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INDONESIA
Indonesian Journal of Chemistry
Published by Universitas Gadjah Mada
ISSN : 14119420     EISSN : 24601578     DOI : -
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry
Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology and Higher Education (RISTEKDIKTI) No : 21/E/KPT/2018 (in First Rank) and indexed in Scopus since 2012. Since 2018 (Volume 18), Indonesian Journal of Chemistry publish four issues (numbers) annually (February, May, August and November).
Arjuna Subject : -
Articles 25 Documents
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Search results for , issue "Vol 22, No 5 (2022)" : 25 Documents clear
A Computational Design of siRNA in SARS-CoV-2 Spike Glycoprotein Gene and Its Binding Capability toward mRNA Arli Aditya Parikesit; Arif Nur Muhammad Ansori; Viol Dhea Kharisma
Indonesian Journal of Chemistry Vol 22, No 5 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.68415

Abstract

COVID-19 pandemic has no immediate ending in sight, and any significant increasing cases were observed worldwide. Currently, there are only two main strategies for developing COVID-19 drugs that predominantly use a proteomics-based approach, which are drug repurposing and herbal medicine strategies. However, a third strategy has existed, called small interfering RNA or siRNA, which is based on the transcriptomics approach. In the case of SARS-CoV-2 infection, it is expected to perform by silencing the viral gene, which brings the surface glycoprotein (S) gene responsible for SARS-CoV-2 viral attachment to the ACE2 receptor on the human host cell. This third approach applies a molecular simulation method comprising data retrieval, multiple sequence alignment, phylogenetic tree depiction, 2D/3D structure prediction, and RNA-RNA molecular docking. The expected results are the prediction of 2D and 3D structures of both siRNA and mRNA silenced S genes along with a complex as the result of a docking method formed by those silenced genes. An Insilco chemical interaction study was performed in testing siRNA and mRNA complex’s stability with the confirmation result of a stable complex which is expected to be formed before mRNA reaches the ribosome for the translation process. Thus, siRNA from the S gene could be considered a candidate for the COVID-19 therapeutic agent.
Phase Transfer Catalyzed Preparation of 4-Methylbenzenesulfonyl Imidazole for Regioselective Synthesis of Mono-6-(4-methylbenzenesulfonyl)-β-cyclodextrin I Wayan Muderawan; I Wayan Mudianta; Made Kurnia Wiastuti Giri
Indonesian Journal of Chemistry Vol 22, No 5 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.70252

Abstract

The preparation of 4-methylbenzenesulfonyl imidazole by using triethylamine as an effective phase‐transfer catalyst (PTC) under mild biphasic conditions has been studied intensively. The method can be used for large-scale preparation with high purity and high yield of 4-methylbenzene-sulfonyl imidazole. The result in 4-methylbenzenesulfonyl imidazole has been successfully applied for the regioselective synthesis of mono-6-(4-methylbenzenesulfonyl)-β-cyclodextrin in an aqueous medium. This synthetic methodology concept, together with the synthetic versatility of PTC, provides a general and reliable general strategy for the practical and industrial regioselective synthesis of highly valuable mono-6-(4-methylbenzenesulfonyl)-β-cyclodextrin as a key intermediate for the single functional isomer mono-substituted cyclodextrin derivatives. As characterized by FTIR, NMR and mass spectrometry, mono-6-(4-methylbenzenesulfonyl)-β-cyclodextrin was obtained in high purity.
Utilizing Organic Aromatic Melamine Moiety to Modify Poly(Vinyl Chloride) Chemical Structure and Micro CuO That Plays an Important Role to Enhance Its Photophysical Features Mohammed Hussein Al-Mashhadani; Ekhlas Abdulkhadiar Salman; Amani Ayad Husain; Mustafa Abdallh; Muna Bufaroosha; Emad Yousif
Indonesian Journal of Chemistry Vol 22, No 5 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.70263

