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Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)

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Published by Perkumpulan Obstetri dan Ginekologi Indonesia

ISSN : 23386401 EISSN : 23387335 DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.

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Articles 1,760 Documents

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Effect of the Feeding of Formula Milk Enriched with Pro-Antioxidants for the Prevention of Preeclampsia; Study of High Sensitivity C-Reactive Protein (hs-CRP) and Cell-Free mRNA of Plasminogen Activator Inhibitor-1 (PAI-1) in Plasma Wibowo, Noroyono
Indonesian Journal of Obstetrics and Gynecology Volume. 35, No. 4, October 2011
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Objective: To evaluate the effect of the feeding of formula milk enriched with pro-antioxidants to high sensitivity C-reactive protein (hs-CRP) and cell-free mRNA of Plasminogen Activator Inhibitor-1 (PAI-1) in the first trimester, second trimester, and post labor for the prevention of preeclampsia. Method: This is double-blinded randomized clinical trial in 8-12 weeks pregnant woman with low (below 900 Î¼mol/l) Ferric Reducing Ability of Plasma (FRAP), as a marker of low systemic antioxidant. A total of 104 samples were collected from patients who had antenatal care in Bunda Hospital Jakarta, Budi Kemuliaan Hospital, and Dr.Cipto Mangunkusumo General Hospital from January 2007 until December 2009. From block randomization, 49 samples were allocated in the case group, and 55 samples to the control group. A formula milk enriched with pro-antioxidants was fed to the case group throughout their pregnancy, and a regular pregnancy formula milk was fed to the control group. Hs-CRP and cell-free mRNA PAI-1 test in the two groups at first trimester, second, and post labour was conducted. The incidence of preeclampsia was then compared in the two groups. Result: Significant difference (p

Pengaruh isoflavone genistein dan daidzein ekstrak tokbi (Pueraria lobata) strain Kangean terhadap jumlah osteoblas dan osteoklas Rattus Novergicus Wistar hipoestrogenik WIYASA, I. W.A.; NORAHMAWATI, E.; SOEHARTONO, SOEHARTONO
Indonesian Journal of Obstetrics and Gynecology Volume. 32, No. 3, July 2008
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Tujuan: Membuktikan pengaruh pemberian isoflavone genistein dan daidzein (IGD) ekstrak tokbi (Pueraria lobata) strain Kangean terhadap jumlah osteoblas (OBL) dan osteoklas (OKL) Rattus novergicus Wistar hipoestrogen. Bahan dan cara kerja: Penelitian eksperimental ini diawali dengan studi pendahuluan untuk menentukan konsentrasi IGD dalam ekstrak tokbi dan membuat model tikus hipoestrogen. Menggunakan 28 tikus betina, 6 tikus normal sebagai kelompok pertama dan 22 tikus hipoestrogen dibagi menjadi 4 kelompok sebagai kelompok 2, 3, 4, dan 5. Kelompok tikus hipoestrogen terdiri dari 6 tikus ovariektomi (OVX), 5 tikus OVX diberi IGD (OVX + IGD) 15 mg/kg BB/hari, 5 tikus OVX + IGD 30 mg/kg BB/hari, dan 6 tikus (OVX + IGD) 60 mg/kg BB/hari. Semua kelompok diterapi selama 21 hari. Parameter yang digunakan adalah jumlah OBL dan OKL. Hasil: Satu ml ekstrak Pueraria lobata mengandung 282,53 ppm IGD dengan komposisi 231,11 ppm daidzein dan 51,41 ppm genistein. Didapatkan perbedaan bermakna jumlah OBL dan OKL antara kelompok OVX dan OVX + IGD pada semua dosis (p < 0,05). Jumlah OBL terbesar dan OKL terkecil terdapat pada kelompok OVX + IGD 30 mg/ kg BB/hari. Kesimpulan: IGD dari ekstrak Pueraria lobata dapat meningkatkan OBL dan menurunkan OKL pada semua dosis, terutama dosis 30 mg/ kg BB/hari. [Maj Obstet Ginekol Indones 2008; 32-3: 148-52] Kata kunci: isoflavone, genistein, daidzein, tokbi, osteoblas, osteoklas, hipoestrogen.

