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Universa Medicina
Published by Universitas Trisakti
ISSN : 19073062     EISSN : 24072230     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Universa Medicina (univ.med) is a four-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Universa Medicina Online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic
Arjuna Subject : -
Articles 602 Documents
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Glycemic control for prevention vascular complication in diabetic patient Pusparini, Pusparini
Universa Medicina Vol 36, No 2 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.77-79

Abstract

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Peran pertanda tulang dalam serum pada tatalaksana osteoporosis Priyana, Adi
Universa Medicina Vol 26, No 3 (2007)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2007.v26.152-159

Abstract

Osteoporosis adalah kelainan tulang yang kronik progresif akibat berkurangnya massa dan kekuatan tulang sehingga menjadi predisposisi meningkatnya risiko fraktur. Pertanda tulang dapat memberikan gambaran proses remodelling yang sedang terjadi. Pemeriksaan ini meliputi pertanda resorpsi tulang yang dilakukan oleh osteoklas dan pertanda formasi tulang yang dilakukan oleh osteoblas. Diagnosis untuk osteoporosis yang dianggap baku adalah pemeriksaan bone mass density (BMD) tetapi BMD tidak dipakai untuk monitoring pengobatan karena membutuhkan waktu lama (2 tahun) untuk melihat perbedaan gambaran massa tulang. Analisis pertanda tulang dapat memberikan gambaran proses remodeling yang sedang terjadi dalam waktu yang lebih singkat (3 – 6 bulan). Artinya analisis pertanda tulang dapat memantau dan menilai respons pengobatan, prognosis penderita dengan risiko osteoporosis, mencari penyebab berkurangnya tulang secara cepat, memilih pengobatan yang sesuai, memantau pasien dengan pengobatan kortikosteroid dan mempelajari patogenesis osteoporosis. Dalam tulisan ini akan diuraikan beberapa analisis pertanda tulang seperti alkaline phosphatase (ALP), osteocalcin, P1-NP dan ß-CrossLaps dan kegunaannya pada tatalaksana osteoporosis.
Impact of smoking and obesity on rheumatic disease in persons of productive age Tana, Lusianawaty; Mutiatikum, Daroham
Universa Medicina Vol 29, No 2 (2010)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2010.v29.96-103

Abstract

Arthritis is a disease of the joints that causes pain and musculoskeletal stiffness, and may cause limitation of joint movement. Age, obesity, smoking behavior, and occupation are risk factors for rheumatic diseases. The objective of the present study was to evaluate the role of body mass index (BMI), smoking behavior, and occupation on rheumatic disease among persons of productive age in Indonesia. A cross-sectional study was conducted using National Basic Health Research data. The inclusion criterion was age 15-64 years. Rheumatic disease diagnosis was based on interview results and was defined as the presence of a history of rheumatic disease diagnosed by health professionals and/or rheumatic symptoms in the past 12 months. The study sample consisted of 609.097 persons who fulfilled the inclusion criterion. Compared to persons with normal BMI, rheumatic disease was more prevalent in the overweight (OR 1.25; 95%CI 1.21—1.29) and the obese (OR 1.52; 95%CI 1.47—1.56), but less prevalent in the underweight (OR 0.91; 95%CI 0.88—0.93). Compared to non-smokers, rheumatic disease was more prevalent in every day smokers (OR 1.65; 95%CI 1.60—1.70), occasional smokers (OR 1.41; 95%CI 1.35—1.47), and ex-smokers (OR 1.85; 95%CI 1.76—1.95). Measures for prevention of rheumatic disease are needed, e.g. through education to increase knowledge about the impact of smoking and obesity on rheumatic disease.
Gender impacts on motor skill proficiency-physical activity relationship in children Diana Samara; Nuryani Sidharta; Dian Mediana; Noviyanti Noviyanti
Universa Medicina Vol. 31 No. 3 (2012)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.192-199

Abstract

BACKGROUND Physical activity is the greatest contributor to achievement of adequate physical activity. Children performing adequate daily physical activity will get positive benefits from their activity. Several studies indicate a difference in motor skills between boys and girls. To understand the development of motor skill proficiency and physical activity in boys and girls, a study was conducted to determine the role of gender on motor skill proficiency and physical activity in children aged 6-12 years. METHODS A cross-sectional observational study was conducted and a total of 162 children were included at a primary school in the Grogol area, West Jakarta. Data collection was by questionnaire-based interviews, covering age, gender, and physical activity (watching TV, playing games, and outdoor play). Assessment of motor skills was performed using the Bruininks-Oseretsky Test–Second Edition (BOT-2). Data analysis was performed using SPSS for Windows release 17.0 and level of significance was set at 0.05. RESULTS Multiple linear regression results showed that in boys the strength subset was the most influential factor on TV watching activity, with the higher scores for strength indicating a lower TV watching activity (â=-0.125;p=0.021). Age was the most influential factor on outdoor playing activity in girls, with older girls having lower outdoor playing activity (â=-0.375;p=0.016). CONCLUSIONS This study revealed that gender difference impacts on motor skills and physical activity in children. Higher motor proficiency increases outdoor playing activity only in boys. Primary school pupils should be given opportunities for performing outdoor playing activities to improve their motor proficiency.
Additional probiotic therapy lowers SCORAD index in children with atopic dermatitis Ekaputri, Jessica; Evalina, Rita; Deliana, Melda
Universa Medicina Vol 35, No 2 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.68-74

