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INDONESIA
CHEMISTRY PROGRESS
Published by Universitas Sam Ratulangi
ISSN : 19795920     EISSN : 27158365     DOI : -
Core Subject : Science,
Chemistry
Majalah Ilmiah Chemistry Progress merupakan media untuk menyebarkan informasi ilmiah dan sarana komunikasi bagi para ilmuan dan cendekiawan melalui tulisan-tulisan ilmiah. Majalah Ilmiah Chemistry Progress terbit dua nomor dalam satu tahun (Mei dan November) berisi kajian penelitian dalam lingkup ilmu kimia (organik, anorganik, analitik, biokimia, fisika, bahan alam, lingkungan, pangan, kelautan, pertambangan, farmasi dan komputasi). Jumlah halaman pervolume adalah 55-65 halaman.
Arjuna Subject : -
Articles 275 Documents
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PRODUKSI SABUN MANDI CAIR BERBAHAN BAKU VCO YANG DITAMBAHKAN DENGAN EKSTRAK WORTEL (Daucus carrota) Predianto, Herwin; Momuat, Lidya I.; Sangi, Meiske
CHEMISTRY PROGRESS Vol 10, No 1 (2017)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.10.1.2017.27971

Abstract

ABSTRAK Penelitian ini bertujuan untuk menentukan jumlah KOH yang dibutuhkan untuk direaksikan dengan VCO mengandung karotenoid wortel dalam pembuatan sabun mandi cair yang berkualitas berdasarkan uji SNI No. 06-4085-1996. Metode yang digunakan dalam penelitian ini adalah metode bilangan penyabunan dan penentuan Kualitas sabun Mandi Cair berdasarkan SNI No. 06-4085-1996. Hasil Penelitian menunjukan bahwa bilangan penyabunan dari VCO mengandung karotenoid wortel sebesar 219,43 mg. Sabun mandi cair yang dihasilkan dalam penelitian ini telah memenuhi SNI berdasarkan parameter uji keadaan, pH sebesar (10,12), alkali bebas sebesar (0%), bahan aktif sebesar (18,10%), dan angka lempeng total (<10). Penelitian ini menyimpulkan bahwa sabun mandi cair dapat dihasilkan dari VCO mengandung karotenoid wortel, dengan jumlah KOH yang dibutuhkan untuk direasikan dengan minyak sesuai bilangan penyabunan yaitu sebesar 219,43 mg. Sabun mandi cair yang dihasilkan memenuhi SNI No. 06-4085-1996.ABSTRACT This study aims to determine the amount of KOH needed to be reacted with VCO carrots contain carotenoids in the manufacture of liquid soap of quality based on test SNI No. 06-4085-1996. The method used in this research is the method of saponification and determination of the quality of liquid bath soap based SNI No. 06-4085-1996. Results showed that the saponification of VCO carrots contain carotenoids amounting to 219.43 mg. Shower gel produced in this study have met the SNI is based on state test parameters, the pH of (10.12), alkali-free at (0%), the active ingredient of (18.10%), and total plate count (<10) , The study concluded that the liquid soap can be produced from the VCO carrots contain carotenoids, with the amount of KOH needed to direasikan with appropriate oil saponification in the amount of 219.43 mg. Shower gel produced meet SNI No. 06-4085-1996.
EFEK HEPAPROTEKTIF GULA AREN TERHADAP KARBON TETRAKLORIDA PADA TIKUS Suoth, Elly Juliana; Herowati, Rina; Pamudji, Gunawan
CHEMISTRY PROGRESS Vol 12, No 1 (2019)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.12.1.2019.27920

