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Jurnal Ilmiah Kedokteran Wijaya Kusuma
Published by Universitas Wijaya Kusuma Surabaya
ISSN : 19782071     EISSN : 25805967     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health
Jurnal Ilmiah Kedokteran Wijaya Kusuma (JIKW) is a periodically scientific publication that contains articles written in Indonesia or english. JIKW receive articles in the scope of Biomedical Sciences, degenerative diseases, infections, congenital abnormalities and public health. JIKW published twice a year. The articles will be published in JIKW only manuscript that has never be published or published in other journal. Writers who will publish the article please follow the JIKW guidelines. The entire management process both admission and review the article is done by online.
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Articles 390 Documents
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Role of Matrix Metalloproteinase in the Progression of Heart Failure: A Narrative Review Sidhi Laksono; Budhi Setianto; Reynaldo Halomoan
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 10, No 1 (2021): MARET 2021
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v10i1.987

Abstract

Heart failure (HF) is a cardiovascular disease with a complex pathological pathway and influenced by many factors. Such a complex pathological mechanism would impair cardiac function and structural stability. One that plays a role in maintaining the function and structure of the heart is the extracellular matrix (ECM), and disruption in the extracellular matrix has a role in causing cardiac dysfunction. ECM regulation is associated with matrix metalloproteinase (MMP). Overexpression of matrix metalloproteinases can lead to ECM degradation process which leads to cardiac remodelling. The role of MMP in heart failure is also related to the increased inflammatory response, which is one of the pathways for progression of heart failure. The close association of MMP with the development of heart failure makes MMP a potential biological marker. This article aims was to understand the role of MMP and its mechanisms in cardiac remodelling pathways leading to heart failure. This narrative review suggests that overexpression of MMP can lead to heart failure. Inflammation is one of the factors triggering the expression of MMP. Inflammation will increase the release of pro-inflammatory cytokines, thereby triggering MMP expression. MMP expression imbalance can damage collagen tissue through ECM degradation and damage the structure and function of the heart. MMP can also be used as a biological marker in heart failure cases. The application of MMP as a biological marker can be used to assess the degree of disease severity as well as a predictor of heart failure. In conclusion, MMP has an important role in the development process of heart failure and can be a biological marker in cases of heart failure.
Perilaku Remaja di Surabaya Barat Dalam Pengobatan Jerawat Stefani Nurhadi; Minarni Wartiningsih
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 10, No 2 (2021): SEPTEMBER 2021
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v10i2.1215

Abstract

Jerawat adalah kelainan kelenjar pilosebasea yang banyak diderita oleh remaja yang meskipun dapat sembuh sendiri tetapi dapat bekomplikasi skar permanen dan dampak psikologis. Oleh karena itu penting untuk meneliti perilaku remaja dalam mengatasi jerawatnya sehingga dapat diberikan edukasi yang sesuai sehingga komplikasi dapat dihindari. Tujuan penelitian ini adalah untuk mengetahui perilaku remaja di Surabaya Barat dalam pengobatan jerawat. Rancangan penelitian ini adalah penelitian analitik observasional menggunakan pendekatan cross sectional. Populasi adalah seluruh remaja yang berada di Surabaya Barat dengan besar sampel 251 responden diambil secara cluster random sampling dan diberikan kuesioner. Hasil penelitian didapatkan sebagian besar subyek penelitian mengobati jerawatnya 185 orang (73.7%), namun hanya 45 orang (24,3%) yang berkonsultasi ke dokter. Subyek yang mengobati jerawatnya sendiri terbanyak memakai produk anti jerawat non sabun yang dibeli di supermarket 76 orang (36,7%), sering mencuci muka dilaporkan 55 orang ( 21,9%), memencet jerawat sendiri dilaporkan 39 orang (15,5%) dan memakai produk anti jerawat non sabun yang dibeli secara online dilaporkan 36 orang (14,3%). Jenis kelamin, lamanya berjerawat dan tingkat pendidikan tidak berhubungan secara statistik dengan perilaku help seeking. Kesimpulannya perilaku help seeking remaja di Surabaya Barat dalam pengobatan jerawat cenderung memilih mengobati jerawatnya daripada berkonsultasi ke dokter. Subyek yang mengobati jerawatnya sendiri mayoritas menggunakan produk anti jerawat non sabun yang dibeli di supermarket. Serta tidak terdapat hubungan antara jenis kelamin, tingkat pendidikan dan lamanya berjerawat dengan perilaku help seeking pada remaja di Surabaya Barat.
Pendekatan Multilevel Sebagai Upaya Meningkatkan Pemberian ASI Eksklusif Nur Khamidah; Yayi Suryo Prabandari; Detty Siti Nurdiati
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 10, No 1 (2021): MARET 2021
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v10i1.942

