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Acta Pharmaciae Indonesia : Acta Pharm Indo
Published by Universitas Jenderal Soedirman
ISSN : 23378433     EISSN : 26214520     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Journal of Acta Pharmaciae Indonesia is a journal published twice a year by Pharmacy Department, Jenderal Soedirman University, Purwokerto with the Number of ISSN 2337-8433 and E-ISSN 2621-4520. Our journal discusses various pharmaceutical fields in terms of Pharmaceutics & Pharmaceutical Technology, Pharmaceutical Biology, Pharmaceutical Chemistry, and Pharmacology & Clinical Pharmacy.
Arjuna Subject : -
Articles 145 Documents
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Propolis bioactive compounds as potential topical agents for atopic dermatitis: an in silico pharmacokinetic screening and molecular docking study Naura Nurnahari; Adinda Salsabila; Tantri Liris Nareswari; Inggit Ariana Herawati; Riska Arini; Melati Utami; Theresia Sarah; Yasinda Oktariza; Annisaa Siti Zulaicha
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 13 No 2 (2025): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2025.13.2.17894

Abstract

Background: Atopic dermatitis (AD) is a common chronic inflammatory skin disease. Current treatments, including corticosteroids and calcineurin inhibitors, are effective but limited by long-term adverse effects. Propolis possesses antimicrobial, anti-inflammatory, antioxidant, and immunomodulatory properties. This study evaluated propolis bioactive compounds as topical therapeutic candidates for AD using molecular docking analysis. Methods: Bioactive compounds from propolis were screened for pharmacokinetic and ADMET properties relevant to topical application. Molecular docking was performed against key protein targets implicated in AD pathogenesis to evaluate binding affinities and interaction profiles versus reference ligands. Results: A total of 31 compounds fulfilled the pharmacokinetic and toxicity criteria for topical use. Tschimgin showed the strongest affinity toward secretory phospholipase A₂ (ΔG = −8.00 kcal/mol; Ki = 1.37 µM) and favorable binding to FK506-binding protein 12 (ΔG = −7.88 kcal/mol; Ki = 1.68 µM), suggesting multitarget potential. Suberosin showed the highest affinity toward PDE4 (ΔG = −6.86 kcal/mol; Ki = 9.35 µM), exceeding the reference drug roflumilast (ΔG = −6.47 kcal/mol; Ki = 18.06 µM). Conclusion: These findings suggest propolis contains bioactive compounds relevant to multiple AD-associated targets. Tschimgin and suberosin may serve as lead compounds for developing safer topical therapies, pending further in vitro and in vivo validation.
Quality of life of hemodialysis patients with anemia in Lombok, Indonesia Candra Eka Puspitasari; Melda Putri Zakiah; Ni Luh Ayu Sri Widyasari; Ithnan Baqi Putra Erlangga; Kerthika Ayu Wandeni; Dinatul Aini; Sulthon Annaji; Widya Wulandari; Mahacita Andalusia; Yoga Dwi Saputra; Ni Made Amelia Ratnata Dewi
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 13 No 1 (2025): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2025.13.1.15611

Abstract

Background: Anemia is a common complication of hemodialysis and is associated with substantial impairment of quality of life. Objective: This study evaluated the relationship between anemia biomarkers (hemoglobin and hematocrit) and health-related quality of life among patients receiving maintenance hemodialysis. Methods: A cross-sectional study was conducted at three hospitals on Lombok Island, Indonesia, involving 186 hemodialysis patients selected by purposive sampling. Quality of life was measured using the Indonesian-language KDQoL-SF36 questionnaire. Associations between hemoglobin, hematocrit, and quality-of-life scores were analyzed using Pearson's correlation and multiple linear regression (IBM SPSS version 29; p<0.05 considered significant). Results: The mean KDQoL-SF36 score was 63.60 ± 9.37. Age was significantly associated with quality of life (p = 0.024). Both hemoglobin and hematocrit showed significant positive correlations with quality of life (p<0.001), remaining significant predictors after multivariable adjustment. Conclusion: Hemoglobin and hematocrit levels are significant determinants of quality of life among hemodialysis patients. Optimizing anemia management, supported by active pharmacist involvement, may improve patient-reported outcomes in this population.
Acute Acute Oral Toxicity Study of Ethanol Extract of Cassava Peel (Manihot esculenta Crantz) on Male ddY Strain Mice (Mus musculus) Ade Shinta Maria Br Napitu
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 13 No 2 (2025): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2025.13.2.17067