Abstract

Three arms Schiff base unit based on melamine moiety was synthesized and introduced to polyvinyl chloride (PVC) to produce a modified PVC polymer. The polymer composite of new modified PVC polymer was blended with micro copper oxide as a reflecting mirror of UV light to enhance the photostability of PVC. Three different concentrations of micro copper oxide (0.01–0.03 wt.%) were mixed with the modified PVC and cast as a thin film. The photostability test has shown high resistance to photodegradation upon exposure to UV light. In this work, different approaches were applied to examining doped modified PVC's thin film efficiency against photodegradation after exposure to UV light for 300 h in an ambient atmosphere. The exhibited studies, such as infrared spectroscopy and weight loss percentage, have demonstrated the improvement of photophysical properties for modified PVC and blended modified films in comparison to blank PVC polymeric films. These outcomes are so interesting as they could contribute to reducing the consumption of PVC around the world hence its waste causing huge environmental problems for the marine ecosystem.
Efficient Degradation of Methylene Blue Using La-PTC-HIna/Ti3C2Tx MXene: Adsorption and Photocatalytic Degradation Agustino Zulys; Adawiah Adawiah; Nasruddin Nasruddin
Indonesian Journal of Chemistry Vol 22, No 5 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.71692

Abstract

Isonicotinic acid is a pyridine carboxylic compound that can be used as a linker to construct coordination complexes. Adding isonicotinic acid (HIna) to the metal-organic framework (MOF) enhanced the MOF surface area, pore volume, and pore size and increased its catalytic activity. Ti3C2Tx MXene nanosheet with excellent metal conductivity was also employed on MOF to optimize its functionality. This work aims to synthesize MOF modulated isonicotinic acid La-PTC-HIna and design the new materials: La-PTC/Ti3C2Tx MXene and La-PTC-HIna/Ti3C2Tx MXene hybrid, then apply them for methylene blue photodegradation. La-PTC-HIna, La-PTC/Ti3C2Tx MXene, and La-PTC-HIna/Ti3C2Tx MXene were synthesized by the sonochemical method. MOF La-PTC-HIna has the highest methylene blue photocatalytic degradation activity than MOF La-PTC, Ti3C2Tx MXene, La-PTC/Ti3C2Tx MXene, and La-PTC-HIna/Ti3C2Tx MXene with degradation efficiency of 99.48% in 20 ppm methylene blue under visible irradiation for 210 min. This study reveals the La-PTC-HIna and La-PTC-HIna/Ti3C2Tx MXene as a new material that has the potential to remove methylene blue from an aqueous solution.
Role of Temperature and Time Exposure for Controlled and Accelerated Synthesis of Graphene Oxide Using Tour Method Uswatul Chasanah; Wega Trisunaryanti; Haryo Satriya Oktaviano; Triyono Triyono; Dyah Ayu Fatmawati
Indonesian Journal of Chemistry Vol 22, No 5 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.71817

Abstract

Synthesis of graphene oxide (GO) with the Tour method has been studied. In this procedure, phosphoric acid was mixed with sulfuric acid in the ratio of 1:9, and then potassium permanganate and graphite with the ratio of 6:1 was added in an ice bath at the variation of oxidation times of 1, 7 and 24 h and temperatures of 40, 50 and 60 °C. The GOs were characterized by UV–Visible spectroscopy, Fourier Transform InfraRed (FT-IR) spectroscopy, X-ray Diffraction (XRD), Scanning Electron Microscopy-Energy Dispersive X-Ray (SEM-EDX), and Transmission Electron Microscopy (TEM). The results show that the GO oxidized at 40 °C for 7 h (GO-7-40) has been successfully formed indicating that GO-7-40 is the most efficient GO. The GO-7-40 is characterized by a peak at 2θ = 10.89° in the XRD diffractogram, resulting calculation of the average distance between graphene layer (d) of 0.81 nm. The average number of graphene layers (n) is 4, the oxidation level (C/O) is 1.50 according to EDX data, λmax at 226 nm attributes to π→π* transitions of C=C bond in UV-Vis spectrum, and the functional groups such as O-H, C=C, C-OH, and C-OC are observed in FT-IR spectrum.
Interaction Studies of Chlorpheniramine Maleate in Mono and Dihydric Alcohols by Density, Viscosity, and HPLC Methods Zainab Khan; Summyia Masood; Nighat Shafi; Rafia Azmat; Salman Khurshid; Samreen Begum
Indonesian Journal of Chemistry Vol 22, No 5 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.72225

