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Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Vol. 3 No. 2 (2015)" : 5 Documents clear
Solubility enhancement of biperidine HCl by complexation with hydroxypropyl β-cyclodextrin Dubey, Amit; Singh, Vikram; Juyal, Divya; Rawat, Geet
Journal of Applied Pharmaceutical Research Vol. 3 No. 2 (2015)
Publisher : Creative Pharma Assent

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Abstract

Oral route is the simplest and easiest way of drug administration, because of the greater stability, lesser bulk, and cheap cost of production, accurate dosage and easy process, solid oral dosage forms have several advantages over other dosage forms. All the poor water soluble drugs after oral administrations are not well absorbed and thus leads to decrease in inherent efficiency of drugs. Therefore, for oral drug delivery system the improvement of drug solubility thereby its oral bio-availability is the most important aspect of drug development process. Biperiden HCl is a potent drug (Maximum daily dose is 16mg/day), having extensive first pass metabolism resulting in poor Bioavailability. The pharmacokinetic profile of this drug showed 33±5 % Bioavailability and 18-24 hours elimination half-life (t1/2). In the present study attempt has been made to prepare and characterize inclusion complex of Biperiden HCl with Hydroxypropyl β-Cyclodextrin. The inclusion complexes prepared by different methods i.e. Physical mixture, Kneading and Solvent evaporation methods. The prepared complexes were characterized using FT-IR. The inclusion complex prepared by Kneading method exhibited greatest enhancing in solubility and faster dissolution (93.98% drug release in 60 min) of Biperiden HCl.
Recent status on carbohydrate metabolizing enzyme inhibitors in regulation of diabetes: a mechanism based review Sinha, Durgeshnandani; Satapathy, Trilochan; Kumar Dewangan, Mehendra; Kumar, Arvind; Roy, Amit
Journal of Applied Pharmaceutical Research Vol. 3 No. 2 (2015)
Publisher : Creative Pharma Assent

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Abstract

The important therapeutic approach for treating type 2 diabetes mellitus is to decrease the post-prandial glucose levels which could be done by decreasing the absorption of glucose through the inhibition of the carbohydrates-hydrolyzing enzymes such as α-amylase and α-glucosidase present in the small intestinal brush border that are responsible for the breakdown of oligosaccharides and disaccharides into monosaccharide’s and suitable for absorption. Inhibition of α-amylase generally considered as strategy for the treatment of disorders in carbohydrate uptake, such as diabetes and obesity. Among the marketed allopathic preparations carbohydrates-hydrolyzing enzymes Inhibitors like acarbose, voglibose etc delay carbohydrate digestion and prolong overall carbohydrate digestion time, causing a reduction in the rate of glucose absorption and consequently blunting the postprandial plasma glucose rise. Some of the plants are also considered as an important source of chemical constituent with potential for inhibition of α-amylase and can be used as therapeutic purposes. In this review our efforts have been devoted to explore the mechanism based carbohydrates-hydrolyzing enzymes Inhibitors for the regulation of diabetes.
Pharmacological screening of Alsotonia scholaris Rathor, Vinod; Wadhwa, Shailendra; Deb, Jyotirmoy; Choudhury, Ananta
Journal of Applied Pharmaceutical Research Vol. 3 No. 2 (2015)
Publisher : Creative Pharma Assent

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Abstract

A large number of medicinal plants are claimed to possess anthelmintic property in traditional systems of medicine and are also utilize by ethnic groups worldwide. The development of anthelmintic resistance and the high cost of conventional anthelmintic drugs led to the evaluation of medicinal plant as an alternative source of anthelmintice. In the current study were conducted to determine the possible anthelmintic and antibacterial effects of leaves of Alstonia scholaris. The plant Alstonia scholaris has been used in different system of traditional medication for the treatment of diseases and ailments of human beings including anthelmintic activity.
Importance of piperidone moiety in pharmaceutical chemistry: a review De, Sourav; Banerjee, Subhasis; Babu, M. Niranjan; Keerithi, C. Navaya
Journal of Applied Pharmaceutical Research Vol. 3 No. 2 (2015)
Publisher : Creative Pharma Assent

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Abstract

Piperidone heterocycle have gained a considerable attention in the field of drug discovery. The wide range of its therapeutic application paved the way to the researchers to insert the nucleus every now and then in diversified pharmacophore, so as to generate novel therapeutic profile. In this review, we have tried to present various therapeutic applications, which have already been demystified by the researchers. The study may prompt the researcher to generate scaffolds of highest therapeutic efficacy considering the importance of 4- Piperidone nucleus.
Subduing the nail barrier with novel herbal penetration enhancers for transungual delivery system Singh, Vikram; Gupta, R. D.; Teotia, U. V. S
Journal of Applied Pharmaceutical Research Vol. 3 No. 2 (2015)
Publisher : Creative Pharma Assent

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Abstract

Nail fungal infections are very common and also very difficult to treat because of nail morphology, deep penetrability of infectious agent inside nail plate and poor permeability of the nail plate. Transungual delivery shall be the first choice for treatment of nail infection if we get the effective penetration enhancers without causing the serious problem. In this study we tried to scanning some extracts penetration potency through the human cadaver nail plate. Five plants selected for the purpose acacia catechu, rosa hybrid, hibiscus rose-sinensis, tagetes patula, tagetes erecta. For penetration potency first defatted the nail plate with chloroform : methanol (2:1) mixture. Extracts of tagetes erecta, acacia catechu shows 100%, tagetes patula 60% and rosa hybrid 40% from dorsal side of plate. Those extracts were stable by it only. That proves that they may be used as a penetration enhancer to increase the penetration of drug

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