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Radioterapi & Onkologi Indonesia
Published by Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia
ISSN : 20869223     EISSN : -     DOI : -
Core Subject : Health, Science, Education,
Education Health Professions Medicine & Pharmacology Physics Other
Majalah Radioterapi & Onkologi Radiasi Indonesia (Journal of the Indonesian Radiation Oncology Society) dengan ISSN 2086-9223, satu-satunya majalah dalam bidang Onkologi Radiasi di Indonesia, merupakan majalah di bawah penerbit Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI). Majalah ini rutin diterbitkan sejak tahun 2010 dengan frekuensi terbitan 2 kali dalam setahun.
Arjuna Subject : -
Articles 108 Documents
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Kadar Plasma Epstein-Barr Virus (EBV) DNA sebagai Parameter Prognosis pada Kanker Nasofaring Tidak Berkeratin Sinta Prastiana Dewi; - Handoko; Marlinda Adham Yudartho; Soehartati Argadikoesoema Gondhowiardjo
Radioterapi & Onkologi Indonesia Vol 11, No 1 (2020): VOLUME 11 NO.1 JANUARI 2020
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v11i1.107

Abstract

Kanker Nasofaring (KNF) merupakan keganasan yang sering ditemukan di Asia.1 Puncak insidensi KNF berada pada usia dewasa muda dan pada pasien usia 55 – 59 tahun.2 Radioterapi merupakan terapi standar untuk KNF stadium awal, sedangkan pada stadium lokal lanjut diberikan kemoradiasi.1 KNF telah terbukti memiliki keterkaitan dengan Epstein Barr Virus (EBV). Dengan berkembangnya biologi molekular, konsentrasi DNA tumor dalam plasma dan serum pada pasien KNF dapat diukur secara kuantitatif dengan polymerase chain reaction (PCR).3 Plasma EBV DNA berguna dalam hal diagnosis, pemantauan respon terapi, dan prediktor prognosis pada pasien KNF.1,3 Penulisan tinjauan pustaka ini ditujukan untuk menambah pengetahuan mengenai manfaat pemeriksaan kadar plasma EBV DNA pada pasien KNF.
The Role of Radiotherapy towards Pediatric Cancer Agustinus Darmadi Hariyanto; Hari Murti Wijaya; Jellyca Anton; Seize Edwiena Yanuarta; Steven Octavianus; Handoko Handoko; Endang Nuryadi; Soehartati Argadikoesoema Gondhowiardjo
Radioterapi & Onkologi Indonesia Vol 11, No 2 (2020): VOLUME 11 NO.2 JULY 2020
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v11i2.117

Abstract

Cancer is the leading cause of death in children worldwide. Pediatric cancer is challenging to detect early because it generally appears with signs and symptoms that are not typical. The increase in cancer cases in pediatric must be followed by an increase in cancer management in all fields of scientific disciplines. Radiation oncology, as one of the areas of science, has an essential role in definitive, adjuvant, palliative, and prophylactic cancer in pediatric. Apart from these uses, radiation management is a significant contributor to the complications of pediatric cancer survivors. Complications that arise can be in the form of growth retardation, tissue changes, secondary cancer, neurocognitive changes, infertility, or other hormonal dysfunction and preterm labor. An increase in radiation techniques followed the development of treatment machines able to reduce radiation-related morbidity and mortality rates. In pediatric radiotherapy, the entire process from the pre-procedure anesthesia to radiotherapy requires special attention. Psychological issues are also worth observing. This study will briefly discuss these matters and the management of some of the most common pediatric cancers in Dr. Cipto Mangunkusumo Hospital.
Radioterapi Pada Meningioma Anak Fenny Tjuatja; Tiara Bunga Mayang Permata; Renindra Ananda Aman; Soehartati A. Gondhowiardjo
Radioterapi & Onkologi Indonesia Vol 11, No 1 (2020): VOLUME 11 NO.1 JANUARI 2020
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v11i1.108

Abstract

Meningioma pada anak termasuk kasus yang jarang dijumpai, hanya dijumpai pada 0,4 - 4,6% dari seluruh tumor otak primer anak. Ada beberapa hal yang membedakan meningioma anak dan dewasa, seperti : ditemukannya gambaran kistik pada pencitraan, lebih sedikit dural tail, lebih agresif dan seringnya ditemukan rekurensi dibanding dewasa. Terapi utama meningioma adalah operasi reseksi tumor, dan pada jenis yang ganas diberikan radioterapi adjuvan. Kemoterapi masih sangat jarang digunakan dengan sedikitnya bukti klinis yang ada. Pada artikel ini, dilaporkan kasus meningioma atipikal pada anak pasca gross tumor resection yang mendapatkan radioterapi untuk mengurangi resiko rekurensi lokal.
Response to External Radiation and Interstitial Brachytherapy in Bulky Vulvar Cancer I.A.Trisna Kumala Dewi; Sri Mutya Sekarutami
Radioterapi & Onkologi Indonesia Vol 11, No 2 (2020): VOLUME 11 NO.2 JULY 2020
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v11i2.112

