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INDONESIA
Majalah Farmaseutik
Published by Universitas Gadjah Mada
ISSN : 1410590x     EISSN : 26140063     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Majalah Farmaseutic accepts submission concerning in particular fields such as pharmaceutics, pharmaceutical biology, pharmaceutical chemistry, pharmacology, and social pharmacy.
Arjuna Subject : -
Articles 10 Documents
 1 
Search results for , issue "Vol 13, No 1 (2017)" : 10 Documents clear
EFEK KOMBINASI EKSTRAK Tithonia diversifolia (HEMSLEY) A.GRAY DAN Curcuma domestica VAL TERHADAP NODUL DAN BERAT BADAN TIKUS MODEL KANKER Halimah, Wahyu Nur; Pratiwi, Woro Rukmi; Wahyuningsih, Mae Sri Hartati
Majalah Farmaseutik Vol 13, No 1 (2017)
Publisher : Fakultas Farmasi Universitas Gadjah Mada

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Abstract

Kembang bulan [Tithonia diversifolia (Hemsley) A. Gray] merupakan kandidat tanaman berpotensi antikanker yang telah dibuktikan sebelumnya memiliki efek sitotoksik terhadap sel kanker WiDr, IC50=61,55 ug/mL. Kunyit (Curcuma domestica Val.) banyak digunakan dalam pengobatan tradisional, mengandung kurkuminoid yang memiliki aktivitas antikanker dengan memodulasi fungsi imun yang dimediasi oleh limfosit. Dengan adanya efek imunostimulan dari kunyit apabila dicampur dengan kembang bulan sebagai kandidat antikanker diharapkan akan bersinergis lebih baik. Tujuan penelitian ini untuk mengkaji potensi kombinasi ekstrak etanol T. diversifolia dan C. domestica pada hewan model kanker dengan cara menghitung berat badan, jumlah nodul dan volume nodul hewan coba. Penelitian ini adalah penelitian kuasi eksperimental. Kombinasi ekstrak etanol 70% daun kembang bulan dan rimpang kunyit dibuat suspensi dan dibagi menjadi 3 dosis yaitu dosis 40:150mg, 80:150mg, dan 160:150mg. Kemudian diberikan peroral pada masing-masing kelompok tikus yang telah mengalami kanker payudara setelah diinduksi dengan DMBA. Kemudian diamati berat badan, jumlah nodul, dan volume nodul tikus yang dibandingkan dengan kelompok kontrol negatif dan kelompok kontrol positif (doksorubisin). Persentase perubahan pada masing-masing kelompok perlakuan dibandingkan dan diuji secara statistik menggunakan analisis Anova. Hasil menunjukkan bahwa perbandingan berat badan tikus antara kelompok kontrol doksorubisin dan kelompok dosis 40:150mg, 80:150mg, dan 160:150mg menunjukkan tidak berbeda signifikan. Perbandingan volume nodul kanker payudara antara kelompok kontrol dan kelompok uji menunjukkan hasil yang tidak berbeda signifikan. Kombinasi ekstrak etanol  kembang bulan dan rimpang kunyit tidak mempunyai efek signifikan terhadap berat badan dan nodul kanker payudara
OPTIMASI RASIO AVICEL PH 102 DENGAN CAB-O-SIL M-5P DAN KONSENTRASI CROSPOVIDONE PADA FORMULA TABLET PIROKSIKAM SISTEM LIKUISOLID Puspita, Rani; Sulaiman, T.N Saifullah; mutmainah, mutmainah
Majalah Farmaseutik Vol 13, No 1 (2017)
Publisher : Fakultas Farmasi Universitas Gadjah Mada

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Abstract

Piroksikam merupakan obat yang sukar larut, sehingga perlu dikembangkan dalam bentuk tablet dengan sistem likuisolid untuk meningkatkan kelarutannya pada saluran pencernaan. Factorial design digunakan untuk optimasi formula sediaan tablet piroksikam sistem likuisolid, optimasi dilakukan dengan membuat empat formula yaitu run I (18%A-2%B), run II (45%A-2%B), run III (18%A-5%B), run IV (45%A-5%B). Komponen A merupakan rasio Avicel PH 102 dengan Cab-O-Sil M-5P dan komponen B adalah konsentrasi crospovidone. Penentuan area formula optimum ditentukan berdasarkan superimposed contourplot beberapa parameter: kekerasan, kerapuhan, waktu hancur, dan disolusi (C45) dengan menggunakan software Design Expert. Berdasarkan superimposed contourplot diperoleh area formula optimum pada rentang rasio Avicel PH 102 dengan Cab-O-Sil M-5P 18-45 dan konsentrasi crospovidone dengan rentang 2-5%.
PENGARUH PENGECILAN UKURAN PARTIKEL PADA KASUS PEMBUATAN PULVERES DARI TABLET IBUPROFEN TERHADAP KECEPATAN DAN PROFIL DISOLUSI SERTA STABILITASNYA bestari, angi nadya; Sulaiman, T.N Saifullah; Purnamasari, Dita Ayu
Majalah Farmaseutik Vol 13, No 1 (2017)
Publisher : Fakultas Farmasi Universitas Gadjah Mada

