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Paediatrica Indonesiana
ISSN : 00309311     EISSN : 2338476X     DOI : -
Core Subject : Health,
Paediatrica Indonesiana is a medical journal devoted to the health, in a broad sense, affecting fetuses, infants, children, and adolescents, belonged to the Indonesian Pediatric Society. Its publications are directed to pediatricians and other medical practitioners or researchers at all levels of health practice throughout the world.
Arjuna Subject : -
Articles 2,127 Documents
Hemostatic abnormalities in children with thalassemia major and liver iron overload Pustika Amalia Wahidiyat; Stephen Diah Iskandar; Novie Amelia Chozie; Damayanti Sekarsari
Paediatrica Indonesiana Vol 58 No 4 (2018): July 2018
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (217.634 KB) | DOI: 10.14238/pi58.4.2018.175-9

Abstract

Background Thalassemia major (TM) patients are susceptible to liver dysfunction due to iron deposition. Pediatric TM patients often present with bleeding. Blood loss necessitates transfusions, leading to increased iron absorption from the gut. Objective To study hemostatic abnormalities in children with TM and iron deposition in the liver. Methods This cross-sectional study involved 190 non-splenectomized children with TM. Liver iron deposition was evaluated using T2* MRI. Prothrombin time (PT), activated partial thromboplastin time (aPTT), and platelet counts were assessed from blood specimens. Results Most subjects were diagnosed with β-thalassemia and β-thalassemia/HbE. The majority of subjects were on deferiprone (DFP) treatment. Approximately 89.5% of subjects had liver iron overload. Prolongation of PT and aPTT, as well as thrombocytopenia were observed in 60%, 27.9%, and 19.5% of subjects, respectively. Prolonged aPTT and thrombocytopenia were observed three times more frequently in subjects with moderate - severe liver iron overload than in subjects with normal - mild liver iron overload (P=0.04 and 0.001, respectively). Conclusion Most TM subjects have liver iron overload ranging from mild to severe. Prothrombin time and prolongation, as well as aPTT prolongation, and thrombocytopenia are easily found in TM children. There were significantly more moderate - severe liver iron deposition patients with aPTT prolongation and thrombocytopenia than normal – mild patients with these conditions. Hence, we suggest that pediatric TM patients undergo liver iron deposition evaluations and use iron chelators in an optimal manner, in order to limit the risk of bleeding.
Valproate use and thyroid dysfunction in children with idiopathic epilepsy Josephine Juliana Sibarani; Melda Deliana; Johannes H. Saing
Paediatrica Indonesiana Vol 58 No 4 (2018): July 2018
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (249.21 KB) | DOI: 10.14238/pi58.4.2018.192-7

Abstract

Background Long-term administration of valproic acid (VPA) has side effects, including thyroid dysfunction. Subclinical hypothyroidism (SCH) identified by elevated serum thyroid stimulating hormone (TSH) concentrations with normal thyroxine (T4) and triiodothyronine (T3), or normal free thyroxine (fT4) and free triiodothyronine (fT3) has been demonstrated in idiopathic epilepsy patients receiving VPA. Objective To evaluate for associations between age at initiation of VPA treatment and duration of treatment with thyroid dysfunction. Methods A cross-sectional study was conducted from October 2012 to May 2013 in Haji Adam Malik and Pirngadi Hospitals, Medan, North Sumatera. Subjects were children ranging from 0 and below 18 years who had been diagnosed with idiopathic epilepsy. Blood specimens were taken to evaluate serum T3, T4, and TSH levels in all subjects. Data were analyzed using bivariate and multivariate analyses. Results A total of 49 subjects were included in the study. Age of ≤ 4 years at initiation of VPA was found to be a significant risk factor for SCH in the bivariate analysis (OR 6.67; 95%CI 1.215 to 36.594, P=0.036). Three factors had P values <0.25 in the bivariate analysis and were subsequently analyzed by stepwise multivariate regression test: age at initiation of VPA, duration of treatment, and drug dosage. The VPA initiation at age <4 years had 6.67 times the risk of SCH than the age of >4 years (95%CI 1.215 to 36.594; P=0.029). Duration of treatment and VPA dosage were not significantly associated with SCH on multivariate analysis Conclusion Age ≤ 4 years old at the initiation of VPA is associated with thyroid dysfunction. However, no significant association was found between duration of treatment as well as drug dosage with thyroid dysfunction.
Transcutaneous billirubinometry to estimate total serum bilirubin in neonatal jaundice Andra Kurnianto; Herman Bermawi; Afifa Darmawanti; Erial Bahar
Paediatrica Indonesiana Vol 57 No 1 (2017): January 2017
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (226.436 KB) | DOI: 10.14238/pi57.1.2017.8-11

