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INDONESIA
Indonesian Journal of Chemistry
Published by Universitas Gadjah Mada
ISSN : 14119420     EISSN : 24601578     DOI : -
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry
Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology and Higher Education (RISTEKDIKTI) No : 21/E/KPT/2018 (in First Rank) and indexed in Scopus since 2012. Since 2018 (Volume 18), Indonesian Journal of Chemistry publish four issues (numbers) annually (February, May, August and November).
Arjuna Subject : -
Articles 2,006 Documents
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Green Synthesis of ZnO/Ag Nanocomposite using Psidium guajava: A Study on Characterization and Potential Clinical Application as Advanced Antibacterial Agents on Cotton Bandages Khairunnisa, Yasmin Hasna; Kunarti, Eko Sri; Nuryono, Nuryono
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.110801

Abstract

The development of innovative green antibacterial agents has been proposed as a strategy to combat bacterial resistance and improve wound healing. This research explores the synthesis of ZnO/Ag nanocomposites using guava leaf extract and evaluates their antibacterial properties. The study focused on optimizing ZnO nanoparticle synthesis by adjusting precursor concentrations, followed by Ag modification through variations in Ag precursor levels, pH, and reaction times to achieve optimal ZnO/Ag nanocomposites properties. The optimized ZnO and ZnO/Ag materials were applied to cotton bandages, and both the nanomaterials and the coated bandages were characterized using FTIR, SEM, TEM, and UV-vis-NIR, with their antibacterial activity tested against Staphylococcus aureus and Escherichia coli. The optimal synthesis conditions were identified as 0.60 M ZnO, 1% Ag, 2 h, and pH 12. The characterization results verified the successful synthesis of the ZnO/Ag nanocomposite and its effective coating on cotton bandages. Antibacterial test revealed that the ZnO/Ag demonstrated significantly greater activity than ZnO alone, with inhibition zones measuring 21.35 mm for S. aureus and 3.85 mm for E. coli. These outcomes highlight the potential of biosynthesized nanomaterials for use in clinical wound dressings to promote wound healing.
Simultaneous HPLC Analysis of Asiaticoside and α-Mangostin in Nanoethosomal Carriers Aswan, Pedro Anugerah; Maggadani, Baitha Palanggatan; Fachri, Wilzar; Iswandana, Raditya
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.111150

Abstract

The development of robust analytical methods is essential for quality control of nanoethosomal formulations containing asiaticoside and α-mangostin, bioactive compounds with anti-inflammatory and antioxidant properties. Simultaneous quantification within nanocarriers is challenging and requires validated techniques. This study established a precise HPLC method, in accordance with ICH Q2(R2) guidelines, for the concurrent determination of both compounds. The technique demonstrated excellent linearity (R2 > 0.999), precision (%RSD < 2%), and accuracy (95–105% recovery). The nanoethosomal system also achieved high encapsulation efficiencies of 94.76% for asiaticoside and 99.27% for α-mangostin. This validated method provides a reliable tool for standardizing these complex nano-formulations, supporting their further development and clinical translation.
Eco-Friendly Hydrogel from Sodium Alginate and Orange Peel for Sustainable Soil Conditioning Mohamed, Hajaratul Najwa; Che Ku Mohd Yassin, Che Ku Mohd Faizuldin; Abdullah, Nabihah; Hashim, Norazlina; Mustafa, Shuhaimi; Ab Razak, Abdul Fattah
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.111205

Abstract

An eco-friendly hydrogel was developed from sodium alginate (ALG) and orange peel (OP) powder through ionotropic gelation for application as a sustainable soil conditioner. Limonene (LMN) at 1.5 wt.% was incorporated to enhance the functional properties of the hydrogel. Fourier-transform infrared spectroscopy (FTIR) results confirmed the successful integration of OP into the ALG network through the presence of characteristic hydroxyl and carboxyl functional groups, while thermogravimetric analysis indicated improved thermal stability with increasing OP content due to its lignocellulosic reinforcement. Swelling analysis revealed that the incorporation of 5 wt.% OP enhanced the swelling capacity to 95.5% compared to 65.8% for ALG–LMN alone. However, further increases in OP content (10–15 wt.%) reduced swelling, suggesting excessive filler restricted water diffusion and polymer relaxation. Lower OP concentrations (1–3 wt.%) maintained high water absorption and structural integrity. These findings demonstrate that moderate OP incorporation optimizes the balance between water retention and mechanical stability, indicating strong potential of the ALG–OP–LMN hydrogel as a biodegradable and sustainable soil conditioning material that valorizes agricultural waste.
Bioactive Compounds, Antioxidant Capacity and HMG-CoA Reductase Inhibitory Potential of Red Fruit Oil (Pandanus conoideus Lam.): An In Silico and In Vitro Study Tande, Ribka; Rimbawan, Rimbawan; Palupi, Eny; Kurniasih, Rini; Haerati, Nur
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.111565

