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Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
Arjuna Subject : -
Articles 459 Documents
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Clock gene variation in type 2 diabetes: a review Parveen, Nushrat; Satapathy, Trilochan; Prasad, Pushpa; Roy, Amit
Journal of Applied Pharmaceutical Research Vol. 3 No. 1 (2015)
Publisher : Creative Pharma Assent

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Abstract

Diabetes mellitus type 2 is a long-standing metabolic disorder that is exemplify by high blood sugar, insulin resistance, and comparative lack of insulin. General symptoms include increased thirst, frequent urination, and unsolved weight loss. Type 2 diabetes is mainly due to obesity and not sufficient work out in public who are heritably prone. Circadian clocks are significant to keep the moment in the sequence of physiological practice, series of behaviour and metabolism. The plasma level of glucose and numerous hormones implicated in glucose homeostasis for example insulin and glucagon exhibit circadian variation. Circadian desynchrony, a feature of alter occupation elevated-fat diet feed and sleep distraction in individual have been linked with metabolic disorders for instance obesity and type 2 diabetes. Circadian rhythm distraction can cause different fitness disarray. Current reading has discovered a seal connection among the pathophysiology of metabolic condition, which is characterized by obesity and hyperglycemia, and the operation of interior molecular clocks
Development of stability indicating, validated single dissolution method for simultaneous estimation of clopidogrel bisulfate and rivaroxaban in tablet dosage formulation by RP-HPLC method Sajjanwar, Rupali; Bhaskaran, Shyamala; Kakati, Kulesh; Jha, Shailendra Kumar
Journal of Applied Pharmaceutical Research Vol. 3 No. 1 (2015)
Publisher : Creative Pharma Assent

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Abstract

A dissolution method was developed for combination of two drugs which are already marketed as an individual product, Clopidogrel Bisulfate Tablets USP 75 mg and another is Rivaroxaban Tablets 10 mg & 20 mg. It was emphasized that both products have several advantages when given as combination therapy. Hence, the preference was given to develop a single dissolution method for the analysis of both the active components. This article presents a single dissolution method to accommodate both drugs. The method uses USP Type II Apparatus (paddles) at 75 rpm in 1000 mL of Acetate buffer (pH 4.5) medium containing 1% Sodium Lauryl Sulfate as surfactant at 37 °C± 0.5°C . This dissolution methodology provides good dissolution profiles for both Clopidogrel Bisulfate and Rivaroxaban and is able to discriminate the changes in composition, manufacturing process and stability for the combination tablets. To quantitate both drugs simultaneously, a rapid isocratic reversed-phase liquid chromatographic method was developed and validated.
Cucumis sativus (cucumber): a review on its pharmacological activity Sahu, Tripti; Sahu, Jyoti
Journal of Applied Pharmaceutical Research Vol. 3 No. 1 (2015)
Publisher : Creative Pharma Assent

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Abstract

Medicinal plants have been used for centuries, and numerous cultures still rely on plants for their primary health care needs. In the recent past there has been a tremendous increase in the use of plant based health products in developing as well as developed countries resulting in an exponential growth of herbal products globally. The present article gives an account of such a medicinally important of Cucumis sativus belonging to family Cucurbitaceae which comprise both wild and cultivated species and is consumed in different ways like vegetable and salads, but less is known about its medicinal importance. Phytochemical analysis of these plants confirms the presence of various phytochemicals like tannins, cardiac glycosides, terpenoides, carbohydrates, resins, Saponins and phytosterols. While other phtochemicals like alkaloids, flavonoids, glycosides, steroidal terpenes and phylobatamins were found to be cucumber fruits. The plant exhibits various pharmacological activities such as anti-bacterial activity, antifungal activity, cytotoxic activity, Antacid & Carminative activity, Activity against ulcerative colitis ,Hepetoprotective activity, Hypoglycemic and Hypolipidemic activity, Wound healing activity etc. A study on safety profile suggests the plant to be safe for its therapeutic uses.
Inspection of a novel penetration enhancer for transungual drug delivery system: Pelargonium hortorum Singh, Vikram; Chandrul , Kaushal Kishore
Journal of Applied Pharmaceutical Research Vol. 3 No. 1 (2015)
Publisher : Creative Pharma Assent

