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Medicinus : Jurnal Kedokteran
  • Medicinus : Jurnal Kedokteran
  • Website
Published by Universitas Pelita Harapan
ISSN : 19783094     EISSN : 26226995     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Medicinus: Jurnal Kedokteran is an official journal of the Faculty of Medicine, Universitas Pelita Harapan launched in the year 2007. Medicinus is a peer-reviewed and open-access journal that covers basic, translational, or clinical aspects of health and medical science. Medicinus accepts original research articles, review articles, and also interesting case reports. Medicinus: Jurnal Kedokteran is published three times a year in February, June, and October.
Arjuna Subject : -
Articles 429 Documents
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BRAF V600E Immunoexpression in Papillary Thyroid Carcinoma and Its Association with Prognostic Factors and Histopathologic Variant Kristiani, Erna; SR Hardjolukito, Endang; S Harahap, Agnes; Makes, Benyamin
Medicinus Vol. 9 No. 3 (2020): June 2020
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v8i1.3120

Abstract

Aim: to provide additional information regarding the clinicopathological characteristics of Papillary Thyroid Carcinoma (PTC). Methods: Fifty patient with PTC were reviewed to determine prognostic factors such as age, gender, size of tumor and histologic variant. BRAF V600E mutation was detected by immunohistochemical staining and assessed with H score. Result: BRAF V600E mutations were detected in 17 (34%) cases. There were seven cases with extrathyroidal extension (ETE) p 0,04, 11 cases with lymph node metastasis (LNM) p < 0,001, and 8 cases with tall cell variant p 0,047.The cases with positive BRAF V600E mutation had mean age of 44.71 years, and the size of the tumor between 0.1-4cm. Six cases of them are male and 11 female.Conclusion: There were significant relationships between BRAF V600E mutation with ETE, LNM, and tall cell variant. There was no significant relationship between BRAF V600E mutation, either with age, gender, or size of the tumor. BRAF V600E immunohistochemical examination can be performed as additional investigation for PTC patients.
Challenge as Physician to Diagnose Pediatric Patient with Laryngopharyngeal Reflux: A case report and literature review Rizki, Niken Ageng
Medicinus Vol. 9 No. 3 (2020): June 2020
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v8i1.3121

Abstract

Background : Laryngopharyngeal reflux (LPR) is the reflux of backflow of gastric acid or refluxate that usually affects the throat and laryngopharynx. Many physicians are unable to differentiate between pediatric LPR with pneumonia. Laryngopharyngeal reflux needs to be widely known and understood by a physician because there are relationships between upper and lower airway disease. In pediatric, LPR may also contribute to many problems in the respiratory tract, the clinical manifestation of pediatric LPR, and remains a challenge for physicians.Objective : To emphasize the new diagnostic symptoms and signs instrument for pediatric LPR using a fiber-optic laryngoscope, also to remind the correlation between the upper and lower respiratory tract and factors which contribute to pediatric airway.Case : A case of a 21-month-old girl with sudden onset of hoarseness, stridor, and wheezing was diagnosed with pneumonia, further investigation showed reflux symptoms, vocal cord abnormalities, and subglottic edema that suggest LPR was the final diagnosis.Conclusion : Pediatric LPR may be difficult to diagnose, there are many differential diagnosis, symptoms, and signs that may occur. The new diagnostic instrument can be used for diagnosing pediatric LPR, it is feasible and applicable in daily practice. Laryngopharyngeal reflux needs to be understood and considered as a differential diagnosis for coughing, hoarseness, in children despite the diagnosis challenge.
Chest CT as a Complement to RT-PCR to Confirm and Follow-up COVID-19 Patients Icksan, Aziza Ghanie; Hafiz, Muhammad; Harlivasari, Annisa Dian
Medicinus Vol. 9 No. 3 (2020): June 2020
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v8i1.3122