Abstract

Vulvar cancer is a gynaecologic malignancy with an incidence of 3-5% of all gynaecologic malignancies. In Indonesia, number of new cases of vulvar cancer reaches 1153 cases with a mortality rate of 420. Multimodal therapy is the main therapy of vulvar cancer at advanced stage which consists of of surgery, radiotherapy, and chemotherapy. The role of brachytherapy as adjunctive therapy combined with EBRT is widely studied, especially its role in the management of patients with comorbidities or contraindications to surgery. The purpose of writing this case report is to assess the response of radiotherapy in the form of external beam radiotherapy (EBRT) and brachytherapy use the MUPIT applicator in patients with vulvar cancer. From the relevant studies, we obtain a good 5-year overall survival rate, disease free survival rate, and local control with tolerable complications. It can be concluded that the combination of EBRT and brachytherapy can be one of the therapeutic modality of choice in vulvar cancer.
The Applicability of Neutrophil-Lymphocyte Ratio in Predicting The Survival of Nasopharyngeal Cancer: An Evidence Based Case Report Vito Filbert Jayalie; Nadiyya Faza Zhafirah; Sri Mutya Sekarutami
Radioterapi & Onkologi Indonesia Vol 12, No 1 (2021): VOLUME 12 NO.1 JANUARY 2021
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v12i1.132

Abstract

Background: Having high prevalence and mortality with a distinctive geographical distribution, nasopharyngeal cancer (NPC) has caused a huge burden in the world. There are several prognostic factors in NPC, however additional marker is needed to give a better picture on disease outcome. Innate and adaptive immunity play a great role in disease progression, however, the role of neutrophil-lymphocyte ratio (NLR) is still controversial. This study aims to investigate the role of NLR status as a prognostic factor in NPC. Methods: Literature searching was conducted through Pubmed, Cochrane, Proquest, EBSCO and Science Direct under specific keywords. Further filtering double and screening for eligibility criteria were performed before critical appraisal and measurement of level of evidence by The Centre for Evidence-Based Medicine (CEBM) University of Oxford. Review for the best available evidence was done by two-independent reviewer.Results: 130 records were retrieved and 6 final articles were finally appraised. All studies were published after 2017 with sample sizes of 140-5973 subjects. NLR cut-off were varied across studies (2.21-3.6) and the overall survival (OS) ranging from 51-82.5%. Moreover, 5-year disease specific survival (DSS) and progression free survival (PFS) for low and high NLR were 76-90.5% vs 53-82.1% and 68-86.2% vs 52-76.5%, respectively. Conclusion: NLR status can be used to predict OS in NPC patients. A careful approach should be taken in determining treatment options. Further research is needed to know the role of NLR in combination with other biomarker in predicting the survival of patients.
Preoperative vs postoperative radiotherapy in the management of rectal cancer: A systematic review Muhammad Fauzi Siregar
Radioterapi & Onkologi Indonesia Vol 12, No 1 (2021): VOLUME 12 NO.1 JANUARY 2021
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v12i1.125

Abstract

Purpose. The objective of this study is to review randomized clinical trials systematically that compare the outcomes of preoperative and postoperative radiotherapy in the management of rectal cancer regarding locoregional recurrance, disease free survival and overall survival.Methods. The relevant randomized clinical trials are searched via online databases such as Pubmed, Ebsco, and Proquest. RCTs publised in English between 2000 until 2020 are selected and reviewed systematically.Result. Locoregional recurrence at 5 years was statistically lower in preoperative radiotherapy group than in postoperative radiotherapy group based on two studies.  Disease free survival at 5-years was statistically higher in preoprative radiotherapy group than the postoperative one based on two studies. Overall survival at 5 years was not statistically significant between two groups for each study.Conclusion. Preoperative radiotherapy is superior to postoperative radiotherapy for controlling locoregional recurrence and disease free survival, but both are equal in overall survival. 
Radiation Therapy Strategies in Geriatric Patients: A Literature Review Steven Octavianus; Soehartati A. Gondhowiardjo
Radioterapi & Onkologi Indonesia Vol 12, No 1 (2021): VOLUME 12 NO.1 JANUARY 2021
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v12i1.133

Abstract

For humans, aging is defined as a universal biological process that manifests itself as a decrease in functional capacity and an increase in the risk of morbidity and mortality over time. Age is considered the single most significant risk factor for many chronic conditions including malignancies. Breast, lungs, prostate, colorectal, stomach, thyroid, pancreas, and ovarian cancers, as well as several types of leukemia, increase exponentially with age. Oncologists are often faced with difficulties when treat this population. Even though elderly and younger individuals seem to be able to get the same benefits result from a treatment, elderly are at greater risk of experiencing toxicity, serious side effects and death. A comprehensive multidisciplinary evaluation in elderly individuals with cancer can identify the risks and benefits of toxicity due to treatment plans including morbidity and mortality. Radiotherapy can be the solution in elderly with cancer, especially in patients at high risk for systemic therapy or surgery. Radiotherapy with modern techniques and fractionation adjustments (hypofractionation) can minimize the toxicity due to therapy and can be well tolerated by elderly individuals with cancer.
Rectal Cancer : A Mini Literature Review I.A.Trisna Kumala Dewi; Soehartati A. Gondhowiardjo
Radioterapi & Onkologi Indonesia Vol 12, No 1 (2021): VOLUME 12 NO.1 JANUARY 2021
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v12i1.115

