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Medicinus : Jurnal Kedokteran
  • Medicinus : Jurnal Kedokteran
  • Website
Published by Universitas Pelita Harapan
ISSN : 19783094     EISSN : 26226995     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Medicinus: Jurnal Kedokteran is an official journal of the Faculty of Medicine, Universitas Pelita Harapan launched in the year 2007. Medicinus is a peer-reviewed and open-access journal that covers basic, translational, or clinical aspects of health and medical science. Medicinus accepts original research articles, review articles, and also interesting case reports. Medicinus: Jurnal Kedokteran is published three times a year in February, June, and October.
Arjuna Subject : -
Articles 429 Documents
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The Relationship Between High Emotional Intelligence and Stress in Medical Students of Medicine Pelita Harapan University During the Covid-19 Pandemic Suryadinata, Neneng; Amadea, Sabrina; Conney, Fred Rich
Medicinus Vol. 12 No. 1 (2022): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i2.7017

Abstract

Background: The World Health Organization (WHO) has declared Coronavirus Disease 2019 (COVID-19) a global pandemic. This also has an impact on students' lives. Most of the students have been in a stressful condition due to changes in the online teaching and learning process as an adaptation to COVID-19. Although it has been reported that emotional intelligence can reduce stress, there are still a few studies that study about the relationship between the two during the COVID-19 pandemic, especially among medical students.Methods: A cross-sectional using comparative numerical analysis was conducted with 305 medical students. Data were collected by an online survey using Emotional Intelligence Appraisal (EIA) questionnaire, and Medical Student Stressor Questionnaire (MSSQ). Statistical analysis was done using Statistical Package for the Social Sciences (SPSS) version 25.Results: The EIA questionnaire showed that there were 1.3% low EI groups, 38.7% normal EI groups, and 60.0% high EI groups. The MSSQ questionnaire showed that there was 24% mild stress, 49% moderate stress, 26% severe stress, and 1% very severe stress. Normal data distribution was obtained through the Kolmogorov-Smirnov test, so that the T-test could be used with a 95% confidence degree (p-value <0.05). T-test analysis in the high EI group with an average stress (1.76±0.64) and the normal EI group with an average stress (1.40±0.75) showed a significant difference with p-value = 0.008.Conclusion: In accordance with the hypothesis in this study, during the COVID-19 pandemic, there is a significant relationship between high emotional intelligence and stress in UPH Medical Faculty students.
A Comparative Efficacy of Atezolizumab plus Bevacizumab Versus Sorafenib in Advanced Hepatocellular Carcinoma: A Review Marbun, Kristin Talia; Jo, Juandy
Medicinus Vol. 12 No. 1 (2022): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i2.7023

Abstract

Hepatocellular carcinoma (HCC) ranks sixth as the most common cancer and fourth as the most common cause of cancer-related death globally. The standard treatment for advanced HCC is by prescribing sorafenib, a tyrosine kinase inhibitor. Despite its moderate efficacy and concerning side effects, there is no better alternative to sorafenib to treat HCC. However, a new combination of atezolizumab (an inhibitor of PD-L1) and bevacizumab (an inhibitor of vascular endothelial growth factor), has shown a potential to surpass the efficacy of sorafenib. This review was written to provide an insight into pharmacodynamics of sorafenib and atezolizumab plus bevacizumab, effectiveness of sorafenib and the one of atezolizumab plus bevacizumab, utilization of atezolizumab plus bevacizumab in the clinical practice, as well as to argue that this combination can replace sorafenib as the standard palliative treatment for HCC.
A Case of Neuropsychiatric Systemic Lupus Erythematosus as A Sequela of Kikuchi’s Disease Yanto, Theo Audi; Mulia, Nathania Raphaeli; Fatah, Abraham
Medicinus Vol. 12 No. 1 (2022): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i2.7024

