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Jurnal Ilmiah Kedokteran Wijaya Kusuma
Published by Universitas Wijaya Kusuma Surabaya
ISSN : 19782071     EISSN : 25805967     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health
Jurnal Ilmiah Kedokteran Wijaya Kusuma (JIKW) is a periodically scientific publication that contains articles written in Indonesia or english. JIKW receive articles in the scope of Biomedical Sciences, degenerative diseases, infections, congenital abnormalities and public health. JIKW published twice a year. The articles will be published in JIKW only manuscript that has never be published or published in other journal. Writers who will publish the article please follow the JIKW guidelines. The entire management process both admission and review the article is done by online.
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Articles 390 Documents
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Gambaran Penggunaan Obat Anti Epilepsi (OAE) pada Penderita Epilepsi Berdasarkan Tipe Kejang di Poli Saraf Rumkital DR. Ramelan Surabaya Eric Hartono Tedyanto; Laurawati Chandra; Olivia Mahardhani Adam
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 9, No 1 (2020): MARET 2020 available online since April 2020
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v9i1.748

Abstract

Epilepsy is a disorder of the central nervous system (CNS) characterized by attacks (seizures, fit, attack, spell) spontaneous (unprovoked) and periodically. The main treatment of epilepsy is with antiepileptic drugs.  It was used the descriptive study design by using secondary data which taken at Medical Record Installation of Dr. Ramelan Naval Hospital Surabaya from September-November 2018. The results showed that the percentage of focal seizures is 41%, seizures general is 36% and unclassified seizures is 23%. From 61 samples, the percentage of anti-epileptic drugs used are phenytoin (31.1%), valproic acid (21.3%) and carbamazepine (4.9%) as a monotherapy. While 42.7% were treated with polytherapy that the combination of phenytoin, valproic acid, carbamazepine and benzodiazepines. Focal seizure that dominate with 41%, the general seizure is 36% and unclassified  seizures is 23%. Anti-epileptic drugs that are widely used class of phenytoin, valproic acid and carbamazepine as monotherapy and the combination of phenytoin, valproic acid, carbamazepine and benzodiazepines as polytherapy.
Kata Pengantar-Daftar Isi Edisi Maret 2020 masfufatun masfufatun
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 9, No 1 (2020): MARET 2020 available online since April 2020
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v9i1.842

Abstract

Uji Zona Hambat Kombinasi Ekstrak Bawang Putih (Allium sativum) dan Buah Mengkudu (Morinda citrifolia) terhadap Bakteri Escherichia coli R Abyseka Prayogo; Dorta Simamora
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 9, No 1 (2020): MARET 2020 available online since April 2020
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v9i1.700

Abstract

Escherichia coli bacteria is the most common cause of gastroenteritis (diarrhea), urinary tract infections (UTI), food poisoning, and other clinical problems such as neonatal miningitis. Garlic (Allium sativum) and Noni fruit (Morinda citrifolia) are plants that have antimicrobial properties, which can be used against bacteria such as E. Coli. This study was conducted to determine the inhibition zone combination of garlic extract (Allium sativum) and Noni fruit (Morinda citrifolia) against gram negative bacteria E. Coli. The research was conducted at the Laboratory of Microbiology at the Faculty of Medicine, University of Wijaya Kusuma Surabaya, and has been ethically feasible. This study was divided into 4 groups with replications 6 times each; group P0 (sterile distilled water), P1 (50% garlic + 25% noni fruit), P2 (50% garlic + 50% noni fruit), P3 (50% garlic + 75% noni fruit). Data were analyzed using One-way ANOVA test. The analysis results showed that the average diameter of the inhibition zone formed was the largest in group P1 (10.7 mm) and the smallest in group P0 (0 mm), while in P2 (9.89 mm), and P3 (9.77 mm). Based on the analysis test, the higher the concentration of noni fruit given to the extract combination resulted in the smaller diameter of the inhibition zone. This occurs due to the combination of garlic and Noni fruit has an antagonistic effect that depend on bacterial species, temperature, pH, chemical structure, chemical reactions, and concentrations or doses of antimicrobial compounds. The results also showed that there was no significant difference between group P1 and group P2, group P1 with group P3 and group P2 with group P3 showing p-value> 0.005.
Ekstrak Metanol Biji Asam Jawa (Tamarindus Indica) Memperbaiki Kerusakan Histopatologi Ginjal Tikus yang Diinduksi Aluminium Anang Dwi Atmoko; Al Munawir; Ika Rahmawati Sutejo
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 9, No 2 (2020): SEPTEMBER 2020
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v9i2.849