Uterine Perforation on Invasive Hydatidiform Mole during EMACO Treatment Pradipta, Bram
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 3, July 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: Improving skill and knowledge to recognize and manage a rare case of uterine perforation on invasive hydatidiform mole. Method: Case report. Result: A 42 years old Indonesian woman, Parity 2 Abortus 2 with history of 2 c-sections and 2 curettage, came with chief complaint of recurrent vaginal bleeding since 4 months before admission. Patient had a history of previous curettage with indication of hydatidiform mole and recurrent bleeding with no histopathology results. On examination we found a vesicular mass with infiltration, destroying the right-front uterine corpus, size 8x6 cm with an internal echo mass. Chest x-ray showed multiple nodules in the lung. The patient, considered as low risk Gestational Trophoblastic Neoplasia patient with FIGO Score of 6, underwent chemotherapy with 2 series of methotrexate . Due to the non-declining level of -hCG, the regimen was added with EMACO. In the process of chemotherapy, the pa-tient’s-hCG declined but then she complained of major abdominal pain. Exploratory laparotomy was performed and we found a mass sized 5x5x5 cm on the right side of the uterus at the broad ligament with a rupture at the posterior part of the mass sized 0.5x0.5 cm. Upon incision of the uterus, we found a mass from the right side protruding to the isthmus of the uterus. Histopathology showed necrosis, blood and chorionic villi in myometrium corresponding to invasive mole. Patient was then given another 5 series of EMACO and her condition was unremarkable during the remaining course of treatment. Conclusion: Invasive mole treatment is determined based on the risk factors. Uterine perforation still occurred in this case regardless of the decreasing hCG level during EMACO treatment. It emphasizes the importance of clinical examination as chemotherapy responsiveness. Long-term treatment can have a good prognosis but good collaboration between the gynecologist and the patient is essential. [Indones J Obstet Gynecol 2014; 3: 162-165] Keywords: EMACO, invasive mole, perforation

Glutathione Peroxidase1 Gene Polymorphism (GPx1 Pro198Leu) in Association with Blighted Ovum Moshtaghi, Asiyeh; Sariri, Reyhaneh; Vaziri, Hamidreza; Shayegan, Horiyeh
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No. 1, January 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To evaluate salivary GPx-1 gene polymorphism in pregnant women suffering from blighted ovum. Method: In this case-control study, 34 blighted ovum patients and 34 healthy controls were studied. Genomic DNA was extracted from the saliva. The genotypes were determined by restriction fragment length polymorphism (RFLP-PCR) technique. Mad Calc (version 12.1) was used for statistical analysis. Result: The frequency of CC, CT, and TT genotypes of GPx-1 gene were 41%, 44% and 14%, respectively in blighted ovum patients and in healthy volunteers were 44%, 47%, and 8.82-9%, respectively. After statistical analysis, the study showed no significant association between this polymorphism and blighted ovum (with p = 0.63). Conclusion: These results indicated no significant association between GPx-1 (Pro198Leu) polymorphism and blighted ovum. However, further research is required to clarify the role of gene polymorphism in blighted ovum. [Indones J Obstet Gynecol 2016; 1: 15-18] Keywords: abortion, blighted ovum, glutathione peroxidase-1, GPx- 1, RFLP-PCR