Abstract

Background Atopic dermatitis (AD) is a common skin disease that is usually chronic, relapsing, causing pruritus and frequent in children. The pathogenesis of AD involves genetic, immunological and environmental factors causing skin barrier dysfunction and dysregulation of the immune system. Probiotic treatment has been claimed to offer several functional properties including stimulation of the immune system and plays an important role in AD. The objective of this study was to evaluate the effect of probiotic therapy on atopic dermatitis in children.Methods A randomized controlled trial was conducted on 62 children suffering from AD from December 2015 to January 2016. AD severity was assessed based on the scoring of atopic dermatitis (SCORAD) index. Subjects were divided into two groups consisting of 32 and 30 children, the probiotic (probiotic + emollient) and control (emollient) groups, respectively. SCORAD index was re-evaluated after 2 weeks of therapy. The data was analyzed using Mann Whitney test.Results After the intervention, the mean SCORAD index in the probiotic group was significantly much lower than the control group (18.09 ± 8.59 vs 23.21 ± 8.71; p=0.001). The mean decrease in SCORAD index in the probiotic group was 40.4 %, much higher than the control group 25.2%. The number needed to treat (NNT) score of probiotic treatment was 5.3.Conclusion The addition of probiotics to conventional therapy effectively lowers SCORAD index by 40.4% in atopic dermatitis. The impact of probiotics on SCORAD indices is thought to be attained by modification of the immunogenicity of potential allergens.
Management of anemia among patients in intensive care units Margo, Eveline
Universa Medicina Vol 27, No 2 (2008)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2008.v27.78-86

Abstract

Anemia is frequently encountered in critically-ill patients in the intensive care unit (ICU). Anemia may occur both at the time of admission, during treatment and after discharge from the ICU. The causes are multifactorial and include acute blood loss, blood loss from diagnostic testing and blunted red blood cell production. Blood transfusions are frequently given to patients in the ICU to treat low hemoglobin levels due to either acute blood loss or subacute anemia associated with critical illness. Although blood transfusion is a life-saving therapy, evidence suggests that it may be associated with an increased risk of morbidity and mortality. A feature of anemia of critical illness is lack of appropriate elevation of circulating erythropoietin concentrations in response to physiological stimuli. One important concern is that anemia may not be well tolerated by a critically ill patient. A number of blood conservation strategies exist that may mitigate anemia in hospital patients and limit the need for transfusion. These strategies include the use of hemostatic agents, hemoglobin substitutes and blood salvage techniques, the reduction of blood loss associated with diagnostic testing, the use of erythropoietin and the use of restrictive blood transfusion triggers. In this article we review the prevalence of anemia during critical illness specifically among patients in the ICU, and discuss the various factors that contribute to its development, the prevention and treatment of anemia by appropriate red cell transfusion and the place of erythropoietin in treatment.
Decreased osteoblasts and increased osteoclasts in rats after coal dust exposure Akbar, Izaak Zoelkarnain; Kania, Nia; Setiawan, Bambang; Nurdiana, Nurdiana; Widodo, M. Aris
Universa Medicina Vol 30, No 2 (2011)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2011.v30.73-79

Abstract

Bone remodeling is a physiological process of cortical and trabecular bone reconstruction, with initial bone resorption, by osteoclasts and concurrent bone formation by osteoblasts. Oxidative stress due to coal dust exposure is not only found in the lungs, but also in the circulation or systemically. The aim of this study was to determine the effect of oxidative stress from coal dust exposure on the number of osteoblasts and osteoclasts in rats. In this experimental study, four groups were evaluated: control; coal dust exposure at 6.25 mg/m3 for 28 days; coal dust exposure at 12.5 mg/m3 for 28 days; coal dust exposure at 25 mg/m3 for 28 days (all exposures were given daily for one hour). Circulatory oxidative stress was measured by malondialdehyde level. Osteoblast and osteoclast numbers were counted by light microscopic examination of distal femoral cross-sections stained with hematoxylin eosin. This study showed that malondialdehyde levels were significantly increased in coal dust exposure groups, in comparison with the control group (p<0.05). There were also significantly decreased numbers of osteoblasts (p<0.05) and significantly increased numbers of osteoclasts (p<0.05) numbers in coal dust exposure groups, as compared with the control group. No correlations were found between malondialdehyde levels (oxidative stress) and respective numbers of osteoblasts and osteoclasts in all coal dust exposure groups (p>0.05). Coal dust exposure increased malondialdehyde level and osteoclast numbers, and decreased osteoblast numbers, but no correlation was found between oxidative stress (caused by coal dust exposure) and osteoblast and osteoclast numbers.
High toluene exposure risk increases risk of olfactory dysfunction in furniture workers Magdalena Wartono; Herkutanto Herkutanto; Niken Lestari
Universa Medicina Vol. 34 No. 1 (2015)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2015.v34.68-76