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Abstract

This study was to search some natural penetration enhancer and formulate them in a transungual drug delivery formulation. This natural penetration enhancer helps to overcome the main problem in front of success of transungual drug delivery system. We selected to formulate fluconazole as a model drug for the nail fungal infection treatment with extracted penetration enhancer (PE). Model drug i.e. fluconazole was formulated with the natural extracted penetration enhancer with different deigned formula. The solvent for PE extraction was methanol and that extracts were air dried. The cadaver human nail plates were used for penetration study, were collected from the same volunteer for negligence in the thickness and chemical composition concentration in the nail plate. The extracted PE (pelargonium hortorum) was selected for formulation on the basis of ethanopharmaceutical history. The human cadaver nail plates were treated with the formulation with and without the extracted PEs. Ex - vivo drug penetration was evaluated by Franz diffusion cells using cadaver human nail plate upto 36 hours. The drug filmability was found to be best with the polymer like HPMC K4M, Ethyl cellulose and hydroxyl propyle cellulose in the ratio of 1:1:1, mixture of propanol and butanol in 7:3 as solvent and 30% w/w DBP as plasticizer. The formula FT25AP4 shows total 35.67% drug penetraion i.e. near about two times of drug penetration across the nail plate when compare to the same formulation but without any penetration enhancer. The “p” value (0.0011) of drug penetration was less than 0.05.
Design and in vitro evaluation of mouth dissolving tablets olanzapine Sharma, Vivek Kumar; Singh, Vikram; Juyal, Divya; Rawat, Geeta
Journal of Applied Pharmaceutical Research Vol. 3 No. 1 (2015)
Publisher : Creative Pharma Assent

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Abstract

The purpose of this research was to design and evaluate the olanzapine fast dissolving tablets. The variable formulation of Olanzapine having challenging methodology. Olanzapine practically insoluble in water so used different polymers and superdisintigrant to make formulation. Direct compression are most desired method for preparation of mouth dissolving tablets. The tablets were evaluated for disintegration and dissolution properties of the formulation. In formulation of mouth dissolving tablet evaluate the precompression parameter and post compression parameter and after evaluation found satisfactory
Solubility enhancement of biperidine HCl by complexation with hydroxypropyl β-cyclodextrin Dubey, Amit; Singh, Vikram; Juyal, Divya; Rawat, Geet
Journal of Applied Pharmaceutical Research Vol. 3 No. 2 (2015)
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Abstract

Oral route is the simplest and easiest way of drug administration, because of the greater stability, lesser bulk, and cheap cost of production, accurate dosage and easy process, solid oral dosage forms have several advantages over other dosage forms. All the poor water soluble drugs after oral administrations are not well absorbed and thus leads to decrease in inherent efficiency of drugs. Therefore, for oral drug delivery system the improvement of drug solubility thereby its oral bio-availability is the most important aspect of drug development process. Biperiden HCl is a potent drug (Maximum daily dose is 16mg/day), having extensive first pass metabolism resulting in poor Bioavailability. The pharmacokinetic profile of this drug showed 33±5 % Bioavailability and 18-24 hours elimination half-life (t1/2). In the present study attempt has been made to prepare and characterize inclusion complex of Biperiden HCl with Hydroxypropyl β-Cyclodextrin. The inclusion complexes prepared by different methods i.e. Physical mixture, Kneading and Solvent evaporation methods. The prepared complexes were characterized using FT-IR. The inclusion complex prepared by Kneading method exhibited greatest enhancing in solubility and faster dissolution (93.98% drug release in 60 min) of Biperiden HCl.
Recent status on carbohydrate metabolizing enzyme inhibitors in regulation of diabetes: a mechanism based review Sinha, Durgeshnandani; Satapathy, Trilochan; Kumar Dewangan, Mehendra; Kumar, Arvind; Roy, Amit
Journal of Applied Pharmaceutical Research Vol. 3 No. 2 (2015)
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Abstract