Abstract

Aluminum is the most widely used metal in everyday and the exposure of aluminum can be accumulate in kidney tubular cells, which cause tubular cell degeneration through oxidative stress because of nephrotoxicity. Tamarindus indica seeds contain high polyphenolic compounds and high antioxidant potential. This study aimed to investigate whether the methanolic extract of Tamarindus indica seeds repair histopathological damage of aluminum-induced kidney rat assessed by the parameters of tubular cell degeneration and necrosis. This experimental study was conducted at the Faculty of Medicine, University of Jember for 10 weeks using 30 male Wistar rats. Rats were divided into 5 groups; 1) K: control group was given a mixture of aquabides-saline (NaCl 0.9%), 2) K (-): negative control group was given aluminum solution (AlCl3), 3) P1: first treatment group was given aluminum solution (AlCl3) and extract (25 mg/kg b.w., po),  4) P2: second treatment group was given aluminum solution (AlCl3) and extract (50 mg/kg b.w., po), 5) P3: third treatment group was given aluminum solution (AlCl3) and extract (100 mg/kg b.w., po). Aluminum solution is given in a dose of 300 mg/kg b.w. po. After being terminated, the rat’s kidney histology were examined to a scoring damage process. Based on cell degeneration parameter, all groups get 5 in score of damage. Meanwhile based on cell necrosis parameter, all group get different score of damage. Based on the cell necrosis parameter, the methanolic extract of Tamarindus indica seeds repair histopathological damage of rat kidney induced by aluminum chloride
Efektivitas Antidiabetes Fraksi Air Daun Karamunting (Rhodomyrtus Tomentosa (Ait.) Hassk.) terhadap Kadar Glukosa Darah dan Sekresi Insulin pada Tikus Model Diabetes Geri Febriyanto; Mgs. Irsan Saleh; Theodorus Theodorus
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 10, No 1 (2021): MARET 2021
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v10i1.1098

Abstract

This study aims to determine the effectiveness of the water fraction of caramunting leaves (Rhodomyrtus tomentosa (Ait.) Hassk). Against a decrease in blood glucose levels 2 hours post prandial and an increase in insulin levels of male white rats induced by streptozotocin. This research is an in vivo laboratory experimental research. The subjects of this study were 30 male white rats divided into 5 groups, namely positive control using glibenclamide, negative control using Na CMC, treatment group using caramunting leaf water fraction 70mg/ KgBB, 140mg/ KgBB, and 280mg / KgBB. The results showed that the caramunting leaf water fraction group was 70mg/ KgBB. 140mg/ KgBB, and 280m / KgBB effectively reduce blood glucose levels 2 hours post prandial and increase insulin levels. Based on the results obtained, it can be concluded that the water fraction of caramunting leaves (Rhodomyrtus tomentosa (Ait.) Hassk). Effectively reducing blood glucose levels 2 hours post prandial and increasing insulin levels with a dose of 280mg / KgBB is the most effective dose.
Molecular Toxicology of Organophosphate Poisoning Fery Setiawan; Arif Rahman Nurdianto; Heribertus Agustinus B Tena; Ahmad Yudianto; Jenny Sunariani; Achmad Basori; Acrivida Mega Charisma
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 11, No 1 (2022): MARET 2022
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v11i1.1596

Abstract

The use of organophosphates (pesticides and other compounds to eradicate pests), currently, to increase the fulfillment of the population's consumption needs has a double-edged sword effect, on the one hand it can increase the need for food to be consumed by the population. The negative effect that can arise is the safety of organophosphate drugs which can contaminate the soil and water sources around the place where organophosphate drugs are used. The negative effects of organophosphates are associated with the effects of xenobiotics on humans who consume them. Xenobiotics are associated with toxicdynamic effects where organophosphates cause irreversible inhibition of the enzyme acetylcholinesterase (ACh). ACh is one of the main enzymes in the nervous system that terminates impulse conduction through the hydrolysis process of acetylcholine enzymes. Acetylcholinesterase is a specific molecular target of organophosphate pesticides. The inhibition of the Ach enzyme causes the inhibition of the acetylcholine enzyme which is normally always hydrolyzed by the Ach enzyme and is a specific biological marker of pesticide poisoning. Inhibition of ACh will cause the accumulation of the enzyme acetylcholine, resulting in negative effects of organophosphate poisoning which can lead to death. In this paper, the authors collect from various sources related to the study of molecular toxicology toxidynamic effects of drug safety and organophosphate poisoning. The results of this review article show that organophosphate poisoning is associated with irreversible inhibition of the acetylcholinesterase enzyme which results in death in the individual concerned.
Profile of The Use of Antihypertension Drug and Blood Pressure Evaluation at Gresik Hospital Prada Marwah Al kamilah; Lusiani Tjandra; Meivy Isnoviana; Ibrahim Njoto
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 12, No 2 (2023): September 2023
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v12i2.2974

