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INDONESIA
Jurnal Kimia Terapan Indonesia
Published by Lembaga Ilmu Pengetahuan Indonesia
ISSN : 08532788     EISSN : 25277669     DOI : -
Core Subject : Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology
Arjuna Subject : -
Articles 283 Documents
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KOTORAN TERNAK SEBAGAI INOKULUM PADA PENGOLAHAN AIR LIMBAH PABRIK GULA SECARA BIOLOGI-AEROB Hendro M Santoso; Yahya Kurniawan
Jurnal Kimia Terapan Indonesia Vol 9, No 1-2 (1999)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3376.482 KB) | DOI: 10.14203/jkti.v9i1-2.200

Abstract

A study on the treatment of Sugar Factory wasted water by using biological aerobic process was carried out at a laboratory sacle. Cow dung and chicken dung were used as inoculum to raduce the organic compounds is waste water. The levels of inoculum concentration used were 5; 10; 15; 20; and 25 per cent. The experiment was conducted bt a one way completely randomize design. The treatment process was followed by observing the changes in the BOD and COD parameters. The results showed that the chicken dung inculum reduce COD content up to 73-76 per cent and BOD content up to 81-86 per cent. The cow dung inculum reduced COD and BOD contents up to 97-92 percent and up to 65-95 per cent respectively.
PENAPISAN VIRTUAL SENYAWA TURUNAN METIL SINAMAT PADA ENZIM SIKLOOKSIGENASE-2 (COX-2 Teni Ernawati
Jurnal Kimia Terapan Indonesia Vol 14, No 2 (2012)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (514.69 KB) | DOI: 10.14203/jkti.v14i2.350

Abstract

Inflammation is the response of living tissue to vascular injury. Non-Steroid Anti-Inflammatory Drugs(NSAIDs)  could  control  pain  caused  by  inflammation.  Therapeutic  effects  of  NSAIDs  are  related  to  themechanism of the cyclooxygenase-1 (COX-1) enzyme and the cyclooxygenase-2 (COX-2) enzyme in inhibiting theproduction of prostaglandins. In this paper, we report the virtual screening of methyl cinnamate derivativecompounds against the COX-2. All methyl cinnamate derivative compounds were  molecular docking simulatedusing the Protein-Ligand ANT System (PLANTS) software with  ZINC03814717 as the reference compound. Fromthe results of virtual screening, it was obtained that  derivative compounds of methyl cinnamate were predicted asactive  COX-2  inhibitors  because  they  have  ChemPLP  score  better  than  that  of  the  reference  compoundsZINC03814717. The compound of acid 3- (4-benzoylphenyl) propionate was predicted as having the best score ofChemPLP.Keywords:  Non-Steroid Anti-Inflammatory (NSAID), virtual screening, enzyme cyclooxygenase-2 (COX-2), methyl cinnamate derivative
PREPARASI CONTOH UJI PROFISIENSI UNTUK IDENTIFIKASI SENYAWA KIMIA BERBAHAYA Evita Boes
Jurnal Kimia Terapan Indonesia Vol 17, No 1 (2015)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (620.877 KB) | DOI: 10.14203/jkti.v17i1.23