Abstract

Colorectal cancer is one of the most common cancer in the world. In Indonesia, as reported in Globocan 2018, colorectal cancer is number eight by cancer site in term of incidence, mortality, and prevalence. It also number five of new cases in 2018. it started  proximally at rectosigmoid junction which is as high as third sacral and extending to anorectal ring, just proximal to dentate line. In general, the upper third is located intraperitoneally and the lower two-thirds of the rectum extraperitoneally. The most common histopatology found in rectal cancer is adenocarcinoma. The etiology  of  rectal  cancer  is believed to be  multifactorial,  including  both  genetic  and  environmental  factors. Hematochezia is the most common presenting symptom in rectal cancer. diagnostic tool of rectal cancer is divided into invasive and non invasive examination. The simplest method of recognizing is digital rectal examination that can detect around 70 % of rectal cancer. TNM classification is used as a standard to evaluate the extend of tumour. Surgery alongside with radiation therapy and chemotherapy play an important role as main treatment modality of rectat cancer. In radiotherapy, if 2D technique preferred, 3 fields that consist of posterior-anterior (PA) field and opposing lateral fields are the most commonly used. If 3D technique preferred, 3D conformal radiotherapy (3DCRT) is more recommended than   intensity-modulated radiation therapy (IMRT). For postoperative the radiation treatment is conventional  fractionation to a total dose of  45 Gy to the entire pelvis, followed  by  a boost of  5.4 Gy  to the tumor bed. For neoadjuvant therapy,  conventional  fractionation to a total dose of 45 Gy to tdioteraphe entire pelvis, followed by a boost of 5.4 Gy to the tumor bed is recommended.
External Beam Radiotherapy in limited setting: Optimizing Cobalt-60 for forward planning field-in-field intensity modulation technique in nasopharyngeal cancer Irradiation Elia Aditya Bani Kuncoro; Piryadi Piryadi; William Alfred Lapian Pandeirot; Yunarti Yunarti; Anita Zakiyah; Galih Puspa Sekarsari
Radioterapi & Onkologi Indonesia Vol 12, No 1 (2021): VOLUME 12 NO.1 JANUARY 2021
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v12i1.119

Abstract

Cobalt-60 adalah salah satu modalitas teleterapi yang paling tua, namun masih digunakan di beberapa negara berkembang. Modifikasi bisa dilakukan untuk mengoptimalkan kemampuan pesawat Cobalt-60 dalam pengobatan kanker nasofaring.Penulis mengembangkan teknik field-in-field pada pesawat Cobalt-60. Beberapa penyulit / keterbatasan berusaha disesuaikan dengan cara mengubah pemberian dosis, peletakan isosenter, collimator, dan blok. Teknik penyinaran ini menggunakan 12-15 lapangan dalam menggunakan 7-9 blok, yang diletakkan dalam 3-5 trays.Teknik ini mampu mencapai kriteria yang ditetapkan untuk planning approval. Sembilan pasien yang telah menjalani terapi mengalami efek samping akut yang dapat diterima, dengan tingkat complete response 71%.Teknik Forward planning field-in-field bisa digunakan untuk membantu mengatasi beberapa keterbatasan pesawat Cobalt-60 dan menunjukkan hasil yang baik.
The effect of bone radiation on hematopoiesis: A literature review Rendhy Tito Apreza; Soehartati A. Gondhowiardjo
Radioterapi & Onkologi Indonesia Vol 12, No 2 (2021): VOLUME 12 NO.2 JULY 2021
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v12i2.135

Abstract

Over time, external radiation techniques have continued to evolve so that they can be used totreat bone malignancies for curative, postoperative adjunct, and metastases purposes. However,in the bone, there is the bone marrow that is sensitive to radiation. Even sublethal doses cancause bone marrow microenvironment deficits, including a decrease in hematopoietic cells.There is a complex relationship between radiotherapy (RT) and the hematopoietic system.Acute radiation injury usually manifests as cytopenia: anemia, neutropenia, andthrombocytopenia. Several potential mechanisms regarding the effects of radiotherapy on bonemarrow, including direct damage to the hematopoietic stem cells (HSC), lead to decreasednumber and function. This literature review will discuss hematopoiesis, the effect of boneradiation on hematopoiesis, and its mechanisms.

Page 9 of 11 | Total Record : 108

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