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Dian Arrisujaya
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Sains Natural: Journal of Biology and Chemistry
Published by Universitas Nusa Bangsa
ISSN : 20863446     EISSN : 2621508X     DOI : https://doi.org/10.31938/jsn
Core Subject : Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry
Jurnal Sains Natural is a peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication with the objectives to explore the knowledge about natural sciences. This journal incorporates not only all branches of chemistry and biology, but also sub-disciplines like Biochemistry, Polymer, Agricultural chemistry, Environmental chemistry, etc.
Arjuna Subject : Ilmu Pertanian dan Biologi (Semua) - Ilmu Pertanian dan Biologi (Lain-Lain)
Articles 263 Documents
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Liver Histological Response of Female Broodstock Catfish to Dietary Soybean Meal Supplementation VIKA MAULIDIYAH; Rizky Kusma Pratiwi; Muhamad Dwi Cahya; Zakiyyah Nur Inayah; Vina Nur Nadiro; Anissa Aprilia Nurkhasanah; Maura Yasmin Dhia; Fajar Maulana Akmal Firdaus
Sains Natural: Journal of Biology and Chemistry Vol. 16 No. 2 (2026): Sains Natural
Publisher : Universitas Nusa Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31938/jsn.v16i2.970

Abstract

Feed is one of the key factors in fish culture, including the use of plant-based ingredients such as soybean meal as an alternative protein source that may affect the physiological condition of organs, particularly the liver. This study aimed to analyse the effect of soybean meal supplementation in feed on the liver histological response of catfish (Clarias sp.). Liver histological characteristics were evaluated in three treatment groups: a control group (without soybean meal supplementation),  5% soybean meal-supplemented diet, and 10% soybean meal-supplemented diet. The results showed that the control group exhibited a relatively normal liver histological structure, characterised by an orderly arrangement of hepatocytes, centrally located nuclei, and clearly visible sinusoids. In the 5% soybean meal treatment, more pronounced histological alterations were observed, particularly cytoplasmic vacuolization of hepatocytes, indicating moderate to severe steatosis. Meanwhile, hepatocyte vacuolization was also observed in the 10% soybean meal treatment, but with a severity ranging from mild to moderate compared with the 5% treatment. These findings indicate that dietary soybean meal supplementation affects liver histology in catfish through a non-linear response pattern. The 5% dose caused greater tissue alterations than the 10% dose, which may be associated with the adaptive response of hepatocytes to feed exposure. These findings indicate that the use of soybean meal in fish feed should consider an appropriate dosage to maintain liver health.
Water Quality Status of Situ Tlajung Hilir Assessed by The STORET Method Mia Azizah; Eva Muzdalifah; Dian Arrisujaya
Sains Natural: Journal of Biology and Chemistry Vol. 16 No. 1 (2026): Sains Natural
Publisher : Universitas Nusa Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31938/jsn.v16i1.1000

Abstract

Situ Tlajung Hilir is a small lake in Wanaherang Village (Gunung Putri, Bogor Regency) that supports irrigation, recreational fishing, and small-scale aquaculture for the surrounding community. After reports of severe pollution in late 2021, when blackened and malodorous water accompanied by fish kills was linked to domestic and industrial discharges, its present condition warranted re-assessment. This study evaluated the lake’s water-quality status using the STORET method against the Class II criteria of Government Regulation No. 22 of 2021. Samples drawn from three representative points (Points 1–3) on a single sampling occasion (19 March 2023) were examined for temperature, TDS, TSS, pH, COD, BOD, DO, total phosphate, sulphate, dissolved cadmium and lead, and fecal coliform, following the relevant Indonesian National Standards (SNI) and Standard Methods (23rd ed.) through gravimetric, titrimetric, spectrophotometric, ICP-OES, and Most Probable Number techniques. Averaged over the three points, the physical indicators and the dissolved metals stayed within Class II limits, whereas COD (27.35 mg/L), BOD (5.43 mg/L), DO (4.2 mg/L), total phosphate (0.10975 mg/L), and fecal coliform (2000 MPN/100 mL) each breached their thresholds. Summing the penalty scores produced a STORET value of –90, classifying the lake as Class D (heavily polluted), with organic and microbial loading from domestic and adjacent land-use activities as the dominant drivers.
Molecular Docking and Clustering of Apple (Malus sylvestris Mill) and Date (Phoenix dactylifera L.) Metabolites as Anti-Inflammatory Agents Amanda Oktaviani Setiawan; Dr. Harry Noviardi; Nina Imaniar
Sains Natural: Journal of Biology and Chemistry Vol. 16 No. 3 (2026): Sains Natural
Publisher : Universitas Nusa Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31938/jsn.v16i3.971

Abstract

Inflammation is the body's defense response to infections, physical injuries, metabolic disorders, and autoimmune diseases. Foreign agents will attach to TLR (Toll Like Receptor) and initiate the activationNF-κB within nucleus. This signaling induce release of IL-1β, IL-6, TNF-α, and iNOS. The manalagi apple and sukari date fruit are known to have bioactive compounds like flavonoids and phenols that could help reduce inflammation. This study seeks to identify the potential compounds in Malus sylvestris Mill, and Phoenix dactylifera L. as anti-inflammatory agents that inhibit the cytokines IL-1β, IL-6, TNF-α, and iNOS. These compounds were tested with parameters such as binding affinity (∆G), inhibition constant (Ki), physicochemical properties, absorption, distribution, metabolism, excretion, and toxicity (ADMET), as well as molecular dynamics. Ellagic acid, one of the 76 compounds obtained, has the potential to be an effective anti-inflammatory agent. It inhibits IL-1β (-4.901 kkal/mol and 0.9918 uM), IL-6 (-6.424 kkal/mol and 0.9892 uM), iNOS (-8.597 kkal/mol and 0.9856 uM), and TNF-α (-9.347 kkal/mol and 0.9843 uM). Ellagic acid has a molecular weight of 302.194 g/mol, a LogP partition coefficient of 1.3128, 4 hydrogen donors, and 8 hydrogen acceptors. Ellagic acid also has good ADME properties with a toxicity class of 6, non-mutagenis, and non-hepatotoxic.

Page 27 of 27 | Total Record : 263

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