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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Indonesian Journal of Tropical and Infectious Disease Journal Of Widya Medika Junior Biomolecular and Health Science Journal IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN) Jurnal Widya Medika
Waworuntu, Gladdy L.
FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA
Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Correlation Between Candida Albicans Colonization Growth And The Addition Of 5%, 10% And 40% Dextrose Level On Saboraud Dextrose Agar Tamara, Abelia; Anggowarsito, Jose L.; Waworuntu, Gladdy L.
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 1, No 1 (2019)
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (261.901 KB)

Abstract

Introduction : Candida albicans is normal flora that can be found on skin, oral mucosa and digestive tract. This organism are commensal or non pathogenic, but when there is other predisposition factor, this commensal tendency may become pathogenic to the human body. In Diabetes Mellitus patients with high blood sugar level can affect Candida Albicans infection events. Aim: The purpose of this research is to prove whether there is a correlation between Candida Albicans colonization growth and the addition of 5%, 10% and 40% Dextrose level on Saboraud Dextrose Agar (SDA). Method: This research is a true experimental research with post test only group design observed in 11 days. Samples are from 15 strains of Candida Albicans cultured in Saboraud Dextrose Agar without the addition of Dextrose, with the addition of Dextrose 5%, 10% and 40% in eleven days and the development were noted. The growth of Candida albicans is observed from the diameter growth. Result: in the culture of Candida albicans in 11 days. Data analysis using Kruskal Wallis with data signification (α = 0,05) obtained P 0,000 (P
The Correlation Between Leukocytosis And Gallbladder Adhesion On Cholecystectomy Patients At X Hospital Lauwrens, Sabrina Sally; Mellow, Prettysun Ang; Waworuntu, Gladdy L.
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 1, No 1 (2019)
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (185.706 KB) | DOI: 10.33508/jwmj.v1i1.1883

Abstract

Background: Gallbladder adhesion is a complication which causes difficulty in cholecystectomy. The author aims to seek for a test that could be used as a predictor factor for gallbladder adhesion. In this research, the elevated white blood cell (leukocyte) count is the factor studied. Aim: This study aims to seek for correlation between leukocytosis and gallbladder adhesion on cholecystectomy patients. Method: This research is an observational analytic study using cross sectional design. The independent variable in this research is leukocytosis, and the dependent variable is gallbladder adhesion. Analysis in this research is carried out with Chi-Square test, using a total sampling of 45 medical records of cholecystectomy patients at X Hospital. Result: The majority of cholelithiasis patients in this research were between 50-59 years old (33,3%), with a mean of 51 years old. The number of cholelithiasis patient was dominated by female (62,2%). According to the cholecystectomy procedure, 26 patients underwent laparoscopic cholecystectomy (58,8%). According to clinical presentation, pain in the upper right of the abdomen was experienced by 25 patients (55,6%). Complication suffered by patients was mostly cholecystitis (n=44), yielding the number of 97,8%, followed by gallbladder adhesion in 34 patients (75,6%). Leukocytosis, which is assumed to be the predictor factor of gallbladder adhesion, was found in 15 patients (33,3%). The Chi-Square test showed no significant correlation between the two variable studied (p=0,62). Conclusion: There is no significant correlation between leukocytosis and gallbladder adhesion in cholecystectomy patients.
Correlation of Routinely Given Yoga Exercise With Level of Anxiety in Elderly of Yuswo Widodo Integrated Service Post Surabaya Margareth, Felicia; Waworuntu, Gladdy S; Maramis, Willy F
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 2, No 3 (2020): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v2i3.2665

