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Universa Medicina
Published by Universitas Trisakti
ISSN : 19073062     EISSN : 24072230     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Universa Medicina (univ.med) is a four-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Universa Medicina Online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic
Arjuna Subject : -
Articles 602 Documents
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Ki-67 marker useful for classification of malignant invasive ductal breast cancer Irmawati Hassan; Twidy Tarcisia; Agnestina Agnestina; Santoso Cornain; I Made Nasar
Universa Medicina Vol. 32 No. 3 (2013)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2013.v32.179-186

Abstract

BACKGROUND Breast cancer is an important health problem in the world. Uncontrolled cell proliferation represents a malignant characteristic of neoplasia such as breast cancer, and can be examined immunohistochemically by measuring the Ki-67 proliferative marker. The objective of this study was to determine the role of Ki-67 for classification of the degree of malignancy in women with invasive ductal breast cancer.METHODSA cross-sectional study was conducted on 20 women with invasive ductal breast cancer. The samples were immuno-histochemically tested for Ki-67 using anti-Ki-67 primary antibody. The Ki-67 proliferative index was determined by enumerating the proportion of Ki-67 positive nuclei among the total number of cells in ten areas observed at 400x magnification, using a 20% cut-off value to distinguish between low and high proliferative indices. Statistical analysis was by means of the chi-square test.    RESULTSSeventy five persent of the high grade malignancies had a high Ki-67 proliferative index (>20%), while only 12.5% of the low grade malignancies had a high Ki-67 index (>20%). The difference in grade malignancy was statistically significant (p=0.022), whereas tumor size was not associated with a statistically significant difference in Ki-67 index (p=0.648). CONCLUSIONThe study showed that invasive ductal breast cancer with high Ki-67 index was significantly associated with high grade of malignacy. The high Ki-67 marker index can be used for classification of the grade of malignancy of invasive ductal breast cancer.
Glycated albumin for glycemic control of diabetic patients on hemodialysis Alvina Alvina
Universa Medicina Vol. 33 No. 1 (2014)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2014.v33.1-2

Abstract

Regular assessment of glycemic control in diabetic patients is very important, because it reduces the incidence of complications and determines prognosis and quality of life of the patients.(1) Uncontrolled and advanced diabetes may lead to complications, such as kidney disease, heart attacks, and stroke, which are on the increase worldwide. Patients with diabetic nephropathy account for almost 50% of dialysis patients in the US, while cardiovascular disease is the main cause of death of patients with complicated diabetes.(2)
Inappropriate complementary feeding practice increases risk of stunting in children aged 12-24 months Hijra, Hijra; Fatimah-Muis, Siti; Kartasurya, Martha Irene
Universa Medicina Vol 35, No 3 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.146-155

Abstract

BackgroundIn 2013, the prevalence of stunting in Central Sulawesi province was 41%, which was higher than the national prevalence of 37.2%. Complementary feeding practice, infectious disease, history of exclusive breastfeeding, birth weight and birth length were assumed to contribute to the prevalence of stunting. The objective of the present study was to identify the risk factors for stunting among children aged 12 to 24 months.MethodsThis study was conducted using a case control design. Subjects were children aged 12-24 months, consisting of 58 cases and 58 controls. Data were obtained with a body length infantometer. Data on complementary feeding practices, history of exclusive breastfeeding, and history of infectious diseases were obtained using questionnaires. Nutrient intakes were measured by semi quantitative food frequency questionnaires. Data on birth weight and birth length were obtained from the buku KIA (maternal and child health record). Data were analyzed by chi-square and logistic regression tests. ResultsThere was no difference in sex, BMI, and parental education between cases and controls (p>0.05). After controlling for history of exclusive breastfeeding and birth weight, the risk factors for stunting were inappropriate complementary feeding practice in terms of quantity and quality (OR=8.26; 95% CI: 2.69-25.44), history of diarrhea (OR=4.73; 95% CI: 1.08-20.69), birth length (OR=5.11; 95% CI: 1.69-15.46) and respiratory tract infection (OR=5.30; 95% CI: 1.03-27.23). Inappropriate complementary feeding practice was the most dominant factor for stunting.ConclusionInappropriate complementary feeding practice increased the risk of stunting in 12-24 months old children by 8.26. This study confirms the need to scale up interventions during the first 2 years of life, including appropriate infant feeding practices.
The quality of life of epileptic patients Harsono, Harsono
Universa Medicina Vol 27, No 4 (2008)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2008.v27.194-203

