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Journal of Applied Pharmaceutical Research

joapr
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Published by Creative Pharma Assent

ISSN : - EISSN : 23480335 DOI : 10.18231

Core Subject : Health,

Medicine & Pharmacology

Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.

Arjuna Subject : -

Articles 459 Documents

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Phytochemical screening and antihelminthic activity of leaf and root extracts of Cassia tora plant Shrestha, Aashish; Ghimire, Kamana; Gupta, Amit Kumar; Pokhrel, Priyanka; Banerjee, Janmajoy; Khanal, Hemanta; Pradhananga, Mahalaxmi
Journal of Applied Pharmaceutical Research Vol. 5 No. 4 (2017)
Publisher : Creative Pharma Assent

Cassia tora is one of the most important sources of medicinally important phytochemicals and widely used in Ayurvedic and Chinese system of medicine. The fresh plants of cassia tora were collected from the different locality of Dharan, Sunsari district during the month of August. In this study leaves and root extracts were subjected to extraction by soxheletion by using ethanol and water and the extracts were subjected to antibacterial activity against Staphylococcus aureus. and Citrobacter koseri, the ethanolic extracts were screened for antihelmenthic activity against Indian adult earth worm (Pheretima posthuma) with a moderate result. The result of antibacterial activity revealed that aqueous extract of leaves and roots showed better activity in comparison to aqueous extracts particularly against gram positive bacteria (Staphylococcus aureus).

Review on natural gums and mucilage and their application as excipient Bahadur, Sanjib; Sahu, Uttam Kumar; Sahu, Dipesh; Sahu, Ghanshyam; Roy, Amit
Journal of Applied Pharmaceutical Research Vol. 5 No. 4 (2017)
Publisher : Creative Pharma Assent

Natural mucilage’s are included in novel drug delivered (NDDS) to multitask functions and in any cases directly or indirectly control the increase and rate of drug release. Substantial research efforts have been directed towards develop safe and efficient natural based mucilage particulate drug delivery systems., natural gums and mucilages and their isolation, purification, standardization and characterization characteristics along with their applications are covered. Recent trend towards the use of plant based and natural products demands the replacement of synthetic additives with natural ones. Today, the whole world is increasingly interested in natural drugs and excipients. These natural mucilages have advantages over synthetic ones since they are chemically inert, nontoxic, less expensive, and widely available.

Dopaminergic agents: back to the basics – a small review Sharma, Neha; Rane, Meenal; Moin, Shaikh Gulam
Journal of Applied Pharmaceutical Research Vol. 5 No. 4 (2017)
Publisher : Creative Pharma Assent

Parkinson’s disease is one of the most common neurodegenerative diseases. The motor system is eventually damaged which affects the voluntary movements in a patient. It leads to the death of vital nerve cells in the brain. Women have lesser prevalence due to the hormone called Estrogen which has been playing a significant role in human body. Most of the treatments focus on the balance of Dopamine in the brain which is done with the help of levodopa but the side effects seen in the patients were mild nausea, loss of appetite, heart burn, diarrhea, and many more. The cause of the disease is still unknown but its occurrence is mainly because of genetic and environmental factors. This review focuses on the combination therapy of levodopa and Carbidopa to treat the symptoms of Parkinson’s disease.

Novel drug delivery system: a promising approach in management of schizophrenia – a review Moin, Shaikh Gulam; Sharma, Neha; Rane, Meenal
Journal of Applied Pharmaceutical Research Vol. 5 No. 4 (2017)
Publisher : Creative Pharma Assent

Schizophrenia is a syndromic condition which is characterized by a set of signs and symptoms like delusions. It is severe non-curable illness of the brain. If not controlled and treated properly, it can lead to severe consequences. One can control these delusions by means of treatment, by using Conventional therapy or Novel therapy. There are various advantages of Novel system over Conventional system. This review focuses on understanding Novel system and its advantages over Conventional system.