Abstract

Background The gold standard for diagnosis of neonatal jaundice is total serum bilirubin (TSB) measurement. This method, however, is invasive, painful, and costly in terms of workload, time, and money. Moreover, repeated blood sampling may lead to significant blood loss, which is of particular concern in preterm infants. To overcome these drawbacks, non-invasive methods of bilirubin measurement have been proposed. Transcutaneous bilirubinometry (TcB) determines the yellowness of the subcutaneous tissue of a newborn infant by measuring the difference between optical densities for light in the blue and green wavelength regions.Objective To evaluate the accuracy of transcutaneous bilirubinometry for estimating TSB levels in neonatal jaundice.Methods Subjects were infants aged < 28 days with jaundice who had never been treated with phototherapy or exchange transfusion. The study was done from February to July 2016 in Mohammad Hoesin Hospital. Subjects underwent transcutaneous bilirubin (TcB) and TSB assays, with a maximum interval of 15 minutes between tests.Results One hundred fifty patients were included in this study. The TcB values > 5 mg/dL were correlated to TSB > 5 mg/dL, with 100% sensitivity and 83.3% specificity. This cut-off point was obtained from a receiver-operator characteristic (ROC) curve with AUC 99.3% (95%CI 97.9 to 100%; P< 0.001).The correlation coefficients (r) for TSB and TcB measurements on the forehead were 0.897 (P<0.001).Conclusion Transcutaneous bilirubinometry can be used to accurately estimate TSB levels in neonatal jaundice, and may be useful in clinical practice as a non-invasive method to reduce blood sampling.
Effect of Low Lactose Milk "Eiwit Melk" (E.M.) on Low Birth Weight Infants with Diarrhoea TB. Bagdadiji; Suharjono Suharjono; Aswitha Boediarso; Sunoto Sunoto
Paediatrica Indonesiana Vol 15 No 7-8 (1975): July - August 1975
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (574.682 KB) | DOI: 10.14238/pi15.7-8.1975.198-206

Abstract

Thirty-nine low birth weight infants suffering from diarrhoea hospitalized in the Department of Child Health, Dr. Tjipto Mangunkusumo Hospital/Medical School University of Indonesia from July 1972 to December 1973 were treated with "Eiwit Melk" (low lactose milk).Results are not satisfactory although better than with the routine formula.9 out of 39 cases (23%) give excellent result.3 out of 39 cases (7.6%) give good result.27 out of 39 cases (69.4%) give poor result.In low birth weight infants, next to lactose intolerance, other factors in causing diarrhoea among others fat malabsorption should be considered. Trials with formulas combining easily absorbable fats should be encouraged.
Epidemiological Trends of Tuberculosis in Low and High Prevalence Countries M.A. Bleiker
Paediatrica Indonesiana Vol 15 No 11-12 (1975): November - December 1975
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (705.373 KB) | DOI: 10.14238/pi15.11-12.1975.273-83