A Comparative Study of Nomegestrol Acetate and a Combination of Ethinylestradiol and Levonorgestrel for Delaying Menstruation among Umrah Pilgrims Tindar, Mirzah; Effendi, Yusuf; Abadi, Adenan; Theodorus, Theodorus
Indonesian Journal of Obstetrics and Gynecology Volume 6. No. 1. January 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To compare the effectiveness efficacy of nomegestrolacetate with and combination of ethinylestradiol and levonorgestrelas a regimen for delaying menstruation in Umrah pilgrims in Palembangcity.Methods: This single-blind randomized controlled trial was conductedin Hajj and Umrah Guidance Group in Palembang city duringDecember 2016 to January 2017. Population of this study was 30women who meet the inclusion and exclusion criteria. Frequencyand distribution of data was described in a table. Effectiveness andthe side effects treatment between the two groups were analyzedwith Chi Square test. Data was were analyzed using SPSS version18.0.Results: There were no differences in age, education, occupation,parity, body weight, height and contraceptive history betweentwo both groups (all p values > 0.05). Statistical analysis showedthere was no difference in spotting between nomegestrol acetate5 mg or a combination of levonorgestrel 150 mcg and 30 mcgethinylestradiol in Umrah pilgrims (p = 1.000). Other side effectssuch as (dizziness, depression, breast tenderness, heavy limbs,nauseam and vomiting) between the two groups could not beanalyzed because all subjects did not experience any other sideeffects.Conclusion: There is no difference in effectiveness betweennomegestrol acetate 5 mg or combination of levonorgestrel 150mcg and 30 mcg ethinylestradiol as a regimen for delayingmenses in Umrah pilgrims in Palembang city.[Indones J Obstet Gynecol 2018; 6-1: 45-49]Keywords: delay menstruation, ethinylestradiol, levonorgestrel,nomegestrol, side effects, spotting, umrah

Management Therapy in Chronic Ectopic Pregnancy Pradana, Aryando
Indonesian Journal of Obstetrics and Gynecology Volume. 34, No. 4, October 2010
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Objective: Improving skill in making a diagnosis and management therapy in chronic ectopic pregnancy. Method: Case Report. Conclusion: Diagnosis of chronic EP is difficult to establish before surgery. Conservative treatment using medication (methotrexate) can not be applied to chronic EP because the Î²-hCG level is difficult to be detected. [Indones J Obstet Gynecol 2010; 34-4: 199-203] Keywords: ectopic pregnancy, chronic ectopic pregnancy

Hubungan pajanan infeksi helicobacter pylori dengan kejadian hiperemesis gravidarum ASIH, D.M.R.
Indonesian Journal of Obstetrics and Gynecology Volume. 33, No. 3, July 2009
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Tujuan: Mengetahui keterkaitan dan besar risiko infeksi Helicobacter Pylori terhadap kejadian Hiperemesis Gravidarum. Tempat: Ruang perawatan kebidanan dan poliklinik RSUPN Dr. Cipto Mangunkusumo, RS Fatmawati, RSPAD Gatot Subroto Jakarta, RSUD Tangerang. Rancangan/rumusan data: Penelitian bersifat Comparative Cross Sectional yang membandingkan adanya Ig G anti Helicobacter Pylori pada kelompok kasus perempuan hamil dengan Hiperemesis Gravidarum dan kelompok kontrol yaitu perempuan hamil yang asimptomatik. Bahan dan cara kerja: Penelitian dilakukan selama 15 bulan (Agustus 2006 - Oktober 2007). Selama periode tersebut didapat 55 perempuan hamil usia gestasi 6-16 minggu yang menderita Hiperemesis Gravidarum dan 55 perempuan hamil asimptomatik dengan usia gestasi yang sama. Dilakukan anamnesa, pemeriksaan fisik, ultrasonografi, pemeriksaan laboratorium: darah tepi, SGOT, SGPT, ureum, kreatinin, gula darah, urinalisa, keton urin dan serologi IgG anti Helicobacter Pylori. Adanya infeksi Helicobacter Pylori ditandai dengan adanya IgG pada serum sampel yang ditegakkan dengan pemeriksaan ELISA di Laboratorium Biomedik RSU Mataram, sedangkan diagnosis Hiperemesis Gravidarum ditegakkan dengan gejala klinis dan keton urin positif. Data penelitian diolah dengan menggunakan program STATA 8, analisa kesetaraan kelompok penelitian dengan uji chi square dan analisa multivariat dengan metoda regresi logistik bagi variabel independen yang menunjukkan kemaknaan pada analisa bivariat. Hasil: IgG anti Helicobacter Pylori positif didapat pada 37 perempuan (67,3%) kelompok kasus, dan 19 perempuan (34,5%) kelompok kontrol. Prevalensi Helicobacter Pylori seropositif pada kelompok kasus 56,97% - 77,63% dan pada kelompok kontrol 29,96% - 39,04% (95% CI). Terdapat hubungan bermakna antara infeksi Helicobacter Pylori dengan kejadian Hiperemesis Gravidarum (p 0,001). Didapati pula hubungan bermakna antara indeks masa tubuh (IMT) 25 dengan kejadian Hiperemesis Gravidarum (p 0,014). Tidak didapati perbedaan bermakna pada usia, pendidikan, pekerjaan serta jumlah anak. Kesimpulan: Perempuan hamil muda yang terinfeksi Helicobacter Pylori dan perempuan hamil muda dengan berat badan berlebih, berisiko lebih tinggi mengalami Hiperemesis Gravidarum. [Maj Obstet Ginekol Indones 2009; 33-3: 143-50] Kata kunci: infeksi helicobacter pylori, serologi, hiperemesis gravidarum

