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Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
Arjuna Subject : -
Articles 459 Documents
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Synthesis and antifungal activity screening of some novel 7–substituted –2–hydroxy–quinoline schiff bases Kumar, M. R. Pradeep
Journal of Applied Pharmaceutical Research Vol. 4 No. 4 (2016)
Publisher : Creative Pharma Assent

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Abstract

With an objective of synthesizing some novel, potent and broad spectrum antifungal activity having compounds, here some novel quinoline derivatives are reported. Initially 7-substituted-2-cholro-3-formylquinolines were prepared using well known Vilsemeir-Hack reagent method. These on microwave irradiation with 4M HCl yielded 7-substituted-2-hydroxy quinoline-3-carbaldehydes I(a, b), which on further treatment with different substituted hydrazides yielded the novel Schiff bases of quinoline II(a-f). The structure of all newly synthesized compounds was confirmed by spectral study such as IR, 1H NMR, 13C NMR and mass spectroscopy. All the synthesized compounds were screened for in-vitro antifungal activity by two fold serial dilution method using fluconazole as the standard drug. Compounds II a, II b and II d showed significant antioxidant activity
Concept of “ama dosha” WSR to free radicals Kumar, Munish; Kumar, Parvesh
Journal of Applied Pharmaceutical Research Vol. 4 No. 4 (2016)
Publisher : Creative Pharma Assent

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Abstract

Ama is considered as root cause of all diseases in the body. It has tremendous capacity to vitiate the Doshas and disturbing the homeostasis (Dhatusamya). Ama is the result of improper digestion or partially digestion of the food particle due to hypo function of Jatharagni and also due to accumulation of mala in the body. In modern physiology, Ama can be correlated with deadly Free radicals. Free radicals are atoms, ions or molecules that contain one or more unpaired electron, which requires neutralization by free radical scavengers. The majority of free radicals that damage biological systems are oxygen free radicals, and these are known as “Reactive oxygen species”. Thus it exists in incomplete metabolic state which is also the state of Ama described as Avipakam (incompletely metabolized). This Ama is responsible for the production of various diseases. In the same way, free radicals are also found to be root cause of many diseases. The aim of present article is to understand the concept of Ama as well as free radicals as a root cause of diseases and its treatment.
Ligand conjugated liposomal drug delivery system for enhanced brain uptake of ampicillin Lala, R.; Nandvikar, N.; Agnihotri, S.
Journal of Applied Pharmaceutical Research Vol. 4 No. 4 (2016)
Publisher : Creative Pharma Assent

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Abstract

Targeting of antimicrobial agents by means of liposomes may be of great value in the treatment of intra or extracellular infections compare to conventional forms of antimicrobial therapy. In the present study Ampicillin loaded non-targeted Polyethylene glycolated liposomes and targeted Glutathione Polyethylene glycollated liposomes of about 132.14 nm size were prepared with 80 % of drug entrapment. Prepared liposomes were evaluated for in vitro, in vivo release profile and brain uptake studies. Results of these studies revealed more absorption of drug than standard Ampicillin solution and non targeted liposomes (Auc0-6h 1858.908 µg h/ml) and 3.5 times increase in brain uptake. Incorporation of polyethylene glycol in the liposomes increased the drug concentration and circulation time in plasma as well as in the extracellular fluid of brain thus improved therapeutic availability of Ampicillin trihydrate.
Short review on domperidone tablet Sharma, Shaveta; Chandel, Diksha; Sudan, Puneet; Jain, Upendra K.
Journal of Applied Pharmaceutical Research Vol. 5 No. 1 (2017)
Publisher : Creative Pharma Assent

