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Indonesian Journal of Chemistry

ijc
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Published by Universitas Gadjah Mada

ISSN : 14119420 EISSN : 24601578 DOI : -

Core Subject : Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry

Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology and Higher Education (RISTEKDIKTI) No : 21/E/KPT/2018 (in First Rank) and indexed in Scopus since 2012. Since 2018 (Volume 18), Indonesian Journal of Chemistry publish four issues (numbers) annually (February, May, August and November).

Arjuna Subject : -

Articles 1,956 Documents

95 96 97 98 99

Structure-Based Design and Molecular Dynamics Simulations of Pentapeptide AEYTR as a Potential Acetylcholinesterase Inhibitor Vivitri Dewi Prasasty; Enade Perdana Istyastono
Indonesian Journal of Chemistry Vol 20, No 4 (2020)
Publisher : Universitas Gadjah Mada

Structure-based virtual screening protocol to identify potent acetylcholinesterase inhibitors was retrospectively validated. The protocol could be employed to examine the potential of designed compounds as novel acetylcholinesterase inhibitors. In a research project designing short peptides as acetylcholinesterase inhibitors, peptide AEYTR emerged as one of the potential inhibitors. This article presents the design of AEYTR assisted by the validated protocol and guided by literature reviews followed by molecular dynamics studies to examine the interactions of the pentapeptide in the binding pocket of the acetylcholinesterase enzyme. The molecular dynamics simulations were performed using YASARA Structure in Google Cloud Platform. The peptide AEYTR was identified in silico as a potent acetylcholinesterase inhibitor with the average free energy of binding (DG) of -19.138 kcal/mol.

DFT Study, POM Analyses and Molecular Docking of Novel Oxazaphosphinanes: Identification of Antifungal Pharmacophore Site Khadidja Otmane Rachedi; Rania Bahadi; Mohamed Aissaoui; Taibi Ben Hadda; Billel Belhani; Abdeslem Bouzina; Malika Berredjem
Indonesian Journal of Chemistry Vol 20, No 2 (2020)
Publisher : Universitas Gadjah Mada

A computational Petra/Osiris/Molinspiration/DFT(POM/DFT) based model has been developed for the identification of physico-chemical parameters governing the bioactivity of series of oxazaphosphinanes derivatives 1a-1f containing potential antifungal O,N-pharmacophore. Molecular docking study was performed in order to evaluate synthesized compounds their possible antifungal properties and their interactions in the binding site. Molecular docking studies revealed that the compounds 1a-1f have the potential to become lead molecules in the drug discovery process. The six compounds 1a–1f analyzed here were previously synthesized by our group.

Manganese(III) Complexes with Tetradentate Schiff Base Ligands: IR, UV/Vis, Electrochemistry and Fluorescence Properties Naser Eltaher Eltayeb
Indonesian Journal of Chemistry Vol 20, No 2 (2020)
Publisher : Universitas Gadjah Mada

Three trivalent manganese complexes have been synthesized, isolated, and characterized, namely, [MnCl(OH2)(Lx)].nH2O (I-III). Lx is a tetradentate Shiff base ligand, where Lx = LI, 2,2'-{1,2-phenylenebis [nitrilomethylylidene]}bis(phenolate), LII, 2,2'-{1,2-phenylenebis[nitrilomethylylidene]}bis(5-methoxyphenolate), and LIII, 2,2'-{1,2-phenylenebis[nitrilomethylylidene]}bis(4-methoxyphenolate), n = 1, 1.5 and 0 for I, II and III, respectively. These complexes were characterized using IR, elemental analysis and UV-Vis spectroscopy. In addition, the fluorescence, photoluminescence (PL), electrochemistry and thermal stability of these complexes were studied.

Preservation of Natural Colorant Extract of Jalawe Fruit Peel (Terminalia bellirica) in Water-Based Solution Edia Rahayuningsih; Ayub Wijayanto; Putri Nurfitasari
Indonesian Journal of Chemistry Vol 16, No 3 (2016)
Publisher : Universitas Gadjah Mada

The general objective of this study is to preserve natural colorant extract of jalawe fruit peel in water-based solution during storing. The specific objectives in this research are finding suitable type and amount of antimicrobial compound to prevent biological degradation of the natural colorant jalawe extract, as well as determining the colorant half-life by evaluating its degradation rate. The colorant extract solution was added to a reactor followed by addition of an antimicrobial compound. Samples were taken at certain periods of time and they were then centrifuged to separate the flock from the mixture. The amounts of colorant compound in the solution and microbes in the flock were analyzed using a gravimetric method. The results showed that solutions of formaldehyde in water and chitosan in acetic acid could inhibit the degradation of jalawe extract. The most effective concentrations of formaldehyde and chitosan in the jalawe extract were 0.015 and 0.125%, respectively, with respect to total volume of the extract. The half-life of jalawe extract in a water based solution with the addition of formaldehyde and chitosan was 140 and 180 days respectively, while that without any addition of the antimicrobial compounds was 25 days.