Abstract

Background : The first case of COVID-19 in Indonesia was recorded in March 2020. Limitation of reverse-transcription polymerase chain reaction (RT-PCR) has put chest CT as an essential complementary tool in the diagnosis and follow up treatment for COVID-19. Literatures strongly suggested that High-Resolution Computed Tomography (HRCT) is essential in diagnosing typical symptoms of COVID-19 at the early phase of disease due to its superior sensitivity  (97%) compared to chest x-ray (CXR).The two cases presented in this case study showed the crucial role of chest CT with HRCT to establish the working diagnosis and follow up COVID-19 patients as a complement to RT-PCR, currently deemed a gold standard.
The Effect of Light Colour During Night Time to Sleep Quality Sylvanus, Peter; Lumbuun, Nicolaski
Medicinus Vol. 9 No. 3 (2020): June 2020
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v8i1.3123

Abstract

Introduction: Sleep is one of the basic human needs, where human uses one third of their time only for sleeping. Some contributing factors towards bad sleep quality are stress, depression, surrounding noise, and the use of a bright light. It is known that white lights cause the activation of melanopsin, causing circadian cycle shift, whereas using yellow light does not. The aim of this research was to analyze whether there is an effect of using either white or yellow light towards sleep qualityMethod: This is RCT on 81 subjects. Sleep quality was measured using PSQI questionnaire on 3 measurements with each measurement taken every week. Result of the analyzed data using the General Linear Model - Repeated Measurement (GLM-RM) method Result: There were significant differences on PSQI score between group that used white light during sleep (7.6 ± 2.3) in comparison to the control group (5.2 ± 1.8) (p = 0.02), but result also showed that there were no significant difference between the group that used yellow light (6.1 ± 1.7) during sleep in comparison with the control group (p = 0.14). Conclusion: There is a significant difference between the uses of white lights during sleep towards sleep quality, but there has not been any significant difference between the uses of yellow light during sleep towards sleep quality
Correlation Between The Knowledge On Health Effects Of Smoking And Motivation On Smoking Cessation In Ex-Smokers Of Lung Department Patients, Siloam General Hospital, Lippo Village. Wong, Clarinda; Lucas, Brian; Sungono, Veli; Kurniawan, Andree; Widysanto, Allen
Medicinus Vol. 10 No. 1 (2020): October:2020
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v8i2.3435

Abstract

Introduction: Data from WHO showed that deaths caused by tobacco reaches approximately ± 6 million deaths annually. There are many information about the danger of smoking which spreading from various sources. The level of  knowledge about the danger of smoking can be associated with motivation to stop smoking. Therefore, motivation toward smoking cessation arises if someone knows the benefits that can be taken, through an adequate knowledge.Aim: To determine the relationship between the level of knowledge on the health effects of  smoking with motivation to stop smoking in ex-smokers of lung department patients at Siloam General Hospital, Lippo Village.Methodology: This is a cross-sectional study, analyzing 138 ex-smokers of Siloam General Hospital’s lung department patients using consecutive sampling techniques.Results: the results showed 73.2% of people have good knowledge about the danger of smoking and 26.8% are not. Then, 58% of people have high motivation to stop smoking and 42% have low motivation. The results of statistical test using Chi Square showed a significant relationship between the level of knowledge and the motivation to quit smoking (OR = 4.293 [95% CI: 1,921-9,594], P<.001). The results of the multivariate logistic regression test showed educational factors (P=0.014), and the frequency of smoking (P=0.007) also influence the motivation to stop smoking.Conclusion : There’s a significant relation between knowledge about the danger of smoking and the motivation to quit smoking.
A Systematic Review of Coronavirus Disease 2019 with Respiratory Distress Syndrome in Adult: Focus on Risk Factors, Mechanism, Diagnosis, and Treatment Jodhinata, Claudia; Kurniawan, Andree; Halim, Devina Adella
Medicinus Vol. 10 No. 1 (2020): October:2020
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v8i2.3442