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Abstract

Oral route is presently the gold standard in the pharmaceutical industry where it is regarded as the safest, most economical and most convenient method of drug delivery resulting in highest patient compliance. Pediatric and geriatric patients find it difficult to swallow solid dosage forms like tablets. Mouth dissolving tablet that dissolve or disintegrate rapidly in oral cavity result in solution, is an ultimate remedy for this problem in addition they give pleasing mouth feeling. ODT has advantages such as patient compliance, quick onset of action, improved bioavailability. Domperidone tablet (ODT) gives relief from nausea, vomiting. This review gives us all information about pharmacokinetic, pharmacodynamic, uses, precautions, side effects of domperidone tablets
A nanocrystal technology: to enhance solubility of poorly water soluble drugs Mirza, R M; Ahirrao, S P; Kshirsagar, S. J.
Journal of Applied Pharmaceutical Research Vol. 5 No. 1 (2017)
Publisher : Creative Pharma Assent

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Abstract

Most of the recently developed new chemical entities are poorly water soluble and they create major problems during formulation and development of new dosage form and due to poor solubility and poor bioavailability. The drugs belong to BCS class II and class IV has problem of solubility, to overcome the solubility problem nanotechnology is most useful technique. In this review article the main focus on Nanocrystals and various techniques used for preparation of Nanocrystals. Drug nanocrystals consists pure poorly water soluble drugs without any matrix material which means that it is carrier free drug delivery. Nanocrystals technologies have been introduced as advantageous, universal formulation approaches for the BCS class II and IV drugs. Nanocrystals, with greater surface to volume ratio, can effectively increase both the dissolution rate and saturation solubility of active ingredients The Nanocrystals is suitable drug delivery system for all commonly used routes of administration such as oral, IV, SC, and IM and topical application. Nanocrystals can also be incorporated into the tablets, capsules, fast-melts and lyophilized for sterile product applications. There are no of techniques which are used for production including precipitation, milling, high pressure homogenization and combination methods such as Nano-Edge, SmartCrystal and Precipitation-lyophilization-homogenization (PLH) technology.
In – vitro anti tubercular activity of flowers of Couroupita guanensis L Aravind, D Sai; Karthikeyan, R; Babu, P Srinivas
Journal of Applied Pharmaceutical Research Vol. 5 No. 1 (2017)
Publisher : Creative Pharma Assent

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Abstract

Modern civilization is facing hundreds of disorders associated with microorganisms. The natural phytochemicals from non-edible plants are gaining importance to fight against these disease The intention of this study is to evaluate the ethanol and dichloromethane extracts of flower of Couroupita guianensis (Lecithydaceae) for anti-tubercular activity. The anti-tubercular activity of all the extracts of Couroupita guianensishave been evaluated against Mycobacterium tuberculosis H73Rv strain using Microplate Alamar Blue Assay (MABA). The activity was documented within MIC range of 0.8 to 100μg/ml. The results of MABA showed that both ethanol and dichloromethane extract exhibited significant anti-tubercular activity. The present investigation suggests that Couroupita guianensis possess remarkable anti-tubercular activity
Bioelectrode based chitosan-nano copper oxide for application to lipase biosensor Bodade, A B; Taiwade, M A; Chaudhari, G N
Journal of Applied Pharmaceutical Research Vol. 5 No. 1 (2017)
Publisher : Creative Pharma Assent

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Abstract

Chitosan (Chit)-nanocrystalline CuO composite prepared from Chitosan and CuO nanoparticles by a spin coating method. CuO nanoparticles (45 nm) synthesized by Sol-gel citrate method and characterized by X-Ray diffraction (XRD), Raman spectroscopy, UV-visible spectroscopy, Fourier transform spectroscopy (FTIR) and Scanning electron microscopy (SEM). The electrochemical studies revels that these Chit-nano CuO electrode provide favorable condition for immobilization of enzyme lipase [LIP] specific enzyme for triglyceride detection, resulting in enhanced electron transfer at the interface. The prepared bioelctrode (LIP/Chit-nano CuO/Au bioelectrode) is utilized for triglyceride [TG] sensing using cyclic voltammetry (CV) with hexacyanoferrate as mediator. The electrochemical response studies shows on improved sensing performance of bioelectrode exhibit high sensitivity, low detection limit and good linearity of tributyrin concentration with fast response time. The low value of Michallis-Menten constant indicates high affinity of LIP towards the analyte (tributyrin). The Redox behavior of nano CuO makes an efficient matrix with chitosan for triglyceride [TG] biosensor.
A review on the pros and cons of online Pharmacies Jain, V H; Tadv, S A; Pawar, S P
Journal of Applied Pharmaceutical Research Vol. 5 No. 1 (2017)
Publisher : Creative Pharma Assent