Production by Lintnerization-Autoclaving and Physicochemical Characterization of Resistant Starch III from Sago Palm (Metroxylon sagu rottb) Wiwit Sri Werdi Pratiwi; Anil Kumar Anal; Surya Rosa Putra
Indonesian Journal of Chemistry Vol 15, No 3 (2015)
Publisher : Universitas Gadjah Mada

Indonesia is one of the biggest central distributions of sago starch. There are some characteristics of sago starch which make it difficult to use in variation of foods. In this study, resistant starch type III (RS3) was produced from sago starch by using lintnerization-autoclaving (LA). Physicochemical characterizations of RS3 were compared by native sago starch (NA), hydrolyzed starch by distilled water (DW) and lintnerized starch (L). Amylose content decreased after hydrolyzed by DW and L, but increasing by using LA. Protein and fat contents decreased after hydrolysis, but crude fiber content increasing, the highest value was obtained lintnerized-autoclaved starch. Lintnerized-autoclaved starch has more compact and rigid structure. The RVA viscosity, swelling power and water holding capacity values reduced after all treatments. Oil in water emulsions were also analyzed by mixture of RS3 and emulsifier (casein or SPI). Viscosities of emulsions from RS casein were lower than those of RS-SPI. Emulsion capacity and emulsion stability values were better gotten using RS-SPI than RS-casein. The highest of emulsion capacity was obtained 11.33%. For storage period, the lowest peroxide and anisidine values of mixture RS-emulsifier were resulted from 5% emulsifier + 5% RS + 5% fish oil.

Production of Reducing Sugar from Cassava Solid Waste by Simultaneous Ultrasonication and Acid Hydrolysis Wasinton Simanjuntak; Heri Satria; Nurul Utami
Indonesian Journal of Chemistry Vol 14, No 3 (2014)
Publisher : Universitas Gadjah Mada

In this study, acid hydrolysis of cassava solid waste under ultrasound irradiation for reducing sugar production was studied. A series of experiments was carried out under a 40 kHz ultrasound irradiation, with the main purpose to examine the effect of pHs, hydrolysis times, and temperatures on the concentration of reducing sugar produced. As a control an untreated sample was subjected to thermal hydrolysis under the optimum condition obtained from the hydrolysis experiments under ultrasound treatment. The results obtained indicated that the highest reducing sugar concentration was obtained from the experiment undertaken at pH = 2.0; hydrolysis time of 90 min, and temperature of 80 °C. Experiment conducted at this optimum condition was found to produce reducing sugar with the concentration of 801 mg/L. This concentration around 11 times over that produced from control sample, demonstrating that simultaneous ultrasonication and hydrolysis is far more effective than conventional thermal hydrolysis. This hydrolysis improvement is attributed to the ultrasound stimulated degradation of starch molecules, leading to accelerated hydrolysis due to the cavitations of the molecules, as evidently shown by the result of SEM characterization of the original and ultrasonicated sample.

Improved Synthesis of 2',6'-Dihydroxy-3,4-dimethoxy Chalcone by Grinding Technique to Synthesize 5-Hydroxy-3',4'-dimethoxy Flavone Elfi Susanti VH; Sabirin Matsjeh; Mustofa Mustofa; Tutik Dwi Wahyuningsih
Indonesian Journal of Chemistry Vol 14, No 2 (2014)
Publisher : Universitas Gadjah Mada

5-hydroxy-3',4'-dimethoxy flavone can be efficiently synthesized in two steps via the formation of 2',6'-dihydroxy-3,4-dimethoxy chalcone with good results. 2',6'-dihydroxy-3,4-dimethoxy chalcone as reactants for synthesis of flavones was prepared through Claisen-Schmidt condensation reaction between 2,6-dihydroxyacetophenones,3,4-dimethoxybenzaldehyde and solid NaOH in mortar for 15 min. The yield of the product (70%) is higher than conventional method (65%). This chalcone then oxidatively cyclized with iodine to form 5-hydroxy-3',4'-dimethoxy flavone (yield 62%). Compounds synthesized were characterized by spectroscopic (IR, 1H-NMR, and 13C-NMR).