Abstract

Abstrak Studi ini meneliti efek gula aren, senyawa bioaktif yang diisolasi dari gula aren, terhadap kerusakan hati akibat karbon tetraklorida (CCl4). Tikus diperlakukan secara intraperitoneal dengan 0,5 ml / kg CCl4 dan kelompok hewan yang berbeda menerima 25, 50, 100, dan 200 mg / kg sudar palem. Pada 24 jam setelah perawatan CCl4, kadar aminotransferase serum dan peroksidasi lipid meningkat secara signifikan, sedangkan kadar glutathione hati menurun. Perubahan ini dilemahkan oleh gula aren. Studi histologis menunjukkan bahwa gula aren menghambat peradangan portal, nekrosis sentrizonal, dan hiperplasia sel Kupffer, yang merupakan tiga karakteristik paling umum dari kerusakan hati yang diinduksi CCl4. Tingkat serum dan mRNA ekspresi tumor necrosis factor-? secara nyata meningkat dengan pengobatan CCl4 tetapi ditekan oleh gula aren. Level mRNA dan ekspresi protein diinduksi nitric oxide synthase dan heme oksigenase-1 meningkat secara signifikan pada 24 jam setelah perawatan CCl4. Gula aren melemahkan peningkatan protein dan ekspresi gen diinduksi nitric oxide synthase tetapi menambah peningkatan heme oxygenase-1. Temuan ini menunjukkan bahwa gula aren melindungi hepatosit dari kerusakan oksidatif yang disebabkan oleh CCl4, dan perlindungan ini kemungkinan disebabkan oleh induksi ekspresi HO-1 dan penghambatan mediator proinflamasi. Abstract This study examined the effects of palm sugar, a bioactive compounds isolated from palm sugar, on carbon tetrachloride (CCl4)-induced liver injury. Mice were treated intraperitoneally with 0.5 ml/kg CCl4 and different groups of animals received 25, 50, 100, and 200 mg/kg palm sudar. At 24 h after the CCl4 treatment, the level of serum aminotransferases and lipid peroxidation was significantly elevated, whereas the hepatic glutathione content was decreased. These changes were attenuated by palm sugar. The histological studies showed that palm sugar inhibited the portal inflammation, centrizonal necrosis, and Kupffer cell hyperplasia, which are the three most common characteristics of CCl4-induced liver damage. The serum level and mRNA expression of tumor necrosis factor-? were markedly increased by the CCl4 treatment but suppressed by palm sugar. The mRNA and protein expression levels of inducible nitric oxide synthase and heme oxygenase-1 increased significantly at 24 h after the CCl4 treatment. Palm sugar attenuated the increase in the protein and gene expression of inducible nitric oxide synthase but augmented the increase in those of heme oxygenase-1. These findings suggest that palm sugar protects hepatocytes from the oxidative damage caused by CCl4, and this protection is likely due to the induction of HO-1 expression and the inhibition of the proinflammatory mediators. 
PEMBUATAN TES KIT KERTAS NITROGEN-AMONIA BERDASARKAN PEMBENTUKAN SENYAWA INDOFENOL BIRU Sulistyarti, Hermin
CHEMISTRY PROGRESS Vol 7, No 1 (2014)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.7.1.2014.4850

Abstract

Pembuatan tes kit nitrogen-amonia berdasarkan metode fenat menggunakan komparator kertas didasarkan pada reaksi pembentukan senyawa indofenol biru. Tes kit diuji validitasnya secara visual dan pembacaan absorbansi melalui metode standar spektrofotometri UV-Vis pada ? 630 nm. Hasil penelitian menunjukkan bahwa peningkatan volume NaOH, NaOCl, HCl MnSO4 dan fenat meningkatkan intensitas warna indofenol biru dengan optimasi volume masing-masing 7, 0,25, 0,3, 0,2 dan 0,1 mL. Uji validasi dengan metode standar distilasi-spektrofotometri menunjukkan metode tes kit dengan media kertas dapat digunakan untuk analisis nitrogen pada pupuk yang mengandung 1-15 % nitrogen ammonia.   Keywords : tes kit kertas, fenat, nitrogen, amonia, indofenol biru
SATU SENYAWA STEROID DARI DAUN GEDI (Abelmoschus manihot L. Medik) ASAL SULAWESI UTARA Mamahit, Lexy
CHEMISTRY PROGRESS Vol 2, No 1 (2009)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.2.1.2009.61

Abstract

This research was aimed to isolate and identify the structure of secondary metabolites from gedi leaf. Inorder to achieve this research aim, an extraction of the gedi leaf tissue with methanol solvent had beencarried out. These extract then was partitioned in several organic solvents such as n-hexane, chloroform,and ethyl acetate. Further, the resulted partition was fractionation and purifying undergoes an appropriatemethod like liquid and vacuum pressure chromatography and also determining the melting points. Todetermine the chemical structure of the isolate, a compilation of several spectroscopic methods, such asinfrared (IR), 1H and 13C nuclear magnetic resonance (NMR), and an advanced NMR techniques(HMQC, HMBC, and COSY). Results of this research shown that one major constituent was isolated fromthe leaf of gedi : b-sitosterol.
AKTIVITAS ANTIOKSIDAN BERAS ANALOG DARI SAGU BARUK (Arenga microcarpha) DAN UBI JALAR UNGU (Ipomea batatas L. Poiret) Kaemba, Almawaty; Suryanto, Edi; Mamuaja, Christine
CHEMISTRY PROGRESS Vol 10, No 2 (2017)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.10.2.2017.27748

