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Jurnal Ilmiah Kedokteran Wijaya Kusuma
Published by Universitas Wijaya Kusuma Surabaya
ISSN : 19782071     EISSN : 25805967     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health
Jurnal Ilmiah Kedokteran Wijaya Kusuma (JIKW) is a periodically scientific publication that contains articles written in Indonesia or english. JIKW receive articles in the scope of Biomedical Sciences, degenerative diseases, infections, congenital abnormalities and public health. JIKW published twice a year. The articles will be published in JIKW only manuscript that has never be published or published in other journal. Writers who will publish the article please follow the JIKW guidelines. The entire management process both admission and review the article is done by online.
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Articles 429 Documents
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The Association Between Hypertension and Non-Hemorrhagic Stroke Desyanti Risky Putri; Saktivi Harkitasari; Sri Masyeni
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol. 15 No. 1 (2026): March 2026
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v15i1.4736

Abstract

Background: Stroke is the leading cause of disability and the third leading cause of death worldwide. This study aims to investigate hypertension as a risk factor for non-hemorrhagic stroke (NHS). Methods: This study was designed as a retrospective, observational, analytic case-control study involving a total of 112 participants. Data analysis utilised the chi-square test, with a significance level set at p < 0.05 and a 95% confidence interval (CI). Results: The findings revealed that NHS patients were predominantly in the 45-60 year age group (44.6%), primarily male (69.6%), and mostly of Balinese ethnicity (94.6%). A significant number of NHS patients were diagnosed with hypertension (53.6%). The most frequently reported clinical symptoms were weakness or paralysis in the extremities (94.6%). An improvement in outcomes was observed in 80.4% of patients, with a median length of hospital stay of 4 days. Laboratory data were normal, and CT scans identified hypodense lesions in 60.7% of cases. The results of the chi-square statistical analysis indicated an odds ratio (OR) of 2.65, with a 95% CI of 1.22–5.74 and p = 0.013. In conclusion, this study suggests that hypertension increases the risk of non-hemorrhagic stroke by 2.65 times compared to individuals without hypertension.
The Role of Micronutrients (Zinc, Vitamin A, C, D and Iron) in Preventing Infectious Diseases in Disaster-Affected Populations: A Literature Review Durry, Fara Disa; Sukma Sahadewa; Zulfan Febriawan; Prasetyaning Estu Pratiwi; Lionesya Sukma Winata
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol. 15 No. 1 (2026): March 2026
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v15i1.4763

Abstract

Background: Micronutrient deficiencies significantly increase vulnerability to infectious diseases, partiularly among disaster-affected populations with limited access to food and healthcare. Despite this, micronutrient interventions are rarely prioritized in emergency health protocols, especially in countries like Indonesia. Objective: This review aims to examine the role of micronutrients in preventing infectious diseases in populations affected by disasters, based on an analysis of primary research articles. Methods: A narrative thematic literature review was conducted using databases such as PubMed, ScienceDirect, and Google Scholar. Inclusion criteria covered primary studies (both experimental and observational) within disaster settings, published between 2013 and 2023. A total of 25 eligible studies were analyzed. Results: Most studies reported that supplementation with micronutrients particularly vitamin A, vitamin D, zinc, vitamin C, and iron was associated with reduced incidence and severity of respiratory tract infections, diarrhea, and pneumonia. Multi-micronutrient interventions proved more effective than single-nutrient approaches. However, implementation in emergency contexts remains limited, and vulnerable groups beyond young childrensuch as adolescent girls, pregnant women, and the elderlyare often underrepresented in the literature. Conclusion: Micronutrient supplementation has substantial potential to strengthen post-disaster health resilience. Integrating micronutrient strategies into emergency logistics, conducting targeted nutritional screening, and enhancing multi-sectoral training are essential steps toward improving disaster response outcomes.  
Breast Cancer Classification Using Support Vector Machine Method and RBF Kernel Function Based on Clinical Data, Cancer Stage, and Immunohistochemistry Results Sherly Nur Ekawati; wati, mudy; Arya Iswara; Ahmad Ilham; Astri Aditya Wardhani
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol. 15 No. 1 (2026): March 2026
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v15i1.4908