Abstract

The sample of proficiency test for hazard chemical compounds in organic and water sample has been made to identify hazard chemical compounds. Here, various matrix was added to these hazard chemical compound. The organic sample derived from organic waste added with dichloromethane as the solvent, undecane 100 µl/mL, 1,2-dimethylbenzene 12 µl/mL, diesel  100 µl/mL and tributhyl phosphate 10,02 µg/mL, whereas water sample derived from  water waste added with magnesium sulfate heptahydrate 120 µg/mL, sodium carbonate anhydrous 106 µg/mL, sodium sulfate anhydrous 284 µg/mL, calsium chloride  dyhidrate 222 µg/mL, dikhloromethane 2,5 µl/mL, polyethylene glycol 505,4 µg/mL, 3,5 dihydroxytoluene 10,05 µg/mL and α methyl-α-propyl succinimide 10,01 µg/mL. Hazard chemical compounds  that being added are Bis (3-methylbutyl) ethylphosphonate 10,04±0,31 µg/mL, Bis (2-chloroethyl) methylamine  20,59±0,14 µg/mL for organic sample and Pinacolyl methylphosphonate 9,80±0,18 µg/mL and Triethanolamine 14,84±0,10 µg/mL for water sample.  Homogeneity and stability are determined quantitatively using  GC-FPD (P-mode) and GC-FID with calibration curve using internal standard dibuty butylphosphonate, 2,6-dimethylphenol, dibutylphosphate and Bis (2-hydroxypropyl) aminoethanol with Relative Standard Deviation (RSD)  8,10 % and 12,40 µg/mL for Bis (3-methylbutyl) ethylphosphonate and 3,46 % and 14,19 µg/mL for Bis (2-chloroethyl) methylamine and 2,22 % and 11,28 µg/mL for Pinacolyl methylphosphonate and 2,70 % and 11,47 µg/mL for Triethanolamine.  Relative Standard Deviation is a homogeneity value with requirements below 20 % and stability is a degradation result which value is less than 30 %.Keywords: hazard chemical compounds, proficiency test, homogeneity, stability, relative standard deviation
PENINGKATAN KUALITAS PAKAN AYAM DENGAN PENAMBAHAN ENZIM : Pengaruh enzim terhadap nilai daya cerna, neraca nitrogen dan neraca energi. Patuan L.P. Siagian
Jurnal Kimia Terapan Indonesia Vol 8, No 1-2 (1998)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4237.162 KB) | DOI: 10.14203/jkti.v8i1-2.205

Abstract

In order to improve the feed quality, enzyme preparatories were added to the diets, wich all of the main components were plant origin. Five treatments in a completely randomized design were 9 fold replicaed, namely: 1. Diet without enzyme addition (control), 2. (-glucanose added to the diet), 3. Hemicellulase added to the diet, 4. Cellulase added to the diet, 5. (-glucanase, hemicellulase and cellulase added to the diet. To ascertain the digestibility of the nutrients of the treated diets, a total of 90 male chicks of LSLBrown were selected and kept in a climate conditioned room (temperature 22 °C, relative humidity 65-70 %, lighting 24 hours per day of 20-25 Lux).The results of this experiment showed that the addition of the enzyme to the diet effected Significantly the digestibility of the fat (p 0,001),ash (p . 0,05) and sugar (p 0,05). The addition of combined (-glucanase, hemicellul ase, and cellulase to the diet improved feed conversion ratio of 9, 7 % compared to the control. The nitrogen effictenoy ratio and anergi efficiency ratio were also significantly better (p O,05), each of 9.8 % and ll.8 %.
Effect of initial inoculum on growth and fatty acid content as an α-glucosidase inhibitor in Colletotrichum sp. TSC13 mycelium that cultures under shake and static conditions Nina Artanti; Leonardus B.S. Kardono; Sanro Tachibana
Jurnal Kimia Terapan Indonesia Vol 19, No 2 (2017)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (536.225 KB) | DOI: 10.14203/jkti.v19i2.353

Abstract

Colletotrichum species were reported producing various bioactive compounds that may potentially be used in the development of anti-microbial, antioxidant, anticancer and anti-diabetes drugs. Our previous studies showed that the methanol extracts of mycelia from Colletotrichum sp. TSC13, an endophytic fungus isolated from Taxus sumatrana (Miq.) de Laub., were found to have α-glucosidase inhibitory activities. The aim of present study was to examine the effects of initial inoculum on growth and the content of fatty acids as an α-glucosidase inhibitor in Colletotrichum sp. TSC13 that grew under shake and static condition. The results showed that shake and static conditions had more effect compared to the initial inocculum on growth and glucose consumption in growth and glucose consumption. However in terms of fatty acids contents and α-glucosidase inhibitor activities the initial inoculum showed more effect than shake and static conditions
EFFECT OF POLYVINYLPYRROLIDONE ADDITIVE ON MEMBRANE CHARACTERISTICS IN THE PREPARATION OF POLYETHERSULFONE HOLLOW FIBER MEMBRANE Syahril Ahmad
Jurnal Kimia Terapan Indonesia Vol 3, No 2 (1993)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4416.398 KB) | DOI: 10.14203/jkti.v3i2.272