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Abstract

Now a day’s buying a medicine online is common practice across the globe, because buyers are used to order for medicines through a click of a button rather than taking a trip to a drug store. Such online websites sell everything from prescription drugs to health related products. Most of such stores are legal outlets that safeguard all traditional procedures related to drug prescription. That is why most buyers are confident about dealing with these stores. But there are quite a few rogue stores that have come up in the recent past over the internet. These stores deal in illegal medications and unapproved drugs, buyers must be aware of such rogue stores. The fact remains that drugs purchased at online drug stores offer high levels of handiness, put forward privacy for the buyer as well as safeguard traditional procedures of prescribing drugs. Thus consumers can use these services with the same confidence as they would have had in the neighbourhood pharmacist. But they must stay away from "rogue sites" that sell unapproved products or sidestep conventional procedures that safeguard the interests of consumers. Additionally, customers have difficulty knowing whether an Internet pharmacy is a legitimate operation.
Development and validation of RP HPLC method for determination of metformin and sitagliptin in bulk and pharmaceutical dosage form D., Kavitha; Sahoo, S K; P., Venkateswara Rao; M., Nagamani; Ch., Bhagyalaxmi
Journal of Applied Pharmaceutical Research Vol. 5 No. 2 (2017)
Publisher : Creative Pharma Assent

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Abstract

A simple and rapid reversed phase-high performance liquid chromatographic method was developed for simultaneous determination of Metformin and Sitagliptin in Tablet Dosage form. The elution was done with a mobile phase of Water: Methanol (60:40) on Intersil-BDS C18 column (250 × 4.6 mm, 5 μm particle size). The wavelength detector was set at 258 nm. Retention times for Metformin and Sitagliptin were around 2.869 min, 3.942 min respectively. The reliability and analytical performance of the proposed HPLC procedure were statistically validated according to the respect of linearity, ranges, precision, accuracy, repeatability, reproducibility, detection and quantification limits. Linear ranges were established between 20-80 μg/mL for both the drug. The LOD and LOQ for Metformin were found to be 0.663, 1.92 and for Sitagliptin were found to be 0.405, 1.228 respectively. The described High Performance Liquid Chromatography method was successfully employed for the analysis of pharmaceutical formulations containing combined dosage form
Chemometric – assisted UV spectrophotometric method for determination of antihyperlipidemic agents in pharmaceutical formulation Gandhi, Santosh V; Mutha, Amit S
Journal of Applied Pharmaceutical Research Vol. 5 No. 2 (2017)
Publisher : Creative Pharma Assent

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Abstract

This presented work is based on application of two multivariate calibration methods for simultaneous UV-VIS spectrophotometric determination of active substances in combined pharmaceutical formulation composed of Atorvastatin calcium (ATV) and Ezetimibe (EZT). The methods used were Principal Component Regression (PCR) and Partial Least Square (PLS). The Spectra of ATV and EZT were recorded at concentrations within their linear range 5.0-30.0 μg/ml for both drugs. 28 set of mixtures were used for calibration and 08 set of mixtures were used for validation in the wavelength range of 230 to 260 nm with the wavelength intervals λ= 0.5 nm in methanol. The methods were validated as per International Conference on HarmonizationQ2 (R1) (ICH) guidelines. These methods were successfully applied for determination of drugs in pharmaceutical formulation (tablet) with no interference of the excipient as indicated by the recovery study results. The proposed methods are simple, rapid and can be easily used as an alternative analysis tool in the quality control as well as in process control of drugs and formulation.

Page 16 of 46 | Total Record : 459

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