Abstract

The aetiology of Kikuchi’s Disease (KD), a benign condition associated with multiple lymph node enlargements, remains unknown but several reported cases associate it with systemic lupus erythematosus (SLE). A 34-year-old Indonesian woman presented with multiple painless lymph node enlargements around the neck with three weeks of fever, myalgia, arthralgia, night sweats, and weight loss. Laboratory examination showed pancytopenia and elevated ESR. HIV and tuberculin skin testing were negative. Lymph node biopsy confirmed the diagnosis of KD. One week later, despite improvement in lymphadenopathy, she developed fever. Her ANA, anti-Smith antibodies, and anti-Ribosomal-P protein antibodies were positive. She was diagnosed with SLE and managed as an inpatient with high dose methylprednisolone. One week later, the patient developed psychotic symptoms and fever. The results of Laboratory examinations with lumbar puncture were unremarkable. She was diagnosed with neuropsychiatric SLE (NPSLE) and managed with methylprednisolone, paracetamol, folic acid, alprazolam, and amitriptyline. One month later, the patient returned with three days of fever and dyspnea. Despite improvement in neuropsychiatric symptoms, pneumonia and tonsillopharyngitis were diagnosed based on physical examination and chest X- rays. Her condition deteriorated into septic shock. She suffered cardiac arrest and was pronounced dead, despite attempted resuscitation.While KD is a benign condition, diagnosis is challenging due to its rarity and similarity to other lymphadenopathy diseases. Its association with SLE and NPSLE carries poor prognosis with higher mortality rate from the disease progression and adverse medication effects. Thus, early intervention and prevention of complications are crucial in managing patientswith KD.
Case Report: Management Penetrating Brain Injury Across Middle Third of Superior Sagittal Sinus Chumaidi, Achmad; July, Julius
Medicinus Vol. 12 No. 1 (2022): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i2.7025

Abstract

Background: Penetrating cranial injuries are rarely reported on thick parietal bone. Goal of its management include removal of the foreign object while minimizing furher damage to the brain and associated neurovascular structures, also prevent further complications.Case Description: We report a case of a 22-year-old male presented with machete stucked in his head following an accidentally fell down of the weapon from a coconut tree. The cranial location affected were midparietal. He was disoriented on admission, with neither neurological focal signs nor seizure. Computed tomography (CT) revealed that the object penetrate middle superior sagittal sinus. After emergency craniotomy to remove the objects, debridement, dural sinus repair were performed. Recovery was complete without sequelae.Conclusion: Laceration of the middle thirds of the superior sagittal sinus require special handling and care during surgery. Operative approach and treatment strategies are among the most important considerations to achieve the best patient outcomes. 
The Difference of Low Density Lipoprotein Cholesterol Levels on Different Severity of Coronary Artery Disease Patients in Siloam Hospital Lippo Village Tanaka, Michael; Santoso, Wilbert; Anggraini, Novita
Medicinus Vol. 12 No. 2 (2023): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i3.7033

Abstract

Background: Coronary artery disease (CAD) is one of the highest causes of death in the world. Hypercholesterolemia, especially low-density lipoprotein (LDL) levels, is a major risk factor, because it is the main precursor of atherosclerosis. Previous studies showed the relationship between LDL level and the number of vessel disease is still inconsistent, therefore it needs to be observed further. The objective of this study was to know the effect of LDL levels on the number of vessel disease in CAD patients who underwent coronary angiography.Methods: It was a cross-sectional and retrospective study, where data were taken from medical records of CAD patients who underwent coronary angiography at Siloam Hospital Lippo Village between January to June 2018. Patients with at least one vessel disease were included. The number of vessel disease was categorized into 3 groups: one-vessel, two-vessels, and multi-vessel. The relationship between LDL levels and the number of vessel disease was analyzed using one way ANOVA.Result: The data includes 90 patients; 70 (77.8%) were male with average age of 56±9 years. There were 32 (35.6%) patients in one-vessel group; 27 (30%) in two-vessel group; and 31 (34.4%) in multi-vessel group with an average LDL levels of 106.43±40.51 mg/dl; 111.15±39.43 mg/dl; and 114.52±32.55 mg/dl respectively. Although it seemed that the increase in LDL cholesterol levels was in line with the number of vessel disease, there was no statistically significant relationship between the two variables (p=0.694).Conclusions: LDL cholesterol level does not affect the number of vessel disease in CAD patients.
Factors Associated With Atopic Dermatitis In Elementary School Children In Suburban Area In Indonesia: Original Research Gunawan, Catherine; Satriajaya, Anthony; Vatvani, Akhil Deepak; Waren, Kalis; Angela, Angela; Broto, Resza; Kalumpiu, Jane Florida; Tan, Sylvia
Medicinus Vol. 12 No. 2 (2023): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i3.7034