Abstract

Context: Coronavirus disease 2019 (COVID-19) is a newly discovered disease, caused by SARS-CoV-2 and currently has become a pandemic. Acute respiratory distress syndrome (ARDS) is the most common complication in COVID-19. There were numerous conflicting results among articles related to it. The aim of this study is to ascertain the most compelling evidence about ARDS in COVID-19.Evidence Acquisition: This systematic review was registered in PROSPERO (CRD42020180379). A systematic search was conducted in PubMed, PubMed central, and Google Scholar on April 16, 2020. Two reviewers independently searched and selected the articles. The risk of bias was evaluated using the Newcastle-Ottawa Quality assessment tool.Results: A total of 1,647 articles were screened, 9 articles were included. Patients were classified as having various degrees of ARDS, the diagnosis of COVID-19 was confirmed by PCR nasopharyngeal swab.  Risk factors of ARDS in COVID-19 reported were older age, male gender, and pre-existing medical conditions. Cytokine storm was thought to play a role in the mechanism of ARDS. The main treatment for COVID-19 was supportive and symptomatic. To date, there is no antiviral treatment recommended for COVID-19 and the given treatment for ARDS in COVID-19 was similar to other pneumonia-induced ARDS. No additional therapy specific for ARDS in COVID-19 has been proposed.Conclusion: Our synthesis of the literature showed that there was no good evidence in the mechanism and treatment of ARDS. Further translation research in the mechanism of ARDS and continuing with clinical trials evaluating drug efficacy for ARDS in COVID-19 is needed.
Coronavirus Disease 2019 and Gastrointestinal Involvement: A Systematic Review Monica, Moryella; Kurniawan, Andree
Medicinus Vol. 10 No. 1 (2020): October:2020
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v8i2.3443

Abstract

Introduction: The World Health Organization (WHO) announced the Coronavirus 2019 (COVID-19) as a Public Health Emergency of International Concern (PHEIC) toward the end of January 2020. There is still limited evidence to explain the gastrointestinal involvement in COVID-19. In this study, we aimed to further investigate current evidence describing the gastrointestinal involvement in COVID-19 patients.Methods: This systematic review has been registered in PROSPERO (CRD42020181584). A systematic search of literature for observational and randomized controlled trial was conducted in PubMed, PubMed central, and Google Scholar through April 16, 2020. Two reviewers independently searched and selected. The risk of bias was evaluated using the Newcastle-Ottawa Quality assessment tool. Results: A total of 1,480 articles were screened from which 12 articles with 5584 subjects were selected. SARS-CoV-2 can invade human body by binding to angiotensin converting enzyme 2 (ACE-2) receptor which also located to small intestinal epithelial cells, crypt cells and colon. The virus itself may cause disorders of the intestinal flora. The diagnosis should be based on a set of symptoms diarrhoea, nausea, vomiting, abdominal discomfort or pain, combined with positivity of faecal PCR test. Treatment of COVID-19 mainly is supportive care. The probiotic may modulate the gut microbiota to alter the gastrointestinal symptoms and reduced enteritis, ventilator associated pneumonia, and reverse certain side effect of antibiotics.Conclusion: Our synthesis of literature showed that there was no good evidence yet in overall area of gastrointestinal manifestations in COVID-19. Future research is needed to explore all areas, especially in mechanism and treatments
Coagulopathy in COVID-19: A Systematic Review Winata, Sharleen; Kurniawan, Andree
Medicinus Vol. 10 No. 1 (2020): October:2020
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v8i2.3444

