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Medicinus : Jurnal Kedokteran
  • Medicinus : Jurnal Kedokteran
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Published by Universitas Pelita Harapan
ISSN : 19783094     EISSN : 26226995     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Medicinus: Jurnal Kedokteran is an official journal of the Faculty of Medicine, Universitas Pelita Harapan launched in the year 2007. Medicinus is a peer-reviewed and open-access journal that covers basic, translational, or clinical aspects of health and medical science. Medicinus accepts original research articles, review articles, and also interesting case reports. Medicinus: Jurnal Kedokteran is published three times a year in February, June, and October.
Arjuna Subject : -
Articles 429 Documents
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Reversible Bilateral Basal Ganglia and Brainstem Lesions in Neuropsychiatric Systemic Lupus Erythematosus: A Case Report Situmeang, Rocksy Fransisca V; Stevano, Reza; Larope, Ekawaty Yasinta Yohana; Sutanto, Ratna
Medicinus Vol. 11 No. 2 (2022): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v9i3.6976

Abstract

The pathophysiology behind neuropsychiatric SLE (NPSLE) remains poorly understood and its clinical and radiological manifestations are highly varied. In this report, we present a complex case of an adolescent female patient with a three-week history of systemic symptoms (fever, nausea, vomiting, weight-loss, polyarticular joint pain), progressive motor weakness, tremor, and altered mental status. Physical examination was significant for oromandibular and cervical dystonia rigidity, and general weakness with imposed right-sided hemiparesis. A head MRI demonstrated bilateral hyperintense lesions of the basal ganglia and brainstem, SS without restricted diffusion. The patient was diagnosed with NPSLE, lupus nephritis, electrolyte imbalance, severe hypoalbuminemia, lupus cardiomyopathy, autoimmune hemolytic anemia, pulmonary tuberculosis, and sepsis. The patient was given treatment in the ICU with pulse dose corticosteroids, intravenous antibiotics, intravenous immunoglobulins (IVIg), and supportive treatment with correction of hematologic and electrolyte abnormalities. Her condition improved rapidly. Full alertness was regained, and symptoms of oromandibular dystonia, tremor, and weakness diminished significantly. A follow-up MRI three weeks later revealed complete disappearance of lesions, which we attribute to resolution of the inflammatory process in the brain.
Characteristics of NSAIDs Prescription in Elderly Knee Osteoarthritis Patients Wong, Janetta; Lumbuun, Nicolaski
Medicinus Vol. 11 No. 3 (2022): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i1.6988

Abstract

Introduction: The prescribing of non-steroidal anti-inflammatory drugs (NSAIDs) as pharmacological therapy for OA was found to be imprecise. In 2018, the rationality of NSAIDs prescribed at Wolter Monginsidi Hospital, Manado showed as much as 100% proper indication, 77% proper dose, and 89% proper medication. This shows that the rationality of NSAIDs prescription is still irrational. Irrational prescribing has the potential to result in side effects or the incidence of drug-related problemsAim: To determine the characteristics and the rationality of NSAIDs prescriptions in elderly knee OA.Methods: This is a descriptive study of 108 medical records for the period January 2020-April 2021 at BS Clinic, Semarang, using purposive sampling method.Result: Results showed the characteristics of elderly knee OA patients at BS Clinic were 74.1% women, 47.2% belonging to obese group, and 41.7% experiencing severe pain. Patient’s age had a median value of 66 years. In the number of comorbidity, the median value was 1. The rationality of NSAIDs prescription was 95,4% proper diagnosis, 100% proper drug, 97.2% proper dose, and 99.1% proper indication with the incidence of side effects of NSAIDs prescribing was 1.9%.
Comparison of Early Postoperative Pain between Lightweight Mesh and Heavyweight Mesh in Lichtenstein Hernia Repair for Geriatric Patients at Rumah Sakit Siloam Karawaci from January 2018 - December 2019 Sidharta, Nicholas Axel; Irawan, Andry; Siregar, Jeremia Immanuel; Lugito, Nata Pratama Hardjo
Medicinus Vol. 11 No. 3 (2022): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i1.6989