Abstract

The examination of a drug in water and other aqueous systems gives insight into the chemistry of biological systems. This work aims to study the physico-chemical properties of chlorpheniramine maleate (drug) in water and aq-MeOH/EG (mono/dihydric alcohols) systems at different temperatures by using different techniques. Densities and viscosities of chlorpheniramine maleate in water and also in MeOH/EG aqueous solutions have been measured over a temperature range of 298.15 to 318.15 K. Number of several parameters, i.e., apparent molar volume (ϕv), partial molar volume (ϕvo), Hepler’s constant (∂CΡ/∂Ρ)T, Falkenhagen coefficient (A), and Jones-Dole coefficient (B) have been calculated by using experimentally measured density and viscosity values. The mentioned calculated parameters were found to be valuable in perceiving drug-drug and drug-solvent interactions. Moreover, one of the liquid chromatographic techniques such as RP-HPLC has also been performed, and the outcomes supported the conclusion procured from the volumetric and viscometric studies. Drug interactions help to understand their behavior in different solvent systems during drug development.
Application of Carbon Dots as Corrosion Inhibitor: A Systematic Literature Review Muhamad Jalil Baari; Ravensky Yurianty Pratiwi
Indonesian Journal of Chemistry Vol 22, No 5 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.72327

Abstract

Corrosion is spontaneity and unavoidable reactions which cause degradation in the quality of the materials. Most industries have been harmed by the corrosion of manufacturing equipment. Several methods can be applied to control this problem. The use of corrosion inhibitors is an effective and practical way to decrease metal deterioration significantly. Many commercial inorganic and organic compounds are effective inhibitors, but most of them are not completely safe and relatively expensive. Carbon dots and their derivatives are potential compounds for resolving corrosion reactions on metal surfaces. Carbon dots can be synthesized from various natural sources to be more environmentally friendly. This systematic review aims to summarize the concept of corrosion, types of carbon dots-based corrosion inhibitor and their effectiveness on various metals, inhibition mechanism, surface analysis of the protected metals, kinetics, thermodynamics, and quantum computational chemistry studies. This review also presents the significance and the prospects of carbon dots-based corrosion inhibitors.
Effect of Bridging Atom and Hydroxyl Position on the Antioxidant Capacity of Six Phenolic Schiff Bases Abdelhakim Kheniche; Imededdine Kadi; Abderrahim Benslama; Samiya Rizoug; Sarra Bekri; Abdenassar Harrar
Indonesian Journal of Chemistry Vol 22, No 5 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.72379