Korelasi Akurasi antara Kateter dengan Ultrasonografi Transabdominal untuk Mengukur Volume Kandung Kemih DEWI, T. I.; Santoso, Budi I; KARSONO, B.; JUNIZAF, JUNIZAF
Indonesian Journal of Obstetrics and Gynecology Volume. 30, No. 2, April 2006
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Tujuan: Mencari korelasi antara kateterisasi dengan USG transabdominal untuk mengukur volume KK dan volume urin sisa dan menentukan nilai diagnostik USG transabdominal untuk mendiagnosa retensio urin. Rancangan penelitian: Penelitian ini merupakan studi observasional analitik dengan rancangan potong lintang (cross sectional) untuk menilai korelasi dan menentukan nilai diagnostik. Tempat penelitian: (1) Klinik Anggrek Divisi Fetomaternal Departemen Obstetri dan Ginekologi RS Dr. Cipto Mangunkusumo (RSCM), (2) IGD Lt. III RSCM. Bahan dan cara kerja: Selama kurun Oktober 2003 sampai Agustus 2004, dilakukan pengukuran volume KK dan volume urin sisa pada 90 pasien postpartum nifas hari pertama, kedua dan ketiga. Volume KK dan volume urin sisa diukur secara USG transabdominal dibandingkan dengan hasil pengukuran secara kateterisasi yang merupakan baku emas. Volume KK dianggap merupakan kapasitas KK dan volume urin sisa ialah urin yang masih terdapat dalam KK segera setelah pasien berkemih. USG transabdomina1 digunakan untuk mendiagnosa adanya retensio urin dengan titik potong urin sisa 200 ml dan kateterisasi sebagai baku emas. Dilakukan 3 formula USG (formula 1, 2 dan 3). Hasil: Untuk pengukuran volume KK didapatkan korelasi yang kuat antara USG formula 1, 2 dan 3 dengan tindakan kateterisasi, masingmasing dengan R 0,84, 0,87 dan 0,80, tapi hanya formula 2 USG yang menghasilkan pengukuran volume KK yang tidak berbeda bermakna dengan tindakan kateterisasi. Pada pengukuran volume urin sisa didapatkan korelasi yang kuat antara USG formula 1, 2 dan 3 dengan kateterisasi masing-masing R 0,85, 0,87 dan 0,85, juga hanya formula 2 yang menghasilkan pengukuran urin sisa yang tidak berbeda bermakna dengan tindakan kateterisasi. USG formula 2 dapat mendiagnosa kondisi retensio urin dengan Se 87%, Sp 95,5%, NDP (nilai duga positif) 87% dan NDN (nilai duga negatif) 96%. Kesimpulan: Pengukuran volume KK dan volume urin sisa secara ultrasonografi transabdominal mempunyai korelasi yang kuat dengan tindakan kateterisasi. Sehingga USG transabdominal dapat dijadikan sebagai alternatif dari penggunaan kateter. Hal ini akan membuat tindakan kateterisasi menjadi lebih selektif. Terutama dalam hal diagnostik seperti kondisi retensio urin, sehingga penggunaan USG transabdominal akan mengurangi efek samping berupa infeksi dan trauma akibat penggunaan kateter yang bersifat invasif. [Maj Obstet Ginekol Indones 2006; 30-2: 104-11] Kata kunci: vo1ume KK, volume urin sisa. USG transabdominal, kateterisasi.