Abstract

Introduction: Corona Virus Disease 2019 (COVID-19) firstly appeared in Wuhan, China in December 2019 and defined as a pandemic in March 2020. COVID-19 divided into asymptomatic, mild, and severe symptoms. Coagulopathy may have happened in severe COVID-19 infection, it was also associated with high mortality in COVID-19 patients. Laboratory examination is the main protocol to identify coagulopathy, thereby it also determined the prognosis of COVID-19 patients with coagulopathy. Here, we review the current evidence describing the mechanism, diagnosis, treatment, and mortality of coagulopathy in COVID-19.Method: We identify 8 studies and/or review articles evaluating coagulopathy in COVID-19 patients by searching PubMed and EMBASE databases.Results: DIC is most commonly found in death with COVID-19, the risk of VTE also higher in severe COVID-19 because of immobility and long-term bed rest. Sepsis-induced DIC is associated with organ dysfunction as in the patient with viral infection as in COVID-19 infection. Sepsis-induce Coagulopathy (SIC) score, D-dimer, and prothrombin time (PT) measured at the time the patient classified as severe COVID-19. Higher D-dimer and FDP levels, longer PT and activated partial thromboplastin time (APTT) may have a poor prognosis. Treatment with Low Molecular Weight Heparin (LMWH) effective to reduced 28-day mortality in patients with SIC ‰¥ 4 and D-dimer > six-fold of the upper limit of normal. Conclusion: Coagulopathy plays a big role to determine the prognosis of COVID-19 patients. Treatment with LMWH may give some benefits to COVID-19 patients.
Late Intra-Uterine Fetal Demise with Fetal Hydrops: Challenges of Management Planning in Indonesia Hermawan, Gezta Nasafir; Wibisono, Jacobus Jeno; Nainggolan, Julita D.L.
Medicinus Vol. 10 No. 1 (2020): October:2020
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v8i2.3445

Abstract

Intra-Uterine Fetal Demise (IUFD) is defined as death of human conception at age of 20 weeks’ gestation or older or with a minimum 500-g birthweight before complete delivery from the mother and induced termination involved. In 2015, Indonesia has contributed a stillbirth rate of 13 out of 1,000 total births in which 17.1% of the cases were caused by congenital anomalies. Fetal Hydrops as a pathological condition in which there is an accumulation of fluid in fetal soft tissues and serous cavities. With the advancements of sonographic technology, identification of fetal hydrops has become uncomplicated. However, what remains a challenge is to investigate etiology and determine management. In order to plan proper management, the etiology of fetal hydrops must first be determined to predict the prognosis of fetal hydrops. In Indonesia; limited facilities and experts combined with high costs in etiology determination and management have complicated the matter. Furthermore, the strong influence of several Eastern communities’ norms and religious views have further complicated both physicians and patients in decision making. In this report, we present a case of late intra-uterine fetal demise with fetal hydrops, whom was admitted on her 35 weeks age gestation. We performed elective Caesarean Section in order to deliver the stillborn fetus, with no significant post-operative complication. Unfortunately, this condition was actually diagnosed earlier during 20th weeks of gestation, hence advised to continue the pregnancy without further evaluation and information to the mother regarding the hydrops condition.
Correlation Between Aphasia in Stroke Patients and Severe Depression of Family Members as Primary Caregivers. Gunawan, Pricilla Yani; Iswara, Kalista Ardelia
Medicinus Vol. 10 No. 2 (2021): February : 2021
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v8i3.3765

Abstract

Background and Objective: Stroke is a disease with an increasing annual prevalence. One of the most frequent clinical manifestation seen in stroke patients is aphasia which greatly affects the patient’s ability to communicate. The burden and the pressure of taking care of the patient placed on the family members often results in psychological impacts such as depression.  We intend to know the association between aphasia in stroke patients with severe depression on family members. Methodology: This was a cross sectional study, using an unpaired categorical comparative analysis. Inclusion criteria were family members of patients with and without aphasia. Patients and caregivers who gave their consent verbally were guided to fill in the Hamilton Depression Rating Scale questionnaire. The association between aphasia status and the depression scale was analyzed using Chi-Square.Results:  Out of 54 respondents included in the study, there were 25 caregivers (46,3%) taking care stroke patients without aphasia, and 29 caregivers (53,7) taking care stroke patients with aphasia. As much as35 (64.8%) were categorized as normal- moderate level of depression and 19 (35.2%) categorized as major depression. From those with major depression, 14 (73.7%) were found in the aphasic group and 5 were in the non-aphasia group. Chi-Square analysis shows a significant correlation [P=0.03; OR=3.73 (1.1-12.7)] between aphasia in stroke patients and severe depression of the caregivers.Conclusion: There is a significant association between aphasia in stroke patients and the incidence of severe depression on their caregivers.

Page 32 of 43 | Total Record : 429

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