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INDONESIA
Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Published by Perkumpulan Obstetri dan Ginekologi Indonesia
ISSN : 23386401     EISSN : 23387335     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.
Arjuna Subject : -
Articles 11 Documents
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Search results for , issue "Volume 12 No. 3 Jully 2024" : 11 Documents clear
The Antibiotic Prescribing Practices of Gynecologists in Abdominal Hysterectomy Tjokroprawiro, Brahmana Askandar; Khoirunnisa Novitasari; Ulhaq, Renata Alya; Aldika Akbar, Muhammad Ilham
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 3 Jully 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i3.1954

Abstract

Objective: To evaluate the pattern of antibiotics used for abdominal hysterectomy by gynecologists in infected and non-infected cases. Methods: Data was collected through an online survey of gynecologists in Surabaya, Indonesia. Results: A total of 200 gynecologists were involved in this study. All of them used prophylactic antibiotics in all cases of abdominal hysterectomy, and the most commonly used was cefazoline (70.5%), followed by ceftriaxone (15.5%) and cefotaxime (9%). Most gynecologists (68%) gave 2 grams of prophylactic antibiotic, and 79,5% of antibiotics were administered within 30 minutes before surgery. Additional antibiotics during surgery were given in prolonged surgery (79.01%) and intraoperative bleeding > 1500 mL (48.14%). The most common additional dosage used was 1 gram (72.9%), and most gynecologists (37.2%) continued antibiotics for one day ahead. The type of therapeutic antibiotics used for infected cases was varied, consisting of ceftriaxone (50.5%), metronidazole (42%), cefotaxime (17%), cefazoline (15.5%), gentamicin (12%), ampicillin-sulbactam (4%), and amoxicillin-clavulanic acid (3.5%). Most gynecologists (43.7%) gave these antibiotics for three days. Conclusion: The majority of gynecologists in Surabaya already use prophylactic antibiotics for abdominal hysterectomy and therapeutic antibiotics for infected cases following the existing guidelines
Expression of Yap Signaling Hippo Pathway in Cervical Pre-cancerous Lesions and Cervical Cancer Rizal, M Masrur; Arifa Mustika; Wita Saraswati
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 3 Jully 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i3.1983

Abstract

Abstract Objective: To determine the expression of YAP in cervical pre-cancerous and cervical cancer lesions.Methods: Researchers systematically searched five databases using the checklist for Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) guideline and Newcastle-Ottawa Scale (NOS).. Inclusion criteria were the original study of YAP expression in cervical pre-cancerous lesions and cervical cancer, observational and experimental study, and using immunohistochemical techniques. The study protocol was registered in the PROSPERO database of systematic review (IDCRD42023407469). Results: The data search in this study followed the PRISMA Guideline, which includes phases of identification, screening, and inclusion of studies. Initially, 245 articles were identified across five databases: Pubmed (105), ScienceDirect (8), Scopus (29), Web of Science (26), and ProQuest (77). After removing duplicates, 157 studies remained. During the initial screening, 142 studies were excluded, leaving 15 studies for further evaluation. These were assessed based on the use of immunohistochemistry staining for YAP expression and staining result. Subsequently, ten studies were excluded for either not using immunohistochsmistry or lacking staining result, resulting in five studdies selected for qualitative analysis. These five studies were evaluated using the New Ottawa Scale, as detailed in Table 1, and their YAP Expression characteristics are summarized in Table 2. Conclusion: This systematic review showed that YAP expression at all levels ranging from normal tissue, cervical intraepithelial neoplasia, squamous cell carcinoma, and adenocarcinoma had increased expression in the cytoplasm or cell nucleus following the development of cervical cancer and tumorigenesis influenced by intra-tumor heterogeneity for YAP expression. YAP is expressed in the cytoplasm and nucleus, with different functions. YAP expression in these two sites Excessive YAP expression will trigger epithelial changes into mesenchyme which also plays a role in cancer development. This YAP expression also correlates with HPV, in which YAP levels will be maintained and increased.Keywords: cervical cancer, cervical pre-cancerous lesions, YAP expression.
Anemia in Pregnancy and Its Maternal Perinatal Outcome Indra Putra, Iriawan; Joice Margaretha Mathilda Sondakh; Juneke Joice Kaeng
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 3 Jully 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i3.1989