Compatibility between Menstrual Pictogram Assessment and Haemoglobin Assessment in Abnormal Uterine Bleeding Yulianti, Fitri; Manan, Heriyadi; Nurtjahyo, Awan; Husin, Syarif
Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 3 July 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the amount of wasted blood and diagnosedAUB and determine amount of decrease in haemoglobinlevels by adjusting the examination of menstrual pictogramwith haemoglobin.Methods: Diagnostic test was conducted in the DepartmentObstetrics and Gynecology Dr. Mohammad Hoesin/Faculty ofMedicine Universitas Sriwijaya Palembang, start from January 2015through January 2017. Sample was obtained from 39 patients withabnormal uterine bleeding who meet the inclusion and exclusioncriteria. Frequency and distribution of data are described in tablesand cross analyze (cut-off point) to find cut points differencemenstrual pictogram and a decrease in haemoglobin levels usingROC curve. Accuracy is measured by the value of Kappa. Dataanalysis using SPSS version 21.Results: From 39 samples that obtained, majority characteristicsage > 35 years (59%), ideal BMI (59%) and multiparous(48.7%). From statistical analysis, there was significanceassociation between haemoglobin measurement toolsand menstrual pictogram (p = 0.063). Both measuring deviceshave compatibility in predicting the type of AUB (p = 0.047),with the degree of conformity is weak (Kappa = 0.232).Conclusion: Accuracy of menstrual pictogram examination andhaemoglobin has a weak degree of conformity, so menstrualpictogram examination can’t be used to determine a decrease inhaemoglobin levels. Menstrual pictogram menstruation only usedas an evaluation of therapeutic response.[Indones J Obstet Gynecol 2018; 6-3: 172-178]Keywords: abnormal uterine bleeding, haemoglobin, menstrual pictogram

Giant Condyloma Acuminatum in a Woman with AIDS Nuranna, Laila
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 4, October 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Objective: To describe a case of Giant Condyloma Acuminatum with aspect of HIV and some concerns about the CD4. Result: We describe 2 cases, the first case is a giant Condyloma in HIV patient and the second case is a giant Condyloma in pregnant woman. The patient in the first case was a 40-year-old woman with AIDS (CD4 is 290) who was undergoing anti-retroviral therapy. She was found to have a giant condyloma acuminatum of the vulva. Electrocautery excision was performed, and afterwards the quality of life has improved significantly. The second case patient is a 30-year-old G4P3A0 woman with a giant condyloma acuminatum. She was 30 weeks pregnant with a single fetus. On the external genitalia there was a giant condyloma mass on the vulva extending towards the peri-anal area, obstructing the introitus. The electrocautery excision was performed. She was discharged from the hospital on the second day in good condition. She had a spontaneous delivery after reaching full term. Conclusion: Although the giant Condyloma Acuminatum is combined with HIV, but itâs not as difficult as imagined because the tumorâs base is not wide, but shaped like inverted mushroom and it is not necessary to do local flap reconstruction. [Indones J Obstet Gynecol 2012; 36-4: 206-10] Keywords: electrocautery excision, giant condyloma acuminatum, surgery in AIDS

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