CONVERSION OF THE LOW QUALITY INDONESIAN NATURALLY-OCCURRING MINERALS INTO SELECTIVE TYPE OF ZEOLITES BY SEED-ASSISTED SYNTHESIS METHOD Rino R. Mukti; Shofarul Wustoni; Agus Wahyudi; Ismunandar Ismunandar
Indonesian Journal of Chemistry Vol 13, No 3 (2013)
Publisher : Universitas Gadjah Mada

An X-ray diffraction (XRD) revealed that Indonesian naturally-occurring mineral from Nanggung, Bogor shows to be a low quality product as it does not seem to contain any zeolite materials. As located in the volcanic area, Indonesia essentially has abundant source of natural zeolites and the country has put much efforts on these treasured materials for export commodity. In order to bring the local natural mineral into high value and to discover whether the mineral has at least zeolitic fragments, we have implemented seed-assisted synthesis to see the possibility of growing zeolite and turn this mineral into high quality. In principle, once the mineral has zeolitic fragment or nuclei, recrystallization of the mineral may occur. By utilizing this mineral as seed in aluminosilicate mother solution, selective mordenite-type (MOR) zeolite can be obtained after hydrothermal treatment. Characterization by XRD showed that this MOR zeolite has high crystallinity and scanning electron microscopy (SEM) depicted the crystal morphology. The natural mineral is conclusively essential for the formation of MOR zeolite by seeding the aluminosilicate mother solution. In the absence of aluminosilicate mother solution, natural mineral can be recrystallized into selective analcime-type (ANA) zeolite. MOR zeolite is known to be useful for several applications such as catalysis whereas ANA zeolite has been considered to be less potential due to relatively small microporosity.

Inhibition of Lipid Peroxidation Induced by Ultraviolet Radiation by Crude Phlorotannis Isolated from Brown Algae Sargassum hystrix v. buxifolium C. Agardh Agnes Nora Iska Harnita; Ign. Edi Santosa; Sudibyo Martono; Sudarsono Sudarsono; Sitarina Widyarini; Frans J.M. Harren
Indonesian Journal of Chemistry Vol 13, No 1 (2013)
Publisher : Universitas Gadjah Mada

This study examines the antioxidant activity of crude phlorotannins from the brown algae Sargassum hystrix v. buxifolium (Chauvin) J. Agardh, through the inhibition of a lipid peroxidation reaction that is induced by the UV radiation. The antioxidant activity during the UV exposure was investigated using the laser-based photoacoustic method for the detection of the ethylene as indicator for lipid peroxidation. This involves an experiment that isolated crude phlorotannins from the ethyl acetate fraction of the Sargassum hystrix methanol extract, hereafter referred to as PFSH. It results in the antioxidant activity as a potent lipid peroxidation inhibitor. Statistically, such antioxidant activity is not significantly different than the commercial antioxidant, which is vitamin C (p > 0.05). The amount of the total phlorotannins, using the Folin-Ciocalteu method, was measured to be approximately 0.13% w/w. In addition, it is found that PFSH contains phlorotannins with low molecular weight (MW) (

Transesterification of Coconut Oil Using Dimethyl Carbonate and TiO2/SiO2 Heterogeneous Catalyst Kamisah D. Pandiangan; Wasinton Simanjuntak
Indonesian Journal of Chemistry Vol 13, No 1 (2013)
Publisher : Universitas Gadjah Mada

In this study, transesterification of coconut oil with dimethyl carbonate (DMC) for preparing biodiesel has been studied using TiO2/SiO2 as heterogeneous catalyst, with the main purpose to investigate the effect of molar ratio of DMC to oil. The product was analyzed by GC-MS to identify the fatty acid methyl esters (FAMEs) composting the biodiesel. The significant role of the DMC to oil ratio was observed in this study, in which the oil conversion was found to increase with increasing molar ratio of DMC : Oil, with the highest percent of conversion of 88.44%. The GC-MS analysis revealed the presence of methyl esters in accordance with the composition of coconut oil commonly reported. Formation of FAMEs was verified by 1H-NMR spectroscopic analysis, which also suggested that some of the fatty acids remain unconverted into biodiesel. The biodiesel produced was found to have kinematic viscosity of 2.4 mm2/S at 40 °C, flash point of 103 °C, and cetane number of 54.

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