Abstract

Background: Inguinal hernias are one of the most often cases in surgery. Inguinal hernias are usually found in males rather than females. There are two types of meshes in inguinal hernia repairs: heavyweight and lightweight mesh. There were still a lot of differences in the outcome of each mesh that was used. Therefore, with various different post operative pain results from past research, the author expresses an interest to conduct a research on this topic towards geriatric patients.Methods: In this cross-sectional comparative study, 45 patients using heavyweight mesh and 45 patients using lightweight mesh herniorrhaphy with Lichtenstein technique in inguinal hernias at RS Siloam Karawaci Lippo Village and RSU were reviewed retrospectively. Patient's data were taken from medical record using purposive-sampling method. Early Postoperative pain on day 1 until 7 were classified following the Visual Analogue Scale (VAS). Incidence of postoperative infection and seroma were assessed in both groups. Collected samples will be processed using Pearson's Chi-Squared test.Result: This study shows that there is a significant difference between the use of lightweight mesh in reducing moderate early postoperative pain for men above the age of 60 years old (p = 0.025) rather than the use of heavyweight mesh. Incidence of other postoperative complications such as infection and seroma have no statistically difference between both groups.Conclusions: The use of lightweight mesh has the advantage in reducing early postoperative pain from herniorrhaphy using Lichtenstein technique rather than heavyweight mesh in men above 60 years old.
Failure Factors & Prediction Model of Indonesian Medical Doctor Proficiency & Competency Test (UKMPPD) within COVID-19 Pandemic Salim, Jonathan; Arnindita, Jannatin Nisa; Tandy, Sutiono; Wibisono, Jacobus Jeno; Wibisono, Maria Georgina
Medicinus Vol. 11 No. 3 (2022): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i1.6990

Abstract

Background: Coronavirus Disease 2019 drastically modulate the healthcare world. The pandemic's immense transmission and lethality rate enforce the Indonesian Medical Doctor Proficiency & Competency Test to discard practical measures and rely only on a written exam. These with pandemic social and physical restrictions impede prospective doctors’ learning opportunities leading to easier failure. Henceforth, the present study has high urgency to identify and manage failure factors, especially in the pandemic.Methods: The cross-sectional study examines 75 clinical medical students through purposive analysis with an online questionnaire in August 2021. Data are analyzed with Chi-Square, Mann-Whitney, and binary logistics.Result: Respondents have an average age of 24.15 (1.322) years old, majorly female (82.7%), and pass as first takers (86.7%) with 1.27 (0.949) off-campus tutelage. The significant factors for the test failure are depression and economic status. The study developed a failure prediction model with the area under the curve 0.845, cut-off 366.5, 80.0% sensitivity, and 84.6% specificity.Conclusion: Intrinsic, extrinsic, and academic factors have significant roles in the failure outcome. For this reason, preparation is crucial not only among individuals but also institutions. The study also provides feedback about the importance of mental health and economic status for Indonesian medical students
The Correlation of Insomnia and Anxiety in Students of The Faculty of Medicine, University of Pelita Harapan Dhinata, Kinley; Lumbuun, Nicolaski
Medicinus Vol. 11 No. 3 (2022): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i1.6991