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Abstract

Pelepasan zat aktif dari sediaan salah satunya bergantung pada sifat fisika kimia obat yaitu luas kontak muka. Semakin kecil ukuran partikel maka luas kontak muka akan semakin besar. Luas kontak muka akan mempengaruhi disolusi dan stabilitasnya. Penelitian ini bertujuan untuk mengetahui pengaruh perubahan bentuk sediaan tablet menjadi sediaan pulveres terhadap kecepatan disolusi, profil disolusi dan stabilitasnya.Tablet ibuprofen konvensional utuh digerus dan diblender menjadi sediaan pulveres dan dilakukan uji disolusi menggunakan alat disolusi USP tipe II yaitu metode paddle dengan medium dapar fosfat pH 7,2. Pengungkapan hasil uji disolusi meliputi nilai Q30, DE45, konstanta laju disolusi (k). Kemiripan profil disolusi setiap sediaan dapat diketahui melalui perhitungan similarity factor (f2). Pulveres hasil penggerusan mortir-stamper dan blender ditinjau stabilitasnya dari aspek sifat organoleptis, profil disolusi, kecepatan disolusi dan kadarnya setelah masa penyimpanan selama 1, 2, 3 dan 4 minggu.Hasil disolusi menunjukkan bahwa perubahan bentuk sediaan dari sediaan tablet menjadi sediaan pulveres meningkatkan kecepatan dan profil disolusi dari 0,0627 menit-1 menjadi 0,3466 menit-1 dan 0,2981 menit-1 (p=0,029) serta nilai DE45 dari  66,52% menjadi 96,76% dan 96,17% (p=0). Pulveres gerus dan pulveres blender stabil selama 4 minggu penyimpanan karena tidak menunjukkan perubahan sifat organoleptis dan nilai DE45 (%), konstanta laju disolusi (k) serta kadar zat aktif yang tidak berbeda secara signifikan (p>0,05).
KAJIAN KEANEKARAGAMAN JENIS TUMBUHAN OBAT DI DAERAH ALIRAN SUNGAI OPAK, DAERAH ISTIMEWA YOGYAKARTA Santoso, Djoko; Wahyuono, Subagus; Riyanto, Sugeng; Widyastuti, SM
Majalah Farmaseutik Vol 13, No 1 (2017)
Publisher : Fakultas Farmasi Universitas Gadjah Mada

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Abstract

Telah dilakukan penelitian tentang keanekaragaman jenis tumbuhan obat di darah aliran sungai Opak. Tujuan penelitian ini adalah untuk mengetahui komposisi jenis-jenis tumbuhan obat, distribusi dan potensi pengembangan sebgai bahan baku herbal.Area kajian dibagi menjadi 6 lokasi berdasarkan ketinggian tempat, yaitu wilayah Kecamatan Cangkringan (CNK), Ngemplak (NPL), Prambanan (PRB), Kalasan (KLS), Imogiri (IMO), dan Pundong (PDO).  Setiap lokasi diletakkan plot kuadrat berukuran 2x1 m sebanyak 30 plot. Di dalam plot kuadrat dihitung jenis tumbuhan dan cacah individu setiap jenis tumbuhan.Hasil penelitian menunjukkan terdapat sebanyak 79 jenis tumbuhan yang dikelompokkan dalam 27 suku. Berdasarkan kontribusi jenis di dalam lingkungan dan studi literatur Eupatorium riparium,  Andrographis paniculata, dan Scoparia dulcis merupakan jenis-jenis tumbuhan yang potensial untuk dikembangkan sebagai bahan baku obat herbal. 
FORMULASI DAN UJI STABILITAS FISIK SEDIAAN LOTION O/W PATI KENTANG (Solanum tuberosum L.) SERTA AKTIVITASNYA SEBAGAI TABIR SURYA Oktaviasari, Luky; Zulkarnain, Abdul Karim
Majalah Farmaseutik Vol 13, No 1 (2017)
Publisher : Fakultas Farmasi Universitas Gadjah Mada

