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Pharmacology and Clinical Pharmacy Research
Published by Universitas Padjadjaran
ISSN : 25277332     EISSN : 26140020     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Pharmacology and Clinical Pharmacy Research (PCPR) is an international, peer-reviewed journal, publishing original research, review, case reports, and commentaries on all aspects of pharmacology and clinical pharmacy. The journal aims to contribute to the scientific committee by publishing the high quality articles. It is published 3 times a year to provide a forum for pharmacologists, pharmacists, and other healthcare professionals to share best practice, encouraging networking, and a more collaborative approach in pharmacology and clinical pharmacy.
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Articles 5 Documents
 1 
Search results for , issue "Vol 5, No 2" : 5 Documents clear
The Pharmacokinetic Drug-Drug Interactions of Andrographis paniculata and Ibuprofen in the Plasma of Healthy Oryctolagus cuniculus Rabbits Mutakin Mutakin; Sandra Megantara; Batari A. Larasati; Yogiyanto Yogiyanto; Jutti Levita; Slamet Ibrahim
Pharmacology and Clinical Pharmacy Research Vol 5, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (542.05 KB) | DOI: 10.15416/pcpr.v5i2.27508

Abstract

An HPLC method was developed and validated for the pharmacokinetic drug-drug interaction between Andrographis paniculata and ibuprofen in the plasma of Oryctolagus cuniculus rabbits after a single oral administration of the mixture. Nine healthy rabbits (6 males and 3 females, weight 1.68-2.42 kg) were acclimatized for 7 days and were randomly divided into 3 groups. At day-8th the rabbits were group (1) treated with a single oral administration of ibuprofen (dose of 28 mg/kg BW); group (2) treated with a single oral administration of Andrographis paniculata infusion (7.04 mL/kg BW); group (3) treated with a single oral administration of a mixture of Andrographis paniculata (7.04 mL/kg BW) infusion and ibuprofen (dose of 28 mg/kg BW). Plasma samples were prepared by collecting the blood from the marginal ear vein at 0, 30, 60, 90, and 120 minutes after the mixture administration, followed by centrifuging it for 30 minutes 3000 rpm. Chromatographic separation was performed on a LiChrosorb RP-18 with methanol and double-distilled water (70:30) as the mobile phase, flow rate 1 mL/minute. UV detection was set at 227 nm. The absorption and distribution of ibuprofen were fast (Tmax = 30 min; Cmax = 4.02962 mcg/mL), however, interestingly this drug could improve the absorption and distribution of andrographolide in Oryctolagus cuniculus rabbits
Potential Tracking OF Cytotoxic Activities Of Mangrove Perepate (Sonneratia alba) Root Extract as an Anticancer Candidate Madyawati Latief; Nelson Nelson; Hilda Amanda; Indra Lasmana Tarigan; Siti Aisyah
Pharmacology and Clinical Pharmacy Research Vol 5, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (315.145 KB) | DOI: 10.15416/pcpr.v5i2.26790

Abstract

Mangrove plants are one of the most extensive biodiversity in Jambi. Besides functioning as a coastal ecosystem protector, it also has any potential of its chemical content. The study of mangrove’s bioactive compound is important to generate a new therapeutic agent. This study aims to obtain chemical compounds that have cytotoxic activity, reveal the chemical formula and molecular structure of that active compound, and determine the cytotoxic activity level of active compound from perepat (Sonneratia alba) root extract. The extract was isolated and purified using Liquid Vacuum Chromatography, Graphitation Column Chromatography, and Thin Layer Chromatography. The isolate was characterized using FT-IR spectrophotometry. Our result found that it corresponds to the β-sitosterol compound group with a high similarly chromophore. Furthermore, both of the extract and isolate was tested for toxicity activity using the Brine Shrimp Lethality Test (BSLT) method using Artemia salina shrimp larvae. Herein, we reported that acetone isolated extract possesses lower cell death average 100% (start 200 μg/ml) than isolate extract 80% (50μg/ml). Furthermore the toxicity of total extract has LC50 23,98 (μg/ml), while Isolate 10,04 (μg/ml). From the LC50 value, it can be concluded that the toxicity of the extract lower than the isolate, and both were classified as very toxic compounds, and very potential to be developed into anti-cancer drug compounds.
Ethanolic Extract of Xestospongia Sp. Induces CD4+ and CD14 Cells Levels on Wistar Male Rat Infected with Staphylococcus aureus Adryan Fristiohady; Wahyuni Wahyuni; Muhammad H Malaka; Dewiyanti Madu; Dayatriana Muthalib; Dian Munasari; La Ode MJ Purnama; Baru Sadarun; Muhammad Ilyas; Idin Sahidin
Pharmacology and Clinical Pharmacy Research Vol 5, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v5i2.26986