Abstract

Background: Breast cancer is one of the leading causes of cancer-related deaths among Indonesian women. Early detection and classification of molecular subtypes are crucial for determining appropriate therapy. Accurate determination of biological subtypes of breast cancer is essential for selecting optimal treatment strategies. This research aims to build and evaluate a breast cancer subtype classification model using the SVM with an RBF kernel. The subtypes classified include Luminal A, Luminal B, HER2+, and Triple Negative Breast Cancer, utilizing a combination of patient clinical data (age, tumor size, and tumor location), cancer stage, and the expression status of hormonal receptors ER and PR. The methodological steps include data preprocessing, feature selection, model training with cross-validation, and performance evaluation using metrics such as accuracy, precision, recall, F1-score, and the ROC-AUC curve. The results showed that the majority of patients' ages were in the range of 40–60 years, with dominant tumor sizes between 1 and 3 cm. Luminal A and B subtypes were more frequently observed in patients aged ≥50 years and at early stages, whereas HER2+ and TNBC were mostly observed in patients under 50 years with advanced stages. The established baseline SVM-RBF model achieved high accuracy (91%) but performed poorly at detecting minority subtypes, such as HER2+, with a recall = 0 and an F1-score = 0, indicating model bias toward the majority class. This study demonstrates that the SVM algorithm with the RBF kernel is effective for modeling breast cancer subtype classification using clinical data, cancer stage, and immunohistochemistry results.
Potential of Local Plants as Sources of Iron, Folic Acid, and Calcium for Preconception Supplementation Nur Cholila; Nur Maziyah Hurin’in; Tri Yunita Fitria Damayanti
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol. 15 No. 1 (2026): March 2026
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v15i1.4922

Abstract

Background: High prevalence of anemia and nutritional deficiencies among Women of Childbearing Age in Indonesia, including Tuban Regency, elevates pregnancy complication risks. Crucial micronutrient supplementation (iron, folic acid, calcium) often overlooks local resources. This study uniquely identifies Tuban's local plants as simultaneous sources of these three vital micronutrients, moving beyond conventional supplements. Objective: To identify and analyze the iron, folic acid, and calcium content of local plants in Tuban for preconception supplementation. Methods: This descriptive quantitative study analyzed dried powder samples from five local leaf species: katuk, sweet potato, moringa, cassava, and spinach. Iron and calcium were measured by AAS, and folic acid by HPLC, in an accredited laboratory. Data were descriptively analyzed and compared with the WCA Recommended Dietary Allowances (RDA) and the Indonesian Food Composition Table (TKPI) 2017. Results: Moringa leaves (Moringa oleifera) were an exceptional source of iron (28.04 mg/100g) and calcium (1783 mg/100g), significantly exceeding WCA RDA. Sweet potato leaves (Ipomoea batatas) emerged as the best folic acid source (1.59 mg/100g), meeting WCA RDA with a small serving (25g). Spinach and katuk leaves also contributed to iron and folate intake. Micronutrient concentrations in dried powder generally surpassed TKPI 2017 fresh leaf data. Conclusion: Local plants, particularly moringa and sweet potato leaves, offer substantial potential as sustainable, economical, and culturally relevant sources of iron, folic acid, and calcium for preconception supplementation, thereby enhancing women's reproductive health in Tuban Regency.
Comparison Effect of Garlic and Bitter Melon Extracts on Kidney Histopathology in Hyperglycemic White Rats Hidayati, Rafidah Nur; Indahsari, Noer Kumala; Noviana, Ayu Cahyani
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol. 15 No. 1 (2026): March 2026
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v15i1.4943