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Abstract

Pati kentang memiliki sifat opaque yang tidak dapat ditembus cahaya tetapi dapat memantulkan sinar, bermanfaat untuk mencegah penetrasi radiasi sinar ultraviolet pada kulit. Secara umum, penelitian ini bertujuan untuk memperoleh suatu produk tabir surya dari bahan alam, yaitu pati kentang dalam bentuk sediaan lotion.Percobaan menggunakan pati kentang yang dibuat sediaan lotion oil in water dengan variasi konsentrasi pati kentang 10; 12.5; 15; 17.5; dan 20% b/b. Evaluasi fisik formulasi lotion yang telah dibuat dilakukan selama penyimpanan dengan pemeriksaan mutu  fisik, homogenitas, pH, viskositas, uji daya sebar, uji daya lekat, serta stabilitas sediaan dengan siklus freeze thaw. Aktivitas tabir surya dilakukan dengan mencari nilai faktor pelindung surya atau Sun Protecting Factor (SPF) sediaan lotion pati kentang yang ditentukan secara in vivo menggunakan kelinci albino yang sebelumnya diinduksi dengan pemberian 8-MOP atau methoksalen, kemudian disinari dengan lampu UV.Variasi konsentrasi pati kentang sebesar 15% memberikan lotion yang stabil berdasarkan dari parameter organoleptis, homogenitas, pH, viskositas, daya sebar, daya lekat dan stabilitas sediaan yang dipercepat. Peningkatan konsentrasi pati kentang memberikan pengaruh terhadap stabilitas fisik selama penyimpanan. Lotion oil in water pati kentang dengan konsentrasi 15% memiliki aktivitas sebagai tabir surya dengan nilai SPF sesuai nilai standar yaitu sebesar 15.
Effect of Tithonia Diversifolia (Hemsley) A.Gray and Curcuma Domestica Val Extracts Combination Against Nodule and Body Weight In Cancer Rats Model Mae Sri Hartati Wahyuningsih; Wahyu Nur Halimah; Woro Rukmi Prtiwi
Majalah Farmaseutik Vol 13, No 1 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (409.174 KB) | DOI: 10.22146/farmaseutik.v13i1.38465

Abstract

Kembang bulan [Tithonia diversifolia (Hemsley) A. Gray] is a potentially anticancer plants  that have been previously shown have cytotoxics effect on WiDr colon cancer cells, IC50=61.55µg/mL. Turmeric (Curcuma domestica Val.) is widely used in traditional medicine. Curcuminoids compounds from turmeric have potential anticancer activity with possibly modulate immune function mediated by lymphocytes. With the immunostimulant effect of turmeric when mixed with kembang bulan as an anticancer candidate is expected to synergize better. This study aims to determine the potential of T. diversifolia and C. domestica ethanolic extracts combination in cancer rats model by measuring weight, number of nodules, and nodule volume animals. The study was a quasi-experimental study. Mixed 70% ethanol extract of kembang bulan’s leaves and turmeric’s rhizome divided into 3 doses, 40:150mg, 80:150mg, and 160:150mg. Then it given to each group of rats by orally that had experienced breast cancer . After that, see potential on body weight, number of nodules, and nodule volume. Then compared with normal group, negative control group, and positive control group. Furthermore, the percentage change in each treatment group were compared and statistically tested using ANOVA analysis. Comparison of the results of rat’s body weight between the control group (doxorubicin) and test group showed significantly no different results. Comparison of the results of rat’s breast cancer nodule volume between the control group and the test group showed significantly no different results. A combination of 70% ethanol extract of kembang bulan’s leaves and turmeric’s rhizome have no significant effect on body weight and breast cancer nodules. 
Optimation of Avicel PH 102 with Cab-O-Sil M-5P Ratio and Crospovidone Concentration on Liquisolid System Piroxicam Tablet T.N. Saifullah Sulaiman; Rani Puspita; Mutmainah Mutmainah
Majalah Farmaseutik Vol 13, No 1 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (425.864 KB) | DOI: 10.22146/farmaseutik.v13i1.38466

