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Pharmacology and Clinical Pharmacy Research
Published by Universitas Padjadjaran
ISSN : 25277332     EISSN : 26140020     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Pharmacology and Clinical Pharmacy Research (PCPR) is an international, peer-reviewed journal, publishing original research, review, case reports, and commentaries on all aspects of pharmacology and clinical pharmacy. The journal aims to contribute to the scientific committee by publishing the high quality articles. It is published 3 times a year to provide a forum for pharmacologists, pharmacists, and other healthcare professionals to share best practice, encouraging networking, and a more collaborative approach in pharmacology and clinical pharmacy.
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Articles 7 Documents
 1 
Search results for , issue "Vol 8, No 3 (2023)" : 7 Documents clear
Off-Label Drug Use in Acute Respiration Infection Patient at Pangandaran Hospital, Pangandaran District, West Java - Indonesia Rahayuningsih, Nur; Priatna, Muharam; Sulistiani, Dewi A.
Pharmacology and Clinical Pharmacy Research Vol 8, No 3 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i3.48103

Abstract

Acute respiratory infections (ARIs) are infectious diseases of the upper or lower respiratory tract that cause a spectrum of illnesses from mild to severe infections. ARI is one of the leading causes of death in children in developing countries. The high incidence of ARI in children results in the use of off-label drugs. Off-label medicine is the use of drugs outside the provisions of the license relating to dose, age, route of administration, contraindications. This study aims to determine the use of off-label drugs in children with a diagnosis of ARI at Pandega Pangandaran Hospital, Pangandaran District, West Java - Indonesia. This study was an observational study with a cross sectional design and data collection was done retrospectively using Chi-square data analysis with a significance level of 0.05. Of the 84 patients who fit the inclusion criteria, there was an off-label drug use of 16.01% with the categories of off-label age (11.16%), off-label dose (4.37%), and off-label indication (0.48%) while in the category of route of administration and contraindications no off-label drug use was found. The most common type of off-label drug used was cetirizine antihistamine.  Based on the results, pharmacist’s supervision related to the risk of drug use is strongly recommended.
Analysis of Potentially Inappropriate Prescriptions (PIP) Based on STOPP/START Criteria in Geriatric Patients with Cardiovascular Disorders at Hasan Sadikin Hospital, Bandung, West Java, Indonesia Fathurrahmi, Fathurrahmi; Wilar, Gofarana; Levita, Jutti; Winarni, Rina
Pharmacology and Clinical Pharmacy Research Vol 8, No 3 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i3.50436

Abstract

The geriatric population in Indonesia is increasing rapidly every year. The large number of drugs consumed by geriatric patients results in potentially inappropriate prescriptions (PIP) in the form of mis-prescribing drugs (potentially inappropriate medicines or PIM) and under-prescribing drugs (potentially prescription omission or PPO). In Indonesia, especially in Bandung, there is limited research on PIP in geriatric patients with cardiovascular disorders (CVDs). This study aims to identify PIP and factors that influence PIM and PPO based on STOPP/START criteria and the relationship between the incidence of PIM and kidney function in geriatric inpatients with CVDs at Hasan Sadikin Hospital, Bandung, West Java, Indonesia. The present retrospective study was cross-sectionally conducted from January to December 2022. The Chi-square tests were carried out to determine factors that were significantly related to PIM and PPO. Of the 192 patients, 33.4% patients experienced PIM with the most being NSAIDs with eGFR <30 mL/min/1.73 m2 (36%). As many as 35% of patients experienced PPO with the most frequent PPO not being given angiotensin-converting enzyme inhibitor (ACEi) in patients with systolic heart failure (41.8%). Factors that were significantly associated with PIM were comorbid kidney dysfunctions (OR 5; 95% CI: 2.367-10.342), and no factors were found that were significantly associated with PPO. Taking everything into consideration, it was found that PIM and PPO were common in hospitalized geriatric patients with CVDs. Kidney dysfunctions are a risk factor for PIM. These findings suggest that it is important to evaluate prescribing for geriatric patients during hospitalization using STOPP/START criteria to reduce the prevalence of PIP
The Effect of Ashitaba (Angelica keiskei (Miq.) Koidz.)) Sap on the Total Cholesterol Levels of Cisplatin-Induced Wistar Rats Wahyuni, Ika; Aulifa, Diah L.; Rosdianto, Aziiz M.; Levita, Jutti
Pharmacology and Clinical Pharmacy Research Vol 8, No 3 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i3.51827