Abstract

Objective: To investigate the relationship between anemia in pregnancy and maternal perinatal outcomes. Methods: This was a retrospective cohort study. This research was held at Prof. Dr. R. D. Kandou General Hospital Manado. Data was taken from January 2021 to December 2022. Results: There were 1953 deliveries which 1304 subjects (66.7%) with anemia 649 subjects with anemia (33.3%), 489 subjects with mild anemia, and 160 subjects with moderate-severe anemia. The median maternal age was 28 years for mild anemia. The majority of mothers have a high school education. A total of 326 study subjects were multigravidas with mild anemia. The results of severe preeclampsia with mild anemia were 30 subjects. Prolonged labor tends to be higher in the mild anemia group. The highest distribution was observed in the mild anemia group, with 12 cases of maternal mortality, 88 cases of premature birth, 78 cases of low birth weight (LBW), 75 cases of disorders leading to decreased scores, and 24 cases of fetal mortality. In research subjects, IUGR tends to be more common in groups with moderate-severe anemia with 14 subjects (8.8%). Hemoglobin levels showed a median of 11.6 g/dL with a distribution midway between 10.5 and 12.6 g/dL. The mean MCV value is 76.1 fL (SD 8 fL). The mean MCH value was 24.8 + 3.6 pg. The MCHC value is 32.5%. Conclusions: There are no significant relation in pregnant women with anemia with preeclampsia, prolonged labor, maternal mortality rate and IUGR, but there are significant relation between anemia in pregnancy with increase rate of caesarean section, premature delivery, low birth weight, low APGAR score and fetal death. Keywords: anemia in pregnancy, maternal outcome, neonatal outcome
Polymorphism specific Allele Frequencies on Cervical Cancer Salih Saihood, Anwar; Jabbar Hussein , Khawlah; Sharif , Yasamin Hamza
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 3 Jully 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i3.2093

Abstract

Objective: To evaluate the correlation of allele frequencies of IL-6 polymorphisms between healthy women and cervical cancer patients.Methods: The study involved gynecologists diagnosing abnormal cervical tissue in 100 women aged 17-60. Each woman provided two tissue samples: one for pap smear analysis and one for genetic research, along with a blood sample for IL-6 polymorphism analysis. Traditional polymerase chain reaction (PCR) was used for genetic analysis to confirm diagnoses. Allele-specific PCR (AS-PCR) was utilized to identify allelic polymorphisms. Pap smears identified cervical intraepithelial neoplasia (CIN) II and III, characterized by dysplastic cells and mitotic figures.Results: The diagnostic PCR data demonstrated that 36% of participants were HPV-infected, with the greatest infection rates (50%). The AS-PCR reported that the IL-6 (rs1800795) gene detected at 174 G/C position was presented with GG, GC, and CC genotypes. Conclusion: The result showed a significant alteration in the IL-6 (rs1800795) gene, strongly correlating with cervical cancer based on human papillomavirus infection.Keywords: cervix cancer, human papillomavirus, interleukin-6 polymorphism, genetic analysis.
Multidisciplinary Approach of Placenta Accreta Spectrum Management to Reduce Blood Loss and Prevent Organ Injury in Referral Center Nugraha, Gagah Baskara Adi; Yuliantara, Eric Edwin
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 3 Jully 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i3.2098

Abstract

Objective: To investigate the differences in blood loss and organ injury at our PAS referral center over the past six years.Methods: This retrospective analytical study included 150 subjects diagnosed with PAS based on histopathological findings from 2018 to 2023 at the PAS Center of Dr. Moewardi Regional Hospital, Surakarta, Indonesia. Subjects were divided into two groups: before 2020 and after 2021, based on multidisciplinary team appointments.Results: The highest number of Placenta Accreta Spectrum (PAS) cases occurred in 2020, with 36 patients. Hysterectomy was the most frequently performed procedure for managing PAS in all groups. However, differences in blood loss, organ injury, and length of hospital stay between the periods from 2018 to 2020 and 2021 to 2023 were statistically significant (p < 0.05).Conclusion: Multidisciplinary approaches involving various medical specialties and teams are essential to ensure maternal safety and effectively manage massive blood loss and organ damage during PAS surgery procedures.Keywords: Placenta accreta spectrum, Blood loss reduction, Organ injury prevention.
Effectiveness of the Telemedicine Approach on Maternal Health Practices among Pregnant Women in Rural Areas Bonifasius; Kayika, I Putu Gede; abdul madjid, omo; Seno Adjie, Josef Maria; Marceliano Rumopa, Harold Immanuel
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 3 Jully 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i3.2100

