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Radioterapi & Onkologi Indonesia
Published by Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia
ISSN : 20869223     EISSN : -     DOI : -
Core Subject : Health, Science, Education,
Education Health Professions Medicine & Pharmacology Physics Other
Majalah Radioterapi & Onkologi Radiasi Indonesia (Journal of the Indonesian Radiation Oncology Society) dengan ISSN 2086-9223, satu-satunya majalah dalam bidang Onkologi Radiasi di Indonesia, merupakan majalah di bawah penerbit Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI). Majalah ini rutin diterbitkan sejak tahun 2010 dengan frekuensi terbitan 2 kali dalam setahun.
Arjuna Subject : -
Articles 108 Documents
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Profile of Cervical Cancer Management with Radiation and Chemoradiation Therapy at The Radiotherapy Installation of RSUP Dr. Mohammad Hoesin Palembang Nurhidayat, Wahyudi; Andriani, Dini; Yuhedi, Lucky Taufika; Diyana, Wahyu
Radioterapi & Onkologi Indonesia Vol 15, No 1 (2024): Vol.15, No. 1(2024): Volume 15 No. 1 January 2024
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v15i1.165

Abstract

Cervical cancer is a gynecologic malignancy that ranks as the second most common cancer affecting women, following breast cancer. Recommended therapy for locally advanced cervical cancer, according to PNPK (National Guidelines for Cancer Services) is chemoradiation or radiotherapy. The aim of this study is to present a comprehensive analysis of the management cervical cancer with chemoradiation and radiation therapy, which will allow for a comparison of outcomes, specifically the clinical tumor response and radiation-related side effects, in patients with locally advanced cervical cancer who received either radiation therapy alone or a combination of chemoradiation. This research is a retrospective observational study using our hospital database in 2022. SPSS was used for the data analysis. The study findings indicated a notable disparity between chemoradiation therapy and radiation alone in terms of treatment outcomes for patients with stage III cervical cancer, with a p-value of 0.011. The findings of this study indicate that the projected number of new cervical cancer cases at the RSMH Palembang Radiotherapy Installation in 2022 was 194 patients. The age ranged from 27 to 75 years, with an average age of 49.59 ± 9.29 years. A significant proportion, specifically 42%, of the domicile addresses of most patients originate from Palembang City and its surrounding areas. Stage III was the most advanced stage of patients, with a prevalence of 76%. The distribution of cervical cancer cell types was predominantly squamous cell carcinoma, accounting for approximately 80%, with adenocarcinoma comprising the remaining 20%. The overall efficacy of therapy for cervical cancer, regardless of the stage, was 63.5%.
AFATINIB MONOTHERAPY FOR DOUBLE-PRIMARY LOCALLY ADVANCED NON-SMALL CELL LUNG CANCER EXON-21 L861Q MUTATION WITH HISTORY OF COLORECTAL CANCER Jamnasi, Juli; Yeoh, Rudiyo; Sudibio, Sudibio; Hendrik, Hendrik
Radioterapi & Onkologi Indonesia Vol 15, No 1 (2024): Vol.15, No. 1(2024): Volume 15 No. 1 January 2024
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v15i1.164