Abstract

Background: The peel of cassava tuber (Manihot esculenta Crantz) is one of the plant materials known to contain active compounds with potential pharmacological activities. One such potential is its use as an antidiabetic agent, indicating the possibility of development into an herbal medicine. However, the safety level of cassava peel has not yet been established. Objective: To obtain information regarding the acute toxicity effects of ethanol extract of cassava tuber peel (Manihot esculenta Crantz), to determine its toxicity category, and to identify the LD₅₀ value of the ethanol extract in male ddY strain mice (Mus musculus). Methods: This study was an experimental research conducted in a laboratory setting using mice as test animals, employing the fixed dose method. Results: The results of the study showed that oral administration of ethanol extract of cassava tuber peel (Manihot esculenta Crantz) in male ddY strain mice (Mus musculus) did not produce symptoms of acute toxicity. Statistical analysis of all parameters showed that there was no significant difference between the normal group and the test group, with a p-value >0.05, indicating that there were no differences among all test animals.. Conclusion: The ethanol extract of cassava tuber peel (Manihot esculenta Crantz), when administered to mice, did not exhibit any acute toxic effects and is categorized as non-toxic with an LD₅₀ value greater than 5000 mg/kg body weight.
Association of antihypertensive therapy intensification on blood pressure control and atherosclerotic cardiovascular disease (ASCVD) risk: a retrospective cohort study in Bali, Indonesia I Putu Denta Nugraha Parahyangan; Dita Maria Virginia; Phebe Hendra
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 13 No 2 (2025): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2025.13.2.17857

Abstract

Background: Hypertension is a major ASCVD risk factor, especially among elderly and diabetic patients. Appropriately intensifying antihypertensive therapy may improve blood pressure (BP) control and reduce ASCVD risk. Objective: This study evaluated the effect of antihypertensive therapy intensification on BP outcomes and 10-year ASCVD risk among hypertensive patients in Bali, Indonesia. Methods: A retrospective cohort study included hypertensive patients aged 40–74 years receiving outpatient care at regional public hospitals in Bali (January–December 2024). Therapy intensification was assessed using a guideline-based treatment intensification (TI) score; primary outcomes were final BP and estimated 10-year ASCVD risk. Results: Of 191 patients (median age 62 years; 75.9% with type 2 diabetes mellitus), those with appropriate therapy intensification achieved significantly lower systolic BP than those with inappropriate intensification (122.77 vs. 143.28 mmHg; p < 0.001) and were more likely to attain controlled BP (OR = 63.462; 95%CI: 8.017–502.354; p < 0.001; estimate based on a small reference cell). Each 0.1-unit increase in the TI score was associated with a 0.35% reduction in estimated ASCVD risk (p < 0.001). Conclusion: Appropriate antihypertensive therapy intensification was associated with significantly better blood pressure control, with a non-significant tendency toward below-target BP among patients receiving appropriate intensification.
Medicinal plants as potential anti-cholesterol agents: a narrative review of in vivo, in vitro, and in silico evidence Made Suta Wahyudi; Luh Putu Mirah Kusuma Dewi; Ni Made Pitri Susanti
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 13 No 2 (2025): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2025.13.2.19148

Abstract

Background: Hypercholesterolaemia is a major cardiovascular risk factor commonly managed with statins, which are frequently associated with hepatotoxicity, myopathy, and new-onset diabetes mellitus, driving interest in medicinal plants as natural alternatives. Objective: This review aimed to identify medicinal plants with demonstrated or predicted anti-cholesterol activity, specifying plant species, plant parts, and evidence from in vivo, in vitro, and in silico studies. Methods: A narrative literature review was conducted following PRISMA 2020 guidelines. Original articles published between 2014 and 2024 were retrieved from Google Scholar, Google, and PubMed. Review articles and studies unavailable in full text were excluded. Results: Nineteen articles met the eligibility criteria. Fourteen medicinal plants demonstrated cholesterol-lowering activity in in vivo and in vitro studies. Five plants were assessed in silico; quercetin-type flavonoids from karamunting, sweet orange, and soursop showed binding free energies more favourable than statin controls against HMG-CoA reductase, while butterfly pea and water clover compounds did not surpass their controls. Conclusion: Extracts from kirinyuh, ceremai, and ketapang achieved notable cholesterol reductions at low effective doses in animal models. Green kiwi fruit extract showed the greatest in vitro potency (EC50 = 7.3 ppm). In silico findings are preliminary and require experimental validation. Further research should isolate active compounds and evaluate efficacy through clinical studies in humans.

Page 15 of 15 | Total Record : 145

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