Abstract

Epilepsy has historically been surrounded by prejudice and myth, and associated with many misconceptions. Even today, people with epilepsy experience psychosocial problems, especially in their relationships and employment. Age, seizure severity and frequency, stigma of epilepsy, social deprivation, fear and anxiety, factors responsible for inadequate treatment, treatment gap, and healthcare needs may affect the quality of life of epileptic patients. Improving the diagnosis, treatment, prevention, and social acceptability are important factors in achieving the objective of the management of epilepsy. Treatment of epilepsy refers to any intervention that is intended to restore health status including quality of life. Quality of life is recognized as an important outcome in epilepsy treatment. Quality of life has been reported to vary across epileptic patients with different clinical, demographic, and socio-economic variables. Seizure type and frequency have been found to be significant predictors of quality of life scores. For measuring quality of life in clinical practice, such as in epileptic patients, a wider range of properties is required to ensure that a measure can be used routinely. These include validity, appropriateness and acceptability, reliability, responsiveness to change, and interpretability.
Light physical activity increased body fat percentage in elderly Javanese Fatmah, Fatmah; Nasution, Yusran
Universa Medicina Vol 30, No 1 (2011)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2011.v30.45-53

Abstract

The prevalence of obesity in Indonesia is rapidly increasing, particularly in older people. Obesity is characterized by increased percentage of body fat in the form of visceral fat and non-visceral or subcutaneous fat. The aim of this study was to analyze body fat percentage (BFP) and associated risk factors, i.e. type of residence (rural or urban), physical activity, gender, age, intakes of energy and fat, and socio-economic background (educational level and occupational status). This cross-sectional study was conducted on 812 older persons (517 females and 295 males) from December 2007- February 2008 in the cities of Surabaya, Semarang, Yogyakarta, Wonogiri, Gunung Kidul, and Magetan subdistricts. BFP was assessed using an Omron Fat Analyzer. Nutritional intakes were collected through interviews using semi-quantitative food frequency questionnaire (FFQ). To obtain overall total energy expenditure for physical activity (PA), the energy expenditures for exercise (sports) PA, daily activities, and leisure time PA were added together. The study results indicated that urban residence and light PA at age 55 years constituted risk factors for high BFP. Light PA at 55 years of age was the most influential risk factor, since it was 4.3 times greater than vigorous PA at the same age (OR=4.3; 95% Confidence interval 2.6-7.1) It is recommended to implement nutritional counseling about adequate intakes for increased PA in all age groups (adolescents, adults, older persons), particularly in urban areas with their greater risk of high BFP.
MUC1 modulates gastric epithelial immune response to bacteria or inflammatory stimuli Shofyatul Y. Triyana; Yong H. Sheng; Michael McGuckin
Universa Medicina Vol. 31 No. 3 (2012)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.141-150