Abstract

Immunomodulator is a substance that increases or suppresses the immune response through the certain mechanism. The marine sponge Xestospongia sp. has immunomodulatory activity by increasing phagocytic activity. In addition, the phagocytic activity is affected by CD4+ and CD14 cells levels. Thus, this study aims to investigate the effect of Xestopongia sp. extract toward CD4+ and CD14 cells level in model rat. Animals were divided into 4 groups (n=5) and treated for 7 days, as follow: Group I (Ethanolic extract of Xestospongia sp. dose of 300 mg/KgBW); Group II (Ethanolic extract of Xestospongia sp. dose of 400 mg/KgBW); Group III (Phylantus niruri extract); and Group IV (0.5% Na CMC). On day 8, animals were infected with Staphylococcus aureus intraperitoneally. And the blood was collected by cardiac puncture and assayed with ELISA kit CD4 (elabscience®) and ELISA kit CD14 (elabscience®). Ethanolic extract of Xestospongia sp. provided high levels of both CD4+ and CD14 cells (Group II) compared to baseline (Group IV)  (p<0.05). Group I provided similar activity to group III (p>0.05) and Group II provided significant activity with higher levels of CD4+ and CD14 cells compared to group III (p<0.05). In conclusion, both doses of Xestospongia sp. extract provide activity as immunomodulator by increasing CD4+ and CD14 cells levels, yet dose of 400 mg/KgBw provides the higher immunomodulatory activity.
Effects of Insulin against Aluminium Induced Neurotoxicity in Wistar Rats Amir Alam; Garima Bansal
Pharmacology and Clinical Pharmacy Research Vol 5, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v5i2.28096

Abstract

Aluminium toxicity is well known to cause neurotoxicity leading to Alzheimer disease with dementia. The aim of the present study is to evaluate the effects of Insulin in Aluminium induced neurotoxicity. Thirty male wistar rats randomized into three groups (group V, C, T) of ten each were used for the study after obtaining institutional animal ethics committee approval. Chronic aluminium neurotoxicity was induced in the rats and the neurobehavior was evaluated using Morris water maze test, elevated plus maze test and rotarod test using standard methodologies. Group C rats exhibited significant deviation in performance of behavioural test of the study during day 1 (Morris water maze test- 18.6±9.5, elevated plus maze test- 34.9±1.9, rotarod test- 118.6±15.2) and day 30 (Morris water maze test- 64.5±4.6, elevated plus maze test- 72.1±3.9, rotarod test- 110.7±9.3). Rats of group T showed decrease in behavioural changes induced by aluminium toxicity (P value: Morris water maze test-0.0002, elevated plus maze test- 0.0007 and rotarod test- 0.015). Insulin may play a role in neuroprotection against toxicity similar to that of aluminium induced neurotoxicity.
Prescription Patterns of Antituberculosis Drugs in Treatment of Tuberculosis at a Tertiary Care Hospital in Andgra Pradesh, a Cross-Sectional Study Krishnakanth K; Chakrapani Cheekavolu; Poojala Kumar; Ravi Shankar K; Jagadeesh A
Pharmacology and Clinical Pharmacy Research Vol 5, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v5i2.29224

Abstract

The success of tuberculosis treatment is based upon the prescription pattern following Revised National Tuberculosis Control Program/National Tuberculosis Elimination Program/World Health Organization guidelines, reflecting the burden of the disease which is increasing yearly. This implicates the variations in prescriptions advised in the treatment of tuberculosis. The present study was aimed to evaluate the prescription patterns of tuberculosis treatment in a tertiary hospital at Andhra Pradesh, India. Ninety-two patients were included in the study after obtaining ethical approval and informed consent. The prescription patterns were evaluated and compared to the standard guidelines. The mean age of the patients was 38.72 and showed male preponderance. Six regimens were used during the treatment. The patients showed good recovery which concludes that following the standard prescription pattern provides a good success rate in the treatment of tuberculosis.

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