Abstract

Increasing exclusive breastfeeding effort was continued in Jember district. Local government collaborates with USAID to increase breastfeeding promotion program. Health promotion program used multilevel approach. This study aimed to evaluate exclusive breastfeeding program and impact program to increasing breastfeeding in Jember district. This study method used cross sectional study in two population with mix method approach (qualitative and quantitative). Collecting qualitative data was using participative observation, indepth interview and focus group discussion to describing program. Collecting quantitative data was using questionare to evaluate impact program in two populations (120 respondent program and 125 respondent non program). Data was analyzed by open code in qualitative data. To analyzed quantitative data was used chi square.  The research result shows that Health promotion program increased exclusive breastfeeding was using multilevel approach. In top level, implementation of the program was regulation government policy number 17, 2013 about save childbirth, initiation breastfeeding and exclusive breastfeeding. In the middle level implementing program by Jember health department and local government clinic through peer breastfeeding support, mother pregnant class and promote by midwife. Lower level evaluation result was that two population program and non program have different significant. Population who give program have 2,4 higher OR value in exclusive breastfeeding than population not give the program. Based on this research it can be concluded that multilevel approach can used to increasing exclusive breastfeeding until six month. Government support was needed to successful program.
Pengaruh Peningkatan Jaringan Adiposa pada Pasien Obesitas Terhadap Tingkat Keparahan Pasien Covid-19 Annas Adimara; Kartika Prahasanti; Muhammad Perdana Airlangga
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 10, No 2 (2021): SEPTEMBER 2021
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v10i2.1453

Abstract

Penyakit COVID-19 telah menjadi pandemi global sejak Desember 2019. Menurut WHO, hingga 28 September 2020, sudah ada 33.137.748 kasus yang dikonfirmasi di seluruh dunia, 3,01% di antaranya meninggal dunia (998.372). Dengan Case Fatality sebesar 3,17% WHO menetapkan Wabah COVID-19 ini di tingkat pandemi. Dari 2,5 juta kematian akibat Covid-19 yang dilaporkan pada akhir Februari 2021, 2,2 juta lebih dari setengah populasinya diklasifikasikan sebagai kelebihan berat badan. Obesitas menjadi salah komorbid yang dikaitkan dengan keparahan gejala COVID-19 dikarenakan Obesitas sendiri dapat menyebabkan gejala seperti gangguan cardiovaskular, gangguan respirasi, gangguan imun, dan juga inflamasi kronis. Tujuan penelitian ini untuk mengetahui pengaruh peningkatan jaringan adiposa pada pasien obesitas terhadap tingkat keparahan pasien COVID-19.
The impact of Pesticides and Workload on Osteoarthritis Incidence in Farmers: A Narrative Review Lailatul Maghfiroh; Heni Fatmawati; Ika Rahmawati Sutejo
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 11, No 1 (2022): MARET 2022
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v11i1.1441

Abstract

An osteoarthritis is a group of pathologies in joints that include cartilage degradation, bone remodeling, osteophyte formation, and synovial inflammation which in turn can cause pain, stiffness, swelling, and loss of normal joint function. The increasing prevalence of osteoarthritis is associated with jobs that require physical strength (physically demanding) or heavy work, one of which is agriculture. This is in line with the World Health Organization's statement, farming for 1-9 years increases the risk of osteoarthritis 4.5 times. Besides, farming for 10 years or more increases the risk of osteoarthritis by 9.3 times. The purpose of this study was to determine the association between pesticide use and workload (which includes work attitude, working period, and heavylifting) and the incidence of osteoarthritis in farmers. This study uses a narrative review method on journals of the last 10 years. The results of this study indicate that pesticides are not associated with osteoarthritis, based on studies on osteoarthritis patients that show no difference in serum concentrations of organophosphate, pyrethroid, and nenonicotinoid pesticides and their metabolites. Conversely, work attitude and working period are associated with osteoarthritis in farmers. The work attitude associated with osteoarthritis especially knee osteoarthritis is the squatting and kneeling posture. Meanwhile, the heavylifting did not have a significant relationship with osteoarthritis, especially knee osteoarthritis among farmers. The conclusion of this study is there is no relationship between the use of pesticide and osteoarthritis. However, there is a relationship between work attitudes & working period and osteoarthritis in farmers.
The Relationship of Fever Onset with NS1 Examination Results, IgM, and IgG in Dengue Hemorrhagic Fever Patients Engla Merizka; Assha Luthfianie Alifah; Sri Wahyuni Handayani; Aninda Dinar Widiantari; Farida Murtiani
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 12, No 2 (2023): September 2023
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v12i2.2645