Abstract

Cardiovascular disease, the leading cause of death worldwide, can result from dyslipidemia's ability to promote atherosclerosis. Therefore, it is important to address this issue by utilizing local food sources, such as red fruit oil, an endemic fruit from Papua, Indonesia. Red fruit oil contains some bioactive compounds, making it a promising candidate for use in functional foods. This study aimed to assess the bioactive components of red fruit oil, its antioxidant capacity, and its inhibitory potential against 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase enzyme, both in silico and in vitro. The results showed that red fruit oil contained total phenolics of 627.42 ± 61.78 mg GAE/g, flavonoids of 128.06 ± 8.94 mg QE/g, and an antioxidant capacity of 2316.15 ± 135.63 μmol TE/g. Based on the outcomes of in silico investigations, the suspected compounds capable of inhibiting HMG-CoA reductase were isochamaejasm, 6-acetylpicropolin, (−)-pinellic acid, and 2-monolinolein, with binding energies of −8.3620, −7.9660, −7.6980, and −7.6970 kcal/mol, respectively. The in vitro results showed that the inhibitory activity of red fruit oil was 48.36 ± 2.46, which was not significantly different from that of lovastatin 50.82 ± 2.46 (p = 0.288). The findings of this study suggest that red fruit oil may be able to manage dyslipidemia by inhibiting HMG-CoA reductase.
Eco-Friendly Synthesis of Zinc Oxide Using Green Alkaline Solution for Enhanced Solar-Driven Photocatalytic Degradation of Methylene Blue Abbes, Nedra; Fridjine, Sana; Barhoumi, Thouraya; Sejri, Nejib; Jaouachi, Boubaker; Xu, Jun; Abbes, Imene Bekri
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.112000

Abstract

Zinc oxide (ZnO) particles were green-synthesized using an aqueous extract of olive wood ash as a sustainable alkaline precipitating agent. The extract pH stabilized near 13 (40 wt.%), confirming strong alkalinity. A two-step process involved forming a zinc carbonate precursor, followed by calcination at 900 °C. X-ray diffraction confirmed highly crystalline hexagonal wurtzite ZnO. Optical analysis revealed a reduced bandgap of 2.80 eV, significantly lower than the conventional value of 3.37 eV, attributed to lattice defects and elemental incorporation. Evaluating the photocatalytic efficiency against methylene blue under natural solar light, the green-synthesized ZnO achieved nearly 99% removal within 2 h, outperforming conventional ZnO due to enhanced solar absorption from its narrowed bandgap. This work validates a zero-waste pathway for synthesizing highly active nanomaterials, setting a strong precedent for circular economy applications in sustainable photocatalysis.
Syringe Solid-Phase Extraction for Cu(II) in Powder Milk Using Alginate-Chitosan-PVA Adsorbents: Method Development and Application Yaqin, Ahmad Akhib Ainul; Siswanta, Dwi; Suherman, Suherman
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.112867

Abstract

This research designed and optimized a syringe solid-phase extraction (SPE) technique employing a modified chitosan, alginate, and PVA (CAP) adsorbent for the determination and preconcentration of Cu(II) ions in powdered milk samples. The material was characterized using FTIR, SEM-EDX, and XPS analyses, which confirmed the detection of predominant –COOH, –NH2, and –OH functional groups. Optimization of the method was performed using both the one-variable-at-a-time (OVAT) approach and the central composite design (CCD) method. Parameters such as pH, CAP dosage, number of samples, and eluent (including HNO3) were evaluated. Optimal OVAT conditions were pH 4.0, 100 mg CAP, 5 samples, and eluent cycles with 2.0 M HNO3, achieving a 100-fold preconcentration. CCD optimization yielded similar results, with slight variations: optimal pH 4.3, CAP mass 105 mg, and 5 eluent cycles with 2.0 M HNO3. CAP exhibited high selectivity (90–99%) and was reusable for up to three adsorption–desorption cycles. Validation using reference material (ERM–BD151) resulted in a recovery of 95.4% for Cu(II). Application of the validated method to real milk samples yielded recoveries of 90.8–97.8%, demonstrating high accuracy. These findings suggest that syringe SPE using CAP is an efficient technique for Cu(II) preconcentration in food matrices.

Page 201 of 201 | Total Record : 2006

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