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Journal of Applied Pharmaceutical Research

joapr
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Published by Creative Pharma Assent

ISSN : - EISSN : 23480335 DOI : 10.18231

Core Subject : Health,

Medicine & Pharmacology

Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.

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Articles 459 Documents

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Liposomes in dermatological diseases Kamra, M.; Diwan, A
Journal of Applied Pharmaceutical Research Vol. 5 No. 2 (2017)
Publisher : Creative Pharma Assent

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Liposomes are vesicles comprising of spherical phospholipids making them useful for topical applications of drugs. Liposome research has been expanded considerably and nowadays, it is possible to construct a wide range of liposomes varying in size, phospholipids composition and surface characteristics. In dermatological diseases, the topical application of liposomes has proven to be of high therapeutic value. Liposomes can be used as carriers for hydrophilic as well as lipophilic therapeutic agents because of their amphipathic character. They may improve stabilization of instable drugs by encapsulating them. They have the potential to target drugs into the pilosebaceous structures and hence have an advantage for treatment of hair follicle-associated disorders. Liposomal encapsulated drugs are found useful in the treatment of acne, atopic dermatitis, psoriasis, vitiligo, superficial vein thrombosis and hair removal etc

Smart ungual biopenetrant from the roots of Beta vulgaris Madhav, N. V. Satheesh; Singh, Kirti
Journal of Applied Pharmaceutical Research Vol. 5 No. 2 (2017)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (328.977 KB)

The main objective of the current research was to isolate biopenetrant from Beta vulgaris and formulate bioadhesive layers loaded with terbinafine using this biopenetrant for delivery through nail. Form the preparation of films, Rosa centifolia and Vitis vinifera were used as a biopolymer. Beta vulgaris was used as biopenetrant. The formulations prepared using Beta vulgaris biopenetrant were compared with formulations containing papain as standard penetrant. Four bio-adhesive films of different ratios were prepared by film casting method using each penetrant. The formulated films were evaluated for various parameters like weight, thickness, nail adhesivity, content uniformity, surface pH, folding endurance, and in-vitro drug permeation. The formulation LB4 (containing 1:4 Beta vulgaris biopenetrant) was found to be the best formulation having R2 value 0.990 with zero order as best fit model. The results obtained conclude that biopenetrants can be used as natural penetration enhancers

A review on mouth dissolving tablet Patil, H. K.; Patil, G M; Jain, V H; Tadvi, S. A.; Pawar, S. P.
Journal of Applied Pharmaceutical Research Vol. 5 No. 2 (2017)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (511.71 KB)

The demand for MDT (Mouth Disintegrating Tablet) has been increasing from the last decade particularly in geriatric, pediatric and patient with some sort of disabilities in swallowing. MDTs are those tablets which when placed in mouth get dissolved rapidly in saliva without the need of liquid and can be swallowed. European pharmacopoeia adopted the term Orodispersible tablet for MDTs. Mouth disintegrating tablets are also known as Fast melting tablets, Orodispersible tablets, fast dissolving/dispersing tablets or melt in mouth tablets. This article reviews the potential benefits offered by MDTs as an oral drug delivery system for various kinds of patients suffering from different diseases and disabilities. Desired characteristics and challenges for developing fast disintegrating drug delivery systems, quality control tests, various techniques used in the preparation of fast disintegrating drug delivery systems like lyophilization technologies, tablet molding method, sublimation techniques, spray drying techniques, mass extrusion technology, direct compression method and uses of super-disintegrates. It also reviews the patented technologies for fast dissolving tablets, advantages and disadvantages of different technologies for preparing fast disintegrating dosage form, future prospective for MDTs. The growing importance for MDTs is due to the potential advantages offered by this technology. MDT is a New Drug Delivery system with least disintegration time and ease of self administration

Bioanalytical method development and validation of bleomycin sulphate Prashar, Yash; Rana, Harkaran Singh; Bais, Souravh
Journal of Applied Pharmaceutical Research Vol. 5 No. 2 (2017)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (485.547 KB)