Abstract

BACKGROUNDFew studies have investigated the impact on olfactory functioning ofoccupational exposure to toluene, an industrial solvent used in paints andcleaning fluids. The estimated olfactory dysfunction prevalence is 0.5–5%. Patients frequently do not complain about olfactory dysfunction.However, occupational exposure to chemicals may affect workers’ healthand safety, because of their continuous inhalation. This study aimed toexamine the relationship between toluene exposure and olfactorydysfunction in furniture workers.METHODSThis was a cross-sectional study involving 65 workers. Data collectionwas by observation and interview on demographic characteristics, historyof habits, and symptoms of chronic rhinitis. Risk of exposure scores wereevaluated from potential hazard, exposure level, duration of employment,type of work, use of masks, ventilation of work space, and education andtraining. Olfactory function was tested using Sniffin’ Sticks, anddetermination of environmental toluene level was by personal sampling.The odds ratio was used to test correlations between variables.RESULTSOnly 44 subjects could be analyzed, 37 (84.1%) of whom had olfactorydysfunction. Workers with high toluene exposure had a significantly 12.5-fold risk of olfactory dysfunction in comparison with those with lowexposure (OR=12.5; CI 95% 1.35 – 115.79).CONCLUSIONSToluene exposure increases risk of olfactory dysfunction in furnitureworkers. Olfactory function testing should be considered for initialscreening or periodic testing of furniture workers. Low toluene levels witha high proportion of olfactory dysfunction indicate that olfactory dysfunctionis an early negative impact of chemical inhalation.
Multimicronutrient supplementation and asymptomatic urinary tract infections in the elderly Boekitwetan, Paul; Surjawidjaja, Julius E.; Aidilfit, Mahyunis; Lesmana, Murad
Universa Medicina Vol 28, No 1 (2009)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2009.v28.25-33

Abstract

As human life expectancy continues to increase, developing countries are reporting higher percentages of elderly in their respective populations. The defense mechanisms of the elderly are reduced due to several factors, such as increased susceptibility to infection, specifically urinary tract infection (UTI). A randomised, placebo-controlled, double-blind trial was conducted to assess whether multimicronutrient supplementation is effective in reducing UTIs in older people in the community. A total of 261 elderly who lived in Mampang Prapatan district, South Jakarta, were randomised to daily multimicronutrient supplementation or control groups. The primary outcomes were the incidence of asymptomatic UTI, the organisms responsible for UTIs and the results of sensitivity tests on UTI microorganisms. UTI was defined as culture-positive urine yielding a single species of organisms in numbers greater than 104 cfu/mL urine specimen. At base-line 19.5% of the elderly had UTI, namely 23.7% patients in the MMN group and 16.7% in the control group, but the difference was not statistically significant (p=0.158). Escherichia coli was the most common microorganism, isolated in 20.7% of the MMN group and 17.5% of the control group. After six months of supplementation, UTI in the MMN group decreased by 40.6% compared with only 14.4% in the control group. The numbers of E. coli also declined by 64.3% in the MMN group compared to 37.8% in the control group. This study has confirmed the beneficial effect of multimicronutrient supplementation on UTI in the elderly.
High free testosterone index increases lung function in adult males Martiem Mawi; Rully Ayu Nirmalasari
Universa Medicina Vol. 31 No. 2 (2012)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.113-119

Abstract

BackgroundIncreasing age and decreased testosterone concentrations in males influence muscle strength and muscle mass, particularly in skeletal muscle. There have been few studies on decreased lung function resulting from reduced mass and strength of respiratory muscles. The aim of the present study was to investigate the existence of an association between free testosterone index (FTI) and lung function in males aged between 40 and 80 years.MethodsThis cross-sectional study involved 167 males aged between 40 and 80 years in Cilandak subdistrict, South Jakarta. Total serum testosterone and sex hormone-binding globulin (SHBG) concentrations were determined by electrochemiluminescence immunoassay (ECLIA) using Roche Elecsys Reagent Kit Cat 11776061 and Elecsys 2010 reagent (Cobas e601), respectively FTI was calculated using the formula free testosterone/SHBG x 100%. Forced expiratory volume in 1 second (VEP1) was assessed by means of an AS 500 spirometer. ResultsMean age of the subjects was 53.32 ± 8.26 years, mean total serum testosterone concentration was 532.59 ± 206.92 ng/dL, mean SHBG concentration 41.26 ± 21.14 nmol/L, mean FTI 48.22 ± 14.34 %, and mean VEP1 was 1.63 ± 0.54 L. There was a significant association between both SHBG and FTI on the one hand and VEP1 on the other, with Pearson correlation coefficients of -0.199 (p=0.010) and 0.271 (p=0.000), respectively. Linear multiple regression analysis indicated that FTI was the most influential variable on lung function (VEP1), higher FTI values indicating higher VEP1 (â=0.008: p=0.004).ConclusionIn males aged 40-80 years, higher FTI values indicate better lung function as determined by means of VEP1.

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