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Radioterapi & Onkologi Indonesia

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Published by Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia

ISSN : 20869223 EISSN : - DOI : -

Core Subject : Health, Science, Education,

Education Health Professions Medicine & Pharmacology Physics Other

Majalah Radioterapi & Onkologi Radiasi Indonesia (Journal of the Indonesian Radiation Oncology Society) dengan ISSN 2086-9223, satu-satunya majalah dalam bidang Onkologi Radiasi di Indonesia, merupakan majalah di bawah penerbit Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI). Majalah ini rutin diterbitkan sejak tahun 2010 dengan frekuensi terbitan 2 kali dalam setahun.

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Articles 108 Documents

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Preoperative Radiotherapy in Rectal Cancer Irwan Ramli; - Sudibio; Fitri Anugrah
Radioterapi & Onkologi Indonesia Vol 10, No 1 (2019): VOLUME 10 NO.1 JANUARI 2019
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Rectal cancer is the third most common types cancer in the world and rank second as a cause of cancer related deaths in 2018. Surgical is the main modality in treatment of rectal cancer, however preoperative radiotherapy significantly reduces local recurrence risk after surgery. At present there are two different schedules of preoperative radiotherapy, short-course preoperative radiotherapy (25 Gy at 5 fractions) followed by immediate surgery and long-course chemoradiotherapy (45-50 Gy at 25-28 fractions) followed by delayed surgery. Although the purpose and local control rate of both schedules is the same, it is indicated in different conditions.

Cancer Profile in South Jakarta: A 5-year descriptive study Soehartati Argadikoesoema Gondhowiardjo; Febryono Basuki Raharjo; Elian Hudiya; Sri Mutya Sekarutami; Nadia Christina; Steven Octavianus; R. Koesmedi Priharto; - Widyastuti
Radioterapi & Onkologi Indonesia Vol 9, No 2 (2018): VOLUME 9 NO. 2 JULI 2018
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

There has been an effort of cancer registry in Cancer Control Program, especially Hospital-based, but it would not be useful if the data and procedure was not standardized. This study was a cross-sectional study with cancer data collected from every health facility in South Jakarta from 2017, April to May. Inclusion criteria was every patient that resided in South Jakarta from 2008, January 1st to 2012, December 31st with no exclusion criteria. Five most common cancers for male are hematopoietic and reticuloendothelial systems, nasopharynx, lung, lymph nodes, and liver cancer, respectively. Five most common cancers in female are breast, cervix uteri, ovarium, hematopoietic and reticuloendothelial systems, thyroid gland cancer, respectively. Cancer patients were comprised by female a lot more than male with 1.86:1 frequency comparison. Compared to data from Malaysia and Singapore in the same period of time, there were some differences in cancer profile between the countries. Based on the data reviewed, the quality was not perfect, one of the examples is shortcoming of SriKandi form which was used to input the data, especially occupation data. This can be a refinement point for future research and registry of cancer in Indonesia.

Nasopharyngeal Carcinoma Profile in dr. Cipto Mangunkusumo Hospital Year 2013 Soehartati Argadikoesoema Gondhowiardjo; Lidya Meidania; Fajar Senoaji; Sri Mutya Sekarutami
Radioterapi & Onkologi Indonesia Vol 10, No 1 (2019): VOLUME 10 NO.1 JANUARI 2019
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Background: Nasopharyngeal carcinoma (NPC) remains as a health burden in Indonesia. It is one of most common cancers in Indonesia, with an overall incidence estimated at 6.2/100,000 or 12,000 new cases per year. Unfortunately, many of these cases are unregistered due to several factors, such as lack of national cancer registry. In most developing countries, cancer registration often begins in hospitals. Hospital-Based Cancer Registry (HBCR) provides the initial and major source of information on patients that leads to the set-up of a population-based registry.Materials and Methods: This was a descriptive retrospective study of all registered NPC patient in HBCR, from January-December 2013. All registered NPC patients in HBCR in the year 2013 is included.Results: There were 299 NPC patients, with a male-to-female ratio of 2.4:1. Median age was 47 years old, with majority of age between 40-49 years old (27.4%). Most common type of histology was undifferentiated NPC (85%). Most patients presented with locally advanced disease, with majority of stage IVA (33.9%). Chemoradiation remained as standard treatment for locally advanced NPC (84.1%).Conclusion: Demographic data of patients, such as age and sex, are consistent with previous studies. Whereas racial distribution was not parallel with previous studies, maybe due to its lack of available data. Moreover, most common histopathology type and presentation was undifferentiated NPC and patients with Stage III to IV cancer.