Abstract

Background: There was limited data of Atopic Dermatitis (AD) prevalence and its associated factors in Indonesia. Therefore, the aim of this study was to identify and evaluate the AD prevalence and factors associated with AD in elementary school children in suburban area in Banten.Methods: A cross-sectional study was conducted in 3 elementary schools children age 6 - 7 years old who were randomly selected. Information was obtained through an Indonesian version of the International Study of Asthma and Allergies in Childhood questionnaire (ISAAC).Results: From 304 school children in semi-urban area, AD was reported as ever had an itchy rash which was reccurent for at least 6 months in 17.4% of the children, 19.5%  of the children had this itchy rash at any time in the past 12 months, and 11.4 % reported doctor-diagnosed AD. The factors found to be associated with an increased risk of AD were allergic rhinitis (OR 2.151 CI: 1.086-4.261), history of premature birth (<37 weeks) (OR 5.306, CI:1.577-17.858), exclusive breastfeeding (OR 3.126 CI:1.314-7.439), and food allergy (OR 2.912 CI:1.386-6.119).Conclusion: The results of this study showed that allergic rhinitis, history of premature birth (<37 weeks), exclusive breastfeeding, and food allergy were factors associated with AD in Indonesian schoolchildren. 
Relationship of Sexual Violence to Depression in Female Students of Faculty of Medicine, Pelita Harapan University Xaviera, Luqyana Ghina; Kristiani, Erna; Suryadinata, Neneng
Medicinus Vol. 12 No. 2 (2023): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i3.7035

Abstract

Background: Sexual violence can take many forms to anyone. The increase in the number of sexual violence against women in Indonesia is quite significant. These incidents are reported to occur frequently in women in young adulthood. These experiences can have long-term effects, one of which is depression. There are several studies that show an association between sexual violence and the incidence of depression. However, there has not been much quantitative research to look at the relationship on this matter in Indonesia, especially on female students. This study aims to understand the relationship between sexual violence and the incidence of depression in female students of the Faculty of Medicine, Universitas Pelita Harapan.Methods: This study use a cross-sectional study design. The data has been collected using questionnaires filled in by the respondents. This study involved 149 female students of the Faculty of Medicine, Pelita Harapan University. The results of the study were processed and statistically analyzed using SPSS 25.Result: Based on research data, there are 149 respondents from female students of the Faculty of Medicine, Universitas Pelita Harapan. with a mean age of 19.29 (SD = 1.086). The youngest age of the respondent is 17 years old and the oldest is 24 years old. A total of 55 respondents had experienced sexual violence. Based on the results of the Beck's Depression Inventory (BDI) questionnaire, 16% had mild depression, 9% had moderate depression, and 2% had severe depression. Chi-square test showed a significant relationship between experiences of sexual violence and the incidence of depression, with p <0.001.Conclusions: Sexual violence is related to the incidence of depression in female students of the Faculty of Medicine, Pelita Harapan University.
Understanding Tsetse Fly (Glossina morsitans) Behavior through its Genome Marbun, Kristin Talia; Nugroho, Satya; Jo, Juandy
Medicinus Vol. 12 No. 2 (2023): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i3.7036