Abstract

The study of the epidemiology of tuberculosis and the need for a rational approach to the problem of tuberculosis control require a sound knowledge of the risk of transmission of tuberculosis infection from host to host. This knowledge is required today both in countries with a high prevalence and in those with a low prevalence of the disease. The risk of transmission of tuberculosis infection in a given community during a particular period of time is most reliably expressed numerically in terms of a series of average annual infection risks in successive calender years.The infection risk indicates the proportion of the population which will be primarily infected, or reinfected, with tubercle bacilli in the course of one year. The risk is usually expressed as a percentage or as a rate. The annual trend (decrease) in the risk of infection is even more important than the actual level of this risk.Tuberculin surveys in schoolchildren, which are repeated, say every five years, in the same area provide us with the necessary information to make estimates for the annual infection risk. In areas where infections with the socalled atypical mycobacteriae are frequent, simultaneous testing with two "Sensitins", one prepared from human tubercle bacilli and one from atypical mycobacteriae will be of value for estimating the proportion of those infected with virulent bacilli and those infected with other mycobacteriae.
Community Pediatrics Sudijanto Sudijanto
Paediatrica Indonesiana Vol 14 No 3-4 (1974): March - April 1974
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (507.13 KB) | DOI: 10.14238/pi14.3-4.1974.69-72

Abstract

It is generally agreed upon thatmedical care in developing countrieshas quite different nature.What really makes it so particular?It is the condition of developing co-untries that determines the kind me-dical care for the majority of people.The developing countries as poor na-tions just have no money and medi-cal skills adequately.
A Child with Nephrotic Syndrome and Late Congenital Syphilis Lilly Zulkarnain-Malaon; R.H. Sardjito Djojohadipringgo; I Wajan Giri; Moch. Soebagyo Singgih
Paediatrica Indonesiana Vol 14 No 7-8 (1974): July - August 1974
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (725.603 KB) | DOI: 10.14238/pi14.7-8.1974.118-22

Abstract

Underneath is a report of a casewith nephrotic syndrome that mightbe due to congenital syphilis.
Human Milk in the Second Year Nutritional and Economic Considerations for Indonesia Jon E. Rohde
Paediatrica Indonesiana Vol 14 No 11-12 (1974): November - December 1974
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (752.402 KB) | DOI: 10.14238/pi14.11-12.1974.198-207

Abstract

That mother milk provides the ideal infant diet is accepted by all but the most myopic diehards of the processed milk industry. Mortality in breast fed infants may be as low as one tenth of that experienced amongst their unfortunate bottle fed peers who often succumb to the ravages of diarrhea, marasmus and opportunistic infections (Harfouche, 1970). Mother milk approaches an ideal composition for the human, is cheap, sterile, readily available and, provides protection against certain infections.
Syndrome of Hyperviscosity in the Neonate A. S. Ongkie
Paediatrica Indonesiana Vol 14 No 11-12 (1974): November - December 1974
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1374.28 KB) | DOI: 10.14238/pi14.11-12.1974.232-48

Abstract

This paper tries to present a brief review on the many-sided problem of the syndrome of hyperviscosity in the neonate.
Age at Menarche and Menstrual Pattern of Elementary School Students in Medan Nurdiani Nurdiani; Evi Kamelia; Rusdi Andid; Ani Ariani; Hakimi Hakimi; Endang D Hamid
Paediatrica Indonesiana Vol 38 No 3-4 (1998): March - April 1998
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (635.171 KB) | DOI: 10.14238/pi38.3-4.1998.75-84

Abstract

This study aimed to determine the age at menarche and its influencing factors and the pattern of menstrual cycles in elementary school students in Medan. Subjects were 227 female students in six primary schools (private and government) in Medan municipal, during October until November 1995. Most students experienced menarche in government primary school (GPS: 35.8%) and private primary school (PPS: 24%), at the age of 10-12 years. The mean age at menarche of these students in government primary school was 11.41 (SD 0.95) years while in private primary school it was 10.65 (SD 0.78) years. Subjects who had had menarche had better nutritional status than who had not (p<0.001). Sports activities are also associated with age at menarche (p<0.001). On the other hand family's economical status and maternal age at menarche were not significantly associated with age at menarche (p>0.05). Most students who had had menarche had regular menstrual cycle; the duration of menarche was 4-6 days for GPS and 3 days for PPS. Dysmenorrhea was a common finding in the first three months of menstruation cycle but gradually diminishing with time. The duration of menstrual cycle was 25-34 days. These findings are useful as a guide for the parents, especially when mothers planning the best time/ the moment to discuss about reproduction and sexual counseling with her daughter.

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