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Acta Pharmaciae Indonesia : Acta Pharm Indo
Published by Universitas Jenderal Soedirman
ISSN : 23378433     EISSN : 26214520     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Journal of Acta Pharmaciae Indonesia is a journal published twice a year by Pharmacy Department, Jenderal Soedirman University, Purwokerto with the Number of ISSN 2337-8433 and E-ISSN 2621-4520. Our journal discusses various pharmaceutical fields in terms of Pharmaceutics & Pharmaceutical Technology, Pharmaceutical Biology, Pharmaceutical Chemistry, and Pharmacology & Clinical Pharmacy.
Arjuna Subject : -
Articles 140 Documents
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Anti-inflammatory activity of combination of ethanol extracts of ginger (Zingiber officinale) and bangle (Zingiber cassumunar) in carrageenan-induced rats Hasyim, Bellia; Yudhawan, Indra; Ekowati, Heny; Rachmani, Eka Prasasti Nur
Acta Pharmaciae Indonesia Vol 11 No 2 (2023): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2023.11.2.11548

Abstract

Background: Inflammation is an essential innate immune response aimed at antigen elimination and preventing their spread. Ginger (Zingiber officinale) and bangle (Zingiber cassumunar) rhizomes have been empirically utilized as medicinal components due to their anti-inflammatory potential. However, the combined efficacy of these rhizomes has not been previously explored. Objective: This study aimed to assess the anti-inflammatory activity of a combination of ginger and bangle rhizome extracts. Method: Ginger and bangle rhizomes were individually subjected to extraction through maceration with 96% ethanol, followed by purification with n-hexane. The anti-inflammatory activity was evaluated via motility tests on subjects administered orally with 1% CMC-Na (control), diclofenac sodium (4.5 mg/kg body weight), ginger ethanol extract (200 mg/kg body weight), bangle ethanol extract (400 mg/kg body weight), and a combination of both extracts (100:200 mg/kg body weight). Observations were made over 6 hours, with motility scores subsequently analyzed using ANOVA and the LSD test for statistical significance. Results: Treatments involving ginger extract, bangle extract, and their combination significantly improved motility scores compared to the negative control. Furthermore, these treatments displayed no significant difference in effectiveness compared to the diclofenac sodium group (p > 0.05). Conclusion: The combined ethanol extracts of ginger and bangle rhizomes demonstrate anti-inflammatory activity comparable to diclofenac sodium, as evidenced by motility score evaluations. This suggests their potential as alternative anti-inflammatory agents.
Total phenolic content and in vitro photoprotective activity of ethanolic extract of torch ginger (Etlingera elatior) Fahmi, Fawnia Alma Arabella; Rehana, Rehana; Pudyastuti, Beti
Acta Pharmaciae Indonesia Vol 11 No 1 (2023): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2023.11.1.11624

Abstract

Background: Previous research highlighted the photoprotective potential of various extracts from torch ginger leaves, but the efficacy of ethanolic extracts, particularly from leaves and other plant parts, remained unexplored. Objective: This study aimed to assess the total phenolic content and SPF value of ethanolic extracts from torch ginger leaves, flowers, and stems, comparing these with a known photoprotective agent, oxybenzone. Method: Ethanolic extraction was performed on approximately 200 grams of each plant part. The total phenolic content was determined using the Folin-Ciocalteu method, while SPF values were measured spectrophotometrically between 290 and 320 nm. Statistical analysis involved Kruskal-Wallis tests followed by post-hoc Fisher's LSD. Results: The leaf extract exhibited the highest phenolic content (483.788 ± 2.57 mg GAE/g) and SPF value at 1000 ppm, surpassing that of flowers, stems, and the positive control, oxybenzone. The correlation between phenolic content and SPF value across plant parts was statistically significant. Conclusion: The ethanolic extract of torch ginger leaves shows superior photoprotective potential, indicated by its high phenolic content and SPF value, suggesting its promising application in natural sunscreen formulations up to the permissible active substance limit of 6% set by BPOM.
In silico screening of pomegranate (Punica granatum) and celery (Apium graveolens) metabolites for potential anti-type 2 diabetes activity Auli, Winni Nur; Aziz, Syaikhul; Karim, Dewi Damayanti Abdul; Evanggeulista, Arnanda; Jannah, Aryn Fatkhul; Mendrofa, Alexander Yoel Harazachi
Acta Pharmaciae Indonesia Vol 11 No 2 (2023): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2023.11.2.11704