Bleomycin is an anti-neoplastic drug that has recently been used for the treatment of vascular anomalies. An expedient method was developed for the determination of plasma bleomycin levels using ion-paired reversed phase high performance liquid chromatography (HPLC). The concentration was found to be proportional to the area and the response of the detector was determined to be linear over the range of 1-6 µg/ml for both Bleomycin A1 and Bleomycin B2. Recovery was approximately 100%. This method provides a simple and rapid way of determining the levels of bleomycin A2 and B2 in human and rat plasma

Acne: current perspective Kamra, Manju; Diwan, Anupama
Journal of Applied Pharmaceutical Research Vol. 5 No. 3 (2017)
Publisher : Creative Pharma Assent

Acne vulgaris or acne is a multi factorial chronic inflammatory disease of pilosebaceous unit. Globally it affects approximately 9.4% of the population. It is characterized by blackheads and white heads, pinheads, large papules which may lead to scarring. Other than scarring, its main effects are psychological, such as distress and reduced self-esteem. Up to 80% of teenage girls and 90% of teenage boys are afflicted with acne. Adult acne, although less common than adolescent acne, is a significant problem for 3% to 6% of adult men and 5% to 12% of adult women. It is the most common chronic skin disorders which require urgent attention. Successful treatment of acne requires careful selection of anti-acne agents.

Screening of poly vinyl chloride degrading bacteria from plastic contaminated area of Baddi Kumar, Sahni; Teotia, U. V. S; Singh, Yogendra
Journal of Applied Pharmaceutical Research Vol. 5 No. 3 (2017)
Publisher : Creative Pharma Assent

Plastic wastes are posing ever increasing environmental concerns. Recent research works have shown that most of the constituents of plastics can be degraded by microbes and the film plastics can be treated by microbial systems. In this study, poly vinyl chloride (PVC), degrading bacteria’s were isolate and characterize from soil dumped with plastics. The PVC degradating bacterial were identified as E.Coli, Staphylococcus, Pseudomonas and Klebsiella. It was observed that maximum degradation by Pseudomonas and degradation after 10 months was 40.53%, 23.06%, 10.92% and 5.32% for Pseudomonas, Klebsiella, Staphylococcus and E.Coli respectively.This work concluded that soil contains bacteria’s that have ability to carry degradation of poly vinyl chloride (PVC)

Development and validation of stability indicating HPTLC method for estimation of dextromethorphan hydrobromide Gandhi, Santosh V; Dyandyan, Shubhangi K.
Journal of Applied Pharmaceutical Research Vol. 5 No. 3 (2017)
Publisher : Creative Pharma Assent

A simple, sensitive and accurate stability indicating HPTLC method has been developed and validated for estimation of Dextromethorphan hydrobromide in bulk and pharmaceutical dosage form. The drug was spotted on precoated silica gel 60 F254 aluminum plates using Toluene: Methanol: Triethylamine (8.5:1:0.5 v/v/v) as mobile phase. The retention factor (Rf) was found to be 0.60±1.92. The detection of band was carried at 225 nm. The drug was subjected to different stress conditions like acid, base, neutral hydrolysis, oxidation, thermal degradation and photolysis. The method was successfully validated according to ICH guidelines Q2 (R1). The data of linear regression analysis indicated a good linear relationship over the concentration range of 2000-20000 ng/band with correlation coefficient 0.991. The method found to be accurate as results of the recovery studies are close to 100 %. The developed method was found to be simple, sensitive, selective, accurate and repeatable for analysis of and can be adopted for routine analysis of drug in bulk and pharmaceutical dosage form

Nitrite contents in various masticatories prevailing in the state of Assam – a pilot study Bharadwaj, Rituraj; Barooah, Prajjalendra; Saikia, Snigdha; Haloi, Jayanta; Deka, Manab; Sahu, Bhanu P; Medhi, Subhas
Journal of Applied Pharmaceutical Research Vol. 5 No. 3 (2017)
Publisher : Creative Pharma Assent