Abstract

Objectives: To systematically evaluate the current evidence on the effectiveness of the telemedicine approach on maternal practices in rural communities. The author hopes that this study offers a breakthrough to draw a solid conclusion regarding the feasibility of implementing telemedicine to improve maternal health in rural areas of Indonesia.Methods: A systematic literature search was performed using international databases, such as Cochrane, PubMed, EBSCOhost, Science Direct, Scopus, and Google Scholar, published from 2012 to August 31, 2022. Risk of bias assessment was conducted using the Cochrane Risk of Bias tools 2.0 for randomized controlled trials and converted to the AHRQ standards.Results: This study included five randomized controlled trials from different countries, namely India, Ethiopia, and Kenya. Telehealth interventions, delivered using mobile applications, phone calls, or short text messaging, improved the number of ANC visits, safe childbirth in hospitals or by skilled staff, exclusive breastfeeding, and immunization compliance, with a significant difference compared to the control group that received no intervention (p<0.05). Nevertheless, considering the already widely used mobile phone technologies in rural settings, it is now clear that the telehealth approach should be scaled up and implemented in clinical settings.Conclusion: Telehealth-based intervention is a promising approach to promote better maternal health practices among pregnant mothers in rural and low-resources settings. This approach has been proved to successfully made a significant difference in terms of antenatal care visits and safe childbirth practice.Keywords: Maternal health practices, pregnant women, rural areas, systematic review, telemedicine.
The impact of Gestational Weight Gain on Preeclampsia During COVID-19 Pandemic Anugra, Lalu Rifal Hadi; Danianto, Ario; Irawati, Deasy
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 3 Jully 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i3.2119

Abstract

Objective : To determine the Effect of Gestational Weight Gain on Preeclampsia During COVID-19 Pandemic in Public Health Centers of The West Lombok Regency Methods : This study is an observational analytic study that uses a case control study design (case control) starting by identifying patients with effects (preeclampsia and/or eclampsia) and groups without effects (no preeclampsia and/or eclampsia) and then retrospectively tracing their risk factors at 3 public health centers, which are located in West Lombok Regency, NTB Province, Indonesia namely Narmada, Kediri and Gunung Sari Health Centers. The analysis was carried out using the SPSS application. Results: Total of 120 samples were obtained, with 60 case samples and 60 control samples. During the COVID-19 pandemic with a time span of 2020-2021, subjects with weight gain that did not meet the recommendations had more preeclampsia, namely 56 people (93.3%) than subjects who did not had preeclampsia, which was 32 people (53.3 %). The value of Odds Ratio (OR) is 12,25 (95% Confidence Interval, 3.941-38.078). Conclusion : Based on this study, there was a significant relationship between the increase in BMI and the incidence of preeclampsia during the COVID-19 pandemic. The increase in BMI that is not in accordance with the recommendations is a risk factor for the occurrence of preeclampsia in pregnant women. The majority of preeclampsia occurs in 3rd trimester pregnant women. In addition, the Odds Ratio value obtained in this study increased by 6 times compared to similar studies conducted in non-pandemic conditions. Keywords : Preeclampsia, Eclampsia, Gestational Weight Gain, COVID-19
Pregnancy after Succesful Fallopian Tube Recanalization Gunardi, Eka Rusdianto; Trisha Alya Rahmi; Nur Fitri Fadila
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 3 Jully 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i3.2219