Abstract

Background: Alpha (α)-amylase is a popular pharmacological target for controlling postprandial blood glucose levels. The exploration of natural ingredients for drug development is particularly promising. Notably, pomegranate (Punica granatum) and celery (Apium graveolens) are rich in phenols and flavonoids, making them potential candidates for anti-type 2 diabetes treatments. Objective: This study aims to identify the most promising derivatives from pomegranate and celery using a combined metabolomic and in silico approach. Methods: The study began by identifying metabolites from the KnapSack database, selecting based on primary and secondary metabolites also selecting them based on their pharmacokinetic profile. The selected metabolites were then docked with alpha-amylase (PDB ID: 2QV4). Furthermore, the interactions were analyzed using Discovery Studio, and toxicity profiles were assessed in silico using ECOSAR and Toxtree software. Results: The analysis identified punicaflavone and 2-deoxybrassinolide as the compounds with the highest binding affinity, at -10.06 kcal/mol and -10.89 kcal/mol respectively, both surpassing acarbose’s -9.33 kcal/mol. These compounds interacted with 11 common residues in alpha-amylase, mirroring acarbose’s interactions. In silico toxicity analysis revealed that punicaflavone might pose risks to aquatic organisms but does not exhibit potential as a genotoxic or non-genotoxic carcinogen. Conversely, 2-deoxybrassinolide displayed moderate toxicity to aquatic organisms but was also free from genotoxic and non-genotoxic carcinogenic potential. Conclusion: Punicaflavone and 2-deoxybrassinolide emerged as the most promising compounds, demonstrating strong binding affinities and similar interaction patterns with α-amylase as acarbose. Although both compounds may pose risks to aquatic environments, they do not show potential as genotoxic or non-genotoxic carcinogens, supporting their further exploration as anti-diabetic agents.
Optimization and evaluation of the physical stability of shampoo preparations containing virgin coconut oil and aloe vera extract Oktosa, Megi; Nareswari, Tantri Liris; Syafitri, Erga; Adliani, Nur
Acta Pharmaciae Indonesia Vol 12 No 1 (2024): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2024.12.1.11718

Abstract

Background: Hair is crucial for both aesthetic appearance and protection against sun damage. Shampoo is vital in hair care, often formulated with natural ingredients to enhance its effectiveness. Virgin coconut oil (VCO) and aloe vera extract are two ingredients known for their roles as moisturizers and conditioners, as well as nutrients and emollients. Objective: The study aimed to evaluate and optimize the stability and physical characteristics of shampoo containing VCO and aloe vera. Methods: The primary surfactant, sodium lauryl sulfate (SLS), was tested in concentrations of 2%, 4%, 6%, 8%, and 10%. The shampoos were prepared using an emulsification method and were evaluated based on organoleptic properties, homogeneity, pH, specific gravity, and viscosity. The formula that met all Indonesia National Standard (SNI) requirements was selected for further testing, including a cycling test to assess stability. Results: The findings indicate that the formula 5 (F5) containing 10% sodium lauryl sulfate exhibited optimal physical characteristics. Throughout six rounds of cycling tests, no phase separation was observed in F5, underscoring its stability. Conclusion: The optimized shampoo formula containing VCO and aloe vera (F5) demonstrated compliance with the required physical characteristics and stability standards. This formula presents a viable option for effective hair care, combining the beneficial properties of its natural ingredients with chemical stability.
Formulation and physical quality evaluation of aromatherapy oil combining patchouli (Pogostemon cablin Benth.) and peppermint (Mentha piperita L.) essential oils Wahyudi, Hendra; Hamzah, Hasyrul; Yudhawan, Indra
Acta Pharmaciae Indonesia Vol 12 No 1 (2024): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2024.12.1.11608