Cancer Profile in West Jakarta: A 5-year descriptive study Soehartati Argadikoesoema Gondhowiardjo; Denny Handoyo; Mahesa Auzan; Sri Mutya Sekarutami; Nadia Christina; Steven Octavianus; R. Koesmedi Priharto; - Widyastuti
Radioterapi & Onkologi Indonesia Vol 9, No 2 (2018): VOLUME 9 NO. 2 JULI 2018
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Background. Cancer burdens the government in terms of health care funding. Unlike Indonesia, cancer information and data in other several countries are handled by a program called The National Program of Cancer Registries (NPCR), managed by the Centers for Disease Control and Prevention (CDC). This study was aimed to describe the cancer profile in West Jakarta Region from 2008 to 2012 due to insufficient data provided by the government.Methods. This was a cross-sectional, descriptive study involving all cancer patients residing in West Jakarta based on the medical record of Cipto Mangunkusumo Hospital, acting as DKI Jakarta Cancer Registry Control Center.Results This study found 4,057 cancer cases in the area. Five most commonly diagnosed cancer cases based on the sites of disease are breast cancer (22,5%), cervical cancer (10,3%), lung and bronchus cancer (7,5%), nasopharyngeal cancer (5,3%), and hemopoietic and reticuloendothelial malignancies (5,3%). Most cases were diagnosed in advance stage (III and IV) and predominantly in women aged 45 – 54 years old. Intraductal carcinoma was the most common morphology type for breast cancer cases.

Cervical Cancer Profile in dr. Cipto Mangunkusumo Hospital Year 2013 Soehartati Argadikoesoema Gondhowiardjo; Adji Kusumadjati; Prasetya Wibisono; Sri Mutya Sekarutami
Radioterapi & Onkologi Indonesia Vol 10, No 1 (2019): VOLUME 10 NO.1 JANUARI 2019
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Background: Cervical cancer ranks in the second place based on the malignancy among female sex in Indonesia with a prevalence of 14.4% and a mortality rate of 10.3%. Hospital-Based Cancer Registry (HBCR) is a system of cancer registration in a hospital that can provide information about the general information of cancer patients, treatment, and outcome of treatment. This study was conducted to obtain the profile of cervical cancer in dr. Cipto Mangunkusumo general hospital (RSCM) in 2013 based on data from HBCR RSCM.Methods: The study was conducted by extracting the epidemiological data and cervical tumor data from HBCR RSCM in 2013 which was then analyzed descriptively.Results: The result showed that cervical cancer ranks at the second place from all the malignancy at RSCM (12%, n= 678), with domicile mostly come from outside Jakarta (52.8%, n = 358). The average age of cervical cancer was 49.48 years, the most common occurs in the age range 45-49 years. In terms of histopathology, squamous cell carcinoma is the most prevalent type of histopathology (74.2%, n = 447). The surgery is a type of action that done for early-stage cervical cancer (83,3%, n = 25), whereas the action of radiation is mostly done in locally advanced cervical cancer (79,9%, n = 273).Conclusion: Nevertheless, cervical cancer has a significant health burden in Dr. Cipto Mangunkusumo general hospital which is needed further management.