A comprehensive review on microbial degradation of plastic waste Kumar, Sahni; Teotia, U. V. S; Singh, Yogendra
Journal of Applied Pharmaceutical Research Vol. 5 No. 4 (2017)
Publisher : Creative Pharma Assent

Plastic is a broad name given to different polymers with high molecular weight, which can be degraded by various processes. However, considering their abundance in the environment and their specificity in attacking plastics, biodegradation of plastics by microorganisms and enzymes seems to be the most effective process. When plastics are used as substrates for microorganisms, evaluation of their biodegradability should not only be based on their chemical structure, but also on their physical properties (melting point, glass transition temperature, crystallinity, storage modulus etc.). In this review, microbial and enzymatic biodegradation of plastics and some factors that affect their biodegradability are discussed. Plastics have become an important part of modern life and are used in different sectors of applications like packaging, building materials, consumer products and much more. Each year about 100 million tons of plastics are produced worldwide. Degradation is defined as reduction in the molecular weight of the polymer. The Degradation types are (a). Chain end degradation/de-polymerization (b).Random degradation/reverse of the poly condensation process. Biodegradation is defined as reduction in the molecular weight by naturally occurring microorganisms such as bacteria, fungi, and actinomycetes. That is involved in the degradation of both natural and synthetic plastics.

Synthesis of some dihydropyrimidinone derivatives and study of their anti-inflammatory activity Podilla, Naresh; Choudhury, Tirthankar
Journal of Applied Pharmaceutical Research Vol. 6 No. 1 (2018)
Publisher : Creative Pharma Assent

This research revealed that the numbers of available heterocyclic compounds are mainly focused on nitrogen containing compounds, such as quinazolines, indoles, benzimidazole, quinoxalines, coumarins and pyrimidines etc. A mixture of substituted aldehydes (0.01 mol) like acetyl acetone (method 1) or ethyl acetoacetate (method 2), urea or thiourea (0.01 mol) and lemon juice (0.5 ml) were taken into a round bottom flask and reflux for 1 hour at 800C under continuous stirring. After completion of the reaction the final product was recrystalized for purification. Simultaneously toxicity and anti-inflammatory activity were performed. But in case of using ethyl acetoacetate in method 2, the percentage yield was more as compare to using of acetyl acetone in method 1. So the derivatives obtained from method 2 were selected for further toxicity and anti- inflammatory activities.

Pharmacognostical, physiochemical and phytochemical evaluation of leaf, stem and root of orchid Dendrobium ochreatum Banerjee, Janmajoy; Chauhan, Neelmani; Dey, Biplab K.
Journal of Applied Pharmaceutical Research Vol. 6 No. 1 (2018)
Publisher : Creative Pharma Assent

The present work was aimed to carry out pharmacognosical and phytochemical evaluation of individual root, stem, and leaves of orchid “Dendrobium ochreatum.” The plant was sun dried and was grounded to fine powder using mechanical grinder followed by sieving. The fine powder was collected and subjected to different pharmacognostical studies like fluorescence analysis under uv light at different wavelength. Physiochemical parameters were also evaluated of the dried plant parts like ash values, loss on drying. Each part of plant like root, stem and leaves were separated and subjected to extraction using soxhletion using different polarity solvents i,e hexane, chloroform, ethanol in gradient elution technique. All total nine plant extracts were obtained, phytochemical screening revealed the presence of important phytoconstituents like alkaloid, glycoside, saponins etc whereas only chloroform extracts of stem exhibited the presence of steroid/phytosterol.