Abstract

Background: Indonesia is a major producer of essential oils, with patchouli and peppermint oils being widely used in aromatherapy. Aromatherapy products, such as wind oil, provide therapeutic benefits but are often underused by younger consumers. Developing formulations that appeal to a broader audience may increase their use. Objective: This study aimed to formulate an aromatherapy oil using patchouli and peppermint essential oils, evaluate its physical properties, and test consumer preferences. Method: Four formulations (F1–F4) were prepared with varying concentrations of patchouli and peppermint oils. Physical tests, including organoleptic, homogeneity, clarity, pH, and spreadability, were conducted over four weeks. A hedonic test with 20 respondents assessed sensory preferences. Results: Formulations remained stable in terms of homogeneity and clarity throughout the study. pH values were within the acceptable range for skin application, though they increased slightly during storage. Spreadability improved over time, with F2, F3, and F4 meeting the ideal range by the fourth week. F4, containing 6% patchouli and 15% peppermint oils, was the most preferred in the hedonic test, particularly for color, smell, and clarity. Conclusion: Patchouli and peppermint essential oils can be effectively combined to create a stable, consumer-preferred aromatherapy oil. F4 showed the best physical and sensory qualities, making it a promising formulation for future development.
Evaluation of drug use in stroke patients at the inpatient unit of Brebes Hospital, Central Java Budiyanti, Nur Aini; Hapsari, Indri; Nurhidayati, Friska Suci
Acta Pharmaciae Indonesia Vol 12 No 1 (2024): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2024.12.1.11944

Abstract

Background: Effective stroke treatment is complicated by factors such as polypharmacy, drug interactions, and side effects, leading to drug-related problems (DRPs) that hinder therapeutic outcomes. Evaluating drug use in stroke patients is crucial to ensure rational, safe, effective, and efficient treatment, ultimately improving therapeutic outcomes. Objective: This study aimed to evaluate the drug use patterns in inpatient stroke patients at Brebes Hospital, focusing on the appropriateness of drug selection, dosage, administration, and the impact of patient characteristics on DRPs. Method: A retrospective, descriptive evaluative design was employed, with data collected from medical records of stroke patients hospitalized at Brebes Hospital between May and July 2022. A total of 135 patients (110 ischemic, 25 hemorrhagic stroke) were included through consecutive sampling. Univariate analysis was used to describe patient characteristics and treatment patterns, while bivariate analysis with the chi-square test assessed the relationship between patient characteristics and DRPs. Results: The most common medications included citicoline (88.15%), clopidogrel (68.85%), and amlodipine (40.48%). DRPs were identified, including non-compliance with guidelines (1 case), contraindicated drugs (5 cases), and inappropriate drug selection (1 case). Notably, five cases of contraindicated use of omeprazole with clopidogrel and one case of phenytoin without indication were observed. Patient characteristics such as age and comorbidities did not significantly influence the incidence of DRPs (p > 0.05). Conclusion: The study found irrational drug use in stroke patients, with DRPs posing challenges for treatment optimization. Addressing DRPs through improved prescribing practices and pharmacist intervention is crucial to enhancing therapeutic outcomes in stroke management.
Analysis of sildenafil citrate in male stamina herbal medicines from the Magelang region, Central Java using thin-layer chromatography and UV spectrophotometry Saputra, Ilham Fahmi; Haresmita, Perdana Priya; Dianita, Puspita Septie; Kholifah, Eva
Acta Pharmaciae Indonesia Vol 12 No 1 (2024): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2024.12.1.11964

Abstract

Background: Male stamina herbal medicines are widely consumed in Indonesia, often believed to enhance sexual performance. However, the illegal addition of medicinal chemicals (BKOs) such as sildenafil citrate in traditional herbal products poses health risks. Objective: To identify and quantify sildenafil citrate in selected herbal medicine samples using thin-layer chromatography (TLC) and UV spectrophotometry. Method: Three samples of male stamina herbal medicine were purchased and subjected to organoleptic tests. Ethanol (96%) was used for extraction, followed by TLC analysis using two mobile phases (methanol: chloroform at 4:1 and 1:1 ratios). UV spectrophotometry was employed to determine the maximum absorbance wavelength and quantify sildenafil citrate. Results: TLC analysis revealed that two samples (K and L) contained sildenafil citrate, with Rf values consistent with the standard. UV spectrophotometry confirmed the presence of sildenafil citrate at a maximum wavelength of 292.5 nm. Sample K contained 0.96%, while sample L had 13.766% sildenafil citrate. Conclusion: The presence of sildenafil citrate in two samples violates Indonesian regulations prohibiting medicinal chemicals in herbal products, raising significant safety concerns.
Antifungal activity of shampoo formulated with water spinach (Ipomoea aquatica) ethanolic extract against Pityrosporum ovale Aisali, Ledyta Asa; Genatrika, Erza; Budiman, Arif
Acta Pharmaciae Indonesia Vol 12 No 1 (2024): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2024.12.1.12011