Abstract

Introduction: Uncommon mutation exon-21 L861Q is a rare type Non-Small Cell LungCancer (NSCLC). Despite the limited data regarding this type of mutation, Afatinib as one of the oral tyrosine kinase inhibitors (TKI) shows good anti-tumor activity.Clinical Features: A 50-year-old woman with a history of post-operative colorectal cancer (2014) without undergoing chemotherapy and radiotherapy; came in October 2020 with severe dyspnea due to massive pleural effusion with a right lower lung bulky mass. Histopathology in 2014 was a low-grade adenocarcinoma colorectal cancer, while the biopsy of the right lung mass in 2020 was a mucinous adenocarcinoma, ALK-negative, TPS 1.75, and exon-21 L861Q mutation.Intervention and Outcomes: The patient underwent thorax drainage to evacuate pleural effusion fluid. Through multidisciplinary discussions, the patient was recommended to take the oral drug TKI Afatinib 40 mg OD in January 2021. On the 2nd week of taking Afatinib, the patient complained of painful swallowing, mouth sores, sore tongue, and joint pain throughout the body; confirmed to be the side effects of the drug. Complaints diminished with supporting drugs, however, did not resolve completely. CT scan in April 2021 showed a significant reduction in lung mass. Due to severe side effects and drastic weight loss, the Afatinib dose was reduced to 20 mg OD. Radiotherapy was incorporated in her treatment session with IMRT to cover the whole tumor.Discussion: Determining the best treatment to treat the patient was initially difficult due to the raising doubt regarding the correlation between the current lung cancer with her previous history of colorectal cancer. Treating the newer lung mass as primary cancer was obviously different rather than treating lung metastatic colorectal cancer. This issue could then be resolved by incorporating more thorough NGS examination. With the finding of exon-21 L861Q mutation in this patient, Afatinib monotherapy is considered the therapy of choice.
The Role of Respiratory Control in Radiation Therapy Management Ronald, Andreas; Gondhowiardjo, Soehartati Argadikoesoema
Radioterapi & Onkologi Indonesia Vol 14, No 1 (2023): Volume 14 No.1 July 2023
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v13i2.146

Abstract

The goal of radiotherapy is to eradicate the tumor but still consider the surrounding normal organs. However, this is not easy to achieve because there are many factors that influence the process of external radiation. These factors are broadly divided into 2, namely intra-fraction motion and inter-fraction motion. It contributes to acute and late effect. These acute and late effects can be an obstacle in attempting to increase the dose in the tumor. this literature review will discuss the problems and developments of radiation techniques in relation to intra-fraction problems due to respiratory movements.
Utilization of hypofractionated radiotherapy for breast cancer among Indonesian Radiation Oncologists during and after pandemic COVID-19 Nugroho, Rafiq Sulistyo; Bani Kuncoro, Elia Aditya; Huswatun, Aida Lufti
Radioterapi & Onkologi Indonesia Vol 15, No 1 (2024): Vol.15, No. 1(2024): Volume 15 No. 1 January 2024
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v15i1.150

Abstract

Background: The incidence of breast cancer (BC) increases over time. However, the availability of radiotherapy machines is minimal, especially after the COVID-19 pandemic. Hypofractionated radiotherapy (HFRT) may provide a solution for this situation. We intended to evaluate the practice of HFRT for BC patients amongst the Indonesian Radiation Oncologist Society members.Material and methods: This study uses a Google Form questionnaire distributed personally in early October 2021. Statistical analysis uses descriptive and Chi-square/Fisher tests.Results: Twenty-nine participants filled out the questionnaire. One-third of participants worked at Academic Hospital and were aged 35 - 45 years old. Most of the participants had working experience of fewer than ten years. 4 (13.8 %) and 3 (10.3 %) participants preferred HFRT for WBI with or without regional node irradiation. Only one participant selected HFRT for PMRT. 9 (31 %) and 8 (27.5 %) participants chose both HFRT and CFRT for postmastectomy with or without reconstruction. Conclusion: The utilization of HFRT in routine practice amongst Indonesian RO is still low despite proven clinical benefits. Continuing medical education about evidence-based may increase the translation of clinical trials into daily practice.
Case Report and Literature Review of Spinal Glioblastoma Multiforme in Childhood Pasaribu, Ulinta Purwati; Primasari, Mirna; Erawati, Dyah
Radioterapi & Onkologi Indonesia Vol 14, No 1 (2023): Volume 14 No.1 July 2023
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v13i2.152