Abstract

Introduction: The percentage proportion of older people in Indonesia is increasing, indicating that Indonesia is a country with a population structure leaning towards the elderly. If one does not die before that, every human being will surely experience an aging process that can cause various problems such as health problems. Anxiety is one of the serious health problems in the elderly. Physical exercise, such as yoga, can help reduce anxiety level. Aim: To analyze correlation between yoga exercise and level of anxiety in the elderly in Posyandu Lansia Yuswo Widodo Surabaya. Method: This research used a pre-experimental study with pre-posttest one group design, held on the 26th of July 2019 until the 16th of September 2019. The samples in this study were 22 people, all of whom were elderlies who routinely visited and have participated in 16x yoga exercise for two months. The research instrument this study used was HARS. Kendall’s Tau B was used for the data analysis. Results: data analysis shows that there was a correlation between routine yoga exercise and the level of anxiety in the elderly in Posyandu Lansia Yuswo Widodo Surabaya p=0,030. Pretest results showed that there were 14 elderly with mild anxiety and eight elderly with moderate anxiety. post-test data showed five elderly with mild anxiety levels and 17 people who did not have anxiety. Conclusion: There was a correlation between the routine of yoga exercise and the level of anxiety in the elderly in Posyandu Lansia Yuswo Widodo Surabaya.
PERBEDAAN PROFIL LIPID TIKUS RATTUS NORVEGICUS PADA PEMBERIAN DIET KETOGENIK LEMAK JENUH DAN LEMAK TIDAK JENUH SELAMA EMPAT MINGGU Dewa Ayu Liona Dewi; Ari Christy Muliono; Gladdy Lysias Waworuntu; Evelyn Ongkodjojo
IJCNP : INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN Vol 4 No 2 (2021): IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN)
Publisher : Perhimpunan Dokter Gizi Klinik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54773/ijcnp.v4i2.83

Abstract

Latar Belakang. Diet ketogenik merupakan diet populer untuk menurunkan berat badan dengan efek terhadap profil lipid masih inkonsisten. Tujuan Penelitian. Menganalisis perbedaan profil lipid tikus Rattus norvegicus pada pemberian pakan ketogenik dengan komposisi lemak 80% (jenuh dan tidak jenuh), protein 15% dan karbohidrat 5% selama 4 minggu. Metodologi. Desain penelitian true experimental dengan posttest only control group design. Tikus jantan dengan berat badan 125-150 g dibagi secara random dalam 3 kelompok (P0, P1 dan P2) menerima diet 25-30 kkal/hari sesuai dengan kebutuhan energi harian tikus. P0 kelompok kontrol menerima pakan tikus biasa. P1 menerima diet ketogenik lemak jenuh dari margarin. P2 menerima diet ketogenik lemak tak jenuh dari minyak zaitun ekstra virgin. Kolesterol total, LDL, HDL dan trigliserida diperiksa pada minggu ke 2 dan 4. Data dianalisis dengan Uji t Independen dan Mann Whitney (p<0,05). Hasil. Pada P1 terdapat perbedaan kadar HDL yang signifikan (38 menjadi 22,40 mg/dL, p=0,005) namun perbedaan kadar kolesterol total, LDL dan kadar trigliserida tidak signifikan. Pada P2 didapatkan perbedaan yang signifikan pada kadar kolesterol total (93,20 menjadi 67,80 mg/dL, p=0,042), HDL (29,40 menjadi 22,20 mg/dL, p=0,004), LDL (25,60 menjadi 13,80 mg/dL, p=0,009), dan trigliserida (100,80 menjadi 51,40 mg/dL, p=0,016). Pada P0 tidak ada perbedaan yang signifikan. Kesimpulan. Diet ketogenik dengan lemak tidak jenuh selama 4 minggu menunjukkan efek yang menguntungkan dalam menurunkan kadar kolesterol total, LDL dan trigliserida pada tikus Rattus norvegicus. kata kunci: diet ketogenik, lemak jenuh, lemak tidak jenuh, kolesterol total, HDL, LDL, trigliserida
Effects of combination of alcohol and Cinnamomum burmannii essential oil against Klebsiella pneumoniae resistance Jennifer Anggraini Sasangka; Handi Suyono; Gladdy Lysias Waworuntu
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 1 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005501202302