Abstract

Background: Hyperglycemia in diabetes mellitus can cause kidney damage through oxidative stress and tubular cell degeneration. Garlic (Allium sativum) and bitter melon (Momordica charantia) are known to possess antihyperglycemic and antioxidant effects that may improve kidney tissue damage. Objective: To determine and compare the effects of garlic and bitter melon extracts on the kidney histopathology of hyperglycemic white rats (Rattus norvegicus). Methods: This laboratory experimental study employed a post-test only control group design using 24 rats divided into four groups: normal control, hyperglycemic control, garlic extract treatment, and bitter melon extract treatment. Kidney histopathological examination was conducted using Hematoxylin-Eosin staining. Results: Administration of garlic and bitter melon extracts showed improvement in kidney structure, indicated by decreased tubular cell degeneration and necrosis compared to the hyperglycemic control group. The improvement effect was more prominent in the garlic extract group. Conclusion: Both garlic and bitter melon extracts have protective effects against kidney damage induced by hyperglycemia, with the garlic extract showing the most significant improvement.
Anesthesia Management in Patient with Eclampsia and HELLP Syndrome: A Case Report Basith, Abd; Adnan, Muhammad Luthfi
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol. 15 No. 1 (2026): March 2026
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v15i1.4955

Abstract

Background: Eclampsia and HELLP Syndrome is one of the emergency that occurs in pregnant women and is one of the causes of death in pregnant women and fetus. It can be a challenge for an anesthesiologist for anesthetic management during and after pregnancy termination. Objective: This report presents anesthetic management using combination propofol, rocuronium, and fentanyl in cases of eclampsia with HELLP syndrome and monitoring during pregnancy termination surgery. Case Presentation: A 24-year-old female patient with a gestation age of 36 weeks came to the emergency room with seizure. During the latest antenatal care found high blood pressure (160/100 mmHg). Based physical and laboratory findings the patients diagnosed eclampsia and HELLP syndrome. The patient was given general anesthesia with induction of propofol 2 mg/kg with a rapid bolus, rocuronium 1 mg/kg IV, and fentanyl 2 mcg/kg with endotracheal intubation. During surgery, the patient was hemodynamically stable and the baby was born with an Apgar score of 9/10. The patient was admitted to the ICU for vital signs monitoring for 4 days before being discharged after the sixth day. Result: Patients with eclampsia and HELLP syndrome require careful anesthetic management because it not only impacts maternal condition, but also the outcome of the neonates. Conclusion: This condition required special treatment including by anesthesiologists. Treatment includes how to deal with seizures, the choice of anesthesia technique, prevention of seizures and intraoperative fluids management and ensuring safety for both the mother and the fetus. Lot of controversies with regard to fluid management and monitoring still remain unanswered.
Incision Wound Healing Activity of Red Betel Leaf (Piper crocatum) in Wistar Rats Maharani Rizki Amanda Barokah; Tjandra, Lusiani; Andra Agnes Al Aska; Atik Sri Wulandari
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol. 15 No. 1 (2026): March 2026
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v15i1.5054

Abstract

Background: Incisional wounds are tissue injuries that requireappropriate management to prevent complications. Red betelleaf (Piper crocatum) contains bioactive compounds with antiinflammatory, antioxidant, and antimicrobial properties thatmay enhance wound healing. Objective: This study aimed toevaluate the wound-healing activity of red betel leaf extract inWistar rats with incisional wounds. Methods: The research usedan experimental laboratory design in which test animals weredivided into five groups.: three treatment groups with extractconcentrations of 5%, 10%, and 15%, a positive control groupusing 10% povidone iodine, and a negative control group using0.9% NaCl. Observed parameters included redness, edema,exudate, granulation tissue formation, and wound lengthchanges during the healing process. Result: The resultsdemonstrated that Piper crocatum extract, particularly at aconcentration of 15%, significantly reduced inflammatory signs(erythema, edema, and exudate) and accelerated granulationtissue formation and wound contraction compared with thecontrol groups (p < 0.05). Conclusion: These findings suggestthat red betel leaf extract possesses pharmacological activitythat accelerates wound healing and has potential as acomplementary therapy in wound management.
Association of Pain Location and Lidocaine Dosage with Clinical Response to Targeted Intramuscular Lidocaine Injection in Diabetic Neuropathic Pain Wiradinata, Harsono; Roethmia Yaniari; I Made Subhawa Harsa; Atik Sri Wulandari; Pratika Yuhyi Hernanda
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol. 15 No. 1 (2026): March 2026
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v15i1.5056