Abstract

Piroxicam is slightly soluble, so it should be developed in a liquisolid system of tablet dosage form to increase its solubility in gastrointestinal tract. Factorial design was applied to optimize the formula of liquisolid system piroxicam tablet by using four formulas: run  I (18%A-2%B), run II (45%A-2%B), run III (18%A-5%B), and run IV (45%A-5%B). Component A is the ratio of Avicel PH 102 with Cab-O-Sil M-5P whether B is the concentration of crospovidone. Optimum formula was determined by superimposed contour plot from various parameters: hardness, friability, disintegrating time, and dissolution concentration (C45) using Design Expert software. Based on superimposed contour plot, optimum formula area was obtained in the range of 18-45 of Avicel PH 102 with Cab-O-Sil M-5P ratio and 2-5% of crospovidone concentration.
The Effect of Particle Size Reduction from Ibuprofen Tablet to Ibuprofen Pulveres on Its Dissolution Rate, Dissolution Profile, and Drug Stability Angi Nadya Bestari; T.N. Saifullah Sulaiman; Dita Ayu Purnamasari
Majalah Farmaseutik Vol 13, No 1 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (704.882 KB) | DOI: 10.22146/farmaseutik.v13i1.38468

Abstract

A factor that influences the release of active ingredient from its dosage form is total particle surface area of drugs that contact with medium. The smaller size of particle can increase the particle surface area which can influence its dissolution and stability. This study aimed to determine the effect of tablet particle size reduction to its organoleptic properties, dissolution rate, dissolution profile, and stability after storage periods of 1, 2, 3, and 4 weeks. Ibuprofen tablet was changed its form by crushing into pulveres dosage form. The pulveres dissolution was conducted by USP type II dissolution tester (paddle method) with phosphate buffer pH 7,2 as the medium. The results of dissolution testing included the value of Q30, DE45, and dissolution rate constant (k). The similarity of dissolution profiles for each preparation could be known by the calculation of similarity factor (f2).  Dissolution results showed that changed in particle sizes from the tablet to pulveres could increase dissolution rate constant from 0,063/minute to 0,347/minute and 0,298/minute (p = 0,029) and the DE45 value from 66,52% to 96,76% and 96,17% (p = 0). Pulveres were stable for 4 weeks of storage which were shown by there were not any changes in organoleptic properties. Furthermore, the value of DE45 (%), dissolution rate constants (k) and levels of active substances were not significantly different (p> 0,05) after 4 weeks of storage. The f2 value of  ibuprofen tablet and ibuprofen pulveres was under 50 that meant the dissolution profil among them was not similar.
Formulation and Physical Stability Test of Lotion O/W Potato Starch (Solanum tuberosum L.) and the Activities as Sunscreen Abdul Karim Zulkarnain; Luky Oktaviasari
Majalah Farmaseutik Vol 13, No 1 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (468.97 KB) | DOI: 10.22146/farmaseutik.v13i1.38464

Abstract

Potato starch has an opaque characteristic that cannot be penetrated by light but can reflect light, therefore it is useful to prevent the penetration of ultraviolet radiation on the skin. This study aims to obtain a sunscreen product from natural material namely potato starch in lotion form. The experiment uses potato starch made into lotion in oil in water form with the concentrations of potato starch 10; 12.5; 15; 17.5 and 20% w/w. Physical evaluations of lotion formulation were done during storage with physical quality controlling, homogeneity, pH, viscosity, dispersive test, adhesion test, and product stability with a freeze-thaw cycle. Sunscreen activity is done by finding the value of sun protection factor  (SPF) of potato starch lotion which determined by in vivo method using albino rabbit that induction by 8-MOP or methoxsalen previously, and irradiated by UV lamp. The 15% concentration variation of potato starch provides the most stable lotion based on the organoleptic parameter, homogeneity, pH, viscosity, dispersive test, adhesion test, and product stability accelerated. The increasing of potato starch concentration gives effect to the physical stability of the lotion during the storage time. Oil in water potato starch lotion with 15% has activity as a sunscreen with SPF value 15.
The Study of Medicinal Plant Diversity at Opak Watershed, Special Region Yogyakarta Djoko Santosa; Subagus Wahyuono; Sugeng Riyanto; S M Widyastuti
Majalah Farmaseutik Vol 13, No 1 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (504.569 KB) | DOI: 10.22146/farmaseutik.v13i1.38462

Abstract

Research on the diversity of medicinal plant at  Opak watershed has been done. The purpose of this study is to determine the composition of medicinal plants, distribution and development potential as herbs raw materials. The study area is divided into 6 locations, namely Cangkringan subdistrict (CNK), Ngemplak (NPL), Prambanan (PRB), Kalasan (KLS), Imogiri (IMO), and Pundong (PDO). Each location is placed 30 plots by squares measuring 2x1 m. In the plot is calculated the number of species and individual of each  species. The results showed there were  79 speies of plants are grouped into 27 families. Based on the type contribution in the environment and the literature study of  Eupatorium riparium, Andrographis paniculata, and Scoparia dulcis are potential plants to be developed as raw materials of herbs medicine.

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