Abstract

Preparation by applying the dry - wet spinning method and characterization of polyethersulfone (PES) hollow fiber membranes for ultrafiltration purpose have been studied. The characteristics of the hallow fibers studied include water flux, rejection rate, molecular weight cut - off and cross section structure. The membrane was prepared using the dope solution composition of 20% PES, 6% Polyvinylpyrrolidone (PVP) and 74% of n-Methyl Pyrrolidone as solvent. The effect of molecular weight of PVP and the small amount of water added in the dope solution have also been studied. The results show that increasing the molecular weight of PVP in the dope solution will decrease the rejection coefficient of the membrane towards dextran solution. Effect of a small amount of water in the dope solution as wetting agent is not obvious as indicated by the fluctuations in the results. Higher operating pressure during ultrafiltration process give higher water flux, but the effect on membrane rejection is not clear. By taking the rejection coefficient as 90 %, the molecular weight cut-off of the hallow fiber prepared are 40,000; 80,000; 25,000 and 110,000.
AKTIVITAS ANTIBAKTERI EKSTRAK BIJI KAPULAGA (Amomum compactum Sol. Ex Maton) Dede Sukandar; Sandra Hermanto; Eka Rizki Amelia; Muhamad Zaenudin
Jurnal Kimia Terapan Indonesia Vol 17, No 2 (2015)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (648.526 KB) | DOI: 10.14203/jkti.v17i2.28

Abstract

Testing of antibacterial activity against ethyl acetate extract local cardamom seeds (Amomum compactum Sol. Ex Maton) has been performed. Extraction was carried out using the soxhlet method with methanol solvent and liquid-liquid partitioned with n-hexane, ethyl acetate and n-butanol solvent, antibacterial activity test was performed using the disc diffusion method, fractionation using column chromatography and characterization of active fractions using chromatography GCMS, UV-vis and FTIR spectroscopy. The test results showed that the antibacterial activity of ethyl acetate extract had the highest antibacterial activity against S. aureus and E. coli with inhibition zone diameter of respectively 15.15 ± 1.34 and 13.50 ± 0.70 mm at a concentration of 3200 mg/mL. Results of fractionation of the ethyl acetate fraction using column chromatography with a mobile phase of ethyl acetate: n-hexane (3: 2) yielded three fractions, namely F1 (14.6 mg), F2 (8.1 mg) and F3 (4.6 mg). Fraction 2 had the highest antibacterial activity against S. aureus with inhibition zone diameter of 12.34 ± 0.07 mm at a concentration of 800 ug/mL. The results of the characterization of the fraction 2 obtained using GCMS analysis of three antibacterial compounds suspected of 2.9-dihydroxy-1,8-cineol; 2,4-dihydroxy-1,8-cineol and 2,2-methylene bis [6- (1,1-dimethylethyl) -4-ethyl] phenol. The results of the F2 fraction characterization using UV-Vis spectroscopy showed the presence of group C = C conjugated chromophore at λmax 223 nm and are based on analysis using FTIR there -OH alcohol functional group (3372 cm-1), aliphatic -CH (2926 and 2854 cm-1) , C = C (1695 cm-1), aliphatic CH2 (1402 cm-1), CH3 aliphatic (1384 cm-1), and C-O (1203; 1126; 1091 and 1043 cm-1). Keywords: Antibacterial, S. aureus, E. coli, Amomum compactum Sol. Ex Maton, disk diffusion
BIOFLOKULASI MIKROORGANISME DAN PERANANNYA DALAM PENGOLAHAN AIR LIMBAH SECARA BIOLOGI Milono Poesponegoro
Jurnal Kimia Terapan Indonesia Vol 8, No 1-2 (1998)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/jkti.v8i1-2.210