Abstract

Fever onset represents the average number of days from the beginning of fever symptoms to the time when IgM and IgG examinations are conducted. Determining the right timing for these examinations can significantly impact their accuracy. In November 2021, there was a notable surge in cases of Dengue Hemorrhagic Fever at the Karawang Health Center, Sukabumi. This study aimed to investigate the relationship between the duration of fever and the results of dengue antigen and antibody tests. The research employed a descriptive analysis with a cross-sectional approach, and a sample of 50 individuals was gathered through consecutive sampling. The data was then analyzed using the Chi-Square test. The study revealed a positive correlation between the duration of fever and the outcomes of the NS1 and IgG Dengue examinations (p<0.05), highlighting the significance of timing when conducting these tests. NS1 was predominantly detected within the first three days of fever, while IgG showed reactivity after more than five days of fever. These findings underscore the importance of timing when conducting these tests and interpreting their results.
Potensi Aloe Vera sebagai Antiviral dan Immunostimulan di Masa Pandemi Covid-19: Review Article I Kadek Wawan Wijaya; Riska Ammalia; Didi Wirdiana; Arya Yudanta; masfufatun masfufatun
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 10, No 2 (2021): SEPTEMBER 2021
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v10i2.1576

Abstract

Aloe Vera merupakan salah satu jenis tanaman obat-obatan yang semakin populer, tidak hanya bermanfaat untuk kecantikan tapi juga untuk kesehatan. Tujuan dari artikel ini yaitu membahas kandungan yang terdapat pada Aloe Vera sebagai antiviral dan imunostimulan. Metode yang digunakan oleh penulis dalam artikel ini menggunakan metode studi pustaka/literatur review, dengan mengumpulkan beberapa sumber tertulis melalui pencarian data yang di akses melalui Google sholar dan Science direct. Hasil dari analisis data menunjukkan bahwa Aloe Vera mengandung senyawa aktif yang memiliki efek biologik yaitu Mucopolysaccharides (MPS) salah satunya adalah polisakarida Acemannan yang mengandung bahan aktif Acetylated mannose yang masuk dalam golongan sakarida dan mempunyai fungsi untuk meningkatkan sistem kekebalan tubuh (immunostimulan). Selain itu  Aloe Vera memiliki kandungan antraquinon dan juga aloe emodin yang berfungsi sebagai antiviral untuk mencegah masuknya virus ke dalam tubuh. Berdasarkan hasil review artikel ini maka dapat disimpulkan bahwa  Aloe Vera bisa sebagai antiviral dan  immunostimulan karena memiliki kandungan Acemannan, antraquinon dan aloe emodin. Dengan mengetahui informasi ini diharapkan masyarakat bisa memanfaatkan Aloe Vera yang berada di lingkungan sekitar sebagai bahan pangan selama Pandemi Covid – 19.
Efek Proteksi dari Terapi Oksigen Hiperbarik terhadap Ekspresi Bcl-2 Miometrium Rattus norvegicus Bunting yang Terinfeksi oleh Tachyzoite Toxoplasma gondii Arif Rahman Nurdianto; Aryati Aryati; Mohammad Guritno Suryokusumo; Mufasirin Mufasirin
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 9, No 1 (2020): MARET 2020 available online since April 2020
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v9i1.730