Background: The habit of using masticatories is quite common among the population of the state Assam. There are numerous types of masticatories available throughout the state, most of which include areca nut in different forms, accompanied with beetle leaves and tobacco leaves and other associated substances added for flavor. Aim: To determine the level of nitrite present in different types of masticatories prevailing in the state. Materials & Methods: The classical Griess method was used for the estimation of nitrite in different types of these masticatories prevailing in the state Assam (n=35) using the basic diazotization principle and spectrophotometric determination. Statistical Analysis used: The results obtained were analyzed statistically by using SPSS V.16 software. Results: The result of the study indicate the amount of nitrite in different types of these masticatories, among which highest levels of nitrite was found in raw areca nut with beetle leaves without lime. The presence of lime decreases the amount of nitrite (p<0.05) whereas, the presence of beetle leaves and unprocessed areca nut increases the amount of nitrite (p<0.05) in the masticatories used by the people of the state. Conclusion: From the study conducted, it can be concluded that the presence of lime reduces the amount of nitrite in the masticatories, whereas the presence of beetle leaves and unprocessed areca nut contribute higher amount of nitrite in the masticatories

Development and evaluation of time controlled release tablet of ketoprofen for the treatment of Rheumatoid Arthritis Sharma, P H; Avari, J. G.
Journal of Applied Pharmaceutical Research Vol. 5 No. 3 (2017)
Publisher : Creative Pharma Assent

The aim of present study was to develop and evaluate time controlled release tablet of Ketoprofen intended for rheumatoid arthritis. The cardinal sign of rheumatoid arthritis are stiffness, swelling and pain of one or more joints of the body characteristically most severe in the morning. Rheumatoid arthritis shows a significant circadian variation in its symptoms. Time controlled release tablet delivers the drug at definite time or in controlled rate. It consist of core tablet coated with two layers, the inner swelling layer and outer rupturable. Before compression of core tablet, drug- excipients compatibility study and precompression parameters were investigated. Core tablet was prepared by direct compression method. The core tablets are coated with crosscarmellose sodium as inner swelling layer with different coating level. The prepared tablet again evaluated and coated with rupturable layer of ethylcellulose. The free film of ethylcellulose was evaluated for various parameters. The effect of microcrystalline cellulose and coating level of rupturable layer and swellable layer on lag time were investigated. The results shows as the amount of microcrystalline cellulose increase in core tablet the lag time decreases. The lag time increases with increase in coating level of swelling layer and rupturable layer. The water uptake study shows that higher ethylcellulose levels retards the water uptake and prolongs the lag time.

Evaluation of phytochemical parameters, antibacterial and antihelminthic activity of leaves and bark extracts of plant Bombax ceiba Shah, Suyogya; Ghimire, Kamana; Gupta, Amit Kumar; Pokhrel, Priyanka; Banerjee, Janmajoy; Khanal, Hemanta; Pradhananga, Mahalaxmi
Journal of Applied Pharmaceutical Research Vol. 5 No. 3 (2017)
Publisher : Creative Pharma Assent

Bombax ceiba, commonly known as the red silk-cotton tree, is a large, briefly deciduous tree occurring in warm monsoon forests in southern Asia. Various phytochemical constituents present in different plant parts has been already reported earlier to possess many biological activities, here in this work extraction was performed by mixture of solvent (distilled water: ethanol) as well as the individual solvents (water) and (ethanol). The phytochemical screening of the leaves and barks was found to exhibit the presence of carbohydrates, glycoside, saponin, phytosterol phenol, tannins, flavonoid, proteins and diterpenes and negative result for alkaloids in all the solvent extracts. The ethanolic extract of leaves was subjected to antihelmenthic activity and the result was found to be moderate

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Plot No. 105/42, Opposite electricity sub station, Changorabhata, Raipur (Chhattisgarh), India 492001

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INDONESIA