Prediction of Sinensetin from Kumis Kucing (Orthosiphon aristatus) as Aspulvinone Dimethylallyltransferase Inhibitor for Anticancer Agent

Prasetyawan, Fendy
Arifin, Chandra
Astutik, Widhi
Rohmah, Eka Hayati
Kadir, Mujtahid Bin Abd
Ariawan, M Wahyu
Marhenta, Yogi Bhakti
Mildawati, Ratna
Saristiana, Yuneka
Rofiq, Abd

Multicore International Journal of Multidisciplinary (MIJM)
Vol. 1 No. 1 (2025): May

Sinensetin, a polymethoxylated flavone found in Orthosiphon aristatus (commonly known as Kumis Kucing), was evaluated in silico for its potential inhibitory activity against Aspulvinone Dimethylallyltransferase, an enzyme implicated in cancer-related biosynthetic pathways. The SMILES structure of sinensetin was retrieved from PubChem and analyzed using the PASS online prediction tool (www.way2drug.com). The results showed a high probability of activity (Pa = 0.865) and a very low probability of inactivity (Pi = 0.016), indicating that sinensetin is likely to act as a potent inhibitor of the enzyme. These findings suggest that sinensetin could be a promising anticancer agent candidate by targeting Aspulvinone Dimethylallyltransferase. Further studies are recommended to validate this prediction through molecular docking and biological assays.