Abstract

Bioflocculation is a direct result of the ability of the microorganims to agglomerate into large flocs with a high settling velocity, and is an important phenomenon often encountered in the biological treatment of wastewater. Bioflocculation is also very important in determining the dewatering characteristics of a sludge.The key 10 the successful operation of biological-oxidation units is the maintenance of adequate nutrients, microorganisms, and a favourable environment for the organisms to grow and utilize the organic matter. Although algae, bacteria, fungi and protozoa are introduced into the activated sludge, bacteria usually dominant as the primary feeders on the organic waste. The dominant bacteria of the sludge must satisfy two conditions: they must be able to utilize the organic waste and also be capable of readily forming flocs to facilitate separation from eflluent and thereby ensure their retention in the system. Therefore, it is essential to ensure that the proper environment is produced and effectively controlled to pave the dominant growth of flocforming bacteria in the system so that the settling characteristics of the sludge obtained are good.Flocculation of discrete microbial cells can either be biologically (bioflocoulation) or chemically induced (chemical flocculation). There seems to be general agreement that bioflocculation of microorganisms was observed to follow mechanism similar to those observed in the chemical flocculation of microorganisms. A review on the bioflocculation of microorganisms in relationship to aerobic wastewater treatment proces and to cultural and microbial growth conditions is presented. The bioflocculation mechanism is also discussed and summarized.
SIFAT FISIKO KIMIA DAN AKTIVITAS ANTIOKSIDAN MINYAK KELAPA MURNI (VCO) HASIL FERMENTASI RHIZOPUS ORIZAE Dede Sukandar; Sandra Hermanto; Eva Silvia
Jurnal Kimia Terapan Indonesia Vol 11, No 2 (2009)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (5284.225 KB) | DOI: 10.14203/jkti.v11i2.157

Abstract

Research on physicochemical properties and antioxidant activity of VCO obtained from Rhizopus orizaefermentation had been done. Antioxidant activity was determined by DPPH method. Production of VCO had been carried out from coconut sample obtained from Pandeglang region with fermentation by Rhizopusorizae in variation of inoculum asfollow 2%, 5%, 7%, 10% and 12 %. Physicochemical test consist of density, refractive index, water content, free fatty acid, iodine value, peroxide value while the composition of fatty acid determined by GCMS, The result showed that variation of inoculum had significantly 0,024 influenced the yielded of VCO producted. Based on this result, quality of VCO still in the range of CODEX Standard, 19-1991rev.2-1999. It was found that antioxidant activity of VCO only 6.3% at 1000 ppm. The composition offatty acid based in lauric acid content measured by GCMS showed a significant result (49.48%-50%) agreed with COD EX Standard.Keyword: Antioxidant, DPPH, veo, Fermentation,Rhizopus oriza.
SKRINING IN SILICO POTENSI SENYAWA ALLICIN DARI ALLIUM SATIVUM SEBAGAI ANTIPLASMODIUM Fatmawaty Fatmawaty; Muhammad Hanafi; Rosmalena Rosmalena; Vivitri Dewi Prasasty
Jurnal Kimia Terapan Indonesia Vol 17, No 2 (2015)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (902.064 KB) | DOI: 10.14203/jkti.v17i2.33

Abstract

Allicin compound (2-propene-1- sulphinothioat acid S-2-propenyl ester) is known to have potential as antiplasmodium in vitro. However, the inhibitory activity mechanism of Allicin to plasmodium is still unknown. In this research, we determined the inhibitory activity of Allicin in silico. Identification of physicochemical properties of Allicin compound and two Allicin derivatives, Alc1, Alc2 and Ac2Alc3 were also conducted.. Furthermore, analysis of drug-likeness and adsorption-distribution-metabolism-excretion (ADME) were carried out on the Allicin compound and its derivatives to find the potential of these compounds as drug candidates. In determining the specific interaction, we utilized molecular docking analysis between Allicin and its derivatives against a protein target Cysteine Protease (SP). Molecular  docking results showed that Allicin derivative, Alc2 (S-prop-2-en-1-yl 3-methylbut-2-ene-1-sulfinothioate, C10H18OS2) has better potential as inhibitors than Allicin, based on the lower bond energies and the inhibition constants, thus Alc2 can be used as an antiplasmodium agent candidate.Keywords: Allicin, Allicin derivatives, drug likeness, ADME, molecular docking

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