The important therapeutic approach for treating type 2 diabetes mellitus is to decrease the post-prandial glucose levels which could be done by decreasing the absorption of glucose through the inhibition of the carbohydrates-hydrolyzing enzymes such as α-amylase and α-glucosidase present in the small intestinal brush border that are responsible for the breakdown of oligosaccharides and disaccharides into monosaccharide’s and suitable for absorption. Inhibition of α-amylase generally considered as strategy for the treatment of disorders in carbohydrate uptake, such as diabetes and obesity. Among the marketed allopathic preparations carbohydrates-hydrolyzing enzymes Inhibitors like acarbose, voglibose etc delay carbohydrate digestion and prolong overall carbohydrate digestion time, causing a reduction in the rate of glucose absorption and consequently blunting the postprandial plasma glucose rise. Some of the plants are also considered as an important source of chemical constituent with potential for inhibition of α-amylase and can be used as therapeutic purposes. In this review our efforts have been devoted to explore the mechanism based carbohydrates-hydrolyzing enzymes Inhibitors for the regulation of diabetes.
Pharmacological screening of Alsotonia scholaris Rathor, Vinod; Wadhwa, Shailendra; Deb, Jyotirmoy; Choudhury, Ananta
Journal of Applied Pharmaceutical Research Vol. 3 No. 2 (2015)
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Abstract

A large number of medicinal plants are claimed to possess anthelmintic property in traditional systems of medicine and are also utilize by ethnic groups worldwide. The development of anthelmintic resistance and the high cost of conventional anthelmintic drugs led to the evaluation of medicinal plant as an alternative source of anthelmintice. In the current study were conducted to determine the possible anthelmintic and antibacterial effects of leaves of Alstonia scholaris. The plant Alstonia scholaris has been used in different system of traditional medication for the treatment of diseases and ailments of human beings including anthelmintic activity.
Importance of piperidone moiety in pharmaceutical chemistry: a review De, Sourav; Banerjee, Subhasis; Babu, M. Niranjan; Keerithi, C. Navaya
Journal of Applied Pharmaceutical Research Vol. 3 No. 2 (2015)
Publisher : Creative Pharma Assent

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Abstract

Piperidone heterocycle have gained a considerable attention in the field of drug discovery. The wide range of its therapeutic application paved the way to the researchers to insert the nucleus every now and then in diversified pharmacophore, so as to generate novel therapeutic profile. In this review, we have tried to present various therapeutic applications, which have already been demystified by the researchers. The study may prompt the researcher to generate scaffolds of highest therapeutic efficacy considering the importance of 4- Piperidone nucleus.
Subduing the nail barrier with novel herbal penetration enhancers for transungual delivery system Singh, Vikram; Gupta, R. D.; Teotia, U. V. S
Journal of Applied Pharmaceutical Research Vol. 3 No. 2 (2015)
Publisher : Creative Pharma Assent

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Abstract

Nail fungal infections are very common and also very difficult to treat because of nail morphology, deep penetrability of infectious agent inside nail plate and poor permeability of the nail plate. Transungual delivery shall be the first choice for treatment of nail infection if we get the effective penetration enhancers without causing the serious problem. In this study we tried to scanning some extracts penetration potency through the human cadaver nail plate. Five plants selected for the purpose acacia catechu, rosa hybrid, hibiscus rose-sinensis, tagetes patula, tagetes erecta. For penetration potency first defatted the nail plate with chloroform : methanol (2:1) mixture. Extracts of tagetes erecta, acacia catechu shows 100%, tagetes patula 60% and rosa hybrid 40% from dorsal side of plate. Those extracts were stable by it only. That proves that they may be used as a penetration enhancer to increase the penetration of drug

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