Abstract

We report a case of a 15 year old girl, with weakness on the lower extremities and sensory loss especially on the right side. MRI showed an intramedullary intraspinal mass at thoracic to lumbar spine level (T10-L1). A partial resection was performed and the result of pathology anatomy was  Glioblastoma multiforme (GBM) WHO grade IV. She received adjuvant chemotherapy and craniospinal irradiation.
RADIOTHERAPY RESPONSE IN ADVANCED STAGE OF CERVICAL CANCER TYPES OF HISTOPATHOLOGY SQUAMOS CELL CARCINOMA AND ADENOCARCINOMA Sindunata, Natasha Bharat; Pratiwi, Eka Indah; lubis, arlavinda asmara
Radioterapi & Onkologi Indonesia Vol 15, No 1 (2024): Vol.15, No. 1(2024): Volume 15 No. 1 January 2024
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v15i1.158

Abstract

Background: Cervical cancer is a malignancy that occurs on the cervix, and it is the most common cancer in the world. According by GLOBOCAN in 2020, cervical cancer ranks seventh globally. The main management of advanced cervical cancer is using radiotherapy. The problem that occurs is the need for radiation for advanced cervical cancer patiens while there is still a lack of availability of radiotherapy equipment, causing under treatment management.Objective: To prove that the response to radiotherapy in patients with advanced cervical cancer types of histopathology squamous cell carcinoma is better than adenocarcinoma in Ulin General Hospital, BanjarmasinMethods: The study used an analytic observational design with a cross sectional approach. The sample was taken over the time span during the study from January 2021 to December 2022 and was taken by total sampling.Results: The total sample was 128 cervical cancer patients with 91 squamous cell carcinoma samples and 37 adenocarcinoma samples. After conducting a chi-square analysis between several variables and response to therapy, a significant relationship was found between histopathology and response to therapy, which concluded that cervical cancer with histopathology of squamous cell carcinoma is more radiosensitive than adenocarcinoma. This is due to the relationship between VEGF and radiation.Conclusion: The response of radiotherapy is more sensitive in type of histopathology squamous cell carcinoma than in cervical cancer with type of histopathology adenocarcinoma.
Radiotherapy-Resistant Pediatric Bladder Rhabdomyosarcoma: A Case Report Dhamiyati, Wigati; Dwidanarti, Sri Retna; Kurniawan, Torana; Ekaputra, Ericko; Mediana, Lidya; Yanuarta, Seize Edwiena
Radioterapi & Onkologi Indonesia Vol 14, No 1 (2023): Volume 14 No.1 July 2023
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v13i2.151

Abstract

AbstractIntroduction : Rhabdomyosarcoma (RMS) is a type of malignancy that is relatively rare and originates from soft tissue. RMS can appear at any age but is most common in children and toddlers. Rhabdomyosarcoma managed use chemotherapy as the main modality, followed by surgery or radiation if there was residual or recurrence.Case Presentation : In this report, the author will review a case of radioresponsiveness pediatric bladder rhabdomyosarcomaThe patient received chemotherapy with cyclophosphamide-mesna, vincristine, and actinomycin. After chemotherapy, the mass was reduced partially and then followed by whole bladder external radiation.Conclusions : Rhabdomyosarcoma in the child's bladder may exhibit radioresistance characteristics Keywords : rhabdomyosarcoma, radiation, pediatric, bladder
Treatment of Primary Hepatocellular Carcinoma (HCC) with Active Pencil Beam Scanning Protons in Singapore Yoo, Seunghoon
Radioterapi & Onkologi Indonesia Vol 15, No 1 (2024): Vol.15, No. 1(2024): Volume 15 No. 1 January 2024
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v15i1.160

Abstract

We report a patient with HCC treated with protons for the first time in Singapore. The prescription was 66 Gy in 10 fractions. Treatment plans and proton beam delivery was performed using an active pencil beam scanning mode using the Probeam system (Varian Medical, Palo Alto, CA). Two treatment plans, one is deep inspiration breath holding (DIBH) and the other is free breathing (FB) plan, were prepared following observation of liver motion during 4DCT image acquisition. For the actual treatment, the free breathing mode plan was selected since the DIBH mode was not advisable following evaluation of patient setup image prior to the first treatment. 

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