Abstract

A series of new phenolic Schiff bases N,N-bis(2,3-dihydroxybenzyl-idene)-4,4’-diphenylmethane (3-DPM), and N,N-bis(2,5-dihydroxybenzylidene)-4,4’-diphenylmethane (5-DPM), for sulfide bridge N,N-bis(2,3-dihydroxybenzyl-idene)-4,4’-diphenyl sulfide (3-DPS), N,N-bis(2,5-dihydroxybenzylidene)-4,4’-diphenyl sulfide (5-DPS), N,N-bis(2,3-dihydroxybenzyl-idene)-4,4’-diphenyl disulfide (3-DPSS), and N,N-bis(2,5-dihydroxybenzylidene)-4,4’-diphenyl disulfide (5-DPSS) were synthesized by condensation of substituted 4,4’-diamino-bis-(4-aminophenyl) methane/sulfide with various substituted aldehydes. The synthesized molecules were characterized by physical data, elemental, IR and 1H-NMR analyses. The antioxidant ability of compounds was determined through the use in vitro assays such as DPPH• scavenging, ABTS, total antioxidant capacity (TAC), hydroxyl radical OH• scavenging, and reducing power capability. The antioxidant activity of the compounds increased slightly after changing the atom bridge and hydroxyl group position. The results showed that the compound 5-DPSS exhibited superior scavenging strength against DPPH (EC50 = 7.10 ± 0.16 μg/mL), whereas 3-DPSS showed the highest activity (EC50 = 1.36 ± 0.08 μg/mL) when inspected by ABTS in relation to butylated hydroxyanisole (BHA) (EC50 = 7.54 ± 0.67). The higher OH• activity was marked by the compound 5-DPS (EC50 = 44.9 ± 3.3 μg/mL) related to BHT at (EC50 = 98.73 ± 0.3 μg/mL). The compounds 5-DPM demonstrated remarkable activity both reducing power (EC50 = 53.2 ± 0.3 μg/mL), and TAC assay (EC50 = 620.0 ± 2.4 μg/mL). These results prove that the modification in hydroxyl group position affect the antioxidant ability of Schiff bases.
Tyrosinase-Based Paper Biosensor for Phenolics Measurement Fretty Yurike; Dyah Iswantini; Henny Purwaningsih; Suminar Setiati Achmadi
Indonesian Journal of Chemistry Vol 22, No 5 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.72607

Abstract

Environmental pollution resulting from various industrial activities is still a problem for developing countries. The high content of phenolics such as phenols, polyphenols, bisphenol A, catechol, m- and p-cresol from industrial activities are discharged into surface water, soil, and air. Periodic monitoring of the impact of these toxic pollutants is needed for proper control and handling. These detrimental chemicals are usually measured using conventional methods with many drawbacks such as expensive analysis costs, long measurement times, requiring competent analysts, and complicated instrument maintenance. However, the presence of tyrosinase-based paper biosensors is now considered the most promising tool in overcoming the challenges mentioned earlier because they can detect these components quickly, precisely, accurately, inexpensively, and can be measured in situ. The working principle of this biosensor sees optical changes such as dyes, redox processes, and physicochemical properties (aggregation or dispersion) due to the presence of analytes accompanied by the occurrence of color changes that appear. This biosensor uses a layer-by-layer electrostatic method, which causes the deposition of multi-layered films on solid surfaces. In this paper, we review the development of the tyrosinase-based paper biosensor method for phenolic measurement in water, air, and food that gives better results than the conventional methods.
3,4,5-Trimethoxychalcones Tubulin Inhibitors with a Stable Colchicine Binding Site as Potential Anticancer Agents Maadh Jumaah; Tutik Dwi Wahyuningsih; Melati Khairuddean
Indonesian Journal of Chemistry Vol 22, No 5 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.72790

Abstract

The development of microtubule perturbing drugs is one of the most promising anticancer therapeutic methods. Unfortunately, limitation such as drug resistance, adverse side effects, complex formulations and synthesis, and limited bioavailability of these microtubule perturbing drugs has aroused the search for a new molecule of the tubulin system. Different substituents of chalcone were designed, synthesized, and determined for inhibition of tubulin assembly and toxicity in human cancer cell lines based on conventional colchicine site ligands and a computer model of the colchicine binding site on tubulin. A molecular docking study indicated that the chalcone scaffold could fit the colchicine site on tubulin in a similar orientation to the natural product. The 3,4,5-trimethoxyphenyl ring, which occupies the same sub-cavity as the equivalent molecule in colchicine, appeared to benefit the ligand of α,β-tubulin interaction. Several 3,4,5-trimethoxychalcone compounds demonstrated improved cytotoxicity against MCF-7 cells and inhibited tubulin assembly in vitro as potently as colchicine. The most active chalcone 1 with the IC50 of 6.18 ± 0.69 μM prevented the proliferation of human cell lines at micromolar concentrations, causing microtubule destabilization and mitotic arrest in humans inhibiting breast cancer cells.

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