Abstract

Alcohol-based antiseptics are widely used in the COVID-19 pandemic to prevent the transmission of infections, including bacterial infections. However, bacterial resistance to the alcohol-based antiseptics is begun reported. Klebsiella pneumonia resistance is one of the bacterial resistances that is prioritized by the WHO to be overcome. Cinnamomum burmannii essential oil, containing cinnamaldehyde and eugenol, was investigated for antimicrobial activity. This study aimed to evaluate the synergistic effect of the combination of alcohol and C. burmannii essential oil in inhibiting bacterial growth. Ethanol 80% in a combination with C. burmannii essential oil at concentrations of 1, 2, and 3% v/v were evaluated against K. pneumoniae using the Kirby-Bauer disc diffusion method. Test was repeated three times in independent experimental. Inhibition zone diameter (IZD, mm) and antimicrobial index (AI, %) were determined and analyzed using Kruskal-Wallis test continued the Mann-Whitney test. The combination of ethanol and C. burmannii essential oil was sensitive to K. pneumoniae, meanwhile, ethanol 80% was not more sensitive. The IZD of the combination solution at 1, 2, and 3% concentration were 6.7±0.19, 9.0±0.58, and 11.0±1.15mm, respectively (p<0.05). The AI of the combination solution at concentrations of 1, 2, and 3% v/v were 7.04±2.04, 30.53±6.79, and 51.64±12.91%, respectively (p<0.05). In conclusion, the combination of ethanol 80% and C. burmannii essential oil active against K. pneumoniae which resistant to the ethanol.
DESCRIPTION OF AGE, CENTRAL CORNEAL THICKNESS AND INTRAOCULAR PRESSURE IN PATIENTS AT DEPARTMENT OF OPHTHALMOLOGY PHC HOSPITAL SURABAYA Ivaldo Hadi Ardhana; Titiek Ernawati; Gladdy Lysias Waworuntu
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 5, No 2 (2023): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v5i2.3716

Abstract

Background: Eyes are one of the most important sense organs in human life. Eyes can help humans in activities and get information visually. Disorders of the eye will hinder and make it difficult for humans to carry out daily activities and reduce the quality of life. The cornea is one of the most important parts of the eye. Central Corneal Thickness (CCT) is the middle part of the cornea. CCT examination is a routine examination that must be carried out, but there are still many who have not carried out routine CCT examinations. Patients with thick CCTs may cause the IOP readings to appear higher than the actual condition, and conversely, patients with thinner CCTs may give the interpretations the impressions that they are lower than the actual condition. Data related to CCT and IOP in Indonesia is still lacking, especially in Surabaya, so a search for research on age, CCT and IOP needs to be done.Objective: The purpose of this study was to describe data on age, CCT and IOP in patients aged 20 to 70 years in the outpatient polyclinic of Ophthalmology, PHC Hospital Surabaya.Methods: This study used a cross-sectional research design. The sampling method used is total sampling.Result: In this study, CCT was examined using a Canon TX-20P measuring instrument and examined on both eyes. The average CCT examination results in the 20-30 age group was 537.67 ± 28.16 μm and the 31-40 age group 544.89 ± 29.28 μm. In the age group 20-30 and 31-40 years, the CCT increased by 7.22 μm, however in the 41-50 age group, the average CCT was 540.09 ± 30.44 μm, which showed a decrease of 4.80 μm compared to 31-40 age group. In the 51-60 age group, the results were 553.35 ± 28.60 μm which showed an increase in CCT compared to the 41-50 age group and the 61-70 age group got the results of 550.35 ± 30.47 μm showing a decrease of 3.00 m compared to the 51-60 age group. IOP in the 20-30 age group obtained results of 16.25 ± 2.93 mmHg, this value is lower than the 31-40 age group. In the age group 31-70 years, the results of IOP decreased over time.Conclusion: Descriptive data obtained regarding age, CCT and IOP that can be used as baseline data or comparison in eye examinations.Keyword: Central Corneal Thickness, Intraocular Pressure, Eyes, Age, Cornea.
Moringa oleifera Leaf Ethanol Extract Inhibits Toxoplasma gondii Tachyzoites Replication Wihanto, Laura; Waworuntu, Gladdy Lysias; Tedyanto, Cecilia Putri; Puspitasari, Heni
Indonesian Journal of Tropical and Infectious Disease Vol. 11 No. 1 (2023)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v11i1.42672

Abstract

The various infection routes of Toxoplasma gondii that are close to daily life strongly support the incidence of toxoplasmosis. The emergence of drug-resistant Toxoplasma gondii strains raises future concerns. Moringa leaf ethanol extract has been shown to have several anti-pathogen activities, which could have an anti-Toxoplasma effect. This research was conducted to analyze the anti-Toxoplasma effect of moringa leaf ethanol extract against tachyzoites replication in Toxoplasma gondii and the correlation between extract doses with the number of tachyzoites. Mice were divided into five groups. The negative control group (Group I) received CMC-Na solution. The positive control group (Group II) received spiramycin 100 mg/kg BW. The treatment groups received moringa leaf ethanol extract 250 mg/kg BW (group III), 500 mg/kg BW (group IV), and 1000 mg/kg BW (group V), respectively. Mice were injected with 1 x 105 tachyzoites/0.1 mL/mice intraperitoneally on the first day. Moringa leaf ethanol extract and spiramycin were given orally once daily for three days. The number of tachyzoites in the intraperitoneal fluid was calculated on the fifth day. The results have shown that there were significantly lower differences (P < 0.05) in group IV (P = 0.021) and group V (P = 0.022) compared to group I. There was also a significant negative correlation between the extract doses and the number of tachyzoites (P = 0.000; r = -0.781). Moringa oleifera leaf ethanol extract has an anti-Toxoplasma effect by inhibiting the tachyzoite replication at     500 mg/kg BW and 1000 mg/kg BW.
Cognitive flexibility and problem-solving in patients with bipolar disorder Nugroho, Maria Yosepha Safira; Daeng, B. Handoko; Waworuntu, Gladdy L.
Biomolecular and Health Science Journal Vol. 2 No. 2 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (278.363 KB) | DOI: 10.20473/bhsj.v2i2.14869