Abstract

Background: Dandruff, primarily caused by Pityrosporum ovale, is a common scalp disorder, especially in tropical regions. Natural alternatives, such as water spinach (Ipomoea aquatica), are increasingly being explored for their antimicrobial properties due to their minimal side effects. Objective: This study aimed to formulate an anti-dandruff shampoo using ethanol extract of water spinach and evaluate its physical properties and antifungal activity against P. ovale. Results: The phytochemical screening of the water spinach extract confirmed the presence of polyphenols, flavonoids, and quinones, known for their antimicrobial properties. The shampoo formulations met pH and foam height standards and remained organoleptically stable over 28 days. However, viscosity decreased below the standard (<400 cps) after 28 days. The 4% extract formulation (F3) showed the highest antifungal activity with an inhibition zone of 10.01 mm, significantly greater than the negative control (p<0.05). Conclusion: Water spinach ethanol extract can be successfully formulated into a shampoo that meets most physical requirements and exhibits antifungal activity against P. ovale. The 4% extract formulation demonstrated the highest effectiveness, though viscosity stability requires further optimization.
In silico analysis of quercetin and its derivatives as potential TRPC6-targeted treatments for diabetic neuropathy Pangestu, Maryo Adjie; Auli, Winni Nur; Saputro, Anjar Hermadi; Pasaribu, Romualdo; Maharani, Gita Putri; Yunita, Nadia Rahma; Choiriah, Ika Putri; Ainun, Hadhistia Nur; Erniningsih, Ni Ketut; Andini, Citra
Acta Pharmaciae Indonesia Vol 12 No 1 (2024): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2024.12.1.12119

Abstract

Background: Diabetic neuropathy is a condition that arises as a complication of diabetes mellitus and often causes pain in patient. Quercetin and its derivatives have antinociceptive activity, making them potential agents for relieving the pain associated with diabetic neuropathy. Objective: This study aims to analyze the interactions between quercetin and its eight derivatives with canonical transient receptor potential channels 6 (TRPC6) as protein target. Method: The TRPC6 structure (PDB ID: 6UZ8) was prepared and validated with redocked to native ligand R0D using Autodock 4.2.6, with the established grid box and grid center settings. The test compounds were then optimized and docked using the same grid box and grid center settings as in the validation process, followed by visualization and analysis of the docking results. Results: The compound with the best affinity for TRPC6 was tamarixetin, with a binding energy value of -3.27 kcal/mol, close to the binding energy value of the native ligand, which was -4.22 kcal/mol. The amino acid residues interacting with tamarixetin at the active site were 702-Asn, 705-Tyr, 706-Val, and 709-Gly. This indicates that tamarixetin and the native ligand bind to the same active site amino acids, resulting in a similar affinity to the native ligand in inhibiting TRPC6. Conclusion: A total of eight quercetin derivatives were predicted to have TRPC6 antagonistic activity against diabetic neuropathy, with tamarixetin exhibiting the highest affinity compared to the other quercetin derivatives.
Antioxidant activity of ethanol extract and ethyl acetate fraction of blue pea flower (Clitoria ternatea L.) Suhesti, Tuti Sri; Rahmahwati, Devita Sukma; Warsinah, Warsinah; Nuryanti, Nuryanti; Utami, Vitis Vini Vera Ratna
Acta Pharmaciae Indonesia Vol 12 No 2 (2024): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2024.12.2.12636

Abstract

Background: The imbalance of free radicals can be mitigated by antioxidants. Natural sources, such as the blue pea flower (Clitoria ternatea L.), have gained attention as potential antioxidant alternatives. Objective: This study aimed to evaluate the antioxidant potential of the blue pea flower by extracting its fractions using n-hexane and ethyl acetate. Methods: The study employed an experimental design involving maceration for extraction, followed by fractionation using n-hexane and ethyl acetate solvents. Antioxidant activity was assessed using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Data from both qualitative identification and antioxidant tests were analyzed descriptively and quantitatively to determine the IC50 values. Results: The analysis revealed that both the extracts and fractions of the blue pea flower contain bioactive compounds with antioxidant potential, including flavonoids, tannins, steroids, and terpenoids. The IC50 values for antioxidant activity were as follows: n-hexane fraction, 85.28 µg/mL; ethyl acetate fraction, 82.94 µg/mL; and ethanol fraction, 78.78 µg/mL. Conclusion: Flavonoids, steroids, and terpenoids were identified in both the blue pea flower extract and ethyl acetate fraction, while tannins were present only in the ethanol extract. Strong antioxidant activity was observed in all fractions, including the ethanol extract, n-hexane, and ethyl acetate fractions.

Page 13 of 14 | Total Record : 140

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