Abstract

Background and Aim: Insomnia and anxiety are common disorders with high prevalence rate especially in medical students. Moreover, many confounding factors playing a role in influencing anxiety. Most studies does not include or measure other confounding factors of anxiety into the analysis. This requires research which examines insomnia and anxiety assessing the contribution of the factors influencing anxiety.Methods: A cross-sectional study methodology with linear regression analysis on a sample of students from the Faculty of Medicine, University of Pelita Harapan using the DASS-21 questionnaire to assess anxiety and ISI to assess insomnia.Results: Prevalence rates of insomnia was 34.29% and anxiety 32.38% in Pelita Harapan University medical student. From the results of the bivariate linear regression, a weak relationship between insomnia and anxiety (r = 0.322; p = 0.000) is seen. In multivariate results, there were confounding stress variables (r = 0.565; p= 0.000) and trauma (r = 0.250; p = 0.005) which contributed greatly to anxiety (In order of largest).Conclusion: There is a weak correlation and anxiety. Moreover, high prevalence rate of anxiety in medical students may be contributed heavily not only by insomnia but also stress and childhood trauma.
The Relationship Between Breastfeeding Pattern and the Risk of Postpartum Depression of Mothers in Tangerang Tancherla, Angeline; Widjaja, Melanie
Medicinus Vol. 11 No. 3 (2022): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i1.6992

Abstract

Background and Aim: Postpartum depression (PPD) has a negative impact on mothers and children, such as breastfeeding (BF) disturbance. However, the relationship between BF pattern and PPD is still unclear due to contrasting results, and no related study has been done in Indonesia. Therefore this study is conducted to evaluate the relationship between BF pattern and the risk of PPD of mothers in Tangerang.Method: This is an analytic observational study with a cross-sectional design. The samples of this study are 58 mothers that fulfill the inclusion criteria. Samples are chosen by purposive sampling method. Data collection is conducted from January to April 2020. The results were analyzed using SPSS program version 22.0 with Chi- Square method.Results: There were 37 samples (63.8%) without PPD risk and 21 samples (36.8%) with PPD risk. Among 37 samples without PPD risk, 70.3% had exclusive BF and 29,7% had non-exclusive BF. Among 21 samples with PPD risk, 14.3% had exclusive BF and 85,7% had non-exclusive BF. Chi-Square analysis result showed that there is a significant association between BF pattern and PPD risk (p=0.0001), with an OR of 0.071 (95% CI: 0.17-0.289).Conclusion: Breastfeeding pattern has a significant association with PPD risk. Exclusive BF has a protective effect on the risk of PPD at one month postpartum.
The Role of Bone Scintigraphy and Parathyroid Scintigraphy on Multiple Osteolytic Lesions Which Misdiagnosed as Primary Bone Tumor (Giant Cell Tumor) Prasetyo, Nora A.; Darmawan, Budi; Affandi, Erwin; Kartamihardja, A. Hussein S.
Medicinus Vol. 11 No. 3 (2022): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i1.6993

Abstract

Brown tumor is a non-neoplastic lesion that resulting from abnormal bone metabolism. It can be manifest in prolonged or untreated hyperparathyroidism. The clinical symptoms, radiological and histopathological examination were similar with giant cell tumor and can be mimicking metastases; or even misdiagnosed with giant cell tumor and mistreated the patient. Biochemical examination of calcium levels and parathyroid hormone should be included in the routine assessment of patients with multiple osteolytic lesions. A multidiscipline approach is needed.Throughout this case report, we would like to report the important role of Nuclear Medicine and Molecular Theranostic imaging modality in 38-year-old male with multiple osteolytic lesions, which was first diagnosed as giant cell tumor and differential diagnosis bone metastases but turnout to be a metabolic bone disease (brown tumor) with parathyroid adenoma as etiology.
Clinical Factors Related to Histopathologic Grade in Meningioma Kristiani, Erna; Agelica, Michelle; Suharyani, Sally; Dharmawan, Kevin
Medicinus Vol. 12 No. 1 (2022): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i2.7011