Abstract

Hyperbaric Oxygen Therapy (HBOT) can increase oxygen delivery to tissues and stimulate the formation of H2O2 as a secondary messenger for phosphorylation of nuclear factor kappa beta (NF-kB) which plays an important role in the transcription of the anti apoptotic gene. This study aimed to determine the effects of Hyperbaric Oxygen Therapy (HBOT) in enhancing the expressions of Bcl-2 in the myometrium of pregnant rats infected by Toxoplasma gondii. This study was an experimental study with a randomized control group of post-test only and designed by 37 pregnant Rattus norvegicus Sprague Dawley. Randomly, the rats were divided into four groups. Group A is infected pregnant rats that exposed by 10 sessions of HBOT 2.4 ATA in 3x30 minutes. Group B is non-infected pregnant rats and exposed by 10 sessions of HBOT 2.4 ATA in 3x30 minutes. Group C is infected pregnant rats without any exposure. Group D is non-infected pregnant rats without any exposure. Each infected pregnant rat was given a 103 tachyzoite of T.gondii by intraperitoneal injection. Bcl-2 expressions were measured through immunohistochemistry. All data were analyzed using ANOVA test through SPSS 21 program application. There was a significant difference in Bcl-2 expression between Group A and Group C because p<α (p<0.017). HBOT can increase the expression of Bcl-2 from infected and not infected rat myometrium, in the provision of HBOT 2.4 ATA for 3x30 minutes, twice a day for 5 days.
Effect of Spirulina Platensis on Liver Malondialdehyde Levels of Male White Rat Induced by High Dose Paracetamol Anggilia Vanny; Sihning E. J. Tehupuring; Indri Ngesti Rahayu; Roostantia Indrawati
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 12, No 2 (2023): September 2023
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v12i2.2700

Abstract

Paracetamol is widely used in therapy, yet it becomes hepatotoxic agent in a high dose using. The CYP450 enzyme metabolizes a small portion of paracetamol to a reactive substance, NAPQI. High dose of paracetamol causes an extensive increase in NAPQI levels. NAPQI then binds to hepatocytes conditions of oxidative stress. Spirulina platensis contains C-phycocyanin, flavonoids, and phenolics that inhibit lipid peroxidation and reduce oxidative stress. This study aims to determine the effect of Spirulina platensis on MDA levels in the liver tissue of male Wistar rats induced by high dose of paracetamol. This research was experimental with a Randomized Post-test Only Control Group design using 24 white male rats divided into three groups; negative control group (G-), positive control group (G+) was given paracetamol at a dose of 1,250 mg/kg on the 8th day, and treatment group (Gt) was given an amount of Spirulina platensis extract 360 mg/kg BW/day for ten days from 1st until 10th day and paracetamol at a single dose of 1,250 mg/kg BW on the 8th. At the 10th day of the treatment, all groups were terminated for liver tissue collection. TBA test was used to calculate MDA levels. Statistical tests analyzed the results of the data. This statistical tests by SPSS software: MDA levels in the treatment group did not significantly differ (p = 0.144) compared to the negative control group. There was a significant difference of liver tissue MDA levels in the treatment group (p = 0.016) compared to the positive control group.  This study concludes that administering Spirulina platensis at a dose of 360 mg/kg/day for ten days can help prevent on increase in tissue MDA levels and maintain liver conditions close to their original state.
Increased Levels of Nerve Growth Factor Indicating Brain Injury In Mice Model Prastiya Indra Gunawan; Riza Noviandi; Sunny Mariana Samosir
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 11, No 2 (2022): SEPTEMBER 2022
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v11i2.2024

Abstract

Hypoxic-ischemic encephalopathy (HIE) brain injury is one of the leading causes of death and disability worldwide. Nerve growth factor (NGF) is a neurotrophin that plays an important role in the natural repair and regeneration of nerves, but the previous study regarding NGF level after brain injury is still scant. This study aims to determine NGF levels in male Wistar rat models that received right Common Carotid Artery (CCA) occlusion.  This study used an experimental and control design conducted in July-August 2021 at the Stem Cell Research and Development Center, Universitas Airlangga. The right CCA occlusion was performed on the Wistar mouse model in the treatment group, then placed in a hypoxic chamber and reperfusion after 60 minutes. Observations of neurology scores were carried out in the first 24 hours.  After 2x24 hours the animal was sacrificed for serum NGF level measurement using the ELISA method. Statistical analysis using t-test for independent sample.  A total of 16 male rats participated in the study.  Eight rats in the treatment group were put into hemiparesis at different levels according to observations of neurological scores.  Statistically meaningful differences in NGF levels were found in the treatment group compared to controls (P<0.05). Average NGF levels in the treatment group were higher than in the controls.  NGF levels in mice with HIE were higher than the control group, which indicates the body's natural mechanism for neuron protection following ischemic hypoxic events.

Page 33 of 39 | Total Record : 390

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