Abstract

ABSTRAK  Tujuan penelitian ini yaitu menganalisis aktivitas antioksidan beras analog sagu baruk dan ubi jalar ungu. Uji warna menggunakan chromameter, senyawa antioksidan yang diuji yaitu total fenolik dan antosianin, sedangkan aktivitas antioksidan yaitu total antioksidan yang diuji secara spektrofotometri. Hasil penelitian menunjukkan bahwa warna beras analog memiliki nilai L= 62,01, a*= 12,49 dan b*= 1,54. Beras analog mengandung total fenolik sebesar 73,98 mg/L dan antosianin sebesar 7,01 mg/L dan memiliki total antioksidan sebesar 62,01 mg/mL. Sagu baruk dan ubi jalar ungu dapat dibuat beras analog yang memiliki potensi antioksidan. Kata kunci: Antosianin, total antioksidan, beras analog, sagu baruk, ubi jalar ungu  ABSTRACT  The aim of this research was to analyze antioxidant activity of rice analog from baruk sago and purple sweet potatoes. Color was evaluated using chromameter, antioxidant compound which evaluated was total phenolic and anthocyanin, and antioxidant activity was total antioxidant which evaluated using spectrophotometry. The result showed that rice analogue possess L= 62,01, a*= 12,49 dan b*= 1,54. Rice analogue possess total phenolic 73,98 mg/L and anthocyanin 7,01 mg/L, and exhibit total antioxidant 62,01 mg/mL. Baruk sago and purple sweet potatoes can be used to produce rice analog which possess antioxidant potency. Keywords: Anthocyanin, total antioxidant, rice analog, baruk sago, purple sweet potatoes
KARAKTERISASI VIRGIN COCONUT OIL (VCO) REMPAH Gugule, Sanusi
CHEMISTRY PROGRESS Vol 3, No 2 (2010)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.3.2.2010.18989

Abstract

ABSTRACTGugule, S. and F. Fatimah. 2010. Characterization of spices virgin coconut oilA study has been carried out to find out the effect of some spices type on quality and characteristic of fatty acid of virgin coconut oil (VCO). The test of spice VCO quality conducted with the determination of iodine and acid number, water content and peroxide number. The profile of fatty acid of VCO was tested with the liquid gas chromatography, using the internal standard of margaric acid. The experimental result showed that control and spice VCO that is VCO nutmeg, leaf of salam, sweet basil and galingale have the quality fulfilling standard APCC, except number iodine. As compared to control, the addition of spice at making VCO nor have an effect to fatty acid percentage in VCO, but having an effect to reduction fatty acid content in VCO (calculated in mg / 100g sample)..Kata kunci : Characterization, virgin coconut oil, spices
TINJAUAN LITERATUR MUTAKHIR - OBITUARI - INDEX Suryanto, Edi
CHEMISTRY PROGRESS Vol 6, No 2 (2013)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.6.2.2013.3502

Abstract

EIKODEKANA DARI DAUN TUMBUHAN GEDI (ABELMOSCHUS MANIHOT L. MEDIK) ASAL SULAWESI UTARA Mamahit, Lexie
CHEMISTRY PROGRESS Vol 2, No 2 (2009)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.2.2.2009.4972

Abstract

This research was aimed to isolate and identify the structure of secondary metabolities from gedileaf. In order to achieve this research aim, an extraction of the gedi leaf tissue with mwthanol solvent hadbeen carried out. These extract then was partitioned in several organic solvents such as n-hexane,chloroform, and ethyl acetate. Further, the resulted partition was fractionation and purifying undergoes anappropriate method like liquid and vacuum pressure chromatography. To determine the chemical structureof the isolate, a complication of several spectroscopic methods, such as infrared (IR), 1H and 13 C nuclearmagnetic resonance (NMR), and an advanced NMR techniques (HMQC, HMBC, and COSY). Results ofthis research shown that one major constituent was isolated from the leaf of gedi: eikodekana Keywords : eikodekana, Abelmoschus manihot
ANALISIS FITOKIMIA TUMBUHAN OBAT DI KABUPATEN MINAHASA UTARA Sangi, Meiske; Runtuwene, Max R. J.; Simbala, Henry E. I.; Makang, Veronica M. A.
CHEMISTRY PROGRESS Vol 1, No 1 (2008)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.1.1.2008.26