Cancer Profile in Central Jakarta : A 5-Year descriptive study Soehartati Argadikoesoema Gondhowiardjo; Montesquieu Silalahi; Donald Arinanda Manuain; Sri Mutya Sekarutami; Nadia Christina; Steven Octavianus; R. Koesmedi Priharto; - Widyastuti
Radioterapi & Onkologi Indonesia Vol 9, No 2 (2018): VOLUME 9 NO. 2 JULI 2018
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Background: Global Burden of Cancer 2012 (GLOBOCAN 2012) estimated 14.1 million new cases of cancer worldwide in 2012. This data was obtained from countries that have a population-based cancer registry. Cancer registration is useful in classifying information from all cancer cases to generate statistics of cancer incidence in a particular population as well as providing a framework for interpreting and controlling the impact of cancer in the community. Indonesia has not had a population-based cancer registry currently. The Minister of Health of Indonesia has designated Dr. Cipto Mangunkusumo Hospital as a control center for cancer registration to establish a population-based cancer registry in Jakarta province.Methods: This cross-sectional descriptive study aimed to describe the cancer profile in Central Jakarta 2008-2012 based on data of RSCM as cancer registry control center in Jakarta province. The data were collected using Srikandi form, a form for cancer registry in Dr. Cipto Mangunkusumo Hospital.Result: The results obtained 1,797 cases of cancer in Central Jakarta from 2008- 2012 with male and female ratio of 1:1.9. The majority of patients came to health providers with advanced stage. The most common cancers were breast cancer, uterine cervical cancer, hematopoietic and reticuloendothelial system cancer, nasopharyngeal cancer, lung and bronchial cancer and lymph node cancer.Conclusions: This research has some similarities with data from GLOBOCAN 2012. However, it is to be noted that data showed that many patients come in an advanced stage of cancer. Moreover, some part of the research data is incomplete due to inadequacy in the filling process of Srikandi form.

Primitive Neuroectodermal Tumour of the Maxilla Sinistra Region Maryam Fathima; Sri Mutya Sekarutami
Radioterapi & Onkologi Indonesia Vol 10, No 1 (2019): VOLUME 10 NO.1 JANUARI 2019
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Primitive neuroectodermal tumors (PNET) are a group of malignant tumors composed of small round cells of neuroectodermal origin that affect soft tissue and bone. PNET have a rare incidence, occurring usualy in children and adolescents, rarely in adults. In this case report are focus of Peripheral primitive neuroektodermal tumors. Peripheral primitive neuroectodermal tumors (PNETp) are a group of aggressive malignancies that most commonly present in multiple tissues and organs including kidney, adrenal, bladder, liver, small intestine, colon and rectum, with a preferred location within the chest area (thoracopulmonary region), in the limbs and around the spine, but rarely, in the head and neck area. Here we present a case of the maxilla sinistra PNETp in a 17-year-old girl and we discuss the clinical features, histopathological characteristics, diagnosis, and treatment.

Cancer Profile in East Jakarta: A 5-year descriptive study Soehartati Argadikoesoema Gondhowiardjo; Fathiya Juwita Hanum; Rizka Hanifah; Sri Mutya Sekarutami; Nadia Christina; Steven Octavianus; R. Koesmedi Priharto; - Widyastuti
Radioterapi & Onkologi Indonesia Vol 9, No 2 (2018): VOLUME 9 NO. 2 JULI 2018
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Background: Global Burden of Cancer (GLOBOCAN) 2012 estimated there were 8.2 million cancer deaths worldwide, 65% of them were in developing countries. In Indonesia, the cancer incidence is 134 per 100,000 population. The magnitude of the burden caused by cancer requires a valid data collection in each country in an effort to plan and evaluate cancer prevention programs in the future. Based on Indonesian Minister of health decree, Dr. Cipto Mangunkusumo Hospital (RSCM) was determined as Cancer Registry Control Center in DKI Jakarta Province. This study aims to report Cancer Profile in East Jakarta 2008-2012 based on RSCM Data.Methods: This research was a cross-sectional descriptive study. Patient data were extracted from DKI Jakarta Cancer Registry Control Center Located at RSCM. The primary site and histology of malignancies were identified and coded based on the International Classification of Diseases for Oncology.Results: There were 3748 cancer patients who live in East Jakarta, with male and female ratio of 1:1.9. Most of them were between 45-54 years old. The majority of patients came to health providers with advanced stage (stage 3 and 4). At both sexes the most frequent cancer were breast cancer, followed by cervical cancer, hematopoietic and reticuloendothelial system malignancy, nasopharyngeal cancer, and lung and bronchial cancer. The five most common cancers in men were nasopharyngeal cancer, hematopoietic and reticuloendothelial system malignancy, lung and bronchial cancer, liver and intrahepatic bile duct cancer, and lymph node cancer, respectively. While in women, the five most common cancers were breast cancer, cervical cancer, ovarian cancer, hematopoietic and reticuloendothelial system malignancy and thyroid gland cancer, respectively.Conclusion: Most of cancer patients are in productive age and the majority of them came at advanced stage. Furthermore, three of five most common cancer charge both genders (hematopoietic and reticuloendothelial system malignancy, nasopharyngeal cancer, and lung and bronchial cancer).