Bio-medical waste management in different hospitals of Guwahati and its effect on environment Changmai, Arabinda; Islam, Tofiqul; Nongsiang, Dibarlan; Deka, Manoj Kumar; Saharia, Bhargab Jyoti; Choudhury, Ananta; Dey, Biplab K.
Journal of Applied Pharmaceutical Research Vol. 6 No. 1 (2018)
Publisher : Creative Pharma Assent

Biomedical waste may be defined as the waste which is produced during the diagnosis, research activities, treatment of patients, treatment of animals, production and testing of biological product and including articles as mentioned in schedule I of the Biomedical Waste (Management and handling) (second amendment) Rules 2000, as per Ministry of Environment and Forests notification. Proper treatment, handling, and disposal of biomedical wastes is essential for healthcare infection control program. There may be a high risk of infections in patients due to the poor management of biomedical waste which can lead to antibiotic resistance. It is not only the health of the patient, but also the health of persons who are associated with health care industry equally important. This article speaks about how the hospitals present in Guwahati treat their waste material and the effect of the waste in the environment

Investigation of anti-diabetic potential of Diodia sarmentosa in alloxan-induced diabetic albino rats Rosalie, Ijomone Oghogho; Ekpe, E L
Journal of Applied Pharmaceutical Research Vol. 6 No. 1 (2018)
Publisher : Creative Pharma Assent

Purpose: Natural remedies from medicinal plants are considered to be effective and safe alternative treatments for diabetes mellitus. Diodia sarmentosa (Rubiaceae) commonly called tropical button weed, has been used locally in the treatment of diabetes. This study demonstrates the hypoglycaemic and anti-diabetic activity of the aqueous ethanol extract and ethylacetate fractions of Diodia sarmentosa in alloxan-induced diabetic rats. Methods: 1000g of the leaves (air dried at 250C for 7days) was subjected to extraction using 80% aqueous ethanol and then fractionated with ethylacetate. This gave a percentage yield of 13.299%w/w, 28.30%w/w, and 11.62%w/w for aqueous ethanol extract, ethylacetate soluble and insoluble fraction respectively. Three doses (1000mg/kg, 500mg/kg and 250mg/kg body weight) of the three samples were administered to the test groups while Glibenclamide at dose of 2.5mg/kg body weight was administered to the control group. Comparing the activity of the plant to the standard drug, the activity of all the doses of the aqueous ethanol extract and ethylacetate insoluble fraction was comparable with that of the standard drug (Glibenclamide). Result: As regard to the dose response, the highest activity resides in the highest dose of sample administered (i.e 1000mg/kg body weight) followed by the 500mg/kg and the 250mg/kg body weight (1000mg/kg>500mg/kg>250mg/kg). The aqueous ethanol and ethylacetate soluble fractions caused a significant (p>0.05) reduction in blood glucose of the diabetic rats. Conclusion: Thus, this present study validates the medicinal potential of Diodia sarmentosa in diabetes treatment

Effect of primary packaging on microbiological status of oral solid dosage form Khana, Meenal; Teotia, U. V. S; Siingh, Yogendra
Journal of Applied Pharmaceutical Research Vol. 6 No. 1 (2018)
Publisher : Creative Pharma Assent

The emergence of microbial contaminants in non-sterile drugs caused not only the degradation of many products, but also proved to be a potential risk to consumer health. The aim of this study was to test microbial load of non sterile solid pharmaceutical product and investigate the effects of different packaging system on microbial status of pharmaceutical product. A total of 18 sample of solid dosage form packaged in different packaging were procured from market. All samples have been tested for the presence of specific microorganisms, Total aerobic microbial counts (TAMC) and Total yeast and mold counts (TYMC) using compendial procedures. Out of 18 sample 72.22 % (n=13) had shown microbial growth and only 16 % (n=3) of samples were non-compliant. Sample containing herbal ingredients, were the most heavily contaminated, showing a bacterial load > 104 CFU/g. The result showed that all the tested samples were free from E. coli. There was no significant difference (p>0.05) in microbial load of product packaged in different primary packaging

Page 18 of 46 | Total Record : 459

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Plot No. 105/42, Opposite electricity sub station, Changorabhata, Raipur (Chhattisgarh), India 492001

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INDONESIA