Abstract

Cisplatin is a platinum-based anticancer drug that, in long-term use, causes nephrotoxicity due to oxidative stress and increases total cholesterol and triglycerides in animal models. Angelica keiskei (Miq.) Koidz., (A. keiskei) or Japanese celery ashitaba, has been reported for its antioxidant and nephroprotective activity. This study aims to determine the activity of A. keiskei sap on total cholesterol levels of cisplatin-induced Wistar rats. The sap of A. keiskeiwas freeze-dried until a yield of 3.62% w/v was obtained. The fat content in A. keiskei sap powder was obtained at 7.36%. A total of 60 g of A. keiskei sap powder was macerated with 96% ethanol solvent (1:10) for 5 x 24 h until the ethanol extract of A. keiskei sap (ASEE) of 82.08% w/w was obtained. The pharmacology activity was conducted on male Wistar rats, which were divided into 5 groups, namely normal (treated with CMC Na 0.3%), negative (nephrotoxicity induced with cisplatin 5 mg/kg BW), positive (nephrotoxicity induced with cisplatin 5 mg/kg BW and treated with quercetin 20 mg/kg BW), and two test groups which were nephrotoxicity induced with cisplatin 5 mg/kg body weight and treated with ASEE 1000 mg/kg BW, and ASEE 1500 mg/ kg BW. It was found that neither dose of ASEE altered the total cholesterol levels in cisplatin-induced male Wistar rats and could maintain the cholesterol levels in the normal range.
Cost-Effectiveness Analysis of Favipiravir and Remdesivir as COVID-19 Treatment in South Tangerang, Banten Province - Indonesia Putro, Wahyu G.; Fahriyati, Andriani R.; Julian, Gilberto A.; Amalia, Tania R.; Riski, Zaki M.
Pharmacology and Clinical Pharmacy Research Vol 8, No 3 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i3.50046

Abstract

COVID-19 is a contagious ailment primarily attributed to the severe acute respiratory syndrome coronavirus. Indonesia persists in confronting the COVID-19 pandemic, and South Tangerang City has emerged as one of the municipalities in Indonesia that has been significantly affected. There are two categories of medications employed for COVID-19 treatment according to government policies, namely favipiravir and remdesivir. This study aims to as- sess the cost-effectiveness of favipiravir and remdesivir medications at the South Tangerang General Hospital, Indonesia. The present study employs a retrospective research design characterized by a quantitative approach, utilizing cross-sectional methodologies. The analy- sis mostly consists of descriptive techniques. The sample consisted of 479 individuals, with 246 individuals receiving outpatient treatment and 233 undergoing inpatient treatment. The inclusion criteria for this study consisted of individuals diagnosed with COVID-19 who had tested positive for the antiviral medications favipiravir and remdesivir. The findings indicated that the Average Cost-Effectivenss Ratio (ACER) for inpatients treated with fa- vipiravir was IDR 2,354,319,859, but for those treated with remdesivir, it amounted to IDR 3,501,513,488. Regarding the outpatient population utilizing favipiravir, the total expendi- ture amounts to IDR 420,083,118. Similarly, patients utilizing remdesivir incur a total ex- penditure of IDR 797,282,432. It is worth noting that the Cost-Effectivenss Ratio (CER) for patients using favipiravir is IDR 1,545,621, whereas patients using remdesivir have a CER of IDR 2,309,705. This study makes a valuable contribution to the existing body of research by demonstrating the cost-effectiveness of favipiravir. Consequently, future studies inves- tigating the overall effectiveness of favipiravir in COVID-19 patients must employ more comprehensive criteria.
Lacked of Breast Cancer Awareness of Indonesian Rural Women: A Descriptive Study to Adult Women in District Pangandaran, Indonesia Alfarafisa, Nayla M.; Bashari, Muhammad H.; Usman, Hermin A.; Nurcahyani, Arima KSD; Pramesti, Defi A.; Azizah, Dika WN.; Yuliani, Lala; Rakhman, Putri HA.; Huda, Fathul
Pharmacology and Clinical Pharmacy Research Vol 8, No 3 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i3.53586