Abstract

Background: Meningiomas are the most common intracranial tumor of central nervous system tumors. Although the prevalence is lower, the WHO grade II and III meningiomas are more aggressive, with higher mitosis rates, are more likely to recur after surgery, and have lower survival rates. The ability to differentiate between WHO I and WHO II/ III meningiomas before surgery can contribute to a significant clinical benefit in helping the neurosurgeon doing the best management planning.Methods: This is a retrospective cross-sectional study of meningioma patients in Siloam Hospital Lippo Village between 2014 - 2018. The sample will be recruited using consecutive sampling. The relationship between analyzed variables and meningioma grades will be investigated using a chi-square test if the data was eligible; otherwise, the Fisher-exact test will be performed.Result: Ninety eight (69%) patients diagnosed as low grade meningioma, and 44 (31%) as high grade meningioma. Tumor location, size, edema, necrosis, age, and gender had significant results with p £0.05. Multivariate results also show that all six variables have a significant relationship with each other.Conclusions: Tumor location, size, edema, necrosis, age, and gender have a significant relationship to histopathological meningioma grade in patients at Siloam Hospital Lippo Village in 2014-2018.
The Calamity Among Medical Students: Sleep Deprivation and Dry Eye Disease Salim, Anastasia Johanna; Salim, Jonathan; Josiah Irma, Josiah x
Medicinus Vol. 12 No. 1 (2022): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i2.7015

Abstract

Background: Medical students’ burden upon academic and professional duties often blinded them from attending to themselves. Piling works and nightshifts interfere ferociously with their self-care behavior, including adequate sleep. The matter not only disrupts concentration and consciousness but also tolls the eye by reducing tear secretion. Hence, the present study urgently assesses sleep quality and dry eye disease (DED) among medical students.Methods: The cross-sectional study observed 172 eyes among medical students in Indonesia. We assessed sleep quality and dry eye disease through Pittsburgh Sleep Quality Index and Schirmer test. Independent statistician analyzed the data with chi-square.Result: From the eligible samples, there is a dominancy of females (55.8%) with poor sleep quality (55.2%). There is no significant difference in DED or sleep quality across gender though they lean toward females. Contrarily, poor sleepers significantly correspond to 2.96 times more risk of DED than an adequate sleeper.Conclusions: Medical students’ well-being is crucial. Aside from the academic burden, institutions and individuals shall strongly emphasize better sleep habits and eye care.
The Appropriate Acquisition Time Interval Following Injection of 99mTc-Sestam ibi with Water Protocol in Single Photon Emission Computed Tomography Myocardial Perfusion Imaging: First Experience in Indonesia Prasetyo, Nora Anggun; Soeriadi, Erwin Affandi; Budiawan, Hendra; Kartamihardja, Achmad Hussein Sundawa
Medicinus Vol. 12 No. 1 (2022): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i2.7016

Abstract

Introduction: According to EANM/ESC guideline, image acquisitions in stress test should be begun at 30-60 minutes after tracer administration. Our center is a referral hospital for nuclear medicine imaging with many patients but limited number of gamma camera. The shorter time between injection of radiopharmaceutical and imaging acquisition will add to the number of examinations that can be performed. The aim of this study was to evaluate the appropriate acquisition time interval with water protocol in 99mTc-Sestamibi SPECT myocardial perfusion imaging.Methods: Patients who were referred to undergo stress MPI between October 2020 to December 2020 were included in this study. Cardiac stress procedure was performed using treadmill with modified Bruce Protocol. Subjects drank a total of 330 mL water following 99mTc-Sestamibi injection. Image acquisitions were performed 10 and 30 minutes afterwards. Quantitative assessment was done by calculating target background ratio (TBR). Statistical analysis was performed using student t-test with Microsoft Excel version 2019. P-value < 0.05 was considered to be statistically significant.Result: Thirty out of 35 subjects were included in this study. Sixteen of them are male and 14 are female with a mean age of 48.7 years old (28 - 80). Mean target background uptake ratio (TBR) in 10- and 30-minutes images were 0.67 (0.44 - 1.11) and 0.76 (0.43 - 1.18) respectively (p-value = 0.15).Conclusion: There was no significant difference of target to background ratio between 10- and 30-minutes acquisition time interval following injection of 99mTc- Sestamibi with water protocol in myocardial perfusion imaging.

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