Abstract

Introduction: This study focuses on the cognitive impairment in patients with bipolar disorder and also the distribution of cognitive flexibility and problem-solving by degree of education, chronicity, and episode of patient is in at the time of evaluation.Methods: This was a cross sectional descriptive study with purposive sampling method. The population was the Harmony in Diversity Group in Surabaya, Indonesia. Twenty-two patients agreed to be subjects and each of them finished the Wisconsin Card Sorting Test (WCST) to measure cognitive flexibility and the Tower of London (TOL) to measure problem-solving. Results: The WCST score are below normal for 90.9% of the patients. Higher cognitive flexibility is found in patients with bachelor's degree and euthymic patients, while lower cognitive flexibility is found in patients in depression episode, manic episode, and mixed episode. No patients could finish the TOL within the minimum required steps. Better problem-solving is found in patients in manic episode and euthymic patients while lower problem-solving is found in mixed episode and depressive episode.Conclusion: The cognitive flexibility and problem-solving in patients with bipolar disorder are lower than the normal cut off. The type of episode and chronicity are contributing factors. Euthymic patients tend to have better cognitive flexibility and manic patients tend to have better problem-solving ability.
THE EFFECT OF URTI ON THE INCIDENCE OF ACUTE OTITIS MEDIA IN CHILDREN AGED 0-5 YEARS AT THE ENT POLYCLINIC OF PHC HOSPITAL SURABAYA Cantika, Cinta; Hadi, Wiyono; Waworuntu, Gladdy Lysias
JURNAL WIDYA MEDIKA Vol. 11 No. 1 (2025): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v11i1.7505

Abstract

Upper respiratory tract infection (URTI) is an acute infection that affects the nose, paranasal sinuses, tonsils, pharynx, and larynx. It is commonly found in children under the age of 5. One of the most frequent and concerning complications of URTI in children is acute otitis media (AOM), a middle ear infection that can negatively impact a child’s health. Understanding the relationship between URTI and AOM is important to enable early prevention and treatment. This study aims to examine the effect of URTI on the incidence of AOM in children aged 0–5 years at the ENT Polyclinic of PHC Hospital Surabaya. This research employs an observational analytic design using a cross-sectional method with non-probability purposive sampling. Data were collected from medical records of pediatric patients aged 0–5 years who visited the ENT Polyclinic between January and December 2022. The data were analyzed using the contingency coefficient test, and a result was considered statistically significant if p < 0.05. Out of 45 patients who met the study criteria, the average age was 2.82 years. There were more males (62%) than females (38%). A total of 19 children (42%) had both URTI and AOM, 6 children (13%) had AOM without URTI, and 20 children (44%) had URTI without AOM. The analysis showed a p-value of 0.019 and a contingency coefficient of 0.331, indicating a moderate association between URTI and AOM. URTI has a significant influence on the incidence of acute otitis media in children aged 0–5 years at the ENT Polyclinic of PHC Hospital Surabaya.
Co-Authors Ari Christy Muliono Cantika, Cinta Daeng, B. Handoko Dewa Ayu Liona Dewi Evelyn Ongkodjojo Hadi, Wiyono Handi Suyono Heni Puspitasari Ivaldo Hadi Ardhana Jennifer Anggraini Sasangka Jose L. Anggowarsito Laura Wihanto Lauwrens, Sabrina Sally Maramis, Willy F Margareth, Felicia Nugroho, Maria Yosepha Safira Prettysun Ang Mellow Tamara, Abelia Tedyanto, Cecilia Putri Titiek Ernawati