Abstract

Glossina morsitans (G. morsitans), commonly known as tsetse fly, have caused public health concerns throughout the years. G. morsitans is the vector for Trypanosoma brucei (T. brucei), the parasite responsible for causing the deadly African sleeping disease (African trypanosomiasis). Researchers have searched for ways to contain this disease, but to little avail. Fortunately, new advances in sequencing methods have given researchers a new opportunity to win the war against the disease. The whole-genome sequence of G. morsitans provides essential data regarding involved genes that transmits T. brucei to humans. Information about those unique genes facilitates researchers to create new methods to prevent G. morsitans from becoming the vector of T. brucei, enabling the containment of this disease. With this, we review the unique genes in the G. morsitans genome, such as those that contribute to blood-feeding ability, establish a relationship with symbionts, and G. morsitans unique sensory genes, with an expectation that it would enhance our knowledge of G. morsitans as the vector for parasites causing African trypanosomiasis.
Future Application of Oncolytic Viruses for Cancer Treatment Lesmana, Jevon Aaron; Jo, Juandy
Medicinus Vol. 12 No. 2 (2023): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i3.7037

Abstract

Cancer treatments have developed over the years. A particular improvement is the utilization of oncolytic viruses to treat cancers. Oncolytic viruses are one of the immunotherapeutic tools that potentially could provide good results and benefits to the patients. Oncolytic viruses could mediate antitumor effects. Indeed, the connection between viral infections and cancer treatment have been reported historically. It is known that oncolytic viruses prefer to infect cancer cells rather than normal cells, resulting in the presentation of tumor-associated antigens to the immune system, boosting immunological activity in the tumor microenvironment, as well as assisting in the expression of inflammatory and immunomodulatory cytokines. Oncolytic viruses are a novel regimen in the cancer therapy, in which knowledge and technology of utilizing oncolytic viruses to treat cancer are still evolving. Importantly, clinical trials demonstrated that the viruses were well tolerated by cancer patients. Considering its potency and prospect, oncolytic viral treatments could be a useful additional tool for cancer therapy.
Postoperative Pain Comparison Between Open Hemorrhoidectomy and Stapled Hemorrhoidopexy on Internal Hemorrhoid at Siloam Hospitals Lippo Village Sudirman, Taufik; Wiguna, Alvin Leonard
Medicinus Vol. 12 No. 2 (2023): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i3.7038

Abstract

Background: Hemorrhoids have a prevalence of 4,4%. Surgery is one of the modalities for treating hemorrrhoids. The method accepted as the "golden standard" is open hemorrhoidectomy. Although considered effective, open hemorrhoidectomy is still often associated with a significant rate of morbidity and pain symptoms that are a complaint of most patients. Therefore, another method is an alternative, namely, stapled hemorrhoidopexy. Some studies showed that stapled hemorrhoidopexy has a lower occurrence of postoperative pain, and others offer the opposite.Methods: This study was conducted at Siloam Hospitals Lippo Village between February and March 2019. Samples were taken as many as 70 patients by taking secondary data from medical records. Patients diagnosed with third or fourth degree hemorrhoids and undergoing open hemorrhoidectomy or stapled hemorrhoidopexy will be taken the pain score from the visual analogue scale. Data is then tabulated using Microsoft Excel and analysed using SPSS.Result: the occurrence of postoperative pain in the stapled hemorrhoidopexy and open hemorrhoidectomy group, respectively, are 80% and 97%, with a p-value of 0,055. The average visual analogue scale score for open hemorrhoidectomy and stapled hemorrhoidopexy was 3±1,39 and 2±1,39, respectively, with a p-value of 0.003.Conclusions: the result showed that the occurrence of postoperative pain was not statistically significant. And the average visual analogue scale score was lower in the stapled hemorrhoidopexy group.

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