Abstract

A potentially fatal non-communicable disease is hypertension. Important organs like the brain, heart, kidneys, retina, big blood vessels (aorta), and peripheral blood vessels are in danger for harm as a result. Heart attacks and even death can result from hypertension. By avoiding and managing risk factors like smoking, sedentary lifestyles, a lack of fruits and vegetables, and obesity, it is crucial to work towards lowering the risk of hypertension. This study's objectives were to assess blood pressure and establish the profile of antihypertensive medicine use. Methods: Data for this retrospective analysis were gathered based on information from patient pharmacy records and medical records. Results: 33.7% hypertension sufferers aged 65-74 years, 62.2% women and 37.8% men, 38.9% The beta-blocker drug group with the drug that is often used Bisoprolol dose of 2.5 mg as much as 26.9 %, 88% in tablet dosage form, which is used in combination form with the rule of using once a day and 64.3% controlled hypertension. This is a retrospective study that obtained data based on medical record information and patient pharmacy data. Conclusion: Hypertension patients are usually aged between 65-74 years, mostly female. Antihypertensive drugs that are often used are in the beta blocker class which is a Bisoprolol dose of 2.5 mg in tablet, used in a single dose or/and combination. Sixty-four point three percent (64.3%) of patients have controlled hypertension.
Efektifitas Aloe vera terhadap Luka Bakar Ashilah Mumtaz Hakim
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 9, No 2 (2020): SEPTEMBER 2020
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v9i2.800

Abstract

Herbal medicines are a form of treatment that is based on the use of plants with high bioactivity potential. These therapies have been used throughout history for the treatment of various diseases. Therapy has been passed down from generation to generation to become general knowledge related to culture, health, and improvement of quality of life for certain diseases. Aloe vera or Aloe vera is a cactus-like plant which, in several studies in experimental animals and humans, has been shown to have benefits. Used to accelerate wound healing, through complex biological processes that are responsible for tissue recovery and have been used since ancient times. Scientific evidence about the benefits of Aloe vera will be very useful, because its use can improve adherence to treatment of patients because the wound is rapidly improving and can also reduce costs. Aloe vera has been used externally to treat various skin conditions such as burns and eczema. Allegedly the sap from Aloe vera alleviates pain and reduces inflammation. Has antiseptic and antibiotic properties. Clinical studies based on scientific evidence are needed to get a better understanding of Aloe vera, its compounds and therapeutic indications).
Neuropati Optik Kompresif Bilateral yang Terinduksi oleh Schwannoma Cinintha Nandini; Lukisiari Agustini
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 9, No 1 (2020): MARET 2020 available online since April 2020
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v9i1.733

Abstract

The aim of this case report was to present further study about diagnosis and management of bilateral compressive optic neuropathy induced by schwannoma. This case report will discuss about the definition, classification, etiology, clinical diagnosis and treatment for compressive optic neuropathy. A case report. 43 years-old woman complained about blurred vision since 2 years ago. She also complained about pain on her right head while she was walking. There was no history of tinnitus or hearing loss. She had a history of contraception pill uses and progesterone injection every 3 months for 5 years alternately. She also suffered from schwannoma in cerebello pontine angle based on MRI and histopathology examination. From physical examination, best corrected visual acuity on right eye was 5/6 PHNI and on left eye was 5/8 PHNI. Ishihara test showed decreased colour vision. There was also ataxic gait. From anterior segment examination, there were decreased light reflex and RAPD. From posterior segment examination, there were papilloedema and elevation on both eyes proved by OCT and fundal imaging.  Neuroprotector therapy and surgery show a good result. Ishihara test are improving, light reflex are increasing and there are no RAPD anymore. From posterior segment, papilloedema are slowly diminished. The patient presents a case of bilateral compressive optic neuropathy induced by schwannoma. Neuroprotector and surgery show a good result.
Nasotracheal Intubation under Videolaryngoscopy in Mandibular Abscess with Trismus Albertus Medianto Walujo; I Gde Agus Shuarsedana Putra; I Wayan Widana; Ida Ayu Manik Manuaba
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 11, No 1 (2022): MARET 2022
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v11i1.1570

Abstract

Management of a difficult airway is a challenge for every anesthesiologist. Mandibular stiffness, trismus, and facial structural deformities often limit the available airway management options. With a variety of techniques that have been developed today, the management of difficult airways is more optimal than conventional management. One technique that can be used is video laryngoscopy. The authors report a case of nasotracheal intubation by video laryngoscopy in a mandibular abscess patient with trismus. The purpose of this case report is to demonstrate the effectiveness of the video laryngoscopy technique to assist nasotracheal intubation and to add insight for nasotracheal intubation technique in difficult airway conditions, especially trismus. Female, 60-year-old, come with a left mandibular abscess with complicated trismus who was planned for incision and drainage of the abscess. Nasotracheal intubation was performed under video laryngoscopy and during the surgical procedure the patient's vital signs were stable. This case report concludes that video laryngoscopy can be an alternative to conventional techniques and awake fiberoptic intubation in the case of nasotracheal intubation.

Page 34 of 39 | Total Record : 390

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