Abstract

Background: Diabetic neuropathic pain (DNP) is often refractory to oral analgesics. It is a complication of diabetes mellitus that causes sensory disturbances. Oral pharmacological therapies, including antidepressants, anticonvulsants, and opioids, often have limited efficacy and may cause systemic adverse effects. Objective: This prospective observational cohort study evaluated whether anatomical pain location and lidocaine dose predict the short-term analgesic response to targeted intramuscular lidocaine injection at the patient’s site of maximal pain in patients with diabetic neuropathic pain. Methods: Thirty-one adults with DNP treated at Bhayangkara Hospital were enrolled. They received 1% plain lidocaine at doses of 3, 4, or 5 mg/kg, administered intramuscularly at the site of maximal pain. Pain intensity was assessed at baseline and at 30 minutes, 1, 2, 4, and 6 hours after injection using the Visual Analog Scale (VAS) and the Neuropathic Pain Symptom Inventory (NPSI). Result: The results showed a dose-dependent decrease in mean VAS scores, and this dose-response trend was statistically significant (ANOVA, p = 0.018). The composite NPSI score decreased by an average of 34.2%. Furthermore, patients with dorsal foot pain and those experiencing electric shock/paresthesia sensory phenotypes showed the greatest reductions in pain scores. Conclusion: These findings indicate that targeted IM lidocaine produced rapid short-term analgesia within 30 minutes, lasting approximately 4 to 6 hours. Anatomical targeting and dose selection may influence analgesic outcomes and may support individualized, symptom-directed strategies for managing diabetic neuropathic pain.  
Alteration of Ca/P Ratio and Hydroxyapatite Stability in Human Teeth Exposed to Lead: An In Vitro Experimental Study Iskandar, Iskandar; Essy Dwi Damayanthi; Gusti Muhammad Perdana Putera; Hapsari Lintang Sekartaji; Eko Suhartono
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol. 15 No. 1 (2026): March 2026
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v15i1.5249

Abstract

Background: Lead (Pb) contamination in aquatic environments has been associated with increased dental health problems in exposed populations. One proposed mechanism underlying this association is the disruption of dental hydroxyapatite (HAp) stability through calcium (Ca) substitution and phosphate (P) degradation, which may alter the Ca/P ratio and mineral integrity. Therefore, this study was conducted to experimentally evaluate the impact of Pb exposure on Ca, P, and Ca/P ratio in human teeth under in vitro conditions. Objective: this study aimed to evaluate the effect of Pb exposure on changes in Ca, P, and Ca/P ratio, as well as the degradation kinetics of HAp in vitro. Methods: This true experimental study employed a completely randomized factorial design. Extracted human teeth were immersed in PbSO₄ solutions at concentrations of 0.01, 0.1, and 1 ppm for 30, 60, and 90 minutes. Ca and P levels were measured, and the Ca/P ratio was calculated. Degradation kinetics were analysed using linear regression to determine reaction order and rate constants. Result: Pb exposure resulted in a consistent reduction of the Ca/P ratio across all concentrations and exposure durations, with values below the stoichiometric hydroxyapatite ratio (1.67), indicating increased mineral instability. Both Ca and P degradation followed zero-order reaction kinetics, with higher degradation rate constants observed at 0.01 and 1 ppm. Conclusion: these findings provide experimental evidence that Pb exposure can destabilize dental hydroxyapatite by accelerating Ca and P degradation, thereby potentially increasing susceptibility to mineral loss.

Page 43 of 43 | Total Record : 429

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