowan; Baunsele, Anselmus Boy
Indonesian Journal of Chemical Research Vol 12 No 2 (2024): Edition for September 2024
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2024.12-rah

Abstract

Na-alginate has been isolated from brown seaweed (Padina sp.) and then used to make na-alginate-chitosan complex polyelectrolyte films as methylene blue adsorbent. Characteristics of na-alginate, chitosan, and PEC films before and after adsorption were carried out using an FT-IR spectrophotometer. Na-alginate-chitosan PEC film was made by mixing a 0.3% (w/v) Na-alginate solution with a 1% (w/v) chitosan solution with a chitosan-alginate volume ratio (1:3). The film formed was tested for its resistance in pH 3-11 for 7 days and showed that the film could survive in acidic or alkaline media. The adsorption study carried out resulted in maximum concentration data occurring at 75 mg/L with a capacity of 30.2768 mg/g.
Co-Authors A. Netty Siahaya Anselmus Boy Baunsele Bandjar, Adriani Bijang, Chaterina Manukpadang Catherina M. Bijang DOMINGGUS MALLE Fensia Analda Souhoka Gaspersz, Nalson Gaspersz, Nelson Hanoch J Sohilait Hasanela, Nurani Hattu, Nikmans Hellna Tehubijuluw Hellna Tehubijuluw I Wayan Sutapa Ivonne Telussa Kapelle, Imanuel B. D. Maahury, Mirella Fonda Nurlete, Samsul Pattiasina, Priska Marisa Priska Marissa Pattiasina Rahayu Rahayu Rahayu Rahayu Rosita Silaban Rosmawaty Harahap Salmawati, Mimi Sekewael, Serly Jolanda Semuel Simra Pada Shielda Natalia Joris Siahaya, Antho Netty Sri, Dewi Yusthinus T. Male