Abstract

Objective: To report a pregnancy that ensued following the successful recanalization of a previously sterilized fallopian tube. The novel aspect of this report is its demonstration of a successful intrauterine pregnancy post-recanalization, despite a prior ectopic pregnancy resulting from tubal sterilization. Methods: Case report Case: A 35-year-old woman successfully conceived after the recanalization of a previously sterilized fallopian tube. It is noteworthy that she had previously experienced an ectopic pregnancy due to the tubal sterilization procedure. Conclusion: This case study highlights the potential for successful pregnancy following fallopian tube recanalization, even after an ectopic pregnancy caused by a prior sterilization procedure. This report underscores the complexity of reproductive outcomes in these scenarios. Keywords: fallopian tube recanalization, pregnancy, tube sterilization.
Peripheral Serum AMH Level Reflects the Size of the Follicle Pool in a Mouse Model Study Suratih, Ni Made Desy; Wiweko, Budi; Maidarti, Mila; Wuyung, Puspita Eka; Jusuf, Ahmad Aulia; Louisa, Melva; Kekalih, Aria
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 3 Jully 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i3.2220

Abstract

Objective: This is to compare peripheral and central serum levels of Anti-Mullerian hormone (AMH) in experimental animals for predicting ovarian reserve. Methods: This is an experimental study involving 20 female Sprague-Dawley rats aged 8–10 weeks with normal estrus cycles as the young control group and 5 female rats aged 28–30 weeks as the old control group (n = 5/group): the young control group, the old control group, the 1x cisplatin group, the 2x cisplatin group, and the 3x cisplatin group. After treatment, tissue collection, histological staining, and blood collection through the retro-orbital bleeding (ROB) and heart were performed. Subsequently, measurements of ovarian weight, follicle counting, and levels of AMH and Follicle-stimulating hormone (FSH) were conducted.Results: The serum AMH levels from ROB in the young control, 1x cisplatin, 2x cisplatin, 3x cisplatin, and the old control groups were 1151, 1818, 2782.96, 1381.352, and 1544 ng/mL, respectively. Cisplatin 2x group was significantly (p<0.005) higher compared to the young control. The average concentrations of serum AMH in the ROB and heart were higher in the 2x cisplatin group compared to the other groups. Meanwhile, cisplatin 3x group decreased in level due to the burn out phenomenon. Conclusion: AMH is a preferred marker compared to FSH. Blood collection through the ROB is considered a less invasive alternative technique in the treatment group, requiring serial observation. Keywords: AMH, follicle pool, ovarian aging, ROB
Hypertriglyceridemia - Induced Acute Pancreatitis in Pregnancy Aziz Pridianto, Faris; Sunarko, Agung
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 3 Jully 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i3.2270

Abstract

Introduction: Acute pancreatitis in pregnancy (APIP) is a rare case. The mortality rate for pregnant women due to pancreatitis is reported at 37 percent and fetal mortality rate is up to 60percent. Hypertriglyceridemia (4percent-10percent) is known as the third most common cause of acute pancreatitis. There is one study reported that hypertriglyceridemia-induced acute pancreatitis (HTGP) reached up to 56percent of APIP cases. CasePresentation: A 33-year-old woman, GIIIP2002 32/33 weeks came with shortness of breath, preceded by severe heartburn, nausea and fever. There was a decrease in consciousness, with high blood pressure, and tachycardia. The patient had no history of high blood pressure during routine ANC. From the laboratory results, leukocytes were 22,670/pL, random blood sugar level 713 mg/dL, severe metabolic acidosis on the results of blood gas analysis, amylase was 1,004.8 U/L, lipase was 899.4 U/L, and triglyceride was 789 mg/dL. From the results of an abdominal CT scan with contrast, were consistent with the description of acute pancreatitis. Discussion: In pregnant patients with severe heartburn, with no previous history of high blood pressure, it may be suspected to be caused by an acute pancreatitis. If there are no risk factors of alcohol abuse, hypertiglyceridemia can be suspected as the cause. Triglycerides normally increase during pregnancy, but their values do not reach a concentration that can cause an acute pancreatitis. Conclusion: Patients with risk factors for increased triglycerides, both in patients and families, require strict monitoring. Quick diagnosis and appropriate therapy are the keys to treat acute pancreatitis. Keywords: Acute pancreatitis, hypertriglyceridemia, pregnancy, preeclampsia

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