Peran Radioterapi pada Melanoma Kulit Fathiya Juwita Hanum; Nana Supriana
Radioterapi & Onkologi Indonesia Vol 10, No 1 (2019): VOLUME 10 NO.1 JANUARI 2019
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Melanoma maligna merupakan keganasan sel penghasil pigmen (melanosit) yang terutama terdapat pada kulit, namun dapat juga ditemukan pada mata, telinga, mulut, saluran cerna, mukosa genital dan leptomeningen. Melanoma adalah kanker kulit yang bersifat sangat agresif dengan peningkatan insiden pada beberapa dekade terakhir.Pembedahan merupakan modalitas utama dan paling efektif pada kasus melanoma. Namun, pada kondisi dimana pembedahan tidak dapat dilakukan secara radikal atau terdapat faktor prognostik yang buruk dari hasil histopatologi pasca operasi, maka diperlukan terapi adjuvan sebagai tambahan. Dalam kaitannya dengan hal tersebut, radioterapi memiliki peran yang efektif. Lebih lanjut, indikasi radiasi, dosis dan fraksinasi serta target volume akan dipaparkan pada tinjauan ini.

Faktor-Faktor yang Memengaruhi Penurunan Body Mass Index Sebelum dan Sesudah Radioterapi pada Pasien Kanker Kepala Leher Putri Elisabet Sinaga; Juli Jamnasi; Sumihar MR Pasaribu; Hendriyo -
Radioterapi & Onkologi Indonesia Vol 10, No 2 (2019): VOLUME 10 NO.2 JULI 2019
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Latar Belakang: Kanker Kepala Leher (KKL) merupakan suatu istilah yang digunakan untuk menggambarkan semua jenis keganasan yang berasal dari saluran aerodigestif atas. Modalitas pengobatan yang efektif untuk pasien KKL adalah radioterapi. Namun demikian, modalitas tersebut berkontribusi terhadap penurunan nilai Body Mass Index (BMI) pasien KKL akibat dari efek samping radioterapi khususnya pada rongga mulut.Tujuan: Penelitian ini bertujuan untuk mengetahui faktor-faktor yang memengaruhi penurunan BMI sebelum dan sesudah menjalani radioterapi pada pasien KKL.Metode Penelitian: Analitik, dengan pendekatan quasi experimental dan rancangan penelitian pre and post design. Penelitian ini melibatkan 26 pasien KKL yang menjalani radioterapi di Rumah Sakit Murni Teguh Medan (RSMT).Hasil Penelitian: Pasien KKL mengalami rata-rata penurunan BMI sebanyak 2,10 poin sampai minggu terakhir radioterapi. Rata-rata penurunan berat badan BB yang dialami pasien sampai minggu terakhir radioterapi adalah sebesar 5,22 kg. Penurunan BMI paling besar terjadi pada minggu ketiga ke minggu keempat radioterapi. Pasien dengan terapi kemoradiasi mengalami penurunan BMI yang lebih besar dibandingkan pasien yang menerima radiasi saja. Hasil analisis menunjukkan terdapat hubungan yang signifikan antara mukositis (p= 0.046) terhadap penurunan BMI. Namun, tidak terdapat hubungan yang signifikan antara disfagia (p=0.548), dan kandidiasis (p=0.235) sebagai efek samping radioterapi yang muncul terhadap besar penurunan BMI pada pasien KKL.Kesimpulan: Dalam penelitian ini, ditemukan adanya hubungan yang signifikan antara mukositis sebagai efek samping radioterapi terhadap besar penurunan BMI pada pasien KKL

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Darmadi Hariyanto

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