Abstract

Breast cancer remains a significant global health challenge, particularly in low and middle-income countries like Indonesia. Patients with advanced metastatic breast cancer have a dismal prognosis. A cancer promotion program’s failure can be attributed to low awareness of breast cancer. This descriptive study aimed to evaluate breast cancer awareness among adult women in District Pangandaran, Indonesia. Data was gathered in July 2018 from 189 individuals using a verified Breast Cancer Awareness Measure instrument developed by Cancer Research UK. Results revealed a concerning lack of awareness among participants regarding various breast cancer risk factors, symptoms, and screening practices. Additionally, reluctance to seek medical help due to fear of diagnosis was observed, particularly among housewives without health insurance. These findings highlight the urgent need for comprehensive health programs to enhance breast cancer awareness and promote early detection strategies tailored to the Indonesian population, especially in rural areas. Healthcare providers and public health workers play a vital role in this effort, along with implementing innovative health promotion policies by the government to improve cancer prevention programs.
Assessment of Drug Adherence and Adverse Effects of Disease-Modifying Antirheumatic Drugs (DMARDs) in Patients of Rheumatoid Arthritis Attending a Tertiary Care Hospital in India Patel, Tejal C.; Pandit, Prasad R.; Doshi, Zankrut R.; Londhe, Vikram A.
Pharmacology and Clinical Pharmacy Research Vol 8, No 3 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i3.39664

Abstract

Adherence to drug treatment is one of the key factors in treating chronic diseases like rheumatoid arthritis (RA) to maintain remission and prevent functional disability. Poor medication adherence is directly associated with a worse prognosis and an increase in healthcare utilization, adding to a financial burden. Hence, the present study was proposed to assess drug adherence in diagnosed patients of RA attending a tertiary care hospital. The study was initiated after obtaining institutional ethics committee permission, and written informed consent was requested from all the eligible patients before their enrolment. This cross-sectional questionnaire based study was conducted on RA patients attending the rheumatology outpatient department. The patient’s adherence to the drugs prescribed was assessed using the 19-item Compliance Questionnaire Rheumatology (CQR), and the correlation betweendrug adherencewithvariousdemographic,disease,andmedication-relatedvariableswasstudied. After screening 103 patients, 75 patients fulfilling the selection criteria were enrolled, and theirdatawasanalyzed. The adherence measured using the CQR score was in therange of 54.39% to 68.42%, with a mean CQR score of 62.27 ± 2.76.Anegative correlation was found between the CQR score and the number of ADRs (r=-0.12,p>0.05) and age (r=-0.06, p>0.05). A positive correlation was found between the CQR score and variables like sex, education, and number of medications, but none were statistically significant. Unsatisfactory compliance was evident in the present study. Therefore, integrating drug treatment with strategies to improve patient adherence may improve clinical outcomes and quality of life, reducing healthcare costs.
FABP4 and Metabolite Profile in Lipopolysaccharide-Induced Mice Model Treated with Moringa oleifera Ethanol Leaf Extract Hanifah, Cenia P.; Sulistiyorini, Ifa; Sumirat, Vanessa A.; Anggraeni, Neni; Putri, Mirasari; Ghozali, Mohammad; Syamsunarno, Mas Rizky A.A
Pharmacology and Clinical Pharmacy Research Vol 8, No 3 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i3.50860

Abstract

Sepsis, a life-threatening organ dysfunction resulting from a dysregulated host response to infection, induces changes in blood cells and metabolic alterations. Fatty acid binding protein 4 (FABP4), a lipid chaperone predominantly expressed in adipose tissue, is modulated in sepsis and may contribute to metabolic and immunologic changes. Moringa oleifera (M. oleifera) leaf extract (MOLE) is known to modulate immune system activity, but its potential for treating acute inflammatory conditions like sepsis remains unclear. This study investigates the ability of MOLE to modulate metabolite and hematological profiles in lipopolysaccharide (LPS)-induced sepsis in mice. Thirty-five male Swiss Webster mice (Mus musculus) were divided into five groups, including healthy control pre-treated with 0.5% carboxymethyl cellulose (CMC), an LPS-induced negative control, an LPS-induced positive control treated with dexamethasone (DMX) 7mg/KgBW/day and two MOLE treatment groups with doses of 5.6 and 11.2 mg/20 gBW. Mice received MOLE pre-treatment for three days before LPS induction. Three hours post-LPS injection, the LPS-induced group exhibited leukopenia (1.4 [0.9-2.5] x109 cells/L) and a 68.3% increase in triglyceride levels. However, the MOLE-treated group showed improved erythrocyte levels compared to the positive control group; [(9.9(9.3-10.0) x1012 cell/L) vs (7.7(7.0-9.0) x1012 cells/L), p<0.05]. The study suggests that MOLE administration may positively impact sepsis conditions, particularly by enhancing RBC levels. Further research with an extended observation period is recommended to address limitations in metabolite level assessment.  

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