Abstract

A research has been done to analyze the phytochemical of medicine plant used by North Minahasa society. The research done qualitatively to know the present of alkaloid component, flavonoid, triterpenoid, steroid, saponin, and tannin. Analyzes of alkaloid component using Mayer, Dragendorff and Wagner reagents showed presipitate when react with alkaloid. Mayer reagent showed white presipitate, Dragendorff reagent showed red-orange presipitate and Wagner reagen showed brown presipitate. In flavonoid analysis, positive result indicated with red solution. Saponim analysis indicated with a stable foam. Tannins analysis indicated with green and blue-black solution and triterpenoid analysis indicated with red-orange or purple solution. Although the steroida analysis indicated with blue solution. The result show that 46 samples from 46 spesies of medicine plant that had been analyzed are 97,83% positive containing alkaloid component; 13,04% containing triterpenoid; 28,26% containing steroid; 47,83% containing flavonoid; 63,04% containing saponin and 63,44% containing tannin.
PENERAPAN TEKNOLOGI NANOPARTIKEL UNTUK SEDIAAN OBAT (ANTIBIOTIK BERBASIS BAHAN ALAM, PROPOLIS TRIGONA SPP) Hasan, H. A. E. Zainal; Artika, I Made; Fahri, Vita Rosaline; Sari, Nurmala
CHEMISTRY PROGRESS Vol 5, No 1 (2012)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.5.1.2012.655

Abstract

Zainal Hasan dkk., 2012. Penerapan teknologi nanopartikel untuk sediaan obat (antibiotik berbasis bahanalam, Propolis Trigona spp.). Propolis Trigona spp telah diteliti dapat menghambat pertumbuhan bakteri patogen seperti Escherichia coli.Senyawa Flavonoid yang terkandung dalam propolis diduga berperan sebagai antibakteri. Jika ukuran partikelmakin kecil maka luas permukaan partikel makin besar sehingga laju dari larutan semakin meningkat danmempercepat penyerapan obat melalui peredaran darah sehingga efek terapeutiknya lebih cepat tercapai.Salah satu cara yang dapat dilakukan untuk memperkecil ukuran partikel guna meningkatkan kelarutan danpenyerapan suatu sediaan farmasi adalah dengan menggunakan nanoteknologi.Pada penelitian ini telah dirancang sediaan propolis dalam bentuk nanopartikel. Tujuan penelitian ini adalahmembuat nanopartikel dari propolis Trigona spp. Proses pembuatan nanopropolis yaitu dengan cara penyalutandan homogenizer pada kecepatan tinggi. Telah dilakukan uji aktivitas dari nanopartikel propolis sebagaiantibakteri dan menentukan konsentrasi hambat tumbuh minimum propolis nanopartikel terhadap bakteriEscherichia coli secara in vitro. Dari hasil penelitian ini menunjukkan bahwa propolis Trigona spp dapat dibuatdalam bentuk nanopartikel. Hasil Scanning Electron Microscopy menunjukkan adanya ukuran diameternanopropolis sebesar 100 ? 322 nm. Hasil uji aktivitas antibakteri menunjukkan pada konsentrasi 10% - 0,02%nanopropolis aktif terhadap E. coli sedangkan propolis bukan nanopartikel aktif sampai konsentrasi 0,15%.Dengan demikian KHTM ?propolis bukan nanopartikel? dicapai pada konsentrasi 0,15%, sedangkannanopropolis KHTM nya lebih rendah dari 0,02%. Propolis nanopartikel lebih efektif dibandingkan ?propolisbukan nanopartikel? dalam menghambat pertumbuhan E. coli.Kata kunci : propolis, nanopartikel, E.coli, KHTMZainal Hasan et al., 2011. Application of nanoparticle technology for medicine preparate (Antibiotic base onnatural product, Propolis Trigona spp.). Trigona spp propolis has been evaluated can inhibit Escherichia coli. Flavonoid in propolis suggested act asantibacterial. If particle size smaller, then its surface area is bigger, so the rate of drugs absorption wereincreased trough blood circulation and its therapy effect can be achieved faster. One of resize way to reduceparticle size to increase its solubility dan absorption pharmaceutical is using nanotechnology.This research has been designed propolis in nanoparticle size. The aims of this research is to makenanoparticle propolis from Trigona spp. The process to make nanopropolis was covered it and homogenize inhigh speed. Nanopropolis activity evaluation has been done as antibacterial and determined its minimuminhibition concentration on Escherichia coli (in vitro). Trigona spp propolis can be made to nanoparticle. ElectronMicroscopy scanning shows nanopropolis diameter was 100 ? 322 nm. Antibacterial activity evaluation showson nanoproposis concentration 10% - 0,02% active on E. Coli, although nonnanopropolis active onconcentration 0,15%. Nanopropolis is more effective than non nanopropolis to inhibit E. coli.Keywords : propolis, nanopartikel, E.coli, KHTM

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