Abstract

BACKGROUND Cell surface mucin glycoproteins are expressed on the mucosal surface. One of these cell surface mucins is mucin-1 (MUC1), which plays a role as a physical barrier and limits inflammation. However, its functional role in modulating responses to pathogens, particularly with respect to intracellular signaling, needs to be investigated. Therefore, the aim of this study was to characterize the modulation of responses of human gastric epithelial cells by MUC1 to common mucosal pathogens and inflammatory stimuli. METHODS Human gastric epithelial cell lines (MKN7) were co-cultured with Campylobacter jejuni (C. jejuni). In order to investigate the effect of MUC1 expression on C. jejuni-induced cytokine production, MKN7 cells were transfected with 1:1 small interfering RNA (siRNA) to knock down the MUC1 gene using MUC1 targeting siRNA or non targeting siRNA as a control. The read out of the experiment was interleukin (IL)-8 concentration as a result of the inflammation process. This cytokine concentration was measured using ELISA and compared between the two groups. RESULTS This study demonstrated that by using siRNA transfection, knockdown of MUC1 expression in MKN7 human gastric epithelial cells suppressed IL-8 production at the early phase of incubation, but promoted an increase in IL-8 production at the late phase, in response to C. jejuni. CONCLUSION Knockdown of the MUC1 gene in MKN7 cells reduced IL-8 levels both in the cells with and without exposure to C. jejuni. This study provides direction for exploration of the intracelular mechanisms by which cell surface mucins modulates inflammation in the response of gastrointestinal epithelial cells to pathogens or other inflammatory stimuli.
Vaccines for prostate cancer : a new era? Mulia, Julius I
Universa Medicina Vol 28, No 3 (2009)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2009.v28.i-iii

Abstract

Prostate adenocarcinoma is the most prevalent type of noncutaneous cancer in the Western world, with an estimated 218,890 new cases and 27,050 deaths in the United States in 2007. Currently prostate cancer is detected by measurement of prostate-specific antigen (PSA), a serine protease synthesized by the prostatic epithelium. PSA is an organ-specific and tumor-associated antigen (TAA) but it is not tumor-specific.(1) Partly because of increased cancer screening with PSA, prostatic cancer may now be diagnosed when it is still localized. Localized tumors of the prostate are generally treated with radical prostatectomy, external-beam radiation therapy (EBRT), brachytherapy, or watchful waiting. Unfortunately, up to 30%-40% of patients fail local therapy. The standard treatment of recurrent or metastatic disease is androgen-deprivation therapy (ADT), but this is only a temporary measure as in the majority of cases the cancer ultimately becomes hormone refractory, the condition being termed androgen-independent prostate cancer (AIPC) or hormone refractory prostate cancer (HRPC), which then progresses rapidly. The only available nonpalliative therapy for androgen-independent prostate cancer is docetaxel in combination with prednisone. However, ADT given prior to the onset of clinical symptoms results in rising PSA levels with castrate levels of testosterone, often with a relatively low tumor burden. This systemic treatment earlier in the disease course combined with effective palliative chemotherapy is implicated in the improvement in median survival time of patients with AIPC from an average of about 12 months to about 17-18 months.
Blood viscosity increases the degree of coronary stenosis in coronary heart disease Indrianto, Antonius Ferika; Samsuria, Indranila Kustarini; Kurniawan, Kusmiyati Deddy
Universa Medicina Vol 34, No 3 (2015)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2015.v34.168-176

Abstract

BackgroundEndothelial dysfunction and associated increased blood viscosity (BV) play an important role in the formation of atherosclerosis during inflammatory processes. C-reactive protein (CRP) is a biomarker of inflammation with an active role in endothelial dysfunction and development of atherosclerosis that is marked by degree of coronary stenosis (CS). The purpose of this study was to determine the relationship of BV and CRP with varying degrees of CS among coronary heart disease (CHD) patients.MethodsThis cross-sectional study involved 24 subjects taken consecutively among patients with CHD who underwent angiography. Blood viscosity levels were determined using an Ostwald viscometer, with reference limits of 1.5 to 1.72 (cP). C-reactive protein was determined by turbidimetric immunoassay, with a normal reference value of <3 mg/L. Degree of CS was examined with angiography, where 0% = no stenosis; <50% = nonsignificant stenosis; > 50% = significant stenosis. Data was analyzed using non-parametric Spearman correlation test.ResultsThere were 17 male and 7 female subjects, with mean age of 55.96 ± 7.29 years. The angiography results were: non-significant stenosis in 2 subjects (8.3%), significant stenosis in 22 subjects (91.7%) and none with normal stenosis. Statistical analysis of the relationship of BV with degree of CS found a moderate significant positive relationship (r=0.549; p=0.005). A poor significant positive relationship was found between CRP and degree of CS (r=0.481; p=0.017).ConclusionBlood viscosity increased the degree of CS in CHD patients. Therapy should target both BV-associated risk and angiographically evident stenosis.
Knowledge of HIV-AIDS a dominant factor of antiretroviral therapeutic adherence in women with HIV-AIDS Surilena Surilena; Jean Valeria
Universa Medicina Vol. 34 No. 2 (2015)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2015.v34.129-137

Abstract

BackgroundAntiretroviral therapy adherence (ART adherence) is a factor significantly extending life expectancy of people living with HIV/AIDS. The objective of this study was determine several factors on ART adherence in women infected with HIV/AIDS. MethodsA cross-sectional study involving 99 women with HIV/AIDS who were infected through their sexual partner or spouse was conducted in Dharmais Hospital between March and August 2014. The instruments used were demographic and self-esteem questionnaires, Hamilton rating scale for depression, Hamilton rating scale for anxiety, knowledge, perception of ART benefits and limitations, family support, peer support as well as assessment of ART adherence. The knowledge questionnaire has been validated with Cronbach’s alpha = 0.823. Data were analyzed using Chi-Square test and multivariate logistic regression. ResultsA total of 99 women with HIV/AIDS participated in the study, with an age range of 30- 60 years and mean age of 36 ± 3.72 years. A total of 57.58% of participants showed poor ART adherence. Multivariate logistic regression analysis showed that knowledge, ART side effects, depression, peer support and ARV availability significantly affected ART adherence (p<0.05). The most dominant factor affecting ART adherence was knowledge, with OR = 64.02 (95% CI 4.99-670.12). ConclusionWith good knowledge about HIV/AIDS infection, ART benefits, and possible ARV side effects, women living with HIV/AIDS are expected to carry out ART adherence according to the recommended rules.
High perceived discrimination and no family support increase risk of poor quality of life in gender dysphoria Hasan, Surilena; Alviany, Yovita; Clarissa, Cerellia; Sudana, Sonia
Universa Medicina Vol 36, No 3 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.187-196

Abstract

BackgroundFamily support and low discrimination perceptions are a factor in protecting against mental disorders and poor quality of life in male to female (MtF) gender dysphoric individuals. The aim of this study was to determine the role of family factors, peer support, self-esteem, perceived discrimination, depression, anxiety, and stress on the quality of life among MtF gender dysphoric individuals. MethodsA cross-sectional study was conducted involving 106 MtF gender dysphoric individuals of Sanggar Swara Jakarta. Respondents filled out questionnaires on demographics, WHOQL-BREF, perceived discrimination, Rosenberg self-esteem, family support, social support (SSQ6), family relations (FACES III), and depression anxiety stress scale (DASS). Simple and multivariate logistic regression tests were used to analyze the data.ResultsAmong the 106 MtF gender dysphoric individuals of Sanggar Swara Jakarta with an age range of 18-45 years, 78.3% had no family support, 64.1% no peer support, 62.3% high perception discrimination, 64.1% low self-esteem, 36% extreme family relations, 44.3% depression, 59.4% anxiety, 35.8% stress and 62.3% poor quality of life. Employment, perception of discrimination, self-esteem, family support, and anxiety were significantly associated with quality of life (p&lt;0.05). Multiple logistic regression analysis showed that perceived discrimination (Odds Ratio=13.89; 95% CI: 5.89-11.99), and family support (Odds Ratio=29.11; 95% CI: 2.45-8.21) were significantly associated with quality of life. Conclusion High perceived discrimination and no family support increase the risk of poor quality of life in MtF gender dysphoric individuals. These findings suggest the need for prevention and intervention of stigmatization and discrimination that should have